EA199800565A1 - Способ и состав для лечения эректильной дисфункции - Google Patents
Способ и состав для лечения эректильной дисфункцииInfo
- Publication number
- EA199800565A1 EA199800565A1 EA199800565A EA199800565A EA199800565A1 EA 199800565 A1 EA199800565 A1 EA 199800565A1 EA 199800565 A EA199800565 A EA 199800565A EA 199800565 A EA199800565 A EA 199800565A EA 199800565 A1 EA199800565 A1 EA 199800565A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- erectile dysfunction
- prostaglandin
- liposomes
- component
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Изобретение относится к лечению эректильной дисфункции и, более конкретно, к внутриканальному (через отверстие) приему липосом, содержащих простагландин, для достижения опухания и твердости. Изобретение предусматривает создание фармацевтических составов и способов лечения эректильной дисфункции. К числу предпочтительных фармацевтических составов относится двухкомпонентная система, причем один компонент содержит липосомы, включающие в себя простагландин, а второй компонент содержит водный раствор возбудителя (активатора), включающий в себя химические средства для контролируемого лизирования липосом с целью высвобождения находящегося в них простагландина. Для лечения эректильной дисфункции два компонента смешиваются вместе с образованием раствора, который затем прикладывается к пенису либо наружно, либо, что предпочтительней, внутриканально для получения удовлетворительной эрекции.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/573,408 US5718917A (en) | 1995-12-15 | 1995-12-15 | PGE-1 containing lyophilized liposomes for use in the treatment of erectile dysfunction |
PCT/US1996/018820 WO1997022334A1 (en) | 1995-12-15 | 1996-11-26 | Pge-1 containing lyophilized liposomes for use in the treatment of erectile dysfunction |
Publications (1)
Publication Number | Publication Date |
---|---|
EA199800565A1 true EA199800565A1 (ru) | 1999-02-25 |
Family
ID=24291879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199800565A EA199800565A1 (ru) | 1995-12-15 | 1996-11-26 | Способ и состав для лечения эректильной дисфункции |
Country Status (17)
Country | Link |
---|---|
US (1) | US5718917A (ru) |
EP (1) | EP0874622A4 (ru) |
JP (1) | JPH11504945A (ru) |
KR (1) | KR20000064392A (ru) |
CN (1) | CN1207671A (ru) |
AU (1) | AU722555B2 (ru) |
BR (1) | BR9612040A (ru) |
EA (1) | EA199800565A1 (ru) |
EE (1) | EE9800182A (ru) |
HU (1) | HUP9902094A2 (ru) |
IL (1) | IL124841A (ru) |
IS (1) | IS4767A (ru) |
NO (1) | NO982727L (ru) |
PL (1) | PL327400A1 (ru) |
SK (1) | SK80998A3 (ru) |
TR (1) | TR199801104T2 (ru) |
WO (1) | WO1997022334A1 (ru) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050065161A1 (en) * | 1996-02-02 | 2005-03-24 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
KR100195348B1 (ko) * | 1996-10-31 | 1999-06-15 | 장용택 | 안정한 프로스타글란딘 e1-함유 주사제 조성물 |
US6103765A (en) | 1997-07-09 | 2000-08-15 | Androsolutions, Inc. | Methods for treating male erectile dysfunction |
KR20010021625A (ko) | 1997-07-09 | 2001-03-15 | 추후보정 | 개선된 남성발기 기능장애 치료방법 및 그 조성물 |
US20020004529A1 (en) * | 1997-10-20 | 2002-01-10 | Gary W. Neal | Methods, compositions, and kits for enhancing female sexual desire and responsiveness |
US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
US6046240A (en) * | 1998-05-01 | 2000-04-04 | Harvard Scientific Corporation | Methods for treating female sexual dysfunction |
KR100350179B1 (ko) * | 1998-09-23 | 2002-08-27 | 구주제약주식회사 | Sedds로 제제화한 발기부전치료용 주입액제 |
WO2000051978A1 (en) * | 1999-03-01 | 2000-09-08 | Nitromed, Inc. | Nitrosated and nitrosylated prostaglandins, compositions and metods of use |
CN1314444C (zh) * | 2003-03-20 | 2007-05-09 | 蔡海德 | 一种治疗糠尿病及其并发症和病毒性肝炎的组合药物及其制备方法 |
EP1643972A4 (en) * | 2003-06-27 | 2010-01-20 | Smithkline Beecham Corp | STABILIZED LIPOSOMAL TOPOTECAN COMPOSITION AND METHOD |
US9005183B2 (en) * | 2007-05-16 | 2015-04-14 | Health Knight, Llc | System and method for treating erectile dysfunction |
CN101095944B (zh) * | 2007-07-10 | 2012-04-18 | 上海市肿瘤研究所 | 一种预防和治疗前列腺炎穴位缓释贴片及其制品、制备方法和用途 |
CN101912363A (zh) * | 2010-07-29 | 2010-12-15 | 蔡海德 | 溶解超滤-喷雾干燥-分子分散包衣-水化制粒-冷冻干燥生产脂质体组合药物 |
CN102133182A (zh) * | 2010-12-30 | 2011-07-27 | 北京中海康医药科技发展有限公司 | 一种依前列醇脂质体及其制备方法 |
US9962393B1 (en) * | 2015-06-21 | 2018-05-08 | Angiosoma Research, Inc. | Method for treating vascular disease by administering a liposomal prostaglandin composition |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US246697A (en) * | 1881-09-06 | wadleigh | ||
US251355A (en) * | 1881-12-27 | Edwin h | ||
US3993754A (en) * | 1974-10-09 | 1976-11-23 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome-encapsulated actinomycin for cancer chemotherapy |
GB1536215A (en) * | 1976-07-05 | 1978-12-20 | Decca Ltd | Clamping circuits for television signals |
US4086257A (en) * | 1976-10-12 | 1978-04-25 | Sears Barry D | Phosphatidyl quaternary ammonium compounds |
US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4533254A (en) * | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
IL63734A (en) * | 1981-09-04 | 1985-07-31 | Yeda Res & Dev | Lipid fraction,its preparation and pharmaceutical compositions containing same |
US4677099A (en) * | 1981-09-04 | 1987-06-30 | Yeda Research And Development Co., Ltd. | Medical processes employing a novel lipid fraction |
US4522803A (en) * | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
JPS58222014A (ja) * | 1982-06-18 | 1983-12-23 | Taisho Pharmaceut Co Ltd | プロスタグランジンe↓1脂肪乳剤 |
US5040453A (en) * | 1982-07-12 | 1991-08-20 | Turn Act Inc. | Actuator housing continuation |
US4588578A (en) * | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
US4478822A (en) * | 1983-05-16 | 1984-10-23 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
US5008050A (en) * | 1984-06-20 | 1991-04-16 | The Liposome Company, Inc. | Extrusion technique for producing unilamellar vesicles |
US4975282A (en) * | 1985-06-26 | 1990-12-04 | The Liposome Company, Inc. | Multilamellar liposomes having improved trapping efficiencies |
US4820732A (en) * | 1985-10-04 | 1989-04-11 | The Upjohn Company | Method and compositions for reducing dysfunction in angioplasty procedures |
US4955878A (en) * | 1986-04-04 | 1990-09-11 | Biotechnology, Inc. | Kit for preventing or treating arterial dysfunction resulting from angioplasty procedures |
US4749585A (en) * | 1986-04-11 | 1988-06-07 | University Of Medicine And Dentistry Of New Jersey | Antibiotic bonded prosthesis and process for producing same |
US4776991A (en) * | 1986-08-29 | 1988-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Scaled-up production of liposome-encapsulated hemoglobin |
US4801587A (en) * | 1987-03-02 | 1989-01-31 | Gene Voss | Impotence ointment |
AU617678B2 (en) * | 1987-05-22 | 1991-12-05 | Liposome Company, Inc., The | Prostaglandin-lipid formulations |
US4776848A (en) * | 1987-07-20 | 1988-10-11 | Anthony Solazzo | Urethral fluid application device and system |
US5256652A (en) * | 1987-11-12 | 1993-10-26 | Pharmedic Co. | Topical compositions and methods for treatment of male impotence |
SE463851B (sv) * | 1988-09-02 | 1991-02-04 | Amsu Ltd | Komposition foer behandling av erektil dysfunktion via uretra |
US4880835A (en) * | 1988-11-03 | 1989-11-14 | Formulations Development Labs, Inc. | Oral liquid pharmaceutical compositions of sulindac |
JPH0395118A (ja) * | 1989-09-07 | 1991-04-19 | Green Cross Corp:The | プロスタグランジン含有脂肪小体製剤 |
US5164320A (en) * | 1990-03-05 | 1992-11-17 | Becton, Dickinson And Company | Method for lysing hard liposomes using polyethyleneglycol mono-n-alkyl ethers |
IT1252603B (it) * | 1990-04-19 | 1995-06-19 | Giorgio Cavallini | 2,4-diamino-6 piperidino pirimidina-3 ossido topico sul glande nel trattamento delle impotenze erettili |
DE69130529T2 (de) * | 1990-04-25 | 1999-06-02 | Vivus, Inc., Menlo Park, Calif. | Behandlung von erektionversagen |
US5242391A (en) * | 1990-04-25 | 1993-09-07 | Alza Corporation | Urethral insert for treatment of erectile dysfunction |
DE59006158D1 (de) * | 1990-11-08 | 1994-07-21 | Boehringer Mannheim Gmbh | Verwendung von Thromboxan-A2-Antagonisten zur Verhinderung von degenerativen Vorgängen im penilen Gewebe. |
US5399581A (en) * | 1990-12-26 | 1995-03-21 | Laragh; John H. | Method and compositions for treatment of sexual impotence |
ATE176401T1 (de) * | 1991-05-07 | 1999-02-15 | Liposome Co Inc | Liposomale prostaglandinformulierungen |
JPH05139977A (ja) * | 1991-05-17 | 1993-06-08 | Green Cross Corp:The | プロスタグランジン類リポソーム複合体を充填した注射器 |
DE4117249C2 (de) * | 1991-05-27 | 1998-05-14 | Christian Dr Stief | Linsidomin zur Behandlung erektiler Dysfunktionen |
WO1993000894A1 (en) * | 1991-07-03 | 1993-01-21 | Scott Nathan E | Prostaglandin e2 treatment of impotence |
US5422371A (en) * | 1992-05-27 | 1995-06-06 | Arch Development Corp. | Methods and compositions for inhibiting 5α-reductase activity |
US5370613A (en) * | 1993-02-11 | 1994-12-06 | Helmy; Ali M. | Catheter apparatus for delivering drugs to the penis |
ES2152324T3 (es) * | 1993-07-28 | 2001-02-01 | Pharmaderm Lab Ltd | Vesiculas lipidicas multilaminares bifasicas. |
US5419763B1 (en) * | 1994-01-04 | 1997-07-15 | Cor Trak Medical Inc | Prostatic drug-delivery catheter |
US5482039A (en) * | 1994-03-25 | 1996-01-09 | Vivus, Inc. | Process for diagnosing erectile dysfunction, and related methods of treatment |
DE69512374T2 (de) * | 1994-08-05 | 2000-05-11 | Inpharma S.A., Lugano | Zusammensetzungen, die troxerutin als komplex mit phosphatidylcholin enthalten, zur topischen behandlung von erektionsimpotenz |
GB9423910D0 (en) * | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
-
1995
- 1995-12-15 US US08/573,408 patent/US5718917A/en not_active Expired - Fee Related
-
1996
- 1996-11-26 EP EP96940603A patent/EP0874622A4/en not_active Withdrawn
- 1996-11-26 JP JP9522803A patent/JPH11504945A/ja active Pending
- 1996-11-26 HU HU9902094A patent/HUP9902094A2/hu unknown
- 1996-11-26 AU AU10242/97A patent/AU722555B2/en not_active Ceased
- 1996-11-26 EE EE9800182A patent/EE9800182A/xx unknown
- 1996-11-26 SK SK809-98A patent/SK80998A3/sk unknown
- 1996-11-26 KR KR1019980704445A patent/KR20000064392A/ko not_active Application Discontinuation
- 1996-11-26 TR TR1998/01104T patent/TR199801104T2/xx unknown
- 1996-11-26 PL PL96327400A patent/PL327400A1/xx unknown
- 1996-11-26 CN CN96199670A patent/CN1207671A/zh active Pending
- 1996-11-26 IL IL12484196A patent/IL124841A/xx not_active IP Right Cessation
- 1996-11-26 BR BR9612040-1A patent/BR9612040A/pt not_active Application Discontinuation
- 1996-11-26 EA EA199800565A patent/EA199800565A1/ru unknown
- 1996-11-26 WO PCT/US1996/018820 patent/WO1997022334A1/en not_active Application Discontinuation
-
1998
- 1998-06-09 IS IS4767A patent/IS4767A/is unknown
- 1998-06-12 NO NO982727A patent/NO982727L/no unknown
Also Published As
Publication number | Publication date |
---|---|
IS4767A (is) | 1998-06-09 |
KR20000064392A (ko) | 2000-11-06 |
EP0874622A1 (en) | 1998-11-04 |
EE9800182A (et) | 1998-12-15 |
SK80998A3 (en) | 1999-01-11 |
US5718917A (en) | 1998-02-17 |
PL327400A1 (en) | 1998-12-07 |
NO982727D0 (no) | 1998-06-12 |
BR9612040A (pt) | 1999-12-28 |
AU1024297A (en) | 1997-07-14 |
IL124841A0 (en) | 1999-01-26 |
NO982727L (no) | 1998-08-17 |
IL124841A (en) | 2001-01-28 |
CN1207671A (zh) | 1999-02-10 |
EP0874622A4 (en) | 1999-02-10 |
WO1997022334A1 (en) | 1997-06-26 |
JPH11504945A (ja) | 1999-05-11 |
TR199801104T2 (xx) | 1998-10-21 |
HUP9902094A2 (hu) | 1999-10-28 |
AU722555B2 (en) | 2000-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA199800565A1 (ru) | Способ и состав для лечения эректильной дисфункции | |
DK0862418T3 (da) | Fremgangsmåde til fremstilling af morphologisk ensartede mikrokapsler såvel som mikrokapsler fremstillet efter denne fremgangsmåde | |
EA200000298A1 (ru) | Агонисты простагландинов и их применение для лечения заболеваний костей | |
RU94040385A (ru) | Композиции клиндамицина и бензоилпероксида для лечения акне, набор для приготовления композиции, способ получения композиции, способ лечения акне | |
EA199700213A1 (ru) | Крем на водной основе для локального применения, способ его приготовления, способ лечения эректильной дисфункции у мужчин, способ лечения аноргазма у женщин, способ лечения микроваскулярных заболеваний и способ лечения ран или хирургических рассечений | |
MX9102814A (es) | Forma de administracion para agentes ecocontrastantes en microburbujas. | |
EA199900647A1 (ru) | Фармацевтический препарат, включающий в себя амоксициллин и клавуланат | |
AR034347A1 (es) | Vehiculo para la liberacion de fosfato de calcio para proteinas osteoinductivas | |
CY1112139T1 (el) | Μια φαρμακευτικη συνθεση περιλαμβανουσα κρυσταλλικη ριτοναβιρη μορφη ιι και ενα παρασκευασμα εξ αυτης | |
EA200200479A1 (ru) | Новые олигосахариды, их получение и содержащие их фармацевтические композиции | |
NO954957D0 (no) | Synergistisk stabiliserte flytende enzymatiske blandinger | |
EA200600686A1 (ru) | Способы получения масляных тел, содержащих активные ингредиенты | |
EA200000196A1 (ru) | Универсальная плазма крови | |
DK0814834T4 (da) | Immunogener, der er blottet for toksicitet, afledt af et retroviralt regulatorprotein, antistoffer, der er rettet mod disse immunogener, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger, der indeholder dem | |
PT99435A (pt) | Processo para a preparacao de derivados de amino-sulfonil-ureia e de composicoes farmaceuticas que os contem | |
DK1109814T3 (da) | 5-Heterocyclylpyrazolo[4,3-d]pyrimidin-7-oner til behandling af mandlig erektil dysfunktion | |
ES2093839T3 (es) | Peroxidos metalicos utilizados en un procedimiento de tratamiento biologico. | |
AU6092090A (en) | A method for the treatment of cardiac and of vascular hypertrophy and hyperplasia | |
EA200001199A1 (ru) | Терапевтические комбинации, содержащие селективный модулятор рецептора эстрогена и паратироидный гормон | |
PT783521E (pt) | Compostos polipeptidos que contem d-2-alquiltriptofano capazes de promover a libertacao da hormona do crescimento | |
Fujimoto et al. | Proposed mechanisms of stimulation and inhibition of guanylate cyclase with reference to the actions of chlorpromazine, phospholipases and Triton X-100 | |
ES2101334T3 (es) | Utilizacion terapeutica de la fosforil-l-serina-n-acil-esfingosina. | |
EA200300388A1 (ru) | 1-аминоалкилциклогексаны в качестве трипаноцидных агентов | |
SE9801705D0 (sv) | Biologically active composition | |
EA199900006A1 (ru) | Препарат и способ для лечения застоной сердечной недостаточности |