EA033550B1 - Способ получения наночастиц нитрида бора для доставки противоопухолевых препаратов - Google Patents

Способ получения наночастиц нитрида бора для доставки противоопухолевых препаратов

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Publication number
EA033550B1
EA033550B1 EA201700214A EA201700214A EA033550B1 EA 033550 B1 EA033550 B1 EA 033550B1 EA 201700214 A EA201700214 A EA 201700214A EA 201700214 A EA201700214 A EA 201700214A EA 033550 B1 EA033550 B1 EA 033550B1
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EA
Eurasian Patent Office
Prior art keywords
boron nitride
nitride nanoparticles
antitumor drug
antitumor
fabrication
Prior art date
Application number
EA201700214A
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English (en)
Other versions
EA201700214A1 (ru
Inventor
Dmitry Vladimirovich Shtansky
Andrey Mikhailovich Kovalskii
Andrei Trofimovich Matveev
Irina Viktorovna Sukhorukova
Natalia Aleksandrovna Gloushankova
Irina Yur'evna Zhitnyak
Original Assignee
Federal State Autonomous Educational Institution Of Higher Education National Univ Of Science And Te
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Application filed by Federal State Autonomous Educational Institution Of Higher Education National Univ Of Science And Te filed Critical Federal State Autonomous Educational Institution Of Higher Education National Univ Of Science And Te
Publication of EA201700214A1 publication Critical patent/EA201700214A1/ru
Publication of EA033550B1 publication Critical patent/EA033550B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
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    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Ceramic Engineering (AREA)
  • Molecular Biology (AREA)
  • Manufacturing & Machinery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к области наномедицинских технологий, а именно к созданию нанотранспортеров лекарственных препаратов для противоопухолевой химиотерапии. Технический результат, достигаемый в предложенном изобретении, заключается в повышении эффективности противоопухолевой химиотерапии, в повышении активности поглощения клетками наноконтейнеров с противоопухолевым препаратом, предотвращении токсичности наноконтейнеров для клеток за счет применения диспергированных наночастиц нитрида бора размером 50-300 нм с развитой наружной поверхностью. Указанный технический результат достигается следующим образом. Способ получения наночастиц нитрида бора для доставки противоопухолевого препарата в опухолевые клетки включает синтез сферических наночастиц нитрида бора размером 50-300 нм с развитой наружной поверхностью методом химического осаждения из газовой фазы с применением реакционного газа, в качестве которого используют аммиак, транспортного газа, в качестве которого используют аргон, и порошковых смесей, состоящих из аморфного бора и реагент-окислителей. Химическое осаждение проводят при следующих условиях:где T - температура порошковой смеси, °C; ξ - отношение удельных потоков газов F/F, где F- удельный поток транспортного газа; F- удельный поток реакционного газа. Далее проводят диспергирование агломератов полученных наночастиц нитрида бора методом ультразвуковой обработки. Затем осуществляют насыщение наночастиц нитрида бора противоопухолевым препаратом методом сорбции. Далее проводят промывку наночастиц нитрида бора в дистиллированной воде.
EA201700214A 2014-11-20 2015-02-04 Способ получения наночастиц нитрида бора для доставки противоопухолевых препаратов EA033550B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2014146689/15A RU2565432C1 (ru) 2014-11-20 2014-11-20 Способ получения наночастиц нитрида бора для доставки противоопухолевых препаратов
PCT/RU2015/000064 WO2016080860A1 (en) 2014-11-20 2015-02-04 Method of boron nitride nanoparticle fabrication for antitumor drug delivery

Publications (2)

Publication Number Publication Date
EA201700214A1 EA201700214A1 (ru) 2017-10-31
EA033550B1 true EA033550B1 (ru) 2019-10-31

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EA201700214A EA033550B1 (ru) 2014-11-20 2015-02-04 Способ получения наночастиц нитрида бора для доставки противоопухолевых препаратов

Country Status (9)

Country Link
US (1) US20170258724A1 (ru)
EP (1) EP3220960B1 (ru)
JP (1) JP6370491B2 (ru)
KR (1) KR101953684B1 (ru)
CN (1) CN107530444B (ru)
EA (1) EA033550B1 (ru)
IL (1) IL252319B (ru)
RU (1) RU2565432C1 (ru)
WO (1) WO2016080860A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2635865C1 (ru) * 2016-07-26 2017-11-16 Федеральное государственное бюджетное учреждение науки Ордена Ленина и Ордена Октябрьской революции Институт геохимии и аналитической химии им. В.И. Вернадского Российской академии наук (ГЕОХИ РАН) Способ получения наночастиц полистирольных ионообменников для доставки противоопухолевых препаратов
RU2722745C1 (ru) * 2018-12-27 2020-06-03 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения наноконтейнеров для химиотерапевтических противоопухолевых препаратов
RU2720458C1 (ru) * 2019-06-06 2020-04-30 Автономное некоммерческое объединение "Международный научно-исследовательский центр инновационных технологий" (АНО "МНИЦИТ МАРТИНЕКС") Способ получения композиции для бор-нейтронозахватной терапии злокачественных опухолей (варианты)
KR102494639B1 (ko) * 2020-08-19 2023-02-02 내일테크놀로지 주식회사 나노 재료의 제조방법 및 장치
CN112972422A (zh) * 2021-03-04 2021-06-18 上海糖愈生物科技有限公司 一种肿瘤细胞膜仿生氮化硼纳米球及其制备方法和应用
CN115607668A (zh) * 2022-09-20 2023-01-17 山西医科大学 基于硼中子俘获治疗的富硼纳米制剂及其制备方法

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Also Published As

Publication number Publication date
JP2018502827A (ja) 2018-02-01
CN107530444B (zh) 2019-04-19
KR101953684B1 (ko) 2019-03-04
WO2016080860A1 (en) 2016-05-26
CN107530444A (zh) 2018-01-02
US20170258724A1 (en) 2017-09-14
JP6370491B2 (ja) 2018-08-08
KR20170102870A (ko) 2017-09-12
EA201700214A1 (ru) 2017-10-31
WO2016080860A8 (en) 2017-06-15
IL252319A0 (en) 2017-08-31
RU2565432C1 (ru) 2015-10-20
EP3220960B1 (en) 2019-12-25
EP3220960A4 (en) 2018-07-04
EP3220960A1 (en) 2017-09-27
IL252319B (en) 2021-04-29

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