EA200100997A1 - Лечение малыми пептидами для усиления антифиброзной активности - Google Patents

Лечение малыми пептидами для усиления антифиброзной активности

Info

Publication number
EA200100997A1
EA200100997A1 EA200100997A EA200100997A EA200100997A1 EA 200100997 A1 EA200100997 A1 EA 200100997A1 EA 200100997 A EA200100997 A EA 200100997A EA 200100997 A EA200100997 A EA 200100997A EA 200100997 A1 EA200100997 A1 EA 200100997A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fibrosis
phe
tyr
adhesions
mammal
Prior art date
Application number
EA200100997A
Other languages
English (en)
Inventor
Джеймс Клэйджетт
Original Assignee
Хистатек, Ллс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хистатек, Ллс filed Critical Хистатек, Ллс
Publication of EA200100997A1 publication Critical patent/EA200100997A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Описаны способы лечения фиброза у млекопитающих. Млекопитающему вводят антифибротически эффективное количество пептида, имеющего формулу f-Met-Leu-X, где X выбирают из группы, состоящей из Tyr, Tyr-Phe, Phe-Phe и Phe-Tyr. Фиброз может возникать из-за патологических изменений в результате, например, фиброза легких, атеросклероза, цирроза, гломерулосклероза, хронического панкреатита, болезни венечной артерии (такой как инфекция, вызванная бактерией Chlamydia Pneumoniae), травмы или хирургических процедур. Примерами хирургических процедур, которые вызывают фиброз, являются послеоперативный периневральный фиброз твердых мозговых оболочек или нервных корешков после проведения спинальной хирургии, тенолиз поврежденных или восстановленных сухожилий со спайками, невролиз поврежденных или восстановленных периферических нервов со спайками, послеоперативные спайки, возникающие после проведения гинекологических операций и операций на брюшной полости, репаративной хирургии семявыносящего протока или маточных труб, проводимой с целью обратимой стерилизации мужчин или женщин, а также после хирургического восстановления иных трубчатых структур, таких как мочеиспускательный канал, кишка или пищевод.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100997A 1999-03-22 2000-03-20 Лечение малыми пептидами для усиления антифиброзной активности EA200100997A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12551499P 1999-03-22 1999-03-22
PCT/US2000/007411 WO2000056349A1 (en) 1999-03-22 2000-03-20 Treatment with small peptides to effect antifibrotic activity

Publications (1)

Publication Number Publication Date
EA200100997A1 true EA200100997A1 (ru) 2002-02-28

Family

ID=22420066

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100997A EA200100997A1 (ru) 1999-03-22 2000-03-20 Лечение малыми пептидами для усиления антифиброзной активности

Country Status (18)

Country Link
US (1) US20020072499A1 (ru)
EP (1) EP1162990B1 (ru)
JP (2) JP4021147B2 (ru)
KR (1) KR100699509B1 (ru)
CN (1) CN1348381A (ru)
AT (1) ATE413184T1 (ru)
AU (1) AU3765100A (ru)
BR (1) BR0009226A (ru)
CA (1) CA2367048A1 (ru)
DE (1) DE60040730D1 (ru)
EA (1) EA200100997A1 (ru)
ES (1) ES2316359T3 (ru)
HK (1) HK1045649A1 (ru)
IL (1) IL145490A0 (ru)
MX (1) MXPA01009504A (ru)
NO (1) NO20014594L (ru)
PL (1) PL203758B1 (ru)
WO (1) WO2000056349A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7604633B2 (en) 1996-04-12 2009-10-20 Cytyc Corporation Moisture transport system for contact electrocoagulation
US8551082B2 (en) 1998-05-08 2013-10-08 Cytyc Surgical Products Radio-frequency generator for powering an ablation device
CN1367700A (zh) * 1999-07-16 2002-09-04 海斯塔泰克有限责任公司 用于下调lgE的小肽和方法
US7731712B2 (en) 2004-12-20 2010-06-08 Cytyc Corporation Method and system for transcervical tubal occlusion
US7674260B2 (en) * 2005-04-28 2010-03-09 Cytyc Corporation Emergency hemostasis device utilizing energy
US8486060B2 (en) 2006-09-18 2013-07-16 Cytyc Corporation Power ramping during RF ablation
US7846160B2 (en) 2006-12-21 2010-12-07 Cytyc Corporation Method and apparatus for sterilization
CN114463249B (zh) * 2021-11-24 2024-04-05 杭州医派智能科技有限公司 一种基于深度学习的用于评估肾小球周围组织纤维化的辅助方法、计算机设备

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2309639C (en) * 1997-11-13 2010-03-23 John C. Houck Small peptides and methods for treatment of asthma and inflammation

Also Published As

Publication number Publication date
PL203758B1 (pl) 2009-11-30
BR0009226A (pt) 2001-12-26
PL350860A1 (en) 2003-02-10
DE60040730D1 (de) 2008-12-18
KR20010109316A (ko) 2001-12-08
CN1348381A (zh) 2002-05-08
EP1162990A1 (en) 2001-12-19
JP2007131635A (ja) 2007-05-31
JP4021147B2 (ja) 2007-12-12
EP1162990A4 (en) 2002-02-06
NO20014594L (no) 2001-11-21
CA2367048A1 (en) 2000-09-28
EP1162990B1 (en) 2008-11-05
HK1045649A1 (zh) 2002-12-06
JP2002539270A (ja) 2002-11-19
WO2000056349A1 (en) 2000-09-28
NO20014594D0 (no) 2001-09-21
AU3765100A (en) 2000-10-09
MXPA01009504A (es) 2003-08-19
US20020072499A1 (en) 2002-06-13
IL145490A0 (en) 2002-06-30
ES2316359T3 (es) 2009-04-16
ATE413184T1 (de) 2008-11-15
KR100699509B1 (ko) 2007-03-26

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