EA033603B1 - 6-альфа-алкил-6,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr - Google Patents

6-альфа-алкил-6,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr Download PDF

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Publication number
EA033603B1
EA033603B1 EA201790885A EA201790885A EA033603B1 EA 033603 B1 EA033603 B1 EA 033603B1 EA 201790885 A EA201790885 A EA 201790885A EA 201790885 A EA201790885 A EA 201790885A EA 033603 B1 EA033603 B1 EA 033603B1
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EA
Eurasian Patent Office
Prior art keywords
general formula
alkyl
compound
compounds
ethyl
Prior art date
Application number
EA201790885A
Other languages
English (en)
Russian (ru)
Other versions
EA201790885A1 (ru
Inventor
Alexander Weymouth-Wilson
Zofia Komsta
James Boydell
Laura Wallis
Carl Otter
Ieuan Davies
Rob Clarkson
Original Assignee
Nzp Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505675.7A external-priority patent/GB201505675D0/en
Application filed by Nzp Uk Ltd filed Critical Nzp Uk Ltd
Publication of EA201790885A1 publication Critical patent/EA201790885A1/ru
Publication of EA033603B1 publication Critical patent/EA033603B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA201790885A 2014-11-19 2015-11-19 6-альфа-алкил-6,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr EA033603B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505675.7A GB201505675D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053519 WO2016079520A1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators

Publications (2)

Publication Number Publication Date
EA201790885A1 EA201790885A1 (ru) 2017-11-30
EA033603B1 true EA033603B1 (ru) 2019-11-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790885A EA033603B1 (ru) 2014-11-19 2015-11-19 6-альфа-алкил-6,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr

Country Status (10)

Country Link
US (2) US20170327531A1 (enExample)
EP (1) EP3221334B1 (enExample)
JP (1) JP6698085B2 (enExample)
KR (1) KR102527821B1 (enExample)
CN (1) CN107207558B (enExample)
CA (1) CA2968310A1 (enExample)
EA (1) EA033603B1 (enExample)
MX (1) MX381239B (enExample)
TW (1) TWI688571B (enExample)
WO (1) WO2016079520A1 (enExample)

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JP6700274B2 (ja) 2014-11-19 2020-05-27 エヌゼットピー ユーケー リミテッド ステロイドｆｘｒモジュレーター製造のための中間体としての６−アルキル−７−ヒドロキシ−４−エン−３−オンステロイド
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WO2016079520A1 (en) 2014-11-19 2016-05-26 Dextra Laboratories Limited 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators
EP3221333B1 (en) 2014-11-19 2019-07-24 NZP UK Limited 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators
CA3009149A1 (en) * 2015-12-22 2017-06-29 Intercept Pharmaceuticals, Inc. Polymorphic crystalline forms of obeticholic acid
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
GB201608779D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
CN106046093A (zh) * 2016-05-30 2016-10-26 华东师范大学 一种石胆酸的合成方法
EP3431486A1 (en) 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CN111285914B (zh) * 2018-12-10 2023-02-17 江西青峰药业有限公司 一种奥贝胆酸的制备方法

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Also Published As

Publication number Publication date
US20190077827A1 (en) 2019-03-14
JP2017534669A (ja) 2017-11-24
MX381239B (es) 2025-03-12
WO2016079520A1 (en) 2016-05-26
MX2017006567A (es) 2018-01-26
TWI688571B (zh) 2020-03-21
US10597423B2 (en) 2020-03-24
EP3221334A1 (en) 2017-09-27
JP6698085B2 (ja) 2020-05-27
US20170327531A1 (en) 2017-11-16
HK1244286A1 (en) 2018-08-03
CN107207558B (zh) 2019-10-29
KR20170099896A (ko) 2017-09-01
TW201632539A (zh) 2016-09-16
KR102527821B1 (ko) 2023-05-02
EA201790885A1 (ru) 2017-11-30
EP3221334B1 (en) 2020-02-19
CA2968310A1 (en) 2016-05-26
CN107207558A (zh) 2017-09-26

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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