EP1077701A4 - Anti-viral compounds - Google Patents

Anti-viral compounds

Info

Publication number
EP1077701A4
EP1077701A4 EP98923565A EP98923565A EP1077701A4 EP 1077701 A4 EP1077701 A4 EP 1077701A4 EP 98923565 A EP98923565 A EP 98923565A EP 98923565 A EP98923565 A EP 98923565A EP 1077701 A4 EP1077701 A4 EP 1077701A4
Authority
EP
European Patent Office
Prior art keywords
viral compounds
viral
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98923565A
Other languages
German (de)
French (fr)
Other versions
EP1077701A1 (en
Inventor
Jesus Ezquerra-Carrera
Joseph Michael Gruber
Chafiq Hamdouchi Hamdouchi
Richard Elmer Holmes
Wayne Alfred Spitzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP1077701A1 publication Critical patent/EP1077701A1/en
Publication of EP1077701A4 publication Critical patent/EP1077701A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
EP98923565A 1998-05-20 1998-05-20 Anti-viral compounds Withdrawn EP1077701A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/010299 WO1999059587A1 (en) 1998-05-20 1998-05-20 Anti-viral compounds

Publications (2)

Publication Number Publication Date
EP1077701A1 EP1077701A1 (en) 2001-02-28
EP1077701A4 true EP1077701A4 (en) 2002-03-20

Family

ID=22267098

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98923565A Withdrawn EP1077701A4 (en) 1998-05-20 1998-05-20 Anti-viral compounds

Country Status (15)

Country Link
EP (1) EP1077701A4 (en)
JP (1) JP2002515433A (en)
KR (1) KR20010025055A (en)
CN (1) CN1292697A (en)
AU (1) AU7583098A (en)
BR (1) BR9815899A (en)
CA (1) CA2332403A1 (en)
CZ (1) CZ289425B6 (en)
EA (1) EA200001208A1 (en)
HU (1) HUP0102117A2 (en)
IL (1) IL139166A0 (en)
NO (1) NO20005795L (en)
SK (1) SK17482000A3 (en)
TR (1) TR200003414T2 (en)
WO (1) WO1999059587A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
AR048650A1 (en) * 2004-05-04 2006-05-10 Tibotec Pharm Ltd DERIVATIVES OF (1,10B-DIHIDRO-2- (AMINOCARBONIL-PHENYL) -5H-PIRAZOLO [1,5 C] [1,3] BENZOXAZIN-5-IL) METHANONE PHENYL AS INHIBITORS OF HIV VIRAL REPLICATION
ES2343640T3 (en) 2004-08-12 2010-08-05 Amgen Inc. BISARIL-SULFONAMIDS.
US7666880B2 (en) 2005-03-21 2010-02-23 S*Bio Pte Ltd. Imidazo[1,2-A]pyridine derivatives: preparation and pharmaceutical applications
EP1863811B1 (en) * 2005-03-21 2014-03-12 MEI Pharma, Inc. Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications
US7910595B2 (en) 2005-12-21 2011-03-22 Abbott Laboratories Anti-viral compounds
WO2007081517A2 (en) 2005-12-21 2007-07-19 Abbott Laboratories Anti-viral compounds
CA2633760A1 (en) 2005-12-21 2007-07-05 Abbott Laboratories Anti-viral compounds
CA2672737A1 (en) 2006-12-20 2008-11-06 Abbott Laboratories Anti-viral compounds
CA2725618C (en) * 2008-05-27 2016-04-12 Biota Scientific Management Pty Ltd Antiviral salts
JP2012513409A (en) 2008-12-23 2012-06-14 アボット・ラボラトリーズ Antiviral compounds
CN102245604A (en) 2008-12-23 2011-11-16 雅培制药有限公司 Anti-viral compounds
CA2758484A1 (en) * 2009-04-15 2010-10-21 David A. Degoey Anti-viral compounds
WO2014060381A1 (en) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclic compounds as pesticides
JP2016503395A (en) 2012-10-31 2016-02-04 バイエル・クロップサイエンス・アクチェンゲゼルシャフト Heterocyclic compounds as pest control agents
CN104370732B (en) * 2014-01-26 2015-08-19 山东信立泰药业有限公司 The preparation method of a kind of clopidogrel and intermediate thereof
CN109535405B (en) * 2017-09-21 2021-07-30 宁波聚嘉新材料科技有限公司 Preparation method of polyarylate based on 2- (4-carboxyphenyl) -5-hydroxypyridoimidazole
CN109810085B (en) * 2019-04-19 2019-07-19 上海皓元生物医药科技有限公司 The preparation method of ACC inhibitor and its intermediate
CN110746450A (en) * 2019-09-17 2020-02-04 济南康和医药科技有限公司 Synthetic method of beraprost sodium key intermediate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0747363A1 (en) * 1995-06-07 1996-12-11 Eli Lilly And Company Anti-viral benzimidazole derivatives
WO1997046235A1 (en) * 1996-06-06 1997-12-11 Eli Lilly And Company Anti-viral compounds
WO1997046236A1 (en) * 1996-06-05 1997-12-11 Eli Lilly And Company Anti-viral compounds
WO1997046237A1 (en) * 1996-06-05 1997-12-11 Eli Lilly And Company Anti-viral compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4096264A (en) * 1975-12-09 1978-06-20 Merck & Co., Inc. Certain substituted imidazo [1,2-a] pyridines
US4250174A (en) * 1979-05-02 1981-02-10 Merck & Co., Inc. 3-Substituted imidazo [1,2-A] pyridines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0747363A1 (en) * 1995-06-07 1996-12-11 Eli Lilly And Company Anti-viral benzimidazole derivatives
WO1997046236A1 (en) * 1996-06-05 1997-12-11 Eli Lilly And Company Anti-viral compounds
WO1997046237A1 (en) * 1996-06-05 1997-12-11 Eli Lilly And Company Anti-viral compounds
WO1997046235A1 (en) * 1996-06-06 1997-12-11 Eli Lilly And Company Anti-viral compounds

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HAMDOUCHI, C. ET AL.: "Amino-3-substituted-6[(E)-1-phenyl-(N-methylcarbamoyl)vinyl]imidazo-[1,2-a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus: Stereospecific ynthesis and Antiviral Activity", J. MED. CHEM., vol. 42, no. 1, 1999, pages 50-59, XP001038336 *
HAMDOUCHI, CHAFIQ ET AL: "A novel application of the Ullmann coupling reaction for the alkylsulfenylation of 2-amino-imidazo[1,2-a]pyridine", TETRAHEDRON (1999), 55(2), 541-548, XP001026248 *
HAMDOUCHI, CHAFIQ ET AL: "Short synthesis and antirhinoviral activity of imidazo[1,2- a]pyridines: the effect of acyl groups at the 3-position", BIOORG. MED. CHEM. LETT. (1999), 9(10), 1391-1394, XP004164898 *
See also references of WO9959587A1 *

Also Published As

Publication number Publication date
HUP0102117A2 (en) 2001-12-28
NO20005795L (en) 2001-01-18
SK17482000A3 (en) 2005-03-04
AU7583098A (en) 1999-12-06
CZ289425B6 (en) 2002-01-16
IL139166A0 (en) 2001-11-25
WO1999059587A1 (en) 1999-11-25
CZ20004278A3 (en) 2001-05-16
CN1292697A (en) 2001-04-25
CA2332403A1 (en) 1999-11-25
EP1077701A1 (en) 2001-02-28
NO20005795D0 (en) 2000-11-16
JP2002515433A (en) 2002-05-28
BR9815899A (en) 2001-02-20
EA200001208A1 (en) 2001-06-25
TR200003414T2 (en) 2001-03-21
KR20010025055A (en) 2001-03-26

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