NO20013085L - Phosphorus-organic compounds and their use - Google Patents
Phosphorus-organic compounds and their useInfo
- Publication number
- NO20013085L NO20013085L NO20013085A NO20013085A NO20013085L NO 20013085 L NO20013085 L NO 20013085L NO 20013085 A NO20013085 A NO 20013085A NO 20013085 A NO20013085 A NO 20013085A NO 20013085 L NO20013085 L NO 20013085L
- Authority
- NO
- Norway
- Prior art keywords
- group
- bio
- substituents
- hydroxamic acid
- phosphorus
- Prior art date
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 abstract 2
- -1 Phosphorus inorganic compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 229910010272 inorganic material Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/62—Isoquinoline or hydrogenated isoquinoline ring systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
- A01N57/24—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing heterocyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Fosfororganiske forbindelser med den generelle formel (I), o II P- R< (D hvor A er valgt blant Ci-9-alkylen- grupper, -C-O-C- og -C-N-C-, eller A har svarer til formel (II), 1' f7 ?' (IQ B2 B« Be Ba Bio hvor ett eller flere karbonatomer valgt fra gruppen bestående av C3, C4, Cs også kan være fraværende sammen med sine substituenter, og minst en av substitu- entene fra BI til BIO er en C3.e-syklo- alkyl-(Co-g)-alkylgruppe, samt hvor RI er valgt blant S- og 6-leddede heterosyk- luser med minst ett nitrogenatom i ringen eller polysykliske hydrokarbon- forbindelser inneholdende minst en av disse heterosykluser, idet minst ett av disse nitrogenatomer hører til en hydroksaminsyregruppe eller en hydroks- aminsyreestergruppe. Forbindelsene er anvendbare for terapeutisk og forebyg- gende behandling av infeksjoner hos mennesker og dyr som forårsakes av virus, bakterier, fungi og parasitter, og som fungicider, baktericider og herbicider overfor planter.Phosphorus inorganic compounds of general formula (I), o II P- R <(D where A is selected from C 1-9 alkylene groups, -COC- and -CNC-, or A is similar to formula (II), 1 'f7?' (IQ B2 B «Be Ba Bio where one or more carbon atoms selected from the group consisting of C3, C4, Cs may also be absent together with their substituents, and at least one of the substituents from BI to BIO is a C3 .e-cycloalkyl (Co-g) alkyl group, and wherein R 1 is selected from S and 6 membered heterocycles with at least one nitrogen atom in the ring or polycyclic hydrocarbon compounds containing at least one of these heterocycles, with at least one of these nitrogen atoms belongs to a hydroxamic acid group or a hydroxamic acid ester group The compounds are useful in the therapeutic and preventive treatment of human and animal infections caused by viruses, bacteria, fungi and parasites .
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19859426A DE19859426A1 (en) | 1998-12-22 | 1998-12-22 | Use of organophosphorus compounds for the therapeutic and prophylactic treatment of infections |
| PCT/EP1999/010274 WO2000037477A1 (en) | 1998-12-22 | 1999-12-22 | Organo-phosphorus compounds and their utilization |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20013085D0 NO20013085D0 (en) | 2001-06-21 |
| NO20013085L true NO20013085L (en) | 2001-08-22 |
Family
ID=7892237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20013085A NO20013085L (en) | 1998-12-22 | 2001-06-21 | Phosphorus-organic compounds and their use |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1140952B1 (en) |
| JP (1) | JP2002533350A (en) |
| KR (1) | KR20010089670A (en) |
| CN (1) | CN1331695A (en) |
| AP (1) | AP2001002168A0 (en) |
| AT (1) | ATE248846T1 (en) |
| AU (1) | AU2538500A (en) |
| BR (1) | BR9916466A (en) |
| CA (1) | CA2356289A1 (en) |
| CZ (1) | CZ20012284A3 (en) |
| DE (2) | DE19859426A1 (en) |
| DK (1) | DK1140952T3 (en) |
| EA (1) | EA200100689A1 (en) |
| ES (1) | ES2204189T3 (en) |
| HU (1) | HUP0104866A3 (en) |
| IL (1) | IL143470A0 (en) |
| MX (1) | MXPA01006456A (en) |
| NO (1) | NO20013085L (en) |
| OA (1) | OA11730A (en) |
| PL (1) | PL349045A1 (en) |
| PT (1) | PT1140952E (en) |
| SK (1) | SK8892001A3 (en) |
| TR (1) | TR200101832T2 (en) |
| WO (1) | WO2000037477A1 (en) |
| ZA (1) | ZA200104443B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002078714A1 (en) * | 2001-03-30 | 2002-10-10 | Jomaa Pharmaka Gmbh | Formulations which are resistant to gastric juice and are used to apply anti-infective compounds inhibiting the 2-c-methylerythrose-4 metabolic pathway, and the salts and esters of the same |
| WO2008040097A1 (en) * | 2006-10-06 | 2008-04-10 | Biosignal Limited | Furanone compounds and lactam analogues thereof |
| EP2018864A1 (en) | 2007-07-23 | 2009-01-28 | Biomet Deutschland GmbH | Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition |
| US8993542B2 (en) | 2008-01-25 | 2015-03-31 | Chimerix Inc. | Methods of treating viral infections |
| US9006218B2 (en) | 2010-02-12 | 2015-04-14 | Chimerix Inc. | Nucleoside phosphonate salts |
| AU2011248620B2 (en) | 2010-04-26 | 2015-11-26 | Chimerix, Inc. | Methods of treating retroviral infections and related dosage regimes |
| PL3010511T3 (en) | 2014-09-12 | 2018-07-31 | Antibiotx A/S | Antibacterial use of halogenated salicylanilides |
| HUE058190T2 (en) * | 2015-03-09 | 2022-07-28 | Univ Texas | Enolase inhibitors and methods of treatment therewith |
| GB201509326D0 (en) | 2015-05-29 | 2015-07-15 | Antibio Tx Aps | Novel use |
| GB201604484D0 (en) | 2016-03-16 | 2016-04-27 | Antibiotx Aps And Københavns Uni University Of Copenhagen | Topical antibacterial compositions |
| US11419834B2 (en) | 2019-02-25 | 2022-08-23 | Rhode Island Hospital | Methods for treating diseases or infections caused by or associated with H. pylori using a halogenated salicylanilide |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4206156A (en) * | 1976-07-27 | 1980-06-03 | Fujisawa Pharmaceutical Company, Limited | Hydroxyaminohydrocarbonphosphonic acids |
| US4693742A (en) * | 1983-12-20 | 1987-09-15 | Rohm And Hass Company | Herbicidal hydroxyamino phosphonic acids and derivatives |
| JPS61106504A (en) * | 1984-10-30 | 1986-05-24 | Teijin Ltd | Herbicide |
| CN1297352A (en) * | 1998-04-14 | 2001-05-30 | 哈桑·朱马 | Use of organophosphoric compounds for therapeutic and preventative treatment of infections |
-
1998
- 1998-12-22 DE DE19859426A patent/DE19859426A1/en not_active Withdrawn
-
1999
- 1999-12-22 EP EP99968365A patent/EP1140952B1/en not_active Expired - Lifetime
- 1999-12-22 EA EA200100689A patent/EA200100689A1/en unknown
- 1999-12-22 CZ CZ20012284A patent/CZ20012284A3/en unknown
- 1999-12-22 CA CA002356289A patent/CA2356289A1/en not_active Abandoned
- 1999-12-22 BR BR9916466-3A patent/BR9916466A/en not_active IP Right Cessation
- 1999-12-22 JP JP2000589547A patent/JP2002533350A/en active Pending
- 1999-12-22 AP APAP/P/2001/002168A patent/AP2001002168A0/en unknown
- 1999-12-22 MX MXPA01006456A patent/MXPA01006456A/en unknown
- 1999-12-22 KR KR1020017007908A patent/KR20010089670A/en not_active Application Discontinuation
- 1999-12-22 WO PCT/EP1999/010274 patent/WO2000037477A1/en not_active Application Discontinuation
- 1999-12-22 DK DK99968365T patent/DK1140952T3/en active
- 1999-12-22 SK SK889-2001A patent/SK8892001A3/en unknown
- 1999-12-22 TR TR2001/01832T patent/TR200101832T2/en unknown
- 1999-12-22 DE DE59906907T patent/DE59906907D1/en not_active Expired - Fee Related
- 1999-12-22 CN CN99814915A patent/CN1331695A/en active Pending
- 1999-12-22 IL IL14347099A patent/IL143470A0/en unknown
- 1999-12-22 OA OA00100153A patent/OA11730A/en unknown
- 1999-12-22 ES ES99968365T patent/ES2204189T3/en not_active Expired - Lifetime
- 1999-12-22 PT PT99968365T patent/PT1140952E/en unknown
- 1999-12-22 PL PL99349045A patent/PL349045A1/en not_active Application Discontinuation
- 1999-12-22 AT AT99968365T patent/ATE248846T1/en not_active IP Right Cessation
- 1999-12-22 HU HU0104866A patent/HUP0104866A3/en unknown
- 1999-12-22 AU AU25385/00A patent/AU2538500A/en not_active Abandoned
-
2001
- 2001-05-30 ZA ZA200104443A patent/ZA200104443B/en unknown
- 2001-06-21 NO NO20013085A patent/NO20013085L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000037477A1 (en) | 2000-06-29 |
| EP1140952A1 (en) | 2001-10-10 |
| NO20013085D0 (en) | 2001-06-21 |
| ZA200104443B (en) | 2002-01-14 |
| CN1331695A (en) | 2002-01-16 |
| AU2538500A (en) | 2000-07-12 |
| HUP0104866A2 (en) | 2002-06-29 |
| ATE248846T1 (en) | 2003-09-15 |
| ES2204189T3 (en) | 2004-04-16 |
| CZ20012284A3 (en) | 2001-10-17 |
| EA200100689A1 (en) | 2001-12-24 |
| IL143470A0 (en) | 2002-04-21 |
| PL349045A1 (en) | 2002-07-01 |
| KR20010089670A (en) | 2001-10-08 |
| MXPA01006456A (en) | 2002-04-24 |
| BR9916466A (en) | 2001-09-25 |
| AP2001002168A0 (en) | 2001-06-30 |
| DK1140952T3 (en) | 2004-01-12 |
| PT1140952E (en) | 2004-02-27 |
| OA11730A (en) | 2005-05-12 |
| CA2356289A1 (en) | 2000-06-29 |
| DE19859426A1 (en) | 2000-07-06 |
| HUP0104866A3 (en) | 2002-08-28 |
| EP1140952B1 (en) | 2003-09-03 |
| SK8892001A3 (en) | 2001-12-03 |
| JP2002533350A (en) | 2002-10-08 |
| DE59906907D1 (en) | 2003-10-09 |
| TR200101832T2 (en) | 2001-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |