EA200802335A1 - Способ получения и поверхностного покрытия гранул - Google Patents
Способ получения и поверхностного покрытия гранулInfo
- Publication number
- EA200802335A1 EA200802335A1 EA200802335A EA200802335A EA200802335A1 EA 200802335 A1 EA200802335 A1 EA 200802335A1 EA 200802335 A EA200802335 A EA 200802335A EA 200802335 A EA200802335 A EA 200802335A EA 200802335 A1 EA200802335 A1 EA 200802335A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- powder mixture
- particle size
- granules
- obtaining
- surface coating
- Prior art date
Links
- 239000008187 granular material Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000011248 coating agent Substances 0.000 title abstract 2
- 238000000576 coating method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 4
- 239000002245 particle Substances 0.000 abstract 3
- 239000000843 powder Substances 0.000 abstract 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 238000013270 controlled release Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 229940095686 granule product Drugs 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 235000011164 potassium chloride Nutrition 0.000 abstract 1
- 239000001103 potassium chloride Substances 0.000 abstract 1
- 238000005563 spheronization Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
Настоящее изобретение относится к способу получения гранулированной массы, где предварительную смесь, которая содержит один или более фармацевтически активных ингредиентов, гомогенизируют с получением исходной порошковой смеси; на указанную порошковую смесь распыляют гранулирующую жидкость; полученные таким образом частицы подвергают сферонизации, сушке и фракционированию, где исходную или частично гранулированную порошковую смесь смешивают с затравочными гранулами идентичного или практически идентичного состава, но с меньшим средним размером частиц по сравнению с размером частиц фракции желаемого продукта гранул. На гранулы, содержащие хлорид калия в качестве активного ингредиента, полученные вышеупомянутым способом или способом, известным при существующем уровне техники, можно наносить покрытие, обеспечивающее контролируемое высвобождение, в аппарате с колеблющимся слоем, имеющем неперфорированные стенки.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0600424A HU0600424D0 (en) | 2006-05-19 | 2006-05-19 | Process for producing and coating pellets of high potassium chloride |
| HU0700343A HUP0700343A3 (en) | 2007-05-15 | 2007-05-15 | Process for producing pellets and process for coating said pellets with surface layer |
| PCT/HU2007/000043 WO2007135470A1 (en) | 2006-05-19 | 2007-05-18 | Process for the preparation and surface coating of pellets |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200802335A1 true EA200802335A1 (ru) | 2009-06-30 |
| EA014262B1 EA014262B1 (ru) | 2010-10-29 |
Family
ID=89987517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200802335A EA014262B1 (ru) | 2006-05-19 | 2007-05-18 | Способ получения гранулированной массы |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2023903B1 (ru) |
| EA (1) | EA014262B1 (ru) |
| WO (1) | WO2007135470A1 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120201893A1 (en) | 2009-07-17 | 2012-08-09 | Bayer Pharma Aktiengesellschaft | Pellets Formulation |
| RU2702690C2 (ru) * | 2015-08-13 | 2019-10-09 | БИОЛИНГУС АйПи ЛЛСи | Способ получения продуктов, содержащих стабилизированные активные вещества, и композиций, содержащих таковые |
| US20210161820A1 (en) * | 2018-04-12 | 2021-06-03 | Sunsho Pharmaceutical Co., Ltd. | Granulation composition |
| CN110354092A (zh) * | 2019-07-24 | 2019-10-22 | 广州誉东健康制药有限公司 | 一种利用骨架和薄膜控制的氯化钾缓释片制作方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU221435B (en) * | 1998-02-20 | 2002-10-28 | Egyt Gyogyszervegyeszeti Gyar | Pellet-based pharmaceutical composition of controlled release with high content of potassium-chloride, and process for it's production |
| HUP0303382A2 (hu) * | 2003-10-10 | 2005-08-29 | EGIS Gyógyszergyár Rt. | Venlafaxin-hidroklorid-tartalmú pelletek |
-
2007
- 2007-05-18 WO PCT/HU2007/000043 patent/WO2007135470A1/en active Application Filing
- 2007-05-18 EA EA200802335A patent/EA014262B1/ru not_active IP Right Cessation
- 2007-05-18 EP EP07733860.6A patent/EP2023903B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA014262B1 (ru) | 2010-10-29 |
| EP2023903A1 (en) | 2009-02-18 |
| WO2007135470A8 (en) | 2009-05-14 |
| WO2007135470A1 (en) | 2007-11-29 |
| EP2023903B1 (en) | 2014-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |