EA039412B1 - 5-ht2c рецепторные агонисты и композиции и способы применения - Google Patents
5-ht2c рецепторные агонисты и композиции и способы применения Download PDFInfo
- Publication number
- EA039412B1 EA039412B1 EA201890402A EA201890402A EA039412B1 EA 039412 B1 EA039412 B1 EA 039412B1 EA 201890402 A EA201890402 A EA 201890402A EA 201890402 A EA201890402 A EA 201890402A EA 039412 B1 EA039412 B1 EA 039412B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- azepine
- formula
- cyclopropane
- naphtho
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 263
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- 108010072553 5-HT2C Serotonin Receptor Proteins 0.000 title abstract description 19
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201562199382P | 2015-07-31 | 2015-07-31 | |
| PCT/US2016/044426 WO2017023679A1 (en) | 2015-07-31 | 2016-07-28 | 5-ht2c receptor agonists and compositions and methods of use |
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| EA201890402A1 EA201890402A1 (ru) | 2018-09-28 |
| EA039412B1 true EA039412B1 (ru) | 2022-01-25 |
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| EA201890402A EA039412B1 (ru) | 2015-07-31 | 2016-07-28 | 5-ht2c рецепторные агонисты и композиции и способы применения |
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| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
| WO2020087031A1 (en) | 2018-10-26 | 2020-04-30 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| CN110668951B (zh) * | 2018-12-21 | 2022-09-30 | 安徽贝克生物制药有限公司 | 一种盐酸司来吉兰的合成工艺 |
| CN110642721B (zh) * | 2018-12-21 | 2022-09-30 | 安徽贝克生物制药有限公司 | 盐酸司来吉兰的制备方法 |
| JP2022529353A (ja) | 2019-04-17 | 2022-06-21 | コンパス パスファインダー リミテッド | 神経認知障害、慢性疼痛を治療し、炎症を低減させる方法 |
| EP4363287A2 (en) * | 2021-06-29 | 2024-05-08 | Tusimple, Inc. | Systems and methods for operating an autonomous vehicle |
| US12227206B2 (en) | 2021-10-14 | 2025-02-18 | Tusimple, Inc. | Systems and methods for operating an autonomous vehicle |
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| WO2003091251A1 (en) * | 2002-04-25 | 2003-11-06 | Wyeth | 1,2,3,4,7,8-hexahydro-6h-[1,4]diazepino[6,7,1-1j]quinoline derivatives as antipsychotic and antiobesity agents |
| WO2005003096A1 (en) * | 2003-06-17 | 2005-01-13 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases |
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| US5180733A (en) * | 1990-03-30 | 1993-01-19 | Abbott Laboratories | Biogenic amine uptake inhibitors |
| AU1919592A (en) | 1991-04-16 | 1992-11-17 | National Institutes Of Health | Method of treating trichotillomania and onychophagia |
| US6953787B2 (en) * | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| WO2003086303A2 (en) | 2002-04-12 | 2003-10-23 | The University Of Chicago | Farnesoid x-activated receptor agonists |
| MXPA06003927A (es) * | 2003-10-08 | 2008-02-07 | Lilly Co Eli | Compuestos y metodos para tratar dislipidemia. |
| US20120253036A1 (en) * | 2009-12-11 | 2012-10-04 | Yukinori Nagakura | Agent for treating fibromyalgia |
| WO2013133325A1 (ja) * | 2012-03-06 | 2013-09-12 | 武田薬品工業株式会社 | 三環性化合物 |
| HK1212684A1 (zh) * | 2012-09-14 | 2016-06-17 | AbbVie Deutschland GmbH & Co. KG | 三環喹啉和喹喔啉衍生物 |
| JP6789578B2 (ja) | 2015-07-31 | 2020-11-25 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ｃ受容体アゴニストおよび組成物、ならびに使用方法 |
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2022
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003091251A1 (en) * | 2002-04-25 | 2003-11-06 | Wyeth | 1,2,3,4,7,8-hexahydro-6h-[1,4]diazepino[6,7,1-1j]quinoline derivatives as antipsychotic and antiobesity agents |
| WO2005003096A1 (en) * | 2003-06-17 | 2005-01-13 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6789578B2 (ja) | 2020-11-25 |
| MX2018001380A (es) | 2018-06-15 |
| BR112018001707A2 (pt) | 2018-09-18 |
| MA42527A (fr) | 2021-04-07 |
| JP2018522025A (ja) | 2018-08-09 |
| CN108137508A (zh) | 2018-06-08 |
| AU2016302755A1 (en) | 2018-03-15 |
| EP3328835A1 (en) | 2018-06-06 |
| MX375045B (es) | 2025-03-06 |
| IL257107B (en) | 2021-03-25 |
| NZ739883A (en) | 2021-03-26 |
| US20200383993A1 (en) | 2020-12-10 |
| KR20180031035A (ko) | 2018-03-27 |
| US20180214455A1 (en) | 2018-08-02 |
| HK1255850A1 (zh) | 2019-08-30 |
| AU2016302755B2 (en) | 2020-09-10 |
| CN108137508B (zh) | 2021-08-27 |
| US10272094B2 (en) | 2019-04-30 |
| US11395824B2 (en) | 2022-07-26 |
| EA201890402A1 (ru) | 2018-09-28 |
| EP3328835B1 (en) | 2022-10-12 |
| US20230055376A1 (en) | 2023-02-23 |
| IL257107A (en) | 2018-03-29 |
| CA3002525A1 (en) | 2017-02-09 |
| US20200078368A1 (en) | 2020-03-12 |
| WO2017023679A1 (en) | 2017-02-09 |
| US10624900B2 (en) | 2020-04-21 |
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