EA035550B1 - АНТИТЕЛА, КОТОРЫЕ СВЯЗЫВАЮТСЯ С КОМПЛЕКСОМ hGARP/TGF-B1, И ИХ ПРИМЕНЕНИЕ - Google Patents

АНТИТЕЛА, КОТОРЫЕ СВЯЗЫВАЮТСЯ С КОМПЛЕКСОМ hGARP/TGF-B1, И ИХ ПРИМЕНЕНИЕ Download PDF

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Publication number
EA035550B1
EA035550B1 EA201690314A EA201690314A EA035550B1 EA 035550 B1 EA035550 B1 EA 035550B1 EA 201690314 A EA201690314 A EA 201690314A EA 201690314 A EA201690314 A EA 201690314A EA 035550 B1 EA035550 B1 EA 035550B1
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Eurasian Patent Office
Prior art keywords
antibody
seq
hgarp
human
tgf
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EA201690314A
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English (en)
Russian (ru)
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EA201690314A1 (ru
Inventor
Софи Лукас
Пьерр Кули
Юлиа Куэнде Вилласур
Лор Дюмутье
Жан-Кристоф Рено
Себастиан Ван Де Вонинг
Майкл Сондерс
Ханс Де Хард
Гитте Де Бук
Original Assignee
Юниверсите Католик Де Лувэн
Людвиг Инститьют Фор Кэнсер Рисерч Лтд.
Ардженкс Бвба
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Priority claimed from EP13178958.8A external-priority patent/EP2832747A1/en
Application filed by Юниверсите Католик Де Лувэн, Людвиг Инститьют Фор Кэнсер Рисерч Лтд., Ардженкс Бвба filed Critical Юниверсите Католик Де Лувэн
Publication of EA201690314A1 publication Critical patent/EA201690314A1/ru
Publication of EA035550B1 publication Critical patent/EA035550B1/ru

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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/54—F(ab')2
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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EA201690314A 2013-08-01 2014-08-01 АНТИТЕЛА, КОТОРЫЕ СВЯЗЫВАЮТСЯ С КОМПЛЕКСОМ hGARP/TGF-B1, И ИХ ПРИМЕНЕНИЕ EA035550B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361861008P 2013-08-01 2013-08-01
EP13178958.8A EP2832747A1 (en) 2013-08-01 2013-08-01 Anti-GARP protein and uses thereof
EP14167425 2014-05-07
PCT/EP2014/066650 WO2015015003A1 (en) 2013-08-01 2014-08-01 Anti-garp protein and uses thereof

Publications (2)

Publication Number Publication Date
EA201690314A1 EA201690314A1 (ru) 2016-07-29
EA035550B1 true EA035550B1 (ru) 2020-07-06

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EA201690314A EA035550B1 (ru) 2013-08-01 2014-08-01 АНТИТЕЛА, КОТОРЫЕ СВЯЗЫВАЮТСЯ С КОМПЛЕКСОМ hGARP/TGF-B1, И ИХ ПРИМЕНЕНИЕ

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US (5) US10000572B2 (OSRAM)
EP (2) EP3027650B1 (OSRAM)
JP (3) JP2016529892A (OSRAM)
KR (2) KR20220025174A (OSRAM)
CN (2) CN113583128A (OSRAM)
AU (3) AU2014298373B2 (OSRAM)
BR (1) BR112016002199B8 (OSRAM)
CA (1) CA2919765C (OSRAM)
EA (1) EA035550B1 (OSRAM)
ES (1) ES2860952T3 (OSRAM)
IL (2) IL243899B (OSRAM)
MX (2) MX377091B (OSRAM)
NZ (1) NZ717476A (OSRAM)
SG (2) SG11201600741SA (OSRAM)
WO (1) WO2015015003A1 (OSRAM)
ZA (1) ZA201601085B (OSRAM)

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