EA200600502A1 - Способ асимметрической гидрогенизации бета-аминокетонов - Google Patents

Способ асимметрической гидрогенизации бета-аминокетонов

Info

Publication number
EA200600502A1
EA200600502A1 EA200600502A EA200600502A EA200600502A1 EA 200600502 A1 EA200600502 A1 EA 200600502A1 EA 200600502 A EA200600502 A EA 200600502A EA 200600502 A EA200600502 A EA 200600502A EA 200600502 A1 EA200600502 A1 EA 200600502A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydrogenization
asymmetric
beta amino
amino ketones
ketones
Prior art date
Application number
EA200600502A
Other languages
English (en)
Inventor
Ханс-Петер Меттлер
Original Assignee
Лонца Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лонца Аг filed Critical Лонца Аг
Publication of EA200600502A1 publication Critical patent/EA200600502A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)

Abstract

В заявке описан способ получения энантиомерно обогащенных или энантиомерно чистых (S)- или (R)-N-монозамещенных β-аминоспиртов формулы (I) и их аддитивных солей протонных кислот, где Х обозначает S или О, a R обозначают C-Салкил, С-Сциклоалкил, арил или аралкил.
EA200600502A 2003-09-01 2004-08-31 Способ асимметрической гидрогенизации бета-аминокетонов EA200600502A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03077734A EP1510517A1 (en) 2003-09-01 2003-09-01 Process for the asymmetric hydrogenation of beta-amino ketones
PCT/EP2004/009690 WO2005021527A2 (en) 2003-09-01 2004-08-31 Process for the asymmetric hydrogenation of beta-amino ketones

Publications (1)

Publication Number Publication Date
EA200600502A1 true EA200600502A1 (ru) 2006-08-25

Family

ID=34089676

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600502A EA200600502A1 (ru) 2003-09-01 2004-08-31 Способ асимметрической гидрогенизации бета-аминокетонов

Country Status (11)

Country Link
US (1) US20060252945A1 (ru)
EP (2) EP1510517A1 (ru)
JP (1) JP2007504192A (ru)
KR (1) KR20060123066A (ru)
CN (1) CN1842523A (ru)
AU (1) AU2004268057A1 (ru)
EA (1) EA200600502A1 (ru)
IL (1) IL173577A0 (ru)
NO (1) NO20060763L (ru)
SG (1) SG144912A1 (ru)
WO (1) WO2005021527A2 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1891683A (zh) * 2002-07-09 2007-01-10 隆萨股份公司 N－单取代β－氨基醇的制备方法
CN101484435A (zh) 2006-07-03 2009-07-15 兰贝克赛实验室有限公司 制备n-甲基-3-（1-萘氧基）-3-（2-噻吩基）丙胺及其纯对应异构体盐的方法
SI22839A (sl) * 2008-07-07 2010-01-29 Krka, Tovarna Zdravil, D.D. Sinteza duloksetina in njegovih farmacevtsko sprejemljivih soli z uporabo postopka asimetriäśnega transfer hidrogeniranja
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329013B1 (en) 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2011128370A1 (en) 2010-04-13 2011-10-20 Krka, D.D., Novo Mesto Synthesis of duloxetine and/or pharmaceutically acceptable salts thereof
DK2426116T3 (da) 2010-08-30 2013-09-08 Saltigo Gmbh Fremgangsmåde til fremstilling af (S)-3-N-methylamino-1-(2-thienyl)-1-propanol
CN104056663B (zh) * 2013-03-22 2016-12-28 上海交通大学 一种面手性双反应中心钌催化剂及其合成与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10036516A1 (de) * 2000-07-27 2002-02-07 Asta Medica Ag Verfahren zur Herstellung von enantiomerenreinen 6,8-Dihydroxyoctansäureestern durch assymetrische katalytische Hydrierung
WO2003061825A1 (en) * 2002-01-24 2003-07-31 Dsm Ip Assets B.V. Process for preparing nonracemic chiral alcohols
WO2003061826A1 (en) * 2002-01-24 2003-07-31 Dsm Ip Assets B.V. Process for preparing nonracemic chiral alcohols
WO2003062219A1 (en) * 2002-01-24 2003-07-31 Eli Lilly And Company Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine

Also Published As

Publication number Publication date
WO2005021527A3 (en) 2005-07-14
AU2004268057A1 (en) 2005-03-10
EP1664014A2 (en) 2006-06-07
IL173577A0 (en) 2006-07-05
EP1510517A1 (en) 2005-03-02
NO20060763L (no) 2006-03-17
SG144912A1 (en) 2008-08-28
KR20060123066A (ko) 2006-12-01
JP2007504192A (ja) 2007-03-01
CN1842523A (zh) 2006-10-04
WO2005021527A2 (en) 2005-03-10
US20060252945A1 (en) 2006-11-09

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