WO2010068810A3 - Certain substituted amides, method of making, and method of use thereof - Google Patents

Certain substituted amides, method of making, and method of use thereof Download PDF

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Publication number
WO2010068810A3
WO2010068810A3 PCT/US2009/067575 US2009067575W WO2010068810A3 WO 2010068810 A3 WO2010068810 A3 WO 2010068810A3 US 2009067575 W US2009067575 W US 2009067575W WO 2010068810 A3 WO2010068810 A3 WO 2010068810A3
Authority
WO
WIPO (PCT)
Prior art keywords
making
btk
substituted amides
certain substituted
formula
Prior art date
Application number
PCT/US2009/067575
Other languages
French (fr)
Other versions
WO2010068810A2 (en
Inventor
Peter A. Blomgren
Kevin S. Currie
Scott A. Mitchell
David R. Brittelli
Aaron C. Schmitt
Jr. Antonio J. Barbosa
Original Assignee
Cgi Pharmaceuticals, Inc.
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cgi Pharmaceuticals, Inc., Genentech, Inc. filed Critical Cgi Pharmaceuticals, Inc.
Publication of WO2010068810A2 publication Critical patent/WO2010068810A2/en
Publication of WO2010068810A3 publication Critical patent/WO2010068810A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Abstract

Compounds of Formula (I) that inhibit Btk are described herein. Pharmaceutical compositions comprising at least one compound of Formula (I), together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and / or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.
PCT/US2009/067575 2008-12-10 2009-12-10 Certain substituted amides, method of making, and method of use thereof WO2010068810A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12140308P 2008-12-10 2008-12-10
US61/121,403 2008-12-10

Publications (2)

Publication Number Publication Date
WO2010068810A2 WO2010068810A2 (en) 2010-06-17
WO2010068810A3 true WO2010068810A3 (en) 2011-02-10

Family

ID=41559565

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/067575 WO2010068810A2 (en) 2008-12-10 2009-12-10 Certain substituted amides, method of making, and method of use thereof

Country Status (1)

Country Link
WO (1) WO2010068810A2 (en)

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ES2552514T3 (en) * 2011-11-03 2015-11-30 Hoffmann-La Roche Ag Bicyclic Piperazine Compounds
US9365566B2 (en) 2012-03-27 2016-06-14 Takeda Pharmaceutical Company Limited Cinnoline derivatives
JP6182593B2 (en) 2012-04-20 2017-08-16 アドヴィーナス セラピューティクス リミテッド Substituted heterobicyclic compounds, compositions and medicaments and uses thereof
WO2013157021A1 (en) 2012-04-20 2013-10-24 Advinus Therapeutics Limited Bicyclic compounds, compositions and medicinal applications thereof
TW201414737A (en) * 2012-07-13 2014-04-16 必治妥美雅史谷比公司 Imidazotriazinecarbonitriles useful as kinase inhibitors
JP6575950B2 (en) 2012-07-24 2019-09-18 ファーマサイクリックス エルエルシー Mutations with resistance to Bruton tyrosine kinase (Btk) inhibitors
JO3377B1 (en) 2013-03-11 2019-03-13 Takeda Pharmaceuticals Co Pyridinyl and fused pyridinyl triazolone derivatives
ES2619125T3 (en) 2013-04-25 2017-06-23 Beigene, Ltd. Heterocyclic compounds fused as protein kinase inhibitors
JP6623353B2 (en) 2013-09-13 2019-12-25 ベイジーン スウィッツァーランド ゲーエムベーハー Anti-PD-1 antibodies and their use for therapy and diagnosis
WO2015157955A1 (en) 2014-04-17 2015-10-22 Abbvie Inc. Heterocyclic btk inhibit ors
JP6526189B2 (en) 2014-07-03 2019-06-05 ベイジーン リミテッド Anti-PD-L1 antibodies and their use for therapy and diagnosis
EP3042903B1 (en) 2015-01-06 2019-08-14 Impetis Biosciences Ltd. Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof
WO2016165831A1 (en) 2015-04-17 2016-10-20 Curevac Ag Lyophilization of rna
EP3297682B1 (en) 2015-05-20 2021-07-14 CureVac AG Dry powder composition comprising long-chain rna
WO2016184575A1 (en) 2015-05-20 2016-11-24 Curevac Ag Dry powder composition comprising long-chain rna
AU2017240609B2 (en) 2016-03-31 2021-07-15 Takeda Pharmaceutical Company Limited Isoquinolinyl triazolone complexes
CN109475536B (en) 2016-07-05 2022-05-27 百济神州有限公司 Combination of a PD-l antagonist and a RAF inhibitor for the treatment of cancer
CN109563099B (en) 2016-08-16 2023-02-03 百济神州有限公司 Crystal form of compound, preparation and application thereof
AU2017313085A1 (en) 2016-08-19 2019-03-14 Beigene Switzerland Gmbh Use of a combination comprising a Btk inhibitor for treating cancers
JP2019529419A (en) 2016-09-19 2019-10-17 エムイーアイ ファーマ，インク． Combination therapy
CN110461847B (en) 2017-01-25 2022-06-07 百济神州有限公司 Crystalline forms of (S) -7- (1- (but-2-alkynoyl) piperidin-4-yl) -2- (4-phenoxyphenyl) -4,5,6, 7-tetrahydropyrazolo [1,5-a ] pyrimidine-3-carboxamide, preparation and use thereof
CA3066518A1 (en) 2017-06-26 2019-01-03 Beigene, Ltd. Immunotherapy for hepatocellular carcinoma
CN110997677A (en) 2017-08-12 2020-04-10 百济神州有限公司 Btk inhibitors with improved dual selectivity
WO2019108795A1 (en) 2017-11-29 2019-06-06 Beigene Switzerland Gmbh Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors
CN111825675B (en) * 2019-04-15 2023-08-01 武汉朗来科技发展有限公司 ROCK inhibitor and preparation method and application thereof
WO2022140246A1 (en) 2020-12-21 2022-06-30 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
US11786531B1 (en) 2022-06-08 2023-10-17 Beigene Switzerland Gmbh Methods of treating B-cell proliferative disorder

Citations (2)

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WO2007038314A2 (en) * 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
WO2008116064A2 (en) * 2007-03-21 2008-09-25 Bristol-Myers Squibb Company Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0608252A2 (en) 2005-03-10 2010-04-06 Cgi Pharmaceuticals Inc chemical entities, pharmaceutical compositions comprising them, methods using said chemical entities and use of said chemical entities

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007038314A2 (en) * 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
WO2008116064A2 (en) * 2007-03-21 2008-09-25 Bristol-Myers Squibb Company Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FAUCI, A.S.; BRAUNWALD, E.; ISSELBACHER, K.J.; WILSON, J.D.; MARTIN, J.>B.; KASPER, D.L.; HAUSER, S.L.; LONGO, D.L.: "Harrison's Principles of Internal Medicine", 1998, MCGRAW-HILL, ISBN: 0070202915, XP002566174, 1 *

Also Published As

Publication number Publication date
WO2010068810A2 (en) 2010-06-17

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