EA199801078A1 - COMPOUNDS WITH ANTI-VIRUS ACTIVITY - Google Patents

COMPOUNDS WITH ANTI-VIRUS ACTIVITY

Info

Publication number
EA199801078A1
EA199801078A1 EA199801078A EA199801078A EA199801078A1 EA 199801078 A1 EA199801078 A1 EA 199801078A1 EA 199801078 A EA199801078 A EA 199801078A EA 199801078 A EA199801078 A EA 199801078A EA 199801078 A1 EA199801078 A1 EA 199801078A1
Authority
EA
Eurasian Patent Office
Prior art keywords
virus
compounds
virus activity
coxsakiruses
polioviruses
Prior art date
Application number
EA199801078A
Other languages
Russian (ru)
Other versions
EA001316B1 (en
Inventor
Луи Н. Юнгхейм
Тимоти А. Шеферд
Вейн А. Спитцер
Марк Дж. Теббе
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199801078A1 publication Critical patent/EA199801078A1/en
Publication of EA001316B1 publication Critical patent/EA001316B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Abstract

Данное изобретение обеспечивает ряд производных бензимидазола, которые ингибируют рост пикорнавирусов, таких как риновирусы, энтеровирусы, полиовирусы, Коксакивирусы групп А и В, ЕСНО-вирус и Mengo-вирус, и флавивирусов, таких как вирус гепатита С и вирус бычьей диареи.Международная заявка была опубликована вместе с отчетом о международном поиске.This invention provides a series of benzimidazole derivatives that inhibit the growth of picornaviruses, such as rhinoviruses, enteroviruses, polioviruses, Coxsakiruses of groups A and B, the ECHO virus and the Mengo virus, and flaviviruses such as hepatitis C virus and bovine diarrhea virus. The international application was published with the international search report.

EA199801078A 1996-06-05 1997-06-05 Anti-viral compounds EA001316B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1917096P 1996-06-05 1996-06-05
PCT/US1997/008848 WO1997046237A1 (en) 1996-06-05 1997-06-05 Anti-viral compounds

Publications (2)

Publication Number Publication Date
EA199801078A1 true EA199801078A1 (en) 1999-04-29
EA001316B1 EA001316B1 (en) 2001-02-26

Family

ID=21791797

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199801078A EA001316B1 (en) 1996-06-05 1997-06-05 Anti-viral compounds

Country Status (9)

Country Link
EP (1) EP0906097A4 (en)
JP (1) JP2000511899A (en)
KR (1) KR20000016346A (en)
CN (1) CN1220601A (en)
AU (1) AU3212897A (en)
BR (1) BR9709528A (en)
CA (1) CA2257296A1 (en)
EA (1) EA001316B1 (en)
WO (1) WO1997046237A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821242A (en) * 1996-06-06 1998-10-13 Eli Lilly And Company Anti-viral compounds
AU6031898A (en) * 1997-01-22 1998-08-07 Eli Lilly And Company Anti-viral compounds
JP2002503253A (en) * 1997-06-04 2002-01-29 イーライ・リリー・アンド・カンパニー Antiviral compounds
EP1077701A4 (en) * 1998-05-20 2002-03-20 Lilly Co Eli Anti-viral compounds
ID30204A (en) * 1999-12-27 2001-11-15 Japan Tobacco Inc COMPOUNDS OF DIFFUSED RING AND ITS USE AS A MEDICINE
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
CN1829709A (en) 2003-08-01 2006-09-06 健亚生物科技公司 Bicyclic imidazol derivatives against flaviviridae
US20070049593A1 (en) 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
DE602005013922D1 (en) 2004-02-24 2009-05-28 Japan Tobacco Inc CONDENSED HETEROTETRACYCLIC COMPOUNDS AND THEIR USE AS HCV POLYMERASE INHIBITOR
US7659263B2 (en) 2004-11-12 2010-02-09 Japan Tobacco Inc. Thienopyrrole compound and use thereof as HCV polymerase inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434288A (en) * 1982-04-08 1984-02-28 Eli Lilly And Company Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles
US4420479A (en) * 1982-04-08 1983-12-13 Eli Lilly And Company Olefinic benzimidazoles, formulations, and antiviral methods
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles

Also Published As

Publication number Publication date
BR9709528A (en) 1999-08-10
CN1220601A (en) 1999-06-23
CA2257296A1 (en) 1997-12-11
EA001316B1 (en) 2001-02-26
WO1997046237A1 (en) 1997-12-11
AU3212897A (en) 1998-01-05
EP0906097A1 (en) 1999-04-07
JP2000511899A (en) 2000-09-12
KR20000016346A (en) 2000-03-25
EP0906097A4 (en) 2000-12-13

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU