EA199900306A1 - Применение бензопиранолов для лечения неврологических расстройств - Google Patents

Применение бензопиранолов для лечения неврологических расстройств

Info

Publication number
EA199900306A1
EA199900306A1 EA199900306A EA199900306A EA199900306A1 EA 199900306 A1 EA199900306 A1 EA 199900306A1 EA 199900306 A EA199900306 A EA 199900306A EA 199900306 A EA199900306 A EA 199900306A EA 199900306 A1 EA199900306 A1 EA 199900306A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
diseases
benzopiranols
application
pain
Prior art date
Application number
EA199900306A
Other languages
English (en)
Inventor
Эндрю А. Парсонс
Мервин Томпсон
Нейл Аптон
Джон Моррис Эванс
Original Assignee
Смитклайн Бичам Плс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичам Плс filed Critical Смитклайн Бичам Плс
Publication of EA199900306A1 publication Critical patent/EA199900306A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Раскрываются производные и аналоги бензопирана, пригодные для лечения и/или профилактики дегенеративных заболеваний, таких как хорея Гентингтона, шизофрения, связанные со СПИДом неврологические дефициты, нарушения сна (включая нарушения циркадных ритмов, бессонницу и нарколепсию), тики (такие как синдром Жиль де ла Туретта), травматические повреждения головного мозга, шум в ушах, невралгия, особенно тройничного нерва, невропатические боли, зубная боль, боль при злокачественных новообразованиях, неадекватная активность нейронов, проявляющаяся нейродистезией при таких заболеваниях как диабет, PC и заболевание двигательных нейронов, атаксии, мышечная ригидность (спастичность) и дисфункция височно-нижнечелюстного сустава.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900306A 1996-09-18 1997-09-15 Применение бензопиранолов для лечения неврологических расстройств EA199900306A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9619492.3A GB9619492D0 (en) 1996-09-18 1996-09-18 Novel treatment
PCT/EP1997/005168 WO1998011890A1 (en) 1996-09-18 1997-09-15 Use of benzopyranols to treat neurological disorders

Publications (1)

Publication Number Publication Date
EA199900306A1 true EA199900306A1 (ru) 1999-08-26

Family

ID=10800127

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900306A EA199900306A1 (ru) 1996-09-18 1997-09-15 Применение бензопиранолов для лечения неврологических расстройств

Country Status (30)

Country Link
EP (1) EP0939630B1 (ru)
JP (1) JP2001500520A (ru)
KR (1) KR20000036184A (ru)
CN (1) CN1230885A (ru)
AP (1) AP9901473A0 (ru)
AR (1) AR008838A1 (ru)
AT (1) ATE270102T1 (ru)
AU (1) AU730465B2 (ru)
BG (1) BG103252A (ru)
BR (1) BR9712030A (ru)
CA (1) CA2266681A1 (ru)
DE (1) DE69729735T2 (ru)
DZ (1) DZ2311A1 (ru)
EA (1) EA199900306A1 (ru)
ES (1) ES2223075T3 (ru)
GB (1) GB9619492D0 (ru)
HU (1) HUP9904638A3 (ru)
ID (2) ID23175A (ru)
IL (1) IL128786A0 (ru)
MA (1) MA24321A1 (ru)
NO (1) NO991292L (ru)
NZ (1) NZ334271A (ru)
OA (1) OA10998A (ru)
PE (1) PE109898A1 (ru)
PL (1) PL332313A1 (ru)
SK (1) SK35199A3 (ru)
TR (1) TR199900527T2 (ru)
UY (1) UY24717A1 (ru)
WO (1) WO1998011890A1 (ru)
ZA (1) ZA978359B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119214B2 (en) * 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
MX2010013313A (es) * 2008-06-05 2011-05-30 Minster Res Ltd Tratamientos novedosos.
EP2296646A2 (en) * 2008-06-05 2011-03-23 Minster Research Limited Novel treatments
AU2010276537B2 (en) 2009-07-27 2015-04-16 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
MX2012006353A (es) * 2009-12-03 2012-06-27 Proximagen Ltd Tratamiento de enfermedades infecciosas.
CN102970991A (zh) * 2009-12-03 2013-03-13 普罗克西梅根有限公司 异常性疼痛和痛觉增敏的治疗
MX2012015096A (es) 2010-07-02 2013-05-28 Gilead Sciences Inc Compuestos heterociclicos fusionados como moduladores del canal ion.
EP2707361B1 (en) 2011-05-10 2017-08-23 Gilead Sciences, Inc. Fused heterocyclic compounds as sodium channel modulators
TWI622583B (zh) 2011-07-01 2018-05-01 基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (ru) 2011-07-01 2018-04-28
CN106397317B (zh) * 2016-09-26 2019-03-22 天津师范大学 1,2,3,4-四氢喹啉化合物及其合成方法与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
US5510375A (en) * 1993-11-19 1996-04-23 Warner-Lambert Company Coumarin derivatives as protease inhibitors and antiviral agents
GB9411635D0 (en) * 1994-06-10 1994-08-03 Smithkline Beecham Plc Novel treatment
DK0764157T3 (da) * 1994-06-10 2002-04-22 Smithkline Beecham Plc Benzopyraner og deres anvendelse som terapeutiske midler

Also Published As

Publication number Publication date
DZ2311A1 (fr) 2002-12-28
AP9901473A0 (en) 1999-03-31
EP0939630A1 (en) 1999-09-08
ZA978359B (en) 1999-03-17
ID19542A (id) 1998-07-23
CA2266681A1 (en) 1998-03-26
MA24321A1 (fr) 1998-04-01
OA10998A (en) 2003-03-04
NO991292D0 (no) 1999-03-17
SK35199A3 (en) 2000-07-11
DE69729735D1 (de) 2004-08-05
AU4704797A (en) 1998-04-14
JP2001500520A (ja) 2001-01-16
PE109898A1 (es) 1999-03-21
BG103252A (en) 1999-09-30
HUP9904638A2 (hu) 2001-05-28
CN1230885A (zh) 1999-10-06
PL332313A1 (en) 1999-08-30
IL128786A0 (en) 2000-01-31
ID23175A (id) 2000-03-23
KR20000036184A (ko) 2000-06-26
AU730465B2 (en) 2001-03-08
NO991292L (no) 1999-03-17
WO1998011890A1 (en) 1998-03-26
AR008838A1 (es) 2000-02-23
UY24717A1 (es) 2001-08-27
HUP9904638A3 (en) 2001-08-28
ATE270102T1 (de) 2004-07-15
GB9619492D0 (en) 1996-10-30
NZ334271A (en) 2001-03-30
BR9712030A (pt) 1999-08-24
DE69729735T2 (de) 2005-07-14
EP0939630B1 (en) 2004-06-30
TR199900527T2 (xx) 1999-06-21
ES2223075T3 (es) 2005-02-16

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