EA039626B1 - Применение везикулярной композиции для лечения сниженной подвижности сустава - Google Patents

Применение везикулярной композиции для лечения сниженной подвижности сустава Download PDF

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Publication number
EA039626B1
EA039626B1 EA201491583A EA201491583A EA039626B1 EA 039626 B1 EA039626 B1 EA 039626B1 EA 201491583 A EA201491583 A EA 201491583A EA 201491583 A EA201491583 A EA 201491583A EA 039626 B1 EA039626 B1 EA 039626B1
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EA
Eurasian Patent Office
Prior art keywords
composition
lipid
surfactant
edta
bht
Prior art date
Application number
EA201491583A
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English (en)
Russian (ru)
Other versions
EA201491583A1 (ru
Inventor
Ричард Вольф Гаррэвэй
Майкл Эрл
Сарухан Юрдакул
Николас Баверсток
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Ооо "Про Боно Био"
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Application filed by Ооо "Про Боно Био" filed Critical Ооо "Про Боно Био"
Publication of EA201491583A1 publication Critical patent/EA201491583A1/ru
Publication of EA039626B1 publication Critical patent/EA039626B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/688Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EA201491583A 2012-04-12 2013-04-12 Применение везикулярной композиции для лечения сниженной подвижности сустава EA039626B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1206486.1A GB201206486D0 (en) 2012-04-12 2012-04-12 Vesicular formulations and uses thereof
PCT/EP2013/057742 WO2013153221A1 (en) 2012-04-12 2013-04-12 Vesicular formulations for use in the treatment of pain or reduced mobility of a joint

Publications (2)

Publication Number Publication Date
EA201491583A1 EA201491583A1 (ru) 2015-05-29
EA039626B1 true EA039626B1 (ru) 2022-02-17

Family

ID=46208989

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491583A EA039626B1 (ru) 2012-04-12 2013-04-12 Применение везикулярной композиции для лечения сниженной подвижности сустава

Country Status (26)

Country Link
US (3) US20150065461A1 (es)
EP (1) EP2836203B1 (es)
JP (1) JP2015512926A (es)
KR (1) KR102204725B1 (es)
CN (1) CN104363894B (es)
AU (1) AU2013246822A1 (es)
BR (1) BR112014025507B1 (es)
CA (1) CA2870111A1 (es)
CL (1) CL2014002706A1 (es)
CO (1) CO7141430A2 (es)
DK (1) DK2836203T3 (es)
EA (1) EA039626B1 (es)
ES (1) ES2916803T3 (es)
GB (2) GB201206486D0 (es)
HR (1) HRP20220700T1 (es)
HU (1) HUE058972T2 (es)
IL (1) IL234862A0 (es)
IN (1) IN2014DN08259A (es)
LT (1) LT2836203T (es)
MX (1) MX2014012198A (es)
PH (1) PH12014502079A1 (es)
PL (1) PL2836203T3 (es)
PT (1) PT2836203T (es)
SG (1) SG11201406251VA (es)
SI (1) SI2836203T1 (es)
WO (1) WO2013153221A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100255080A1 (en) * 2009-04-02 2010-10-07 Sesvalia Usa, Llc Liposomal ALA pharmaceutical and cosmeceutical compositions and methods of treatment
MX336482B (es) 2009-08-21 2016-01-21 Henk-Andre Kroon Formulaciones vesiculares.
GB201205642D0 (en) 2012-03-29 2012-05-16 Sequessome Technology Holdings Ltd Vesicular formulations
GB201505532D0 (en) * 2015-03-31 2015-05-13 Sequessome Technology Holdings Ltd Formulations
WO2017001625A1 (en) 2015-06-30 2017-01-05 Sequessome Technology Holdings Limited Multiphasic compositions
BR112020003767B1 (pt) * 2017-08-22 2023-10-10 Moebius Medical Ltd Composição farmacêutica que compreende lipossomas e uso da dita composição para tratar dor ou irritação em uma articulação
JP2020534285A (ja) 2017-09-15 2020-11-26 アンパサンド バイオファーマシューティカルズ インコーポレイテッドAmpersand Biopharmaceuticals Inc. 投与および処置の方法
CN110314137B (zh) * 2018-03-30 2022-04-05 北京泰德制药股份有限公司 一种含有脂质囊泡的冻干制剂
KR20230041954A (ko) 2021-09-17 2023-03-27 서울대학교산학협력단 골관절염 예방 또는 치료용 약학 조성물 및 건강기능식품

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5853753A (en) * 1992-07-08 1998-12-29 Dianorm G. Maierhofer Gmbh Liposomes, method of preparing the same and use thereof in the preparation of drugs
US20050123593A1 (en) * 2001-06-25 2005-06-09 Jonathan Thompson Liposomal encapsulation of glycosaminoglycans for the treatment of arthritic joints
US20100098749A1 (en) * 2006-09-28 2010-04-22 Hadasit Medical Research Services & Development Limited Methods for joint lubrication and cartilage wear prevention making use of glycerophospholipids
WO2010140061A2 (en) * 2009-06-03 2010-12-09 John Charles Mayo Formulations for the treatment of deep tissue pain
WO2011022707A1 (en) * 2009-08-21 2011-02-24 Henk-Andre Kroon Vesicular formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPN723395A0 (en) * 1995-12-19 1996-01-18 Macnaught Medical Pty Limited Lubrication methods
CN1547474A (zh) * 2001-05-31 2004-11-17 含选择性环加氧酶-2抑制剂及一元醇的可渗透皮肤的组合物
US7115666B2 (en) * 2002-10-15 2006-10-03 Renovis, Inc. Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain
EP2971075B1 (en) * 2013-03-13 2018-08-15 Roche Diagnostics GmbH Methods and compositions for detecting mutations in the human pi3kca (pik3ca) gene

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5853753A (en) * 1992-07-08 1998-12-29 Dianorm G. Maierhofer Gmbh Liposomes, method of preparing the same and use thereof in the preparation of drugs
US20050123593A1 (en) * 2001-06-25 2005-06-09 Jonathan Thompson Liposomal encapsulation of glycosaminoglycans for the treatment of arthritic joints
US20100098749A1 (en) * 2006-09-28 2010-04-22 Hadasit Medical Research Services & Development Limited Methods for joint lubrication and cartilage wear prevention making use of glycerophospholipids
WO2010140061A2 (en) * 2009-06-03 2010-12-09 John Charles Mayo Formulations for the treatment of deep tissue pain
WO2011022707A1 (en) * 2009-08-21 2011-02-24 Henk-Andre Kroon Vesicular formulations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KAWANO T, ET AL: "Mechanical effects of the intraarticular administration of high molecular weight hyaluronic acid plus phospholipid on synovial joint lubrication and prevention of articular cartilage degeneration in experimental osteoarthritis.", ARTHRITIS & RHEUMATISM, WILEY INTERSCIENCE, US, vol. 48, no. 7, 1 July 2003 (2003-07-01), US , pages 1923 - 1929, XP002301692, ISSN: 0004-3591, DOI: 10.1002/art.11172 *

Also Published As

Publication number Publication date
MX2014012198A (es) 2015-06-04
EA201491583A1 (ru) 2015-05-29
CN104363894A (zh) 2015-02-18
AU2013246822A1 (en) 2014-10-16
KR102204725B1 (ko) 2021-01-19
CO7141430A2 (es) 2014-12-12
HRP20220700T1 (hr) 2022-07-08
CN104363894B (zh) 2016-11-23
WO2013153221A1 (en) 2013-10-17
US20150065461A1 (en) 2015-03-05
JP2015512926A (ja) 2015-04-30
PT2836203T (pt) 2022-06-15
SG11201406251VA (en) 2014-10-30
CL2014002706A1 (es) 2015-04-24
EP2836203A1 (en) 2015-02-18
KR20150008869A (ko) 2015-01-23
GB201419074D0 (en) 2014-12-10
US20170128473A1 (en) 2017-05-11
IL234862A0 (en) 2014-12-31
IN2014DN08259A (es) 2015-05-15
EP2836203B1 (en) 2022-03-09
PH12014502079A1 (en) 2014-12-10
PL2836203T3 (pl) 2022-07-11
SI2836203T1 (sl) 2022-07-29
GB201206486D0 (en) 2012-05-30
DK2836203T3 (da) 2022-06-07
LT2836203T (lt) 2022-06-10
BR112014025507A2 (pt) 2017-08-08
BR112014025507B1 (pt) 2022-01-04
GB2515439A (en) 2014-12-24
GB2515439B (en) 2017-08-23
ES2916803T3 (es) 2022-07-06
HUE058972T2 (hu) 2022-09-28
US20210393655A1 (en) 2021-12-23
CA2870111A1 (en) 2013-10-17

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