EA033106B1 - Производное пуринил-n-гидроксипиримидинформамида, способы его получения и его применения - Google Patents

Производное пуринил-n-гидроксипиримидинформамида, способы его получения и его применения

Info

Publication number
EA033106B1
EA033106B1 EA201792215A EA201792215A EA033106B1 EA 033106 B1 EA033106 B1 EA 033106B1 EA 201792215 A EA201792215 A EA 201792215A EA 201792215 A EA201792215 A EA 201792215A EA 033106 B1 EA033106 B1 EA 033106B1
Authority
EA
Eurasian Patent Office
Prior art keywords
purinyl
hydroxyl pyrimidine
pyrimidine formamide
preparation methods
methods therefor
Prior art date
Application number
EA201792215A
Other languages
English (en)
Russian (ru)
Other versions
EA201792215A1 (ru
Inventor
Лицзюань Чэнь
Юйцюань Вэй
Original Assignee
Гуйчжоу Бэйлинг Груп Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гуйчжоу Бэйлинг Груп Фармасьютикал Ко., Лтд. filed Critical Гуйчжоу Бэйлинг Груп Фармасьютикал Ко., Лтд.
Publication of EA201792215A1 publication Critical patent/EA201792215A1/ru
Publication of EA033106B1 publication Critical patent/EA033106B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EA201792215A 2015-04-21 2016-04-12 Производное пуринил-n-гидроксипиримидинформамида, способы его получения и его применения EA033106B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510189476 2015-04-21
PCT/CN2016/079022 WO2016169417A1 (zh) 2015-04-21 2016-04-12 嘌呤基-n-羟基嘧啶甲酰胺衍生物及其制备方法和用途

Publications (2)

Publication Number Publication Date
EA201792215A1 EA201792215A1 (ru) 2018-05-31
EA033106B1 true EA033106B1 (ru) 2019-08-30

Family

ID=57143713

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201792215A EA033106B1 (ru) 2015-04-21 2016-04-12 Производное пуринил-n-гидроксипиримидинформамида, способы его получения и его применения

Country Status (10)

Country Link
US (1) US10227347B2 (zh)
EP (1) EP3287459B1 (zh)
JP (1) JP6518833B2 (zh)
KR (1) KR102015826B1 (zh)
CN (1) CN107849045B (zh)
AU (1) AU2016250972B2 (zh)
CA (1) CA2983042C (zh)
EA (1) EA033106B1 (zh)
ES (1) ES2833473T3 (zh)
WO (1) WO2016169417A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111646995B (zh) * 2019-03-04 2023-03-21 四川大学 4-氨基-嘧啶并氮杂环-苯基脲类衍生物及其制备方法和用途
CN113413389B (zh) * 2021-07-19 2024-03-15 成都赜灵生物医药科技有限公司 一种组蛋白去乙酰化酶抑制剂的制剂及其制备方法和用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102341108A (zh) * 2009-01-08 2012-02-01 柯瑞斯公司 具有锌结合半族的磷酸肌醇3-激酶抑制剂
CN102970868A (zh) * 2010-04-16 2013-03-13 柯瑞斯公司 具有k-ras突变的癌症的治疗
CN103582483A (zh) * 2011-04-01 2014-02-12 柯瑞斯公司 具有锌结合位的磷脂酰肌醇3-激酶抑制剂
CN104066722A (zh) * 2012-02-01 2014-09-24 克莱斯托生物药业有限公司 新型治疗药物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2563699C (en) * 2004-04-23 2014-03-25 Exelixis, Inc. Kinase modulators and method of use
FR2880626B1 (fr) * 2005-01-13 2008-04-18 Aventis Pharma Sa Derives de la purine, compositions les contenant et utilisation
US20080233127A1 (en) * 2007-03-21 2008-09-25 Wyeth Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors
WO2009017838A2 (en) * 2007-08-01 2009-02-05 Exelixis, Inc. Combinations of jak-2 inhibitors and other agents
WO2009146406A1 (en) * 2008-05-30 2009-12-03 Genentech, Inc. Purine pi3k inhibitor compounds and methods of use
SG190211A1 (en) * 2010-11-16 2013-06-28 Acetylon Pharmaceuticals Inc Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
WO2015137887A1 (en) * 2014-03-13 2015-09-17 Agency For Science, Technology And Research Fused pyrimidine-based hydroxamate derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102341108A (zh) * 2009-01-08 2012-02-01 柯瑞斯公司 具有锌结合半族的磷酸肌醇3-激酶抑制剂
CN102970868A (zh) * 2010-04-16 2013-03-13 柯瑞斯公司 具有k-ras突变的癌症的治疗
CN103582483A (zh) * 2011-04-01 2014-02-12 柯瑞斯公司 具有锌结合位的磷脂酰肌醇3-激酶抑制剂
CN104066722A (zh) * 2012-02-01 2014-09-24 克莱斯托生物药业有限公司 新型治疗药物

Also Published As

Publication number Publication date
EP3287459A1 (en) 2018-02-28
EA201792215A1 (ru) 2018-05-31
EP3287459A4 (en) 2018-10-24
JP6518833B2 (ja) 2019-05-22
EP3287459B1 (en) 2020-09-02
US10227347B2 (en) 2019-03-12
KR20180011068A (ko) 2018-01-31
JP2018521111A (ja) 2018-08-02
AU2016250972B2 (en) 2019-01-17
AU2016250972A1 (en) 2017-11-09
CA2983042A1 (en) 2016-10-27
CA2983042C (en) 2020-01-07
WO2016169417A1 (zh) 2016-10-27
ES2833473T3 (es) 2021-06-15
CN107849045B (zh) 2019-12-24
CN107849045A (zh) 2018-03-27
KR102015826B1 (ko) 2019-08-29
US20180134709A1 (en) 2018-05-17

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Legal Events

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PC4A Registration of transfer of a eurasian patent by assignment