EA032372B1 - Комбинация гликозаминогликанов и циклодекстринов - Google Patents

Комбинация гликозаминогликанов и циклодекстринов Download PDF

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Publication number
EA032372B1
EA032372B1 EA201691246A EA201691246A EA032372B1 EA 032372 B1 EA032372 B1 EA 032372B1 EA 201691246 A EA201691246 A EA 201691246A EA 201691246 A EA201691246 A EA 201691246A EA 032372 B1 EA032372 B1 EA 032372B1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyclodextrin
weight
chondroitin sulfate
combination
hyaluronic acid
Prior art date
Application number
EA201691246A
Other languages
English (en)
Russian (ru)
Other versions
EA201691246A1 (ru
Inventor
Анджело Пиццони
Паоло Пиццони
Original Assignee
Афарм С.Р.Л.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Афарм С.Р.Л. filed Critical Афарм С.Р.Л.
Publication of EA201691246A1 publication Critical patent/EA201691246A1/ru
Publication of EA032372B1 publication Critical patent/EA032372B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
EA201691246A 2013-12-18 2014-12-15 Комбинация гликозаминогликанов и циклодекстринов EA032372B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002116A ITMI20132116A1 (it) 2013-12-18 2013-12-18 Associazione di glicosamminoglicani e ciclodestrine
PCT/IB2014/002774 WO2015092516A1 (en) 2013-12-18 2014-12-15 Combination of glycosaminoglycans and cyclodextrins

Publications (2)

Publication Number Publication Date
EA201691246A1 EA201691246A1 (ru) 2016-10-31
EA032372B1 true EA032372B1 (ru) 2019-05-31

Family

ID=50115999

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691246A EA032372B1 (ru) 2013-12-18 2014-12-15 Комбинация гликозаминогликанов и циклодекстринов

Country Status (13)

Country Link
US (1) US9974803B2 (zh)
EP (1) EP3082869B1 (zh)
CN (1) CN105899233B (zh)
BR (1) BR112016013834B1 (zh)
CA (1) CA2932987C (zh)
EA (1) EA032372B1 (zh)
ES (1) ES2707971T3 (zh)
IT (1) ITMI20132116A1 (zh)
MA (1) MA39077A1 (zh)
PT (1) PT3082869T (zh)
TN (1) TN2016000206A1 (zh)
TR (1) TR201819270T4 (zh)
WO (1) WO2015092516A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITUB20153110A1 (it) * 2015-08-13 2017-02-13 Alfakjn S R L Composizione liquida iniettabile per uso nella terapia infiltrativa intra-articolare
IT201600075246A1 (it) 2016-07-19 2018-01-19 Jointherapeutics S R L Composizioni comprendenti una matrice polisaccaridica per il rilascio controllato di principi attivi.
IT201800010415A1 (it) * 2018-11-19 2020-05-19 Innate S R L Composizione iniettabile comprendente acido ialuronico e trealosio e uso della detta composizione.

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001066601A1 (en) * 2000-03-10 2001-09-13 Fidia Farmaceutici S.P.A. Clathrate complexes formed by hyaluronic acid derivatives and use thereof as pharmaceuticals
WO2003041724A1 (en) * 2001-11-13 2003-05-22 Alcon, Inc. Use of a mixture of sodium hyaluronate and chondroitin sulfate for the treatment of osteoarthritis
CN1451369A (zh) * 2003-03-13 2003-10-29 吉林大学 环糊精衍生物在化妆品中的应用
US20080003257A1 (en) * 2002-10-16 2008-01-03 Marcum Frank D Composition and Method for Treating Connective Tissue Damage
CN101112381A (zh) * 2006-07-24 2008-01-30 凌沛学 一种关节腔内注射用药物组合物
US20080193425A1 (en) * 2002-10-07 2008-08-14 Zymogenetics, Inc. Methods for administering fgf18
EP1967186A1 (en) * 2005-12-27 2008-09-10 Lion Corporation Composition for soft contact lens and adsorption suppressing method
WO2010031876A1 (en) * 2008-09-22 2010-03-25 Universiteit Gent Carboxyethylated cyclodextrin polysulfates useful as medicaments
US20100098764A1 (en) * 2007-11-30 2010-04-22 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
CH705713B1 (de) * 2012-09-21 2013-05-15 Labo Cosprophar Ag Dermokosmetische Zusammensetzung zur topischen Anwendung.
CN103301118A (zh) * 2013-06-27 2013-09-18 海南卫康制药(潜山)有限公司 注射用精氨酸布洛芬组合物
WO2013144867A1 (en) * 2012-03-30 2013-10-03 Fidia Farmaceutici S.P.A. Pharmaceutical formulations comprising chondroitin sulfate and hyaluronic acid derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811572B1 (fr) 2000-07-17 2003-04-18 Adir Utilisation de cyclodextrines polysulfatees pour le traitement de l'arthrose
CN101259139A (zh) * 2008-03-13 2008-09-10 北京阜康仁生物制药科技有限公司 一种用于消炎镇痛的药用组合物

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001066601A1 (en) * 2000-03-10 2001-09-13 Fidia Farmaceutici S.P.A. Clathrate complexes formed by hyaluronic acid derivatives and use thereof as pharmaceuticals
WO2003041724A1 (en) * 2001-11-13 2003-05-22 Alcon, Inc. Use of a mixture of sodium hyaluronate and chondroitin sulfate for the treatment of osteoarthritis
US20080193425A1 (en) * 2002-10-07 2008-08-14 Zymogenetics, Inc. Methods for administering fgf18
US20080003257A1 (en) * 2002-10-16 2008-01-03 Marcum Frank D Composition and Method for Treating Connective Tissue Damage
CN1451369A (zh) * 2003-03-13 2003-10-29 吉林大学 环糊精衍生物在化妆品中的应用
EP1967186A1 (en) * 2005-12-27 2008-09-10 Lion Corporation Composition for soft contact lens and adsorption suppressing method
CN101112381A (zh) * 2006-07-24 2008-01-30 凌沛学 一种关节腔内注射用药物组合物
US20100098764A1 (en) * 2007-11-30 2010-04-22 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
WO2010031876A1 (en) * 2008-09-22 2010-03-25 Universiteit Gent Carboxyethylated cyclodextrin polysulfates useful as medicaments
WO2013144867A1 (en) * 2012-03-30 2013-10-03 Fidia Farmaceutici S.P.A. Pharmaceutical formulations comprising chondroitin sulfate and hyaluronic acid derivatives
CH705713B1 (de) * 2012-09-21 2013-05-15 Labo Cosprophar Ag Dermokosmetische Zusammensetzung zur topischen Anwendung.
CN103301118A (zh) * 2013-06-27 2013-09-18 海南卫康制药(潜山)有限公司 注射用精氨酸布洛芬组合物

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AZQFAN: "Bionova skincare with nano technology on at 1 a.m.", INTERNET CITATION, 27 April 2008 (2008-04-27), pages 1-8, XP002537745, Retrieved from the Internet:URLrhttp://community.qvc.com/topic/Beauty-Banter/Bionova-Skincare-Nano/5700022656, [retrieved on 2009-07-17], the whole document *
SINHA V R, NANDA A, KUMRIA R: "CYCLODEXTRINS AS SUSTAINED-RELEASE CARRIERS", PHARMACEUTICAL TECHNOLOGY, ADVANSTAR COMMUNICATIONS, EUGENE, OR, US, vol. 26, no. 10, 1 October 2002 (2002-10-01), US, pages 36 + 38 + 40 + 42 + 44 + 46, XP008013880, ISSN: 0147-8087 *
WPI / Thomson Week 200417, 29 October 2003 Derwent World Patents Index; Class B04, XP002728093, LUO G; MOU Y; YAN G: "Use of cyclodextrin derivatives in cosmetics for eliminating wrinkles, delaying skin senility and preventing and treating pigmentation, chloasma, is an artificial analogue enzyme with the activity of glutathione peroxidase" *
WPI / Thomson Week 200852, 30 January 2008 Derwent World Patents Index; Class B04, XP002728092, LING P; RONG X: "Drug composition used in articular cavity injection for treating arthritis contains sodium hyaluronate and chondroitin sulfate having predetermined molecular weight" *
WPI / Thomson Week 201404, 18 September 2013 Derwent World Patents Index; Class B05, XP002728091, HAO J; LI B; WANG J; WANG L; WU H: "Arginine ibuprofen injection composition used for treating arthritis comprises arginine ibuprofen, melatonin and cyclodextrin, where melatonin contains quick release part and slow release part" *

Also Published As

Publication number Publication date
EA201691246A1 (ru) 2016-10-31
CN105899233B (zh) 2020-01-17
CA2932987A1 (en) 2015-06-25
ES2707971T3 (es) 2019-04-08
MA39077A1 (fr) 2017-11-30
TN2016000206A1 (en) 2017-10-06
ITMI20132116A1 (it) 2015-06-19
CA2932987C (en) 2021-10-12
CN105899233A (zh) 2016-08-24
BR112016013834A2 (zh) 2017-08-08
US9974803B2 (en) 2018-05-22
BR112016013834B1 (pt) 2022-11-22
US20170035799A1 (en) 2017-02-09
EP3082869A1 (en) 2016-10-26
EP3082869B1 (en) 2018-10-31
WO2015092516A1 (en) 2015-06-25
TR201819270T4 (tr) 2019-01-21
PT3082869T (pt) 2019-02-06

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