EA032104B1 - Морфолин- и 1,4-оксазепан-амиды в качестве агонистов соматостатинового рецептора подтипа 4 (sstr4) - Google Patents

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Publication number

EA032104B1

EA032104B1 EA201791058A EA201791058A EA032104B1 EA 032104 B1 EA032104 B1 EA 032104B1 EA 201791058 A EA201791058 A EA 201791058A EA 201791058 A EA201791058 A EA 201791058A EA 032104 B1 EA032104 B1 EA 032104B1

Authority

EA

Eurasian Patent Office

Prior art keywords

mmol

hplc

group

compound according

compound

Prior art date

2014-11-14

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• -1 1,4-oxazepane amides Chemical class 0.000 title claims abstract description 57
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• 108010064556 somatostatin receptor subtype-4 Proteins 0.000 title abstract description 10
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• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 10
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• 229910052799 carbon Inorganic materials 0.000 claims description 27
• 229910052736 halogen Inorganic materials 0.000 claims description 26
• 125000005842 heteroatom Chemical group 0.000 claims description 26
• 150000002367 halogens Chemical class 0.000 claims description 23
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 20
• 229910052739 hydrogen Inorganic materials 0.000 claims description 19
• 125000004122 cyclic group Chemical group 0.000 claims description 18
• 125000001072 heteroaryl group Chemical group 0.000 claims description 18
• 125000002950 monocyclic group Chemical group 0.000 claims description 18
• 229920006395 saturated elastomer Polymers 0.000 claims description 18
• 125000003118 aryl group Chemical group 0.000 claims description 14
• 125000001424 substituent group Chemical group 0.000 claims description 13
• 125000004432 carbon atom Chemical group C* 0.000 claims description 11
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 8
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
• 125000000623 heterocyclic group Chemical group 0.000 claims description 7
• 125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 6
• 239000003814 drug Substances 0.000 claims description 6
• 230000000694 effects Effects 0.000 claims description 6
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 5
• 125000005843 halogen group Chemical group 0.000 claims description 4
• 125000006413 ring segment Chemical group 0.000 claims description 4
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 3
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 3
• 239000003937 drug carrier Substances 0.000 claims description 3
• 125000001054 5 membered carbocyclic group Chemical group 0.000 claims description 2
• 125000004008 6 membered carbocyclic group Chemical group 0.000 claims description 2
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