EA037232B1 - Lotion for treatment of acne manifestations, such as comedones, seborrhea, acneiform rash, red spots on skin - Google Patents

Abstract

The invention relates to the field of medical and hygienic cosmetics, namely to cosmetic lotions intended for the care of oily skin prone to acne, in particular, to acneiform rash, comedones, seborrhea and red spots. The objective of the invention is to create a more concise means against comedones, seborrhea and acne in the form of a lotion. The problem is solved by providing, according to the invention, a lotion for the treatment of comedones, seborrhea, acne and red spots including the following ingredients by mass fractions: clindamycin - 1.0-2.0, cinnamon extract (thick) - 0.5-1.5, clover extract (thick) - 1.0-2.0, calendula extract (thick) - 1.5-2.0, aloe extract (dry) - 1.0-5.0, urea - 1.0-2.0, propylene glycol - 2.0-3.0, salicylic acid - 0.04-0.06, lemon essential oil - 0.4-0.6, ethyl alcohol 60% - 40.8-60.8, water - the balance.

Description

(12) DESCRIPTION OF THE INVENTION TO THE EURASIAN PATENT (45) Date of publication and grant of the patent (51) Int. CI

2021.02.24 (21) Application number

201700533 (22) Application Filing Date

2017.07.18

A61K36 / 54 (2006.01)

A61K36 / 48 (2006.01)

A61K36 / 28 (2006.01)

A61K9 / 08 (2006.01)

A61K31 / 7056 (2006.01) A61K 8/9789 (2017.01)

A61R17 / 00 (2006.01)

A61R17 / 08 (2006.01)

А61Р17 / 70 (2006.01) (54) LOTION FOR TREATMENT OF SUCH ACNE MANIFESTATIONS AS COMEDONS, SEBORHA, ACNE RASH, RED SPOTS ON SKIN (43) 2019.01.31 (96) 2017/029 (AZ) 2017.07.18 (71) ( 73) Applicant and Patent Owner:

MEKHRALIEVA SEVIL JABRAIL KYZY (AZ) (72) Inventor:

Mehralieva Sevil Dzhabrail kyzy, Suleimanova Tarana Hafiz kyzy, Abishova Khayala Teyyub kyzy, Mammadli Nargiz Vahid kyzy (AZ) (oo) Remedies for acne of the propeller trademark. 09/24/2013 [online] [found 04/18/2018] Found at <http://desert-man.org.ua/ post292737813 />

EA-B1-19383

RU-C2-2548714

CN-A-106727100

RU-C1-2026669

KR-A-20070093948 (57) The invention relates to the field of medical and hygienic cosmetics, namely to cosmetic lotions intended for the care of oily skin prone to acne, in particular acne, comedones, seborrhea and red spots. The objective of the present invention is to create a more concise remedy against comedones, seborrhea and acne in the form of a lotion. The problem is solved by the fact that according to the invention, the lotion for the treatment of comedones, seborrhea, acne and red spots includes the ingredients in mass fractions: clindamycin 1.0-2.0; extract (thick) cinnamon - 0.5-1.5; extract (thick) clover - 1.0-2.0; extract (thick) calendula - 1.5-2.0; extract (dry) aloe - 1.0-5.0; urea - 1.0-2.0; propylene glycol - 2.0-3.0; salicylic acid - 0.04-0.06; lemon essential oil - 0.4-0.6; ethyl alcohol 60% - 40.8-60.8; water is the rest.

037232 Bl

037232 B1

The invention relates to the field of medical and hygienic cosmetics, namely to cosmetic lotions intended for the care of oily skin prone to acne, in particular acne, comedones, seborrhea and red spots.

Distinguish between non-inflammatory and inflammatory acne.

Non-inflammatory forms are of the following types: closed (white) comedones, open (black) comedones, milia.

Inflammatory forms of acne are superficial and deep.

Most patients on the skin of the face and trunk have non-inflammatory forms, superficial abscesses.

Acne is a common skin condition in humans that is characterized by areas of skin affected by seborrhea (red skin with scales), comedones (blackheads and whiteheads), papules (the size of a pinhead), pustules (pustules), nodules (large papules), and possibly scarring.

Acne mainly affects the skin with the densest accumulation of the sebaceous glands of the hair. Acne most often occurs during adolescence and affects more than 96% of adolescents, and often continues into adulthood. During adolescence, acne is usually caused by increased levels of male sex hormones, which increase in both sexes during puberty.

The cause of acne is associated with changes in the young body during its formation from childhood to puberty (puberty).

The hormones that lead to the physical maturation of the body also cause the sebaceous glands, which secrete sebum, to work too much. In men, these are androgens (male sex hormones), they are also in women, but in large quantities only in men. The sebaceous glands are located alongside the hair shaft in a node called the sebaceous follicle. During puberty, the skin becomes sebum more rapidly.

Also, people with acne tend to get sebum more quickly than people without acne. When the pores become clogged from excessive sebum, the ducts of the skin follicles become clogged. While the ducts are clogged, the sebaceous glands work continuously and produce sebum. From the continuous process, clogged follicles swell, not removing sebum outside, to the surface of the skin. Sometimes the follicle walls rupture, spreading inflammation to the surrounding skin. This is the process of skin acne lesions, from blackheads to pimples and nodular pimples.

Known creams for the care of oily skin prone to acne, which occurs more often in adolescence during puberty, such as Anti-Ugrin cream, Smile, containing emulsion waxes, stone oil, calendula infusion, or Eucalyptus cream containing spermaceti, cocoa butter, stone seed oil, eucalyptus oil, vitamins A and D, emulsifier, water, perfume.

However, when caring for oily skin, they are not absorbed well enough and do not remove the oily sheen.

Known cosmetic agent for the skin of the face, including a gel-forming component - polyethylene oxide, bacteriostatic, anti-inflammatory substances of plant origin, including extract of calendula (marigold), perfume, tanning agents and balanced salt solutions of Hanks or Earl. The main bioactive components in the given gel are plant extracts (oak, berry, birch, plantain, wormwood), which, although they have antiseptic and tanning properties, their action together with Hanks' or Earl's saline solution cannot solve the complex problem of preventing the occurrence of acne and skin care complicated by acne (RF patent No. 2124350, 1999).

Known patents, where calendula is used as medicinal diluents in anti-acne creams (RF patents No. 2026669, 1995, No. 2150234, 2000)

Known patents, where clindamycin is contained as an antimicrobial, antibiotic, antibacterial or antifungal agent (RF patents No. 2122412, 1998, No. 2134568, 1999). However, the formulations are more complex.

The objective of the present invention is to create a more concise remedy against comedones, seborrhea and acne in the form of a lotion.

The problem is solved by the fact that according to the invention, the lotion for the treatment of comedones, seborrhea and acne includes ingredients in mass fractions:

- 1 037232

Clindamycin 1.0-2.0 Extract (thick) cinnamon 0.5-1.5 (Thick) clover extract 1.0-2.0 Extract (thick) calendula 1.5-2.0 Extract (dry) aloe 1.0-5.0 Urea 1.0-2.0 Propylene glycol 2.0-3.0 Salicylic acid 0.04-0.06 Lemon essential oil 0.4- 0.6 Ethyl alcohol 60% 40.8-60.8 Water rest

The essence of the proposed lotion lies in the fact that, although the ingredients used, each individually, are used in compositions for the treatment of acne, however, in conjunction with the proposed thick extracts of medicinal plants, we have used them for the first time.

The introduction of a thick extract of clover and cinnamon enhances the antimicrobial, anti-inflammatory, anti-allergic and antifungal effects.

Clindamycin is a semi-synthetic antibiotic of the lincosamide group, Clindamycin is active against the causative agent of acne, the antimicrobial antibiotic inhibits the growth of bacteria (acne) Proplonibacterium acnes.

The extract of (thick) cinnamon has antiseptic, anti-inflammatory and antibacterial properties.

It contains eugenol, which kills germs. Stimulates the protective functions of the body, strengthens the immune system. It is a natural antioxidant. The biochemical composition of this spice is very diverse: cinnamon is rich in antioxidants and tannins, it is able to relieve inflammation and stimulate blood circulation, which means it accelerates the breakdown of fats (fhttp: //irinazavtseva.ru/korica-poleznve-svoistva-i-protivopokazaniva.html) ...

Extract (thick) clover has antimicrobial, anti-inflammatory, anti-allergic and antifungal effects, its preparations strengthen the walls of blood vessels.

The extract of (thick) calendula has a powerful bactericidal effect, therefore it is successfully used to heal wounds. Calendula in combination with other medicinal herbs has a very good effect on various diseases. For the treatment of skin diseases, an infusion of calendula flowers is used. Calendula flowers contain many useful acids (ascorbic, malic, salicylic) and other compounds, including carotenoids, which are especially rich in varieties with bright colors of flowers. Various decoctions, infusions and tinctures are prepared from them.

Aloe (dry) extract is a versatile herb that has several healing properties that can be used to treat acne scars, soothe skin, relieve inflammation, and promote healing and regeneration of damaged skin tissues. Aloe acne extract helps in that it can regenerate the skin by providing the necessary building blocks needed for damaged skin areas (http://aloe-vera.pro/treatment/item/21-akne).

Propylene glycol is used in cosmetics as an excellent moisturizer and absorbent.

Thanks to its excellent moisturizing properties, cosmetics with urea significantly alleviate dry skin. Improved skin properties such as softness, elasticity, firmness, smoothness. Dry skin areas disappear and skin texture is improved. Urea becomes an ideal ingredient for dry to very dry, flaky skin.

Salicylic acid is used as a formulation stabilizer.

Lemon essential oil is used as a perfume.

60% ethyl alcohol is used as a disinfectant, so it is added to cosmetics for problem skin.

Distilled water, freshly distilled.

The use of the composition below the claimed limit is impractical, since there is a protracted period of treatment, and in some cases complete healing of acne does not occur and red spots do not completely disappear, and an increase in the claimed composition limit may cause unwanted allergy to some ingredients of the composition, for example, to alcohol, clindamycin.

To prepare the lotion, first prepare a 60% solution of ethyl alcohol and prepare the claimed ingredients in mass fractions. The plant extracts are mixed and pre-dissolved in 7 ml of purified water. A predetermined amount of propylene glycol and lemon essential oil are measured.

- 2 037232

The lotion is prepared as follows: in a clean flask, with a capacity of 150 ml, set on a magnetic stirrer and first introduce clindamycin, salicylic acid, urea and ethyl alcohol and stir until completely dissolved. Then a solution of plant extracts is added to the resulting mixture, continuing stirring until a homogeneous mass is obtained, where propylene glycol and essential oil are gradually introduced.

The resulting lotion has a pleasant lemon scent, orange-brown color, viscous consistency, the pH of the solution is 5.5-7.0.

Table 1 shows the data on the preparation of the lotion.

Table 1

No. p / p Ingredients, wt% Examples of one 2 3 one clindamycin 1.0 1.5 2.0 2 Thick cinnamon extract 1.5 0.5 0.75 3 Dense clover extract 1.0 1.5 2.0 four Dense extract of calendula 1.5 2.0 1.75 five Dry extract of aloe 1.0 3.0 5.0 6 urea 2.0 1.5 1.0 7 propylene glycol 2.0 2.5 3.0 8 Salicylic acid 0.04 0.06 0.05 nine Ethanol 40.8 50.8 60.8 ten Lemon essential oil 0.6 0.5 0,4 AND Purified water rest rest rest 12 pH 7.0 6.0 5.0

Microbiological studies of the proposed lotion were carried out.

Three formulations were considered for the study:

1) an alcoholic solution of clindamycin hydrochloride;

2) plant extracts;

3) plant extracts with clindamycin hydrochloride.

The studies were carried out by the diffusion disk method.

As a result of the research, it was revealed that the investigated solutions 1 and 11 have a fungicidal and bactericidal effect.

Unlike clindamycin, plant extracts differ slightly from E. coli microorganisms and completely have the detrimental effect of St. aureus b Candida albicansa.

The data are presented in table. 2.

table 2

Test solutions test microorganisms gram negative gram-positive mushroom culture Psevdomonas aeruginoza E.Coli St.aureus Candida albicans Control alcoholic solution of clindamycin hydrochloride (-) (-) (++++) 11mm (-) Lotion I- prepared in the laboratory (plant extracts + clindamycin (-) (++) 5mm (++++) 22mm (++++) 20mm Lotion P prepared in the laboratory (herbal extracts) (-) (++) 5mm (++++) 18mm (++++) 16mm

Considering all this, the presence of Candida albicans and Staphylococcus aureus in lotion-I causes a number of skin infections, as well as superficial mycoses, local infections, so a local antiseptic treatment of acne can be used. Also, given the fact that a certain group of people undergo antibiotic reactions (high allergic sensitivity), as well as during repeated use, lotion-II is considered more suitable for topical application.

It is necessary to take into account the pathogenetic factors that can contribute to the long and persistent course of the disease (upset from the gastrointestinal tract, liver function, etc.). It is imperative to eliminate the existing foci of infection; chronic tonsillitis, sinusitis, etc. In complex therapy, much attention is paid to the diet.

Patients are advised to limit the diet of animal fats (pork, lamb), smoked meats, easily digestible carbohydrates (honey, jam), as well as extractives. Food should be rich in fiber, vitamins, lactic acid products.

Prepare the skin before cleansing. After washing with detergents, the face is steamed over a saucepan of hot water. Any scrub composition is applied to wet skin. Spread the mixture evenly over the face and massage gently in a circular motion. After that, rinse your face with cool water and apply a healing cream on it.

Claims (1)

Lotion for the treatment of such manifestations of acne as comedones, seborrhea, acne, red spots on the skin includes ingredients in mass fractions: clindamycin - 1.0-2.0; extract (thick) cinnamon - 0.5-1.5; extract (thick) clover - 1.0-2.0; extract (thick) calendula - 1.5-2.0; extract (dry) aloe - 1.0-5.0; urea - 1.0-2.0; propylene glycol - 2.0-3.0; salicylic acid - 0.04-0.06; lemon essential oil - 0.4-0.6; ethyl alcohol 60% - 40.8-60.8; water is the rest. Evra Eurasian Patent Organization, EAPO Russia, 109012, Moscow, Maly Cherkassky per., 2