EA200700594A1 - Биотинилированные гексадекасахариды, их получение и применение - Google Patents

Биотинилированные гексадекасахариды, их получение и применение

Info

Publication number
EA200700594A1
EA200700594A1 EA200700594A EA200700594A EA200700594A1 EA 200700594 A1 EA200700594 A1 EA 200700594A1 EA 200700594 A EA200700594 A EA 200700594A EA 200700594 A EA200700594 A EA 200700594A EA 200700594 A1 EA200700594 A1 EA 200700594A1
Authority
EA
Eurasian Patent Office
Prior art keywords
radical
hexacadehesaccharides
biotinylinated
receiving
application
Prior art date
Application number
EA200700594A
Other languages
English (en)
Other versions
EA012587B1 (ru
Inventor
Филипп Дюшоссуа
Жан Паскаль Эро
Жан Марк Эрбер
Морис Петиту
Пьер Сави
Original Assignee
Санофи-Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34948342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200700594(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of EA200700594A1 publication Critical patent/EA200700594A1/ru
Publication of EA012587B1 publication Critical patent/EA012587B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)

Abstract

Настоящее изобретение относится к новым биотинилированным гексадекасахаридам общей формулы (I), в которой Biot обозначает производное биотина; R, Rи Rобозначают независимо друг от друга (C-C)алкоксирадикал или радикал -OSO, Rобозначает (C-С)алкоксирадикал или радикал -OSO, или же Rобразует мостик -О-СН-; - Ре обозначает сахаридную последовательность; а также к их фармацевтически приемлемым солям и к применению их в качестве лекарственных средств.
EA200700594A 2004-09-09 2005-09-07 Биотинилированные гексадекасахариды, их получение и применение EA012587B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0409557A FR2874924B1 (fr) 2004-09-09 2004-09-09 Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
PCT/FR2005/002218 WO2006030104A1 (fr) 2004-09-09 2005-09-07 Hexadecasaccharides biotinyles, leur preparation et leur utilisation

Publications (2)

Publication Number Publication Date
EA200700594A1 true EA200700594A1 (ru) 2007-08-31
EA012587B1 EA012587B1 (ru) 2009-10-30

Family

ID=34948342

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700594A EA012587B1 (ru) 2004-09-09 2005-09-07 Биотинилированные гексадекасахариды, их получение и применение

Country Status (39)

Country Link
US (3) US20070270342A1 (ru)
EP (1) EP1791872B1 (ru)
JP (1) JP5108519B2 (ru)
KR (1) KR101223364B1 (ru)
CN (1) CN101039963B (ru)
AR (1) AR051286A1 (ru)
AT (1) ATE420118T1 (ru)
AU (1) AU2005284080B2 (ru)
BR (1) BRPI0515078A (ru)
CA (1) CA2577258C (ru)
CY (1) CY1109126T1 (ru)
DE (1) DE602005012287D1 (ru)
DK (1) DK1791872T3 (ru)
EA (1) EA012587B1 (ru)
EC (1) ECSP077272A (ru)
ES (1) ES2320576T3 (ru)
FR (1) FR2874924B1 (ru)
GT (1) GT200500250A (ru)
HK (1) HK1113686A1 (ru)
HN (1) HN2005000518A (ru)
HR (1) HRP20090180T1 (ru)
IL (1) IL181569A (ru)
MA (1) MA28859B1 (ru)
MX (1) MX2007002875A (ru)
MY (1) MY140666A (ru)
NI (1) NI200700063A (ru)
NO (1) NO20071754L (ru)
PA (1) PA8644201A1 (ru)
PE (1) PE20060663A1 (ru)
PL (1) PL1791872T3 (ru)
PT (1) PT1791872E (ru)
RS (1) RS50762B (ru)
SI (1) SI1791872T1 (ru)
SV (1) SV2006002221A (ru)
TN (1) TNSN07053A1 (ru)
TW (1) TW200612970A (ru)
UY (1) UY29102A1 (ru)
WO (1) WO2006030104A1 (ru)
ZA (1) ZA200702255B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2912409B1 (fr) * 2007-02-14 2012-08-24 Sanofi Aventis Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
FR2912408A1 (fr) * 2007-02-14 2008-08-15 Sanofi Aventis Sa Heparine comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine,leur procede de preparation,leur utilisation
TW201006479A (en) * 2008-07-18 2010-02-16 Sanofi Aventis Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
EP2145624A1 (en) * 2008-07-18 2010-01-20 Sanofi-Aventis Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
EP2233143A1 (en) * 2009-03-24 2010-09-29 Sanofi-Aventis Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
FR2935387B1 (fr) * 2008-08-26 2010-09-10 Sanofi Aventis Hexadecasaccharides a activite antithrombotique comprenant une liaison covalente avec une chaine amine
FR2952935B1 (fr) 2009-11-20 2011-12-02 Sanofi Aventis Procede de preparation du n-biotinyl-6-aminocaproate de n succinimidyle

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU563351C (en) 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
EP0300099A1 (en) 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
IL102758A (en) 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
FR2704226B1 (fr) 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
EP0649854B1 (en) 1993-09-01 2000-03-15 Akzo Nobel N.V. Bisconjugates comprising two saccharides and a spacer
FR2751334B1 (fr) 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2773801B1 (fr) 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
FR2773804B1 (fr) 1998-01-19 2000-02-18 Sanofi Sa Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine

Also Published As

Publication number Publication date
BRPI0515078A (pt) 2008-07-01
WO2006030104A1 (fr) 2006-03-23
IL181569A0 (en) 2007-07-04
TNSN07053A1 (fr) 2008-06-02
AR051286A1 (es) 2007-01-03
CA2577258A1 (fr) 2006-03-23
ZA200702255B (en) 2008-09-25
IL181569A (en) 2011-08-31
ATE420118T1 (de) 2009-01-15
HN2005000518A (es) 2009-06-01
FR2874924B1 (fr) 2006-12-01
ECSP077272A (es) 2007-03-29
KR101223364B1 (ko) 2013-01-16
DE602005012287D1 (de) 2009-02-26
FR2874924A1 (fr) 2006-03-10
RS50762B (sr) 2010-08-31
KR20070051887A (ko) 2007-05-18
PA8644201A1 (es) 2006-05-16
CN101039963A (zh) 2007-09-19
NO20071754L (no) 2007-04-02
UY29102A1 (es) 2006-04-28
HRP20090180T1 (en) 2009-05-31
HK1113686A1 (en) 2008-10-10
JP5108519B2 (ja) 2012-12-26
EP1791872B1 (fr) 2009-01-07
PT1791872E (pt) 2009-03-27
PE20060663A1 (es) 2006-08-21
CN101039963B (zh) 2011-07-27
AU2005284080B2 (en) 2011-10-13
US8703738B2 (en) 2014-04-22
EP1791872A1 (fr) 2007-06-06
DK1791872T3 (da) 2009-05-04
MA28859B1 (fr) 2007-09-03
NI200700063A (es) 2008-03-07
GT200500250A (es) 2006-04-10
CA2577258C (fr) 2013-05-21
US20100279960A1 (en) 2010-11-04
TW200612970A (en) 2006-05-01
AU2005284080A1 (en) 2006-03-23
US20070270342A1 (en) 2007-11-22
SV2006002221A (es) 2006-01-13
CY1109126T1 (el) 2014-07-02
MY140666A (en) 2010-01-15
EA012587B1 (ru) 2009-10-30
MX2007002875A (es) 2007-05-16
US8557968B2 (en) 2013-10-15
US20130004551A1 (en) 2013-01-03
JP2008512538A (ja) 2008-04-24
PL1791872T3 (pl) 2009-06-30
SI1791872T1 (sl) 2009-06-30
ES2320576T3 (es) 2009-05-25

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU