EA200500014A1 - Иммуностимулятор противоопухолевого действия и способ его получения - Google Patents

Иммуностимулятор противоопухолевого действия и способ его получения

Info

Publication number
EA200500014A1
EA200500014A1 EA200500014A EA200500014A EA200500014A1 EA 200500014 A1 EA200500014 A1 EA 200500014A1 EA 200500014 A EA200500014 A EA 200500014A EA 200500014 A EA200500014 A EA 200500014A EA 200500014 A1 EA200500014 A1 EA 200500014A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tumor
strain
enterovirus
culture
immunosism
Prior art date
Application number
EA200500014A
Other languages
English (en)
Other versions
EA007839B1 (ru
Inventor
Айна Муцениеце
Original Assignee
Венскус, Дайт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Венскус, Дайт filed Critical Венскус, Дайт
Publication of EA200500014A1 publication Critical patent/EA200500014A1/ru
Publication of EA007839B1 publication Critical patent/EA007839B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32333—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32361—Methods of inactivation or attenuation
    • C12N2770/32364—Methods of inactivation or attenuation by serial passage

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Иммуностимулятор противоопухолевого действия представляет собой апатогенную вирусную культуру, которая получена путем адаптирования в опухоль штамма энтеровирусов Picnoviridae Enterovirus типа ECHO, обычно выделяемого из кишечника человека Отличительным является то, что штамм энтеровирусов выделен из кишечника ребенка в возрасте 2-5 лет, а пассивирование проведено на опухолевых тканях различных больных с последовательным размножением пассивированного штамма на культуре фибробластов эмбриона человека. Разработанный способ получения обеспечивает максимальную иммуностимулирующую активность препарата. Иммуностимулятор активно противодействует рецидивам опухоли, увеличивает время диссеминации, причем при рецидивах образуются только метастазы подкожные и в лимфоузлах, которые нетрудно удалить.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500014A 2002-06-14 2003-06-13 Иммуностимулятор противоопухолевого действия и способ его получения EA007839B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LVP-02-108A LV12861B (lv) 2002-06-14 2002-06-14 Imūnstimulators ar pretaudzēja aktivitāti un tā iegūšanas paņēmiens
PCT/LV2003/000006 WO2003105875A1 (fr) 2002-06-14 2003-06-13 Immunostimulateur presentant une activite anticancereuse et procede de preparation correspondant

Publications (2)

Publication Number Publication Date
EA200500014A1 true EA200500014A1 (ru) 2005-06-30
EA007839B1 EA007839B1 (ru) 2007-02-27

Family

ID=19735339

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500014A EA007839B1 (ru) 2002-06-14 2003-06-13 Иммуностимулятор противоопухолевого действия и способ его получения

Country Status (7)

Country Link
EP (1) EP1537872B1 (ru)
AU (1) AU2003241866A1 (ru)
EA (1) EA007839B1 (ru)
ES (1) ES2678053T3 (ru)
LV (1) LV12861B (ru)
TR (1) TR201809382T4 (ru)
WO (1) WO2003105875A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2566146T3 (es) 2013-07-16 2016-04-11 Sia Latima Virus de ARN oncolítico genéticamente estable, método de fabricación y uso del mismo
GB201808500D0 (en) 2018-05-23 2018-07-11 Ditesan Ltd Virus and virus use
WO2020035423A1 (en) 2018-08-13 2020-02-20 Ditesan Ltd. Combination therapy of cancer by administrating echo-7 virus and a pharmaceutically effective anti-cancer drug

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US435914A (en) * 1890-09-09 Device for replacing cars on railroad-tracks
US4315914A (en) * 1980-04-04 1982-02-16 Seiji Arakawa Pharmaceutical compositions useful as cellular immunopotentiator and antitumor agent and process for production thereof
AUPQ425699A0 (en) * 1999-11-25 1999-12-23 University Of Newcastle Research Associates Limited, The A method of treating a malignancy in a subject and a pharmaceutical composition for use in same

Also Published As

Publication number Publication date
EP1537872A1 (en) 2005-06-08
EP1537872A4 (en) 2008-03-12
EA007839B1 (ru) 2007-02-27
LV12861B (lv) 2002-10-20
ES2678053T3 (es) 2018-08-08
AU2003241866A1 (en) 2003-12-31
WO2003105875A8 (en) 2005-03-24
EP1537872B1 (en) 2018-05-09
TR201809382T4 (tr) 2018-07-23
WO2003105875A1 (fr) 2003-12-24

Similar Documents

Publication Publication Date Title
CN104814985B (zh) 一种海藻多糖的应用
DE60142683D1 (de) Immunostimulierende polynukleotide sequenzen zur verwendung bei der verhinderung und behandlung von viralen erkrankungen
RU2008109858A (ru) Способ электростимуляционной тренировки мышц
EA202191508A1 (ru) Размножение естественных клеток-киллеров и клеток ilc3 с использованием новых ароматических соединений
RU2017121191A (ru) Методика размножения гамма-дельта Т-клеток
SE9903619D0 (sv) Use and method of treatment
ATE455576T1 (de) Herzschrittmacher
ATE420099T1 (de) Medikament zur wachstumsinhibierung von tumoren
ATE452186T1 (de) Cephalosporin-c-acylase-mutante und verfahren zur herstellung von 7-aca damit
EA200500014A1 (ru) Иммуностимулятор противоопухолевого действия и способ его получения
GT200200075A (es) Nuevas arilsulfonamidas como agentes antivirales
EA201690232A1 (ru) Генетически стабильный онколитический рнк вирус, способ его производства и применения
EA199900633A1 (ru) Способы терапевтического введения анти-cd40l соединений
PT1002055E (pt) Recuperacao de virus a partir de culturas celulares utilizando uma solucao salina hipertonica
RU2012108227A (ru) Вакцина, направленная против актинобациллезной плевропневмонии, и способ получения такой вакцины
CN202605550U (zh) 智能声波激发奶牛提高产奶品质干扰仪
HK1080712A1 (en) Ihnv g protein for immune stimulation
CN105238755A (zh) 一种人参提取物fqr1及其在肿瘤免疫治疗中的应用
DE60130775D1 (de) Stimulierung der neutrophilfunktion zur behandlung von entzündlichen darmerkrankungen
CN110257274B (zh) 一种伪结核棒状杆菌致弱方法及应用
CA3010529A1 (en) Ester of aminoglycan and uses thereof
Nieder Addressed exponential delay line theory of cochlear organization
RU2003129888A (ru) Производные калопорозида, способ их получения и их применение
WO2019164451A8 (en) Cancer therapeutic targeting using mutant p53-specific sirnas
ATE266444T1 (de) Gerät zur stimulation mehrerer herzbereiche mit resynchronisationsvorrichtung zur behandlung von herzinsuffizienz

Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ