EA200100965A1 - Синергизм между низкомолекулярным гепарином и ингибиторами агрегации тромбоцитов, обеспечивающий комбинированную терапию для профилактики и лечения различных тромбоэмболических нарушений - Google Patents

Синергизм между низкомолекулярным гепарином и ингибиторами агрегации тромбоцитов, обеспечивающий комбинированную терапию для профилактики и лечения различных тромбоэмболических нарушений

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Publication number
EA200100965A1
EA200100965A1 EA200100965A EA200100965A EA200100965A1 EA 200100965 A1 EA200100965 A1 EA 200100965A1 EA 200100965 A EA200100965 A EA 200100965A EA 200100965 A EA200100965 A EA 200100965A EA 200100965 A1 EA200100965 A1 EA 200100965A1
Authority
EA
Eurasian Patent Office
Prior art keywords
low molecular
againstation
synergism
platelets
inhibitors
Prior art date
Application number
EA200100965A
Other languages
English (en)
Inventor
Панкрас К. Вонг
Шейкер А. Муса
Original Assignee
Дюпон Фармасьютикалз Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дюпон Фармасьютикалз Компани filed Critical Дюпон Фармасьютикалз Компани
Publication of EA200100965A1 publication Critical patent/EA200100965A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение относится к комбинированной терапии, включающей введение низкомолекулярного гепарина, такого как тинзапарин, и антагониста тромбоцитарного GPIIb/IIIa, такого как роксифибан, для лечения, профилактики и снижения риска тромбоэмболических нарушений.Отчет о международном поиске был опубликован 2002.01.24.
EA200100965A 1999-03-11 2000-03-10 Синергизм между низкомолекулярным гепарином и ингибиторами агрегации тромбоцитов, обеспечивающий комбинированную терапию для профилактики и лечения различных тромбоэмболических нарушений EA200100965A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12382099P 1999-03-11 1999-03-11
PCT/US2000/006452 WO2000053168A2 (en) 1999-03-11 2000-03-10 Synergy between low molecular weight heparin and platelet aggregation inhibitors, for preventing and treating thromboembolic disorders

Publications (1)

Publication Number Publication Date
EA200100965A1 true EA200100965A1 (ru) 2002-08-29

Family

ID=22411088

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100965A EA200100965A1 (ru) 1999-03-11 2000-03-10 Синергизм между низкомолекулярным гепарином и ингибиторами агрегации тромбоцитов, обеспечивающий комбинированную терапию для профилактики и лечения различных тромбоэмболических нарушений

Country Status (10)

Country Link
US (2) US6346517B1 (ru)
EP (1) EP1189663A2 (ru)
JP (1) JP2003526617A (ru)
CN (1) CN1378472A (ru)
AR (1) AR022909A1 (ru)
AU (1) AU3625500A (ru)
BR (1) BR0010380A (ru)
CA (1) CA2364252A1 (ru)
EA (1) EA200100965A1 (ru)
WO (1) WO2000053168A2 (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
US7192726B1 (en) * 1999-08-13 2007-03-20 Hemodyne, Inc. Method of using platelet contractile force and whole blood clot elastic modulus as clinical markers
US20050032745A1 (en) * 2000-05-04 2005-02-10 Hamilton Civic Hospitals Res Dev., Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
US20050084514A1 (en) * 2000-11-06 2005-04-21 Afmedica, Inc. Combination drug therapy for reducing scar tissue formation
US7651695B2 (en) * 2001-05-18 2010-01-26 Advanced Cardiovascular Systems, Inc. Medicated stents for the treatment of vascular disease
AU2002365408B2 (en) * 2001-11-26 2008-04-24 Genentech, Inc. Catheter composition and uses thereof
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
JP4828795B2 (ja) 2002-03-11 2011-11-30 モメンタ ファーマシューティカルズ インコーポレイテッド 硫酸化多糖類の分析
US20030199457A1 (en) * 2002-04-17 2003-10-23 El-Naggar Mawaheb M. Prevention and treatment of thromboembolic disorders associated with arterial & venous thrombosis
US6908907B2 (en) * 2002-04-22 2005-06-21 El-Naggar Mawaheb M. Prevention and treatment of tumor growth, metastasis, and thromboembolic complications in cancer patients
IES20030299A2 (en) * 2002-04-23 2003-10-29 R Stephen Porter Inhibition of platelet aggregation
US20070014779A1 (en) * 2002-11-14 2007-01-18 Genentech, Inc. Plasminogen activator variant formulations
EP1679067A4 (en) * 2003-09-19 2010-04-07 Kissei Pharmaceutical COMBINED MEDICINES
GB2407040B (en) * 2003-10-15 2007-09-19 Sheikh Arshad Saeed Anti-platelet aggregation compositions
CN1322863C (zh) * 2004-10-29 2007-06-27 武汉远大制药集团股份有限公司 一种抑制血小板凝聚的注射液及其制备方法
US20080039362A1 (en) * 2006-08-09 2008-02-14 Afmedica, Inc. Combination drug therapy for reducing scar tissue formation
JP5871449B2 (ja) 2006-11-07 2016-03-01 ジェネンテック， インコーポレイテッド 組織プラスミノゲン活性化因子バリアントの使用
GB2444956A (en) * 2006-12-19 2008-06-25 Pentapharm Ag An apparatus and method for measuring the coagulation characteristics of a test liquid
US9139876B1 (en) * 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US20110217301A1 (en) * 2009-12-22 2011-09-08 The Children's Research Instute Methods for treating or screening for compounds for the treatment of sepsis
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
IT1400232B1 (it) * 2010-05-07 2013-05-24 Advance Holdings Ltd Composizione farmaceutica topica comprendente eparina
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN104062375B (zh) * 2014-07-01 2015-08-26 合肥合源药业有限公司 一种同时检测药品及其对映异构体杂质的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2582174B1 (fr) * 1985-05-15 1990-03-09 Thomson Csf Dispositif de chiffrement par substitutions-permutations
US5001754A (en) * 1990-02-01 1991-03-19 The Trustees Of Princeton University Encryption system and method
BR9408137A (pt) 1993-11-24 1997-08-12 Du Pont Merck Pharma Composto éster de prodroga método de tratamento composição farmacêutica e método de inibição
GB2288519A (en) * 1994-04-05 1995-10-18 Ibm Data encryption
EP0735050B1 (en) 1995-03-31 2002-09-25 Hamilton Civic Hospitals Research Development, Inc. Compositions for inhibiting thrombogenesis
WO1997035615A1 (en) 1996-03-27 1997-10-02 Merck & Co., Inc. Compositions and methods for inhibiting clot formation
CA2318215A1 (en) * 1998-02-02 1999-08-05 Merck & Co., Inc. Platelet aggregation inhibition using low molecular weight heparin in combination with a gp iib/iiia antagonist

Also Published As

Publication number Publication date
BR0010380A (pt) 2002-03-26
JP2003526617A (ja) 2003-09-09
EP1189663A2 (en) 2002-03-27
CA2364252A1 (en) 2000-09-14
US20020068719A1 (en) 2002-06-06
WO2000053168A2 (en) 2000-09-14
AR022909A1 (es) 2002-09-04
WO2000053168A3 (en) 2002-01-24
CN1378472A (zh) 2002-11-06
AU3625500A (en) 2000-09-28
US6346517B1 (en) 2002-02-12

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