EA200001208A1 - ANTI-VIRUS COMPOUNDS - Google Patents

ANTI-VIRUS COMPOUNDS

Info

Publication number
EA200001208A1
EA200001208A1 EA200001208A EA200001208A EA200001208A1 EA 200001208 A1 EA200001208 A1 EA 200001208A1 EA 200001208 A EA200001208 A EA 200001208A EA 200001208 A EA200001208 A EA 200001208A EA 200001208 A1 EA200001208 A1 EA 200001208A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
hydrogen
halogen
virus
formula
Prior art date
Application number
EA200001208A
Other languages
Russian (ru)
Inventor
Хесус Эскера-Каррера
Джозеф Майкл Грубер
Чафик Амдоучи Амдоучи
Ричард Элмер Холмс
Вейн Альфред Шпицер
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200001208A1 publication Critical patent/EA200001208A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I) и к его фармацевтически приемлемым солям, подавляющим рост пикорнавирусов, вируса гепатита С, энтеровирусов, кардиовирусов, полиовирусов, вирусов коксаки групп A и B, ЕСНО-вируса и вируса Менго. В указанной формуле A представляет собой фенил, пиридил, замещенный фенил, замещенный пиридил или бензил; R представляет собой водород, CORили COCF; X представляет собой N-OH, O или CHR; Rпредставляет собой водород, галоген, CN, (C-C)-алкил, -C≡CH, CO((C-C)-алкил), CO((C-C)-алкил) или CONRR; Rи Rпредставляют собой независимо водород или (C-C)-алкил; A представляет собой водород, галоген, (C-C)-алкил, бензил, нафтил, тиенил, фурил, пиридил, пирролил, COR, S(O)Rили группу формулы (II); Rпредставляет собой (C-C)-алкил, фенил или замещенный фенил; n равен 0, 1 или 2; Rпредставляет собой, каждый раз независимо, водород или галоген; m равен 1, 2, 3 или 4; и Rпредставляют собой водород, галоген, CF, OH, COH, NH, NO, CONHOCH, (C-C)-алкил или CO((C-C)-алкил), (C-C)-алкокси.Международная заявка была опубликована вместе с отчетом о международном поиске.The present invention relates to compounds of formula (I) and to its pharmaceutically acceptable salts, which suppress the growth of picornaviruses, hepatitis C virus, enteroviruses, cardioviruses, polioviruses, coxsaki viruses of groups A and B, ECHO virus and Mengo virus. In this formula, A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR or COCF; X is N-OH, O or CHR; R4 is hydrogen, halogen, CN, (C-C) -alkyl, -C≡CH, CO ((C-C) -alkyl), CO ((C-C) -alkyl) or CONRR; R <4> and R <10> are independently hydrogen or (C--C-) alkyl; A represents hydrogen, halogen, (C-C) -alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrrolyl, COR, S (O) R or a group of formula (II); R4 is (C-C) alkyl, phenyl or substituted phenyl; n is 0, 1 or 2; R <r> is each time independently hydrogen or halogen; m is 1, 2, 3 or 4; and R 5 is hydrogen, halogen, CF, OH, COH, NH, NO, CONHOCH, (CC) -alkyl or CO ((CC) -alkyl), (CC) -alkoxy. The international application was published with the international search report .

EA200001208A 1998-05-20 1998-05-20 ANTI-VIRUS COMPOUNDS EA200001208A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/010299 WO1999059587A1 (en) 1998-05-20 1998-05-20 Anti-viral compounds

Publications (1)

Publication Number Publication Date
EA200001208A1 true EA200001208A1 (en) 2001-06-25

Family

ID=22267098

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001208A EA200001208A1 (en) 1998-05-20 1998-05-20 ANTI-VIRUS COMPOUNDS

Country Status (15)

Country Link
EP (1) EP1077701A4 (en)
JP (1) JP2002515433A (en)
KR (1) KR20010025055A (en)
CN (1) CN1292697A (en)
AU (1) AU7583098A (en)
BR (1) BR9815899A (en)
CA (1) CA2332403A1 (en)
CZ (1) CZ289425B6 (en)
EA (1) EA200001208A1 (en)
HU (1) HUP0102117A2 (en)
IL (1) IL139166A0 (en)
NO (1) NO20005795L (en)
SK (1) SK17482000A3 (en)
TR (1) TR200003414T2 (en)
WO (1) WO1999059587A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
AR048650A1 (en) * 2004-05-04 2006-05-10 Tibotec Pharm Ltd DERIVATIVES OF (1,10B-DIHIDRO-2- (AMINOCARBONIL-PHENYL) -5H-PIRAZOLO [1,5 C] [1,3] BENZOXAZIN-5-IL) METHANONE PHENYL AS INHIBITORS OF HIV VIRAL REPLICATION
ATE462697T1 (en) 2004-08-12 2010-04-15 Amgen Inc BISARYL SULFONAMIDES
US7666880B2 (en) 2005-03-21 2010-02-23 S*Bio Pte Ltd. Imidazo[1,2-A]pyridine derivatives: preparation and pharmaceutical applications
WO2006101455A1 (en) * 2005-03-21 2006-09-28 S*Bio Pte Ltd Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications
ES2395386T3 (en) 2005-12-21 2013-02-12 Abbott Laboratories Antiviral compounds
AU2006330924B2 (en) 2005-12-21 2012-03-15 Abbvie Inc. Anti-viral compounds
DE602006015861D1 (en) 2005-12-21 2010-09-09 Abbott Lab ANTIVIRAL CONNECTIONS
TWI399380B (en) 2006-12-20 2013-06-21 Abbott Lab Anti-viral compounds
CN102046621B (en) * 2008-05-27 2014-11-12 生物区科学管理控股有限公司 Antiviral salts
JP2012513409A (en) 2008-12-23 2012-06-14 アボット・ラボラトリーズ Antiviral compounds
CN102245604A (en) 2008-12-23 2011-11-16 雅培制药有限公司 Anti-viral compounds
RU2541571C2 (en) * 2009-04-15 2015-02-20 Эббви Инк. Antiviral compounds
WO2014060381A1 (en) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclic compounds as pesticides
EP2914587A1 (en) 2012-10-31 2015-09-09 Bayer CropScience AG Novel heterocyclic compounds as pest control agents
CN104370732B (en) * 2014-01-26 2015-08-19 山东信立泰药业有限公司 The preparation method of a kind of clopidogrel and intermediate thereof
CN109535405B (en) * 2017-09-21 2021-07-30 宁波聚嘉新材料科技有限公司 Preparation method of polyarylate based on 2- (4-carboxyphenyl) -5-hydroxypyridoimidazole
CN109810085B (en) * 2019-04-19 2019-07-19 上海皓元生物医药科技有限公司 The preparation method of ACC inhibitor and its intermediate
CN110746450A (en) * 2019-09-17 2020-02-04 济南康和医药科技有限公司 Synthetic method of beraprost sodium key intermediate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4096264A (en) * 1975-12-09 1978-06-20 Merck & Co., Inc. Certain substituted imidazo [1,2-a] pyridines
US4250174A (en) * 1979-05-02 1981-02-10 Merck & Co., Inc. 3-Substituted imidazo [1,2-A] pyridines
US5693661A (en) * 1995-06-07 1997-12-02 Eli Lilly And Company Anti-viral compounds
US5891874A (en) * 1996-06-05 1999-04-06 Eli Lilly And Company Anti-viral compound
BR9709528A (en) * 1996-06-05 1999-08-10 Lilly Co Eli Antiviral compounds
US5821242A (en) * 1996-06-06 1998-10-13 Eli Lilly And Company Anti-viral compounds

Also Published As

Publication number Publication date
BR9815899A (en) 2001-02-20
JP2002515433A (en) 2002-05-28
CA2332403A1 (en) 1999-11-25
NO20005795D0 (en) 2000-11-16
EP1077701A4 (en) 2002-03-20
SK17482000A3 (en) 2005-03-04
TR200003414T2 (en) 2001-03-21
CZ20004278A3 (en) 2001-05-16
HUP0102117A2 (en) 2001-12-28
AU7583098A (en) 1999-12-06
IL139166A0 (en) 2001-11-25
CN1292697A (en) 2001-04-25
EP1077701A1 (en) 2001-02-28
WO1999059587A1 (en) 1999-11-25
NO20005795L (en) 2001-01-18
CZ289425B6 (en) 2002-01-16
KR20010025055A (en) 2001-03-26

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