EA037815B1 - ПОЛУЧЕНИЕ ПРОИЗВОДНЫХ ФАКТОРА Xa - Google Patents

ПОЛУЧЕНИЕ ПРОИЗВОДНЫХ ФАКТОРА Xa Download PDF

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Publication number
EA037815B1
EA037815B1 EA201990052A EA201990052A EA037815B1 EA 037815 B1 EA037815 B1 EA 037815B1 EA 201990052 A EA201990052 A EA 201990052A EA 201990052 A EA201990052 A EA 201990052A EA 037815 B1 EA037815 B1 EA 037815B1
Authority
EA
Eurasian Patent Office
Prior art keywords
seq
acid sequence
amino acid
heavy chain
chain consisting
Prior art date
Application number
EA201990052A
Other languages
English (en)
Russian (ru)
Other versions
EA201990052A1 (ru
Inventor
Марк Карбарз
Памела Б. Конли
Гэньминь Лу
Original Assignee
Портола Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60663351&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA037815(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Портола Фармасьютикалз, Инк. filed Critical Портола Фармасьютикалз, Инк.
Publication of EA201990052A1 publication Critical patent/EA201990052A1/ru
Publication of EA037815B1 publication Critical patent/EA037815B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201990052A 2016-06-17 2017-06-19 ПОЛУЧЕНИЕ ПРОИЗВОДНЫХ ФАКТОРА Xa EA037815B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662351841P 2016-06-17 2016-06-17
US62/351,841 2016-06-17
PCT/US2017/038169 WO2017219034A2 (en) 2016-06-17 2017-06-19 Preparation of factor xa derivatives

Publications (2)

Publication Number Publication Date
EA201990052A1 EA201990052A1 (ru) 2019-05-31
EA037815B1 true EA037815B1 (ru) 2021-05-25

Family

ID=60663351

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990052A EA037815B1 (ru) 2016-06-17 2017-06-19 ПОЛУЧЕНИЕ ПРОИЗВОДНЫХ ФАКТОРА Xa

Country Status (21)

Country Link
US (4) US10604748B2 (cg-RX-API-DMAC7.html)
EP (3) EP3472314B1 (cg-RX-API-DMAC7.html)
JP (3) JP6959268B2 (cg-RX-API-DMAC7.html)
KR (1) KR102373215B1 (cg-RX-API-DMAC7.html)
CN (3) CN116425860B (cg-RX-API-DMAC7.html)
AU (2) AU2017283720C1 (cg-RX-API-DMAC7.html)
CL (2) CL2018003654A1 (cg-RX-API-DMAC7.html)
CO (1) CO2019000120A2 (cg-RX-API-DMAC7.html)
DK (1) DK3472314T3 (cg-RX-API-DMAC7.html)
EA (1) EA037815B1 (cg-RX-API-DMAC7.html)
ES (2) ES3038834T3 (cg-RX-API-DMAC7.html)
HU (1) HUE054597T2 (cg-RX-API-DMAC7.html)
IL (1) IL263591B2 (cg-RX-API-DMAC7.html)
MX (1) MX2018015873A (cg-RX-API-DMAC7.html)
PE (1) PE20190661A1 (cg-RX-API-DMAC7.html)
PH (1) PH12018502614A1 (cg-RX-API-DMAC7.html)
PL (1) PL3472314T3 (cg-RX-API-DMAC7.html)
PT (1) PT3472314T (cg-RX-API-DMAC7.html)
SG (1) SG11201810915QA (cg-RX-API-DMAC7.html)
SI (1) SI3472314T1 (cg-RX-API-DMAC7.html)
WO (1) WO2017219034A2 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3604510T (lt) * 2009-03-30 2025-07-10 Alexion Pharmaceuticals, Inc. Faktoriaus xa inhibitorius neutralizuojančios medžiagos ir jų naudojimo būdai
EP2948168B1 (en) * 2013-01-24 2018-07-18 Portola Pharmaceuticals, Inc. Inhibition of tissue factor pathway inhibitor with factor xa derivatives
CN116425860B (zh) * 2016-06-17 2025-03-04 阿雷克森制药公司 因子xa衍生物的制备
JP2021527435A (ja) 2018-06-19 2021-10-14 アレクシオン ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子阻害剤に対する解毒剤
KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189019A (en) * 1990-04-23 1993-02-23 Merck & Co., Inc. Antistasin derived anticoagulant protein
US5589571A (en) * 1994-10-28 1996-12-31 Cor Therapeutics, Inc. Process for production of inhibited forms of activated blood factors
WO2014116275A1 (en) * 2013-01-24 2014-07-31 Portola Pharmaceuticals, Inc. INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR Xa DERIVATIVES
US20150025011A1 (en) * 2009-07-15 2015-01-22 Portola Pharmaceuticals, Inc. Unit dose formulation of antidotes for factor xa inhibitors and methods of using the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1066572A (ja) * 1996-08-29 1998-03-10 Showa Sangyo Co Ltd 高純度の大豆トリプシンインヒビターの製造方法
ATE311366T1 (de) 2000-02-29 2005-12-15 Millennium Pharm Inc Benzamide und ähnliche inhibitoren vom faktor xa
US7598276B2 (en) 2005-11-08 2009-10-06 Millenium Pharmaceuticals, Inc. Pharmaceutical salts and polymorphs of a factor Xa inhibitor
EP3824902A1 (en) * 2007-09-28 2021-05-26 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
CN102316893B (zh) 2008-11-14 2015-02-18 博尔托拉制药公司 因子Xa抑制剂的解毒剂及其与血液凝固剂组合使用的方法
LT3604510T (lt) * 2009-03-30 2025-07-10 Alexion Pharmaceuticals, Inc. Faktoriaus xa inhibitorius neutralizuojančios medžiagos ir jų naudojimo būdai
SG11201408028YA (en) * 2012-06-14 2015-01-29 Portola Pharm Inc METHOD FOR PURIFICATION OF RECOMBINANT FACTOR Xa DERIVATIVES
US20140346397A1 (en) * 2012-12-27 2014-11-27 Portola Pharmaceuticals, Inc. Compounds and methods for purification of serine proteases
SG11201601221XA (en) * 2013-09-24 2016-04-28 Pfizer Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins
KR20250150675A (ko) * 2014-08-20 2025-10-20 포톨라 파마슈티컬스, 인코포레이티드 인자 xa 해독제용 동결건조된 제형
CN116425860B (zh) * 2016-06-17 2025-03-04 阿雷克森制药公司 因子xa衍生物的制备

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189019A (en) * 1990-04-23 1993-02-23 Merck & Co., Inc. Antistasin derived anticoagulant protein
US5589571A (en) * 1994-10-28 1996-12-31 Cor Therapeutics, Inc. Process for production of inhibited forms of activated blood factors
US20150025011A1 (en) * 2009-07-15 2015-01-22 Portola Pharmaceuticals, Inc. Unit dose formulation of antidotes for factor xa inhibitors and methods of using the same
WO2014116275A1 (en) * 2013-01-24 2014-07-31 Portola Pharmaceuticals, Inc. INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR Xa DERIVATIVES

Non-Patent Citations (1)

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Title
JUSTESEN et al. "Recombinant chymosin used for exact and complete removal of a prochymosin derived fusion tag releasing intact native target protein," Protein Science, 16 March 2009 (16.03.2009), Vol. 18, Pgs. 1023-1032, entire document *

Also Published As

Publication number Publication date
EP3926044B1 (en) 2025-06-04
US10954504B2 (en) 2021-03-23
DK3472314T3 (da) 2021-07-26
PH12018502614A1 (en) 2019-09-30
EP4588932A2 (en) 2025-07-23
CN110167575B (zh) 2024-03-15
EP3472314A2 (en) 2019-04-24
EP3926044A1 (en) 2021-12-22
WO2017219034A3 (en) 2019-03-14
EP4588932A3 (en) 2025-10-01
SG11201810915QA (en) 2019-01-30
US20240076642A1 (en) 2024-03-07
WO2017219034A2 (en) 2017-12-21
IL263591A (en) 2019-02-03
PE20190661A1 (es) 2019-05-08
US11845966B2 (en) 2023-12-19
SI3472314T1 (sl) 2021-11-30
US20200208131A1 (en) 2020-07-02
US20210348149A1 (en) 2021-11-11
PT3472314T (pt) 2021-06-18
ES3038834T3 (en) 2025-10-15
IL263591B2 (en) 2023-03-01
KR20190019134A (ko) 2019-02-26
JP7273918B2 (ja) 2023-05-15
CN116425860B (zh) 2025-03-04
EP3472314B1 (en) 2021-05-05
JP6959268B2 (ja) 2021-11-02
CL2020001733A1 (es) 2020-09-25
US20170369862A1 (en) 2017-12-28
AU2017283720B2 (en) 2022-11-17
AU2023200825A1 (en) 2023-03-16
US10604748B2 (en) 2020-03-31
ES2875538T3 (es) 2021-11-10
JP2019528242A (ja) 2019-10-10
JP2022000477A (ja) 2022-01-04
HUE054597T2 (hu) 2021-09-28
CN118271391A (zh) 2024-07-02
CL2018003654A1 (es) 2019-01-25
BR112018075964A2 (pt) 2019-04-02
CN116425860A (zh) 2023-07-14
JP2023086970A (ja) 2023-06-22
AU2017283720A1 (en) 2019-01-03
KR102373215B1 (ko) 2022-03-10
PL3472314T3 (pl) 2021-11-22
IL263591B (en) 2022-11-01
EA201990052A1 (ru) 2019-05-31
CO2019000120A2 (es) 2019-03-29
MX2018015873A (es) 2019-08-12
CN110167575A (zh) 2019-08-23
CA3027457A1 (en) 2017-12-21
AU2017283720C1 (en) 2024-07-25
EP3472314A4 (en) 2020-01-22

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM