EA200800279A1 - Модифицированные полипропилениминовые дендримеры и их применение в качестве трансфицирующих агентов для доставки анионных биологически активных веществ - Google Patents

Модифицированные полипропилениминовые дендримеры и их применение в качестве трансфицирующих агентов для доставки анионных биологически активных веществ

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Publication number
EA200800279A1
EA200800279A1 EA200800279A EA200800279A EA200800279A1 EA 200800279 A1 EA200800279 A1 EA 200800279A1 EA 200800279 A EA200800279 A EA 200800279A EA 200800279 A EA200800279 A EA 200800279A EA 200800279 A1 EA200800279 A1 EA 200800279A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dendr
dab
dendrimers
nhcoph
nhcoch
Prior art date
Application number
EA200800279A
Other languages
English (en)
Other versions
EA014327B1 (ru
Inventor
Фредерик Так
Хенрикус Мария Янссен
Эгберт Виллем Мейер
Мишель Мари Франсуа Жанико
Маркус Эли Брюстер
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200800279A1 publication Critical patent/EA200800279A1/ru
Publication of EA014327B1 publication Critical patent/EA014327B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/50—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • C08G83/004—After treatment of dendrimers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к модифицированным полипропилениминовым дендримерам, содержащим катионные внутренние аммониевые группы и внешние нетоксичные концевые группы; к фармацевтическим композициям, содержащим указанные дендримеры; к способам получения указанных дендримеров и к их применению в качестве агентов для переноса анионных биологически активных терапевтических средств, и в генотерапии, а в частности, для лечения рака. Указанный модифицированный полипропилениминовый дендример 1, 2, 3, 4 или 5 генерации, а также неполные дендримеры и их смеси, содержащие внешние концевые группы и внутренние аминогруппы, отличаются тем, что в них: а) по существу, все внешние концевые группы представляют собой группы формулы (I), где R представляет собой радикал, выбранный из группы, состоящей из Cалкила, полиэтиленгликолевого радикала и полиэтиленгликоль-галлильного радикала, и (b) по существу, все внутренние аминогруппы представляют собой четвертичные катионные аммониевые группы. Наиболее предпочтительными являются кватернизированные соединения: DAB-dendr- (NHCOCH), DAB-dendr-(NHCOCH), DAB-dendr-(NHCOCH), DAB-dendr-(NHCOCH), DAB-dendr-(NHCOCH), DAB-dendr-(NHCOPh((ЕО)OMe)), DAB-dendr-(NHCOPh((ЕО)OMe)), DAB-dendr-(NHCOPh((ЕО)OMe)), DAB-dendr-(NHCOPh((ЕО)OMe))и DAB-dendr-(NHCOPh((ЕО)OMe)).
EA200800279A 2005-07-08 2006-07-05 Модифицированные полипропилениминовые дендримеры, содержащая их фармацевтическая композиция и их применение для лечения злокачественных опухолей EA014327B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05106266 2005-07-08
PCT/EP2006/063888 WO2007006700A1 (en) 2005-07-08 2006-07-05 Modified poly(propylene-imine) dendrimers and their use as transfection agents for anionic bioactive factors

Publications (2)

Publication Number Publication Date
EA200800279A1 true EA200800279A1 (ru) 2008-04-28
EA014327B1 EA014327B1 (ru) 2010-10-29

Family

ID=35735139

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800279A EA014327B1 (ru) 2005-07-08 2006-07-05 Модифицированные полипропилениминовые дендримеры, содержащая их фармацевтическая композиция и их применение для лечения злокачественных опухолей

Country Status (8)

Country Link
US (1) US20100298403A1 (ru)
EP (1) EP1904436A1 (ru)
JP (1) JP2009501245A (ru)
CN (1) CN101218204A (ru)
AU (1) AU2006268736B2 (ru)
CA (1) CA2612211A1 (ru)
EA (1) EA014327B1 (ru)
WO (1) WO2007006700A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2906806B1 (fr) * 2006-10-09 2012-12-14 Centre Nat Rech Scient Complexes chelates dendritiques, leurs procedes de fabrication et compositions pharmaceutiques les contenant
WO2009004639A1 (en) * 2007-07-04 2009-01-08 Indian Institute Of Science A dendritic macromolecule and a process thereof
CN101492900B (zh) * 2009-01-12 2010-12-01 山东轻工业学院 阳离子树枝状大分子造纸助留助滤剂及其制备方法与应用
WO2012024396A2 (en) * 2010-08-17 2012-02-23 Rutgers, The State University Of New Jersey Compositions and methods for delivering nucleic acid molecules and treating cancer
CN101974154B (zh) * 2010-11-10 2012-07-25 中国科学院长春应用化学研究所 一种改性聚乙烯亚胺及其制备方法
AU2012242455A1 (en) 2011-04-15 2013-11-28 Molecular Transfer, Inc. Agents for improved delivery of nucleic acids to eukaryotic cells
EP4085930A1 (en) 2012-10-05 2022-11-09 BioNTech Delivery Technologies GmbH Hydroxylated polyamine derivatives as transfection reagents for rna
ES2902839T3 (es) * 2012-10-08 2022-03-30 Biontech Delivery Tech Gmbh Derivados de poliaminas carboxiladas como reactivos de transfección

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9504664A (es) * 1994-03-07 1997-05-31 Dow Chemical Co Conjugados de dendrimeros bioactivos y/o dirigidos.
AUPP584298A0 (en) * 1998-09-14 1998-10-08 Starpharma Limited Antimicrobial and antiparasitic agents
GB0125216D0 (en) * 2001-10-19 2001-12-12 Univ Strathclyde Dendrimers for use in targeted delivery

Also Published As

Publication number Publication date
EP1904436A1 (en) 2008-04-02
EA014327B1 (ru) 2010-10-29
CN101218204A (zh) 2008-07-09
CA2612211A1 (en) 2007-01-18
WO2007006700A1 (en) 2007-01-18
AU2006268736A1 (en) 2007-01-18
AU2006268736B2 (en) 2011-12-22
JP2009501245A (ja) 2009-01-15
US20100298403A1 (en) 2010-11-25

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KZ RU