EA033057B1 - Производные 5-(n-бензил-тетрагидроизохинолин-6-ил)пиридин-3-ил-уксусной кислоты в качестве ингибиторов репликации вируса иммунодефицита человека - Google Patents
Производные 5-(n-бензил-тетрагидроизохинолин-6-ил)пиридин-3-ил-уксусной кислоты в качестве ингибиторов репликации вируса иммунодефицита человекаInfo
- Publication number
- EA033057B1 EA033057B1 EA201890361A EA201890361A EA033057B1 EA 033057 B1 EA033057 B1 EA 033057B1 EA 201890361 A EA201890361 A EA 201890361A EA 201890361 A EA201890361 A EA 201890361A EA 033057 B1 EA033057 B1 EA 033057B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- alkoxy
- ris
- compounds
- tetrahydroisoquinolin
- Prior art date
Links
- WGNUNYPERJMVRM-UHFFFAOYSA-N 3-pyridylacetic acid Chemical class OC(=O)CC1=CC=CN=C1 WGNUNYPERJMVRM-UHFFFAOYSA-N 0.000 title 1
- 241000725303 Human immunodeficiency virus Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 homopiperidinyl Chemical group 0.000 abstract 4
- 125000001188 haloalkyl group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 108010002459 HIV Integrase Proteins 0.000 abstract 1
- 125000002393 azetidinyl group Chemical group 0.000 abstract 1
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000005433 dihydrobenzodioxinyl group Chemical group O1C(COC2=C1C=CC=C2)* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562203791P | 2015-08-11 | 2015-08-11 | |
| PCT/IB2016/054832 WO2017025917A1 (en) | 2015-08-11 | 2016-08-10 | 5-(n-benzyl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201890361A1 EA201890361A1 (ru) | 2018-11-30 |
| EA033057B1 true EA033057B1 (ru) | 2019-08-30 |
Family
ID=56851651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201890361A EA033057B1 (ru) | 2015-08-11 | 2016-08-10 | Производные 5-(n-бензил-тетрагидроизохинолин-6-ил)пиридин-3-ил-уксусной кислоты в качестве ингибиторов репликации вируса иммунодефицита человека |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US10189816B2 (enExample) |
| EP (1) | EP3334716A1 (enExample) |
| JP (1) | JP6782766B2 (enExample) |
| KR (1) | KR20180032649A (enExample) |
| CN (1) | CN108137534A (enExample) |
| AR (1) | AR105653A1 (enExample) |
| AU (1) | AU2016306089B2 (enExample) |
| CA (1) | CA2994791A1 (enExample) |
| CL (1) | CL2018000363A1 (enExample) |
| CO (1) | CO2018001359A2 (enExample) |
| CR (1) | CR20180091A (enExample) |
| DO (1) | DOP2018000035A (enExample) |
| EA (1) | EA033057B1 (enExample) |
| HK (1) | HK1249503A1 (enExample) |
| IL (1) | IL257240B (enExample) |
| MA (1) | MA42614A (enExample) |
| MX (1) | MX2018001722A (enExample) |
| PE (1) | PE20181002A1 (enExample) |
| PH (1) | PH12018500294A1 (enExample) |
| TW (1) | TWI657086B (enExample) |
| UA (1) | UA120464C2 (enExample) |
| WO (1) | WO2017025917A1 (enExample) |
| ZA (1) | ZA201800689B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180032650A (ko) * | 2015-08-12 | 2018-03-30 | 비브 헬스케어 유케이 (넘버5) 리미티드 | 인간 면역결핍 바이러스 복제의 억제제로서 5-(n-[6,5]-융합된 바이사이클릭 아릴 테트라하이드로이소퀴놀린-6-일) 피리딘-3-일 아세트산 유도체 |
| TW201718537A (zh) * | 2015-08-12 | 2017-06-01 | Ｖｉｉｖ醫療保健英國（Ｎｏ．５）有限公司 | 做為人類免疫缺陷病毒複製抑制劑之吡啶－３－基乙酸衍生物 |
| WO2017195113A1 (en) * | 2016-05-11 | 2017-11-16 | VIIV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| EP3455214A1 (en) * | 2016-05-11 | 2019-03-20 | ViiV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| US20200325127A1 (en) * | 2016-05-11 | 2020-10-15 | VIIV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| EP3565809A1 (en) * | 2017-01-03 | 2019-11-13 | ViiV Healthcare UK (No.5) Limited | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
| JP2020503352A (ja) * | 2017-01-03 | 2020-01-30 | ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド | ヒト免疫不全ウイルス複製の阻害剤としてのピリジン−３−イル酢酸誘導体 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010130034A1 (en) * | 2009-05-15 | 2010-11-18 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| WO2015127003A1 (en) * | 2014-02-20 | 2015-08-27 | Bristol-Myers Squibb Company | Pyridin-3-yl acetic acid macrocycles as inhibitors of human immunodeficiency virus replication |
| WO2015126726A1 (en) * | 2014-02-20 | 2015-08-27 | Bristol-Myers Squibb Company | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7939545B2 (en) * | 2006-05-16 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| RU2503679C2 (ru) | 2007-11-15 | 2014-01-10 | Джилид Сайенсиз, Инк. | Ингибиторы репликации вируса иммунодефицита человека |
| US8377960B2 (en) * | 2007-11-15 | 2013-02-19 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| CA2705338A1 (en) | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| WO2009062285A1 (en) | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| ES2475970T3 (es) | 2009-12-23 | 2014-07-11 | Katholieke Universiteit Leuven | Novedosos compuestos antivirales |
| US8633200B2 (en) | 2010-09-08 | 2014-01-21 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US8629276B2 (en) | 2012-02-15 | 2014-01-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9034882B2 (en) | 2012-03-05 | 2015-05-19 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| WO2014164467A1 (en) | 2013-03-13 | 2014-10-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| CN105189503B (zh) | 2013-03-14 | 2017-03-22 | 百时美施贵宝公司 | 人免疫缺陷病毒复制的抑制剂 |
| TW201718537A (zh) * | 2015-08-12 | 2017-06-01 | Ｖｉｉｖ醫療保健英國（Ｎｏ．５）有限公司 | 做為人類免疫缺陷病毒複製抑制劑之吡啶－３－基乙酸衍生物 |
| CN108137552A (zh) * | 2015-08-12 | 2018-06-08 | Viiv保健英国第五有限公司 | 作为人免疫缺陷病毒复制的抑制剂的5-(n-稠合三环芳基四氢异喹啉-6-基)吡啶-3-基乙酸衍生物 |
| KR20180032650A (ko) * | 2015-08-12 | 2018-03-30 | 비브 헬스케어 유케이 (넘버5) 리미티드 | 인간 면역결핍 바이러스 복제의 억제제로서 5-(n-[6,5]-융합된 바이사이클릭 아릴 테트라하이드로이소퀴놀린-6-일) 피리딘-3-일 아세트산 유도체 |
-
2016
- 2016-08-09 TW TW105125345A patent/TWI657086B/zh not_active IP Right Cessation
- 2016-08-09 AR ARP160102438A patent/AR105653A1/es unknown
- 2016-08-10 US US15/749,176 patent/US10189816B2/en active Active
- 2016-08-10 KR KR1020187006791A patent/KR20180032649A/ko not_active Withdrawn
- 2016-08-10 CA CA2994791A patent/CA2994791A1/en not_active Abandoned
- 2016-08-10 EP EP16758283.2A patent/EP3334716A1/en not_active Withdrawn
- 2016-08-10 WO PCT/IB2016/054832 patent/WO2017025917A1/en not_active Ceased
- 2016-08-10 UA UAA201801137A patent/UA120464C2/uk unknown
- 2016-08-10 EA EA201890361A patent/EA033057B1/ru not_active IP Right Cessation
- 2016-08-10 HK HK18108030.5A patent/HK1249503A1/zh unknown
- 2016-08-10 CN CN201680059469.XA patent/CN108137534A/zh active Pending
- 2016-08-10 JP JP2018507010A patent/JP6782766B2/ja active Active
- 2016-08-10 PE PE2018000174A patent/PE20181002A1/es unknown
- 2016-08-10 MA MA042614A patent/MA42614A/fr unknown
- 2016-08-10 AU AU2016306089A patent/AU2016306089B2/en not_active Ceased
- 2016-08-10 MX MX2018001722A patent/MX2018001722A/es unknown
- 2016-08-10 CR CR20180091A patent/CR20180091A/es unknown
-
2018
- 2018-01-30 IL IL257240A patent/IL257240B/en not_active IP Right Cessation
- 2018-02-01 ZA ZA2018/00689A patent/ZA201800689B/en unknown
- 2018-02-06 DO DO2018000035A patent/DOP2018000035A/es unknown
- 2018-02-08 CL CL2018000363A patent/CL2018000363A1/es unknown
- 2018-02-09 CO CONC2018/0001359A patent/CO2018001359A2/es unknown
- 2018-02-09 PH PH12018500294A patent/PH12018500294A1/en unknown
- 2018-11-28 US US16/202,653 patent/US20190092754A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010130034A1 (en) * | 2009-05-15 | 2010-11-18 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| WO2015127003A1 (en) * | 2014-02-20 | 2015-08-27 | Bristol-Myers Squibb Company | Pyridin-3-yl acetic acid macrocycles as inhibitors of human immunodeficiency virus replication |
| WO2015126726A1 (en) * | 2014-02-20 | 2015-08-27 | Bristol-Myers Squibb Company | Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication |
Non-Patent Citations (1)
| Title |
|---|
| ROBERTO DI SANTO: "Inhibiting the HIV Integration Process: Past, Present, and the Future", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 57, no. 3, 13 February 2014 (2014-02-13), pages 539 - 566, XP055207945, ISSN: 00222623, DOI: 10.1021/jm400674a * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2018001722A (es) | 2018-05-16 |
| EP3334716A1 (en) | 2018-06-20 |
| PH12018500294A1 (en) | 2018-08-13 |
| AU2016306089B2 (en) | 2018-08-09 |
| MA42614A (fr) | 2021-05-26 |
| CL2018000363A1 (es) | 2018-07-06 |
| US20190092754A1 (en) | 2019-03-28 |
| US20180230129A1 (en) | 2018-08-16 |
| KR20180032649A (ko) | 2018-03-30 |
| EA201890361A1 (ru) | 2018-11-30 |
| AR105653A1 (es) | 2017-10-25 |
| DOP2018000035A (es) | 2018-03-30 |
| ZA201800689B (en) | 2021-08-25 |
| IL257240B (en) | 2020-02-27 |
| CA2994791A1 (en) | 2017-02-16 |
| WO2017025917A1 (en) | 2017-02-16 |
| AU2016306089A1 (en) | 2018-03-01 |
| HK1249503A1 (zh) | 2018-11-02 |
| PE20181002A1 (es) | 2018-06-26 |
| IL257240A (en) | 2018-03-29 |
| TW201718549A (zh) | 2017-06-01 |
| US10189816B2 (en) | 2019-01-29 |
| CO2018001359A2 (es) | 2018-05-10 |
| CR20180091A (es) | 2018-06-13 |
| UA120464C2 (uk) | 2019-12-10 |
| JP6782766B2 (ja) | 2020-11-11 |
| TWI657086B (zh) | 2019-04-21 |
| JP2018522927A (ja) | 2018-08-16 |
| CN108137534A (zh) | 2018-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM RU |