EA200300638A1 - Вакцинная композиция, содержащая трансформирующий фактор роста альфа - Google Patents
Вакцинная композиция, содержащая трансформирующий фактор роста альфаInfo
- Publication number
- EA200300638A1 EA200300638A1 EA200300638A EA200300638A EA200300638A1 EA 200300638 A1 EA200300638 A1 EA 200300638A1 EA 200300638 A EA200300638 A EA 200300638A EA 200300638 A EA200300638 A EA 200300638A EA 200300638 A1 EA200300638 A1 EA 200300638A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tgfα
- growth factor
- composition containing
- vaccine composition
- egf
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Изобретение относится к области иммунологии и медицины человека, более конкретно, к специфичной активной иммунотерапии злокачественных опухолей, которые зависят от TGFα при своем росте, и к лечению других TGFα-зависимых заболеваний путем использования вакцинного препарата, который может вызывать реакцию иммунологического подавления аутологичного TGFα. Изобретение также относится к способу получения вакцинного препарата, который включает в себя комбинацию TGFα и других лигандов EGF-R, таких как эпидермальный фактор роста (EGF), и который способен ингибировать пролиферацию в опухолях, прогрессирование которых зависит от указанных факторов роста. Это дает возможность избегнуть резистентности опухоли к вакцинам, содержащим каждую из указанных молекул по отдельности.Отчет о международном поиске был опубликован 2003.02.20.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20000286A CU23077A1 (es) | 2000-12-06 | 2000-12-06 | Composicion vacunal que contiene factor de crecimiento transformante (tgf-alfa). su uso en la terapia de enfermedades malignas |
| PCT/CU2001/000011 WO2002045738A2 (es) | 2000-12-06 | 2001-12-06 | Composicion vacunal que contiene factor de crecimiento transformante alfa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200300638A1 true EA200300638A1 (ru) | 2003-10-30 |
| EA006240B1 EA006240B1 (ru) | 2005-10-27 |
Family
ID=34109588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200300638A EA006240B1 (ru) | 2000-12-06 | 2001-12-06 | Вакцинная композиция, содержащая трансформирующий фактор роста альфа |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20030054011A1 (ru) |
| EP (1) | EP1339425B1 (ru) |
| JP (1) | JP2004521091A (ru) |
| KR (1) | KR100834383B1 (ru) |
| CN (2) | CN1482916A (ru) |
| AR (1) | AR031785A1 (ru) |
| AT (1) | ATE439855T1 (ru) |
| AU (2) | AU2152002A (ru) |
| BR (1) | BR0116017A (ru) |
| CA (1) | CA2430621A1 (ru) |
| CU (1) | CU23077A1 (ru) |
| DE (1) | DE60139633D1 (ru) |
| EA (1) | EA006240B1 (ru) |
| ES (1) | ES2332125T3 (ru) |
| MX (1) | MXPA03005031A (ru) |
| MY (1) | MY141122A (ru) |
| NZ (1) | NZ526283A (ru) |
| PE (1) | PE20020696A1 (ru) |
| UY (1) | UY27060A1 (ru) |
| WO (1) | WO2002045738A2 (ru) |
| ZA (1) | ZA200304416B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22979A1 (es) * | 2000-12-08 | 2004-09-09 | Centro Inmunologia Molecular | Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina |
| CU23204A1 (es) * | 2002-12-27 | 2007-05-18 | Ct Ingenieria Genetica Biotech | Combinaciones de factores reguladores del crecimiento y hormonas para el tratamiento de neoplasias |
| EP1493445A1 (en) * | 2003-07-04 | 2005-01-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibition of stress-induced ligand-dependent EGFR activation |
| CU23297A1 (es) * | 2004-11-16 | 2008-07-24 | Ct De Inmunologa A Molecular | Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer |
| CU23652A1 (es) * | 2007-06-29 | 2011-05-27 | Centro Inmunologia Molecular | Composición vacunal homogénea para el tratamiento del cáncer y su método de obtención |
| KR101323845B1 (ko) | 2011-01-21 | 2013-10-31 | 광주과학기술원 | 외막소포체를 유효성분으로 포함하는 항암용 약제학적 조성물 |
| CN113855792B (zh) * | 2021-12-01 | 2022-03-01 | 上海惠盾因泰生物科技有限公司 | 重组hEGF-CRM197肿瘤治疗性疫苗配制剂 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04506662A (ja) * | 1989-07-14 | 1992-11-19 | アメリカン・サイアナミド・カンパニー | 接合体ワクチンのためのサイトカイニンおよびホルモンのキヤリヤー |
| IL98528A0 (en) * | 1990-06-21 | 1992-07-15 | Merck & Co Inc | Pharmaceutical compositions containing hybrid for killing bladder cancer cells |
| CU22302A1 (es) * | 1990-09-07 | 1995-01-31 | Cigb | Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales |
| CA2261433A1 (en) | 1993-12-09 | 1995-06-10 | Belinda Sanchez Ramirez | Composition comprising autologous epidermal growth factor |
| GB2333706A (en) * | 1998-02-02 | 1999-08-04 | Merck & Co Inc | Method for increasing muscle mass in animals |
-
2000
- 2000-12-06 CU CU20000286A patent/CU23077A1/es unknown
-
2001
- 2001-11-29 PE PE2001001201A patent/PE20020696A1/es not_active Application Discontinuation
- 2001-12-05 MY MYPI20015557A patent/MY141122A/en unknown
- 2001-12-05 AR ARP010105663A patent/AR031785A1/es unknown
- 2001-12-06 CA CA002430621A patent/CA2430621A1/en not_active Abandoned
- 2001-12-06 MX MXPA03005031A patent/MXPA03005031A/es not_active Application Discontinuation
- 2001-12-06 ES ES01999383T patent/ES2332125T3/es not_active Expired - Lifetime
- 2001-12-06 CN CNA018214347A patent/CN1482916A/zh active Pending
- 2001-12-06 AT AT01999383T patent/ATE439855T1/de not_active IP Right Cessation
- 2001-12-06 WO PCT/CU2001/000011 patent/WO2002045738A2/es active IP Right Grant
- 2001-12-06 AU AU2152002A patent/AU2152002A/xx active Pending
- 2001-12-06 JP JP2002547521A patent/JP2004521091A/ja active Pending
- 2001-12-06 BR BR0116017-6A patent/BR0116017A/pt not_active IP Right Cessation
- 2001-12-06 EP EP01999383A patent/EP1339425B1/en not_active Expired - Lifetime
- 2001-12-06 AU AU2002221520A patent/AU2002221520B2/en not_active Ceased
- 2001-12-06 UY UY27060A patent/UY27060A1/es unknown
- 2001-12-06 KR KR1020037007631A patent/KR100834383B1/ko not_active IP Right Cessation
- 2001-12-06 NZ NZ526283A patent/NZ526283A/en not_active IP Right Cessation
- 2001-12-06 DE DE60139633T patent/DE60139633D1/de not_active Expired - Lifetime
- 2001-12-06 CN CNA2008100876617A patent/CN101406692A/zh active Pending
- 2001-12-06 EA EA200300638A patent/EA006240B1/ru not_active IP Right Cessation
- 2001-12-06 US US10/003,462 patent/US20030054011A1/en not_active Abandoned
-
2003
- 2003-06-05 ZA ZA200304416A patent/ZA200304416B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200304416B (en) | 2004-07-07 |
| EA006240B1 (ru) | 2005-10-27 |
| CN1482916A (zh) | 2004-03-17 |
| US20030054011A1 (en) | 2003-03-20 |
| UY27060A1 (es) | 2002-03-22 |
| KR100834383B1 (ko) | 2008-06-09 |
| EP1339425A2 (en) | 2003-09-03 |
| PE20020696A1 (es) | 2002-09-19 |
| NZ526283A (en) | 2004-11-26 |
| AU2152002A (en) | 2002-06-18 |
| ATE439855T1 (de) | 2009-09-15 |
| DE60139633D1 (de) | 2009-10-01 |
| AU2002221520B2 (en) | 2007-10-11 |
| BR0116017A (pt) | 2004-01-13 |
| AR031785A1 (es) | 2003-10-01 |
| KR20030061424A (ko) | 2003-07-18 |
| WO2002045738A3 (es) | 2003-02-20 |
| MY141122A (en) | 2010-03-15 |
| EP1339425B1 (en) | 2009-08-19 |
| ES2332125T3 (es) | 2010-01-27 |
| CA2430621A1 (en) | 2002-06-13 |
| CN101406692A (zh) | 2009-04-15 |
| CU23077A1 (es) | 2005-08-17 |
| WO2002045738A2 (es) | 2002-06-13 |
| MXPA03005031A (es) | 2004-09-10 |
| JP2004521091A (ja) | 2004-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY RU |