EA200800706A1 - Способ приготовления кандесартана цилексетила - Google Patents

Способ приготовления кандесартана цилексетила

Info

Publication number
EA200800706A1
EA200800706A1 EA200800706A EA200800706A EA200800706A1 EA 200800706 A1 EA200800706 A1 EA 200800706A1 EA 200800706 A EA200800706 A EA 200800706A EA 200800706 A EA200800706 A EA 200800706A EA 200800706 A1 EA200800706 A1 EA 200800706A1
Authority
EA
Eurasian Patent Office
Prior art keywords
kandesartana
cylexethyl
preparing
candesartan
hypertension
Prior art date
Application number
EA200800706A
Other languages
English (en)
Other versions
EA015727B1 (ru
Inventor
Силво Зупанциц
Original Assignee
КРКА, д.д., НОВО МЕСТО
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SI200500283A external-priority patent/SI22126A/sl
Application filed by КРКА, д.д., НОВО МЕСТО filed Critical КРКА, д.д., НОВО МЕСТО
Publication of EA200800706A1 publication Critical patent/EA200800706A1/ru
Publication of EA015727B1 publication Critical patent/EA015727B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Согласно настоящему изобретению предложен улучшенный способ синтеза для производства кандесартана, а также его фармацевтически приемлемых солей и сложных эфиров в качестве активных ингредиентов лекарственного средства для лечения гипертензии и связанных с ней заболеваний и болезненных состояний, который включает снятие защитной группы с тетразолила в органическом растворителе в присутствии кислоты Льюиса.
EA200800706A 2005-10-07 2006-09-29 Способ получения кандесартана цилексетила EA015727B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI200500283A SI22126A (sl) 2005-10-07 2005-10-07 Postopek za pripravo kandesartan cileksetila
SI200600041A SI22127A (sl) 2005-10-07 2006-03-03 Postopek za pripravo kandesartan cileksetila
PCT/EP2006/009489 WO2007042161A1 (en) 2005-10-07 2006-09-29 Process for the preparation of candesartan cilexetil

Publications (2)

Publication Number Publication Date
EA200800706A1 true EA200800706A1 (ru) 2008-08-29
EA015727B1 EA015727B1 (ru) 2011-10-31

Family

ID=37311160

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800706A EA015727B1 (ru) 2005-10-07 2006-09-29 Способ получения кандесартана цилексетила

Country Status (7)

Country Link
US (3) US7884212B2 (ru)
EP (1) EP1945629B1 (ru)
AT (1) ATE543812T1 (ru)
EA (1) EA015727B1 (ru)
NO (1) NO20082140L (ru)
SI (2) SI22127A (ru)
WO (1) WO2007042161A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR053517A1 (es) 2005-06-06 2007-05-09 Medichem Sa Proceso para la preparacion de compuestos de tetrazolilo, uso de los mismos en el tratamiento de enfermedades circulatorias y formulaciones farmaceuticas que los contienen.
EP2365966A4 (en) * 2008-12-12 2012-05-09 Pharmacostech Co Ltd PROCESS FOR REMOVING THE TRIPHENYLMETHANE GRIP
WO2011080684A1 (en) 2009-12-31 2011-07-07 Ranbaxy Laboratories Limited Process for the preparation of candesartan cilexetil
WO2011092666A1 (en) 2010-01-29 2011-08-04 Ranbaxy Laboratories Limited An improved process for the preparation of candesartan cilexetil, polymorphic forms of n-trityl candesartan and their uses thereof
WO2011145100A1 (en) * 2010-05-20 2011-11-24 Hetero Research Foundation Process for preparation of candesart an cilexetil substantially free of des-candesartan cilexetil impurity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
EP0668272B1 (en) 1994-01-28 2000-07-12 Takeda Chemical Industries, Ltd. A process for the production of tetrazolyl compounds
DE602004029373D1 (de) 2003-08-27 2010-11-11 Zentiva Ks Verfahren zur entfernung der triphenylmethanschutzgruppe
ATE357442T1 (de) 2003-10-16 2007-04-15 Teva Pharma Verfahren zur herstellung von candesartan cilexetil
WO2005051928A1 (en) 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Process for production of tetrazolyl compounds
AR053517A1 (es) 2005-06-06 2007-05-09 Medichem Sa Proceso para la preparacion de compuestos de tetrazolilo, uso de los mismos en el tratamiento de enfermedades circulatorias y formulaciones farmaceuticas que los contienen.

Also Published As

Publication number Publication date
EA015727B1 (ru) 2011-10-31
US20090318706A1 (en) 2009-12-24
EP1945629B1 (en) 2012-02-01
WO2007042161A1 (en) 2007-04-19
US20120029201A1 (en) 2012-02-02
ATE543812T1 (de) 2012-02-15
NO20082140L (no) 2008-06-16
SI1945629T1 (sl) 2012-03-30
SI22127A (sl) 2007-04-30
EP1945629A1 (en) 2008-07-23
US7884212B2 (en) 2011-02-08
US20100197933A1 (en) 2010-08-05

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU