CN107207558B - 作为制备类固醇FXR调节剂的中间体的6α-烷基-6,7-二酮类固醇 - Google Patents

作为制备类固醇FXR调节剂的中间体的6α-烷基-6,7-二酮类固醇 Download PDF

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Publication number
CN107207558B
CN107207558B CN201580062901.6A CN201580062901A CN107207558B CN 107207558 B CN107207558 B CN 107207558B CN 201580062901 A CN201580062901 A CN 201580062901A CN 107207558 B CN107207558 B CN 107207558B
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alkyl
compound
general formula
compounds
logical formula
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CN107207558A (zh
Inventor
A·韦茅斯-威尔逊
Z·科姆斯塔
J·博伊德尔
L·沃利斯
C·奥特
I·戴维斯
R·克拉克森
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Nzp Uk Ltd
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Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1505675.7A external-priority patent/GB201505675D0/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580062901.6A 2014-11-19 2015-11-19 作为制备类固醇FXR调节剂的中间体的6α-烷基-6,7-二酮类固醇 Active CN107207558B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GB1420593.4 2014-11-19
GB1420594.2 2014-11-19
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505675.7A GB201505675D0 (en) 2015-04-01 2015-04-01 Compounds
GB1505675.7 2015-04-01
PCT/GB2015/053519 WO2016079520A1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators

Publications (2)

Publication Number Publication Date
CN107207558A CN107207558A (zh) 2017-09-26
CN107207558B true CN107207558B (zh) 2019-10-29

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CN201580062901.6A Active CN107207558B (zh) 2014-11-19 2015-11-19 作为制备类固醇FXR调节剂的中间体的6α-烷基-6,7-二酮类固醇

Country Status (10)

Country Link
US (2) US20170327531A1 (enExample)
EP (1) EP3221334B1 (enExample)
JP (1) JP6698085B2 (enExample)
KR (1) KR102527821B1 (enExample)
CN (1) CN107207558B (enExample)
CA (1) CA2968310A1 (enExample)
EA (1) EA033603B1 (enExample)
MX (1) MX381239B (enExample)
TW (1) TWI688571B (enExample)
WO (1) WO2016079520A1 (enExample)

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CN107108688B (zh) 2014-11-19 2019-10-29 Nzp英国有限公司 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇
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MX375864B (es) 2014-11-19 2025-03-07 Nzp Uk Ltd Esteroides de 5.beta-6-alquil-7-hidroxi-3-ona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr)
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GB201608779D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
CN106046093A (zh) * 2016-05-30 2016-10-26 华东师范大学 一种石胆酸的合成方法
EP3431486A1 (en) 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CN111285914B (zh) * 2018-12-10 2023-02-17 江西青峰药业有限公司 一种奥贝胆酸的制备方法

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TW201632539A (zh) 2016-09-16
CA2968310A1 (en) 2016-05-26
HK1244286A1 (en) 2018-08-03
KR20170099896A (ko) 2017-09-01
JP6698085B2 (ja) 2020-05-27
MX2017006567A (es) 2018-01-26
EA201790885A1 (ru) 2017-11-30
TWI688571B (zh) 2020-03-21
KR102527821B1 (ko) 2023-05-02
MX381239B (es) 2025-03-12
EP3221334B1 (en) 2020-02-19
CN107207558A (zh) 2017-09-26
EA033603B1 (ru) 2019-11-08
US20190077827A1 (en) 2019-03-14
EP3221334A1 (en) 2017-09-27
WO2016079520A1 (en) 2016-05-26
US20170327531A1 (en) 2017-11-16
JP2017534669A (ja) 2017-11-24
US10597423B2 (en) 2020-03-24

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