EA200800022A3 - Применение ивабрадина для получения лекарственного средства, предназначенного для лечения эндотелиальной дисфункции - Google Patents
Применение ивабрадина для получения лекарственного средства, предназначенного для лечения эндотелиальной дисфункцииInfo
- Publication number
- EA200800022A3 EA200800022A3 EA200800022A EA200800022A EA200800022A3 EA 200800022 A3 EA200800022 A3 EA 200800022A3 EA 200800022 A EA200800022 A EA 200800022A EA 200800022 A EA200800022 A EA 200800022A EA 200800022 A3 EA200800022 A3 EA 200800022A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- dysfunction
- ivabradin
- endotelial
- application
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Применение ивабрадина или 3-{3-[{[(7S)-3,4-диметоксибицикло[4.2.0]окта-1,3,5-триен-7-ил]метил}(метил)амино]пропил}-7,8-диметокси-1,3,4,5-тетрагидро-2H-3-бензазепин-2-она, его аддитивных солей с фармацевтически приемлемой кислотой и его гидратов, для получения лекарственного средства, предназначенного для лечения эндотелиальной дисфункции.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0700189A FR2911279B1 (fr) | 2007-01-11 | 2007-01-11 | Utilisation de l'ivabradine pour l'obtention de medicaments destines au traitement de la dysfonction endotheliale |
Publications (3)
Publication Number | Publication Date |
---|---|
EA200800022A2 EA200800022A2 (ru) | 2008-08-29 |
EA200800022A3 true EA200800022A3 (ru) | 2008-12-30 |
EA015398B1 EA015398B1 (ru) | 2011-08-30 |
Family
ID=38123876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200800022A EA015398B1 (ru) | 2007-01-11 | 2008-01-10 | Применение ивабрадина для получения лекарственного средства, предназначенного для лечения эндотелиальной дисфункции |
Country Status (21)
Country | Link |
---|---|
US (2) | US20080200450A1 (ru) |
EP (1) | EP1944031A1 (ru) |
JP (1) | JP2008169213A (ru) |
KR (2) | KR20080066613A (ru) |
CN (1) | CN101480398B (ru) |
AR (1) | AR064832A1 (ru) |
AU (1) | AU2008200123B2 (ru) |
BR (1) | BRPI0800001A2 (ru) |
CA (1) | CA2617363C (ru) |
EA (1) | EA015398B1 (ru) |
FR (1) | FR2911279B1 (ru) |
GE (1) | GEP20115158B (ru) |
HK (1) | HK1130686A1 (ru) |
MA (1) | MA29720B1 (ru) |
MX (1) | MX2008000023A (ru) |
MY (1) | MY148650A (ru) |
NZ (1) | NZ564997A (ru) |
SG (1) | SG144832A1 (ru) |
UA (1) | UA96574C2 (ru) |
WO (1) | WO2008099091A2 (ru) |
ZA (1) | ZA200800358B (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2938194B1 (fr) * | 2008-11-07 | 2012-08-31 | Servier Lab | Utilisation de l'ivabradine comme agent de diagnostic dans la methode d'angiographie coronaire par tomodensitometrie multicoupe |
FR2961105B1 (fr) * | 2010-06-15 | 2013-02-08 | Servier Lab | Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque |
CN102908327B (zh) * | 2011-08-05 | 2015-03-11 | 江苏恒瑞医药股份有限公司 | 伊伐布雷定或其可药用盐的缓释制剂 |
GB201312386D0 (en) * | 2013-07-10 | 2013-08-21 | Isis Innovation | Pharmaceutical compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2681862B1 (fr) | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
CN1651087A (zh) * | 2000-04-12 | 2005-08-10 | 诺瓦提斯公司 | 有机化合物的联合形式 |
FR2834896B1 (fr) * | 2002-01-23 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible d'ivabradine |
FR2882553B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
-
2007
- 2007-01-11 FR FR0700189A patent/FR2911279B1/fr not_active Expired - Fee Related
-
2008
- 2008-01-04 UA UAA200800220A patent/UA96574C2/ru unknown
- 2008-01-04 GE GEAP200810468A patent/GEP20115158B/en unknown
- 2008-01-07 MA MA30547A patent/MA29720B1/fr unknown
- 2008-01-07 MX MX2008000023A patent/MX2008000023A/es not_active Application Discontinuation
- 2008-01-08 MY MYPI20080032A patent/MY148650A/en unknown
- 2008-01-09 AU AU2008200123A patent/AU2008200123B2/en not_active Ceased
- 2008-01-10 BR BRPI0800001-8A patent/BRPI0800001A2/pt not_active Application Discontinuation
- 2008-01-10 EP EP08290020A patent/EP1944031A1/fr not_active Ceased
- 2008-01-10 WO PCT/FR2008/000027 patent/WO2008099091A2/fr active Application Filing
- 2008-01-10 EA EA200800022A patent/EA015398B1/ru not_active IP Right Cessation
- 2008-01-10 AR ARP080100090A patent/AR064832A1/es not_active Application Discontinuation
- 2008-01-10 CA CA2617363A patent/CA2617363C/fr not_active Expired - Fee Related
- 2008-01-10 NZ NZ564997A patent/NZ564997A/en not_active IP Right Cessation
- 2008-01-11 JP JP2008003835A patent/JP2008169213A/ja active Pending
- 2008-01-11 CN CN2008100095665A patent/CN101480398B/zh not_active Expired - Fee Related
- 2008-01-11 US US12/008,437 patent/US20080200450A1/en not_active Abandoned
- 2008-01-11 ZA ZA200800358A patent/ZA200800358B/en unknown
- 2008-01-11 KR KR1020080003504A patent/KR20080066613A/ko not_active Application Discontinuation
- 2008-01-11 SG SG200800298-2A patent/SG144832A1/en unknown
-
2009
- 2009-09-28 HK HK09108942.3A patent/HK1130686A1/xx not_active IP Right Cessation
-
2010
- 2010-08-30 KR KR1020100083962A patent/KR101359936B1/ko not_active IP Right Cessation
-
2011
- 2011-07-21 US US13/136,033 patent/US20110288072A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AR064832A1 (es) | 2009-04-29 |
NZ564997A (en) | 2009-09-25 |
EA015398B1 (ru) | 2011-08-30 |
AU2008200123A1 (en) | 2008-07-31 |
AU2008200123B2 (en) | 2012-08-16 |
GEP20115158B (en) | 2011-02-10 |
CN101480398B (zh) | 2011-07-27 |
EP1944031A1 (fr) | 2008-07-16 |
WO2008099091A3 (fr) | 2008-10-02 |
KR101359936B1 (ko) | 2014-02-10 |
FR2911279A1 (fr) | 2008-07-18 |
WO2008099091A2 (fr) | 2008-08-21 |
MA29720B1 (fr) | 2008-09-01 |
FR2911279B1 (fr) | 2009-03-06 |
BRPI0800001A2 (pt) | 2010-02-23 |
ZA200800358B (en) | 2008-11-26 |
EA200800022A2 (ru) | 2008-08-29 |
CA2617363A1 (fr) | 2008-07-11 |
UA96574C2 (ru) | 2011-11-25 |
MY148650A (en) | 2013-05-15 |
SG144832A1 (en) | 2008-08-28 |
US20110288072A1 (en) | 2011-11-24 |
JP2008169213A (ja) | 2008-07-24 |
CN101480398A (zh) | 2009-07-15 |
HK1130686A1 (en) | 2010-01-08 |
US20080200450A1 (en) | 2008-08-21 |
CA2617363C (fr) | 2012-12-04 |
KR20080066613A (ko) | 2008-07-16 |
KR20100112540A (ko) | 2010-10-19 |
MX2008000023A (es) | 2009-02-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ593437A (en) | Use of the association of ivabradine and perindopril in the treatment of heart failure | |
HK1080362B (zh) | 合成伊伐布雷定及其與藥學上可接受的酸的加成鹽的新方法 | |
NO20050888L (no) | Ny fremgangsmate for syntesen av 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onforbindelser, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre | |
HRP20110532T1 (hr) | Kombinacija inhibitora if struje sinusnog čvora i inhibitora enzima konverzije angiotenzina | |
HRP20140928T1 (en) | Process for the synthesis of the 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one, and its application to the synthesis of ivabradine as well as its addition salts with a pharmaceutically acceptable acid | |
EA200800022A3 (ru) | Применение ивабрадина для получения лекарственного средства, предназначенного для лечения эндотелиальной дисфункции | |
AR058575A1 (es) | Asociacion de un inhibidor de la corriente sinusal if y de un inhibidor calcico y las composiciones farmaceuticas que la contienen | |
GEP20135970B (en) | New method of synthesis of ivabradine and pharmaceutically acceptable acid-additive salts thereof | |
GEP20156235B (en) | Process for enzymatic synthesis of (7s)-3,4-dimethoxy-bicyclo-[4.2.0]octa-1,3,5-triene-7- carboxylic acid or esters thereof, and application in synthesis of ivabradine and salts thereof | |
EA200901369A1 (ru) | Применение ивабрадина в качестве диагностического средства в методе коронарной ангиографии путем многослойной компьютерной томографии | |
CO6290712A2 (es) | Asociacion de un inhibidor de corriente sinusual if y de un beta -bloqueante | |
MD20130016A2 (en) | New process for the synthesis of ivabradine and addition salts thereof with pharmaceutically acceptable acids | |
NZ622915A (en) | Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine | |
TH107683B (th) | กระบวนการใหม่สำหรับการสังเคราะห์อิวาเบรดีนและเกลือการเติมของสารนี้พร้อม ด้วยกรดที่ยอมรับได้โดยทางเภสัชภัณฑ์ | |
TH137164A (th) | การใช้ประโยชน์จากการร่วมกันของสารยับยั้งกระแสไซนัสโหนด If (sinus node If current inhibitor) และสารยับยั้งเอนไซม์ซึ่งเปลี่ยนผันแองจิโอเทนซิน (angiotensin-converting enzyme inhibitor) ในการบำบัดภาวะหัวใจล้มเหลว | |
TN2009000455A1 (fr) | Utilisation de l'ivabradine comme agent de diagnostic dans la methode d'angiographie coronaire par tomodensitometrie multicoupe | |
TH99437A (th) | สารร่วมสมทบชนิดใหม่ของสารยับยั้งกระแสต่อมไซนัส If และ สารยับยั้งเอนไซม์แปลงเปลี่ยน-แอนไจโอเทนซินและองค์ประกอบในทางเภสัชกรรมที่มีสารนั้น | |
TH137164B (th) | การใช้ประโยชน์จากการร่วมกันของสารยับยั้งกระแสไซนัสโหนด If (sinus node If current inhibitor)และสารยับยั้งเอนไซม์ซึ่งเปลี่ยนผันแองจิโอเทนซิน(angiotensin-converting enzyme inhibitor)ในการบำบัดภาวะหัวใจล้มเหลว |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |