EA031069B1 - АНТИТЕЛА ПРОТИВ ИНТЕГРИНОВ αVβ6 И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННЫХ НОВООБРАЗОВАНИЙ - Google Patents
АНТИТЕЛА ПРОТИВ ИНТЕГРИНОВ αVβ6 И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННЫХ НОВООБРАЗОВАНИЙ Download PDFInfo
- Publication number
- EA031069B1 EA031069B1 EA201491541A EA201491541A EA031069B1 EA 031069 B1 EA031069 B1 EA 031069B1 EA 201491541 A EA201491541 A EA 201491541A EA 201491541 A EA201491541 A EA 201491541A EA 031069 B1 EA031069 B1 EA 031069B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- seq
- antibody
- variable region
- ser
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261600499P | 2012-02-17 | 2012-02-17 | |
| US201261602511P | 2012-02-23 | 2012-02-23 | |
| PCT/US2013/026087 WO2013123152A2 (en) | 2012-02-17 | 2013-02-14 | ANTIBODIES TO INTEGRIN αVβ6 AND USE OF SAME TO TREAT CANCER |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201491541A1 EA201491541A1 (ru) | 2016-05-31 |
| EA031069B1 true EA031069B1 (ru) | 2018-11-30 |
Family
ID=48984888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201491541A EA031069B1 (ru) | 2012-02-17 | 2013-02-14 | АНТИТЕЛА ПРОТИВ ИНТЕГРИНОВ αVβ6 И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННЫХ НОВООБРАЗОВАНИЙ |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9493566B2 (enExample) |
| EP (1) | EP2814509B1 (enExample) |
| JP (1) | JP6273214B2 (enExample) |
| KR (1) | KR102084806B1 (enExample) |
| CN (2) | CN105017420B (enExample) |
| AU (1) | AU2013221585B2 (enExample) |
| BR (1) | BR112014019861A2 (enExample) |
| CA (1) | CA2862319C (enExample) |
| EA (1) | EA031069B1 (enExample) |
| IL (1) | IL233742B (enExample) |
| MX (1) | MX360141B (enExample) |
| SG (1) | SG11201404354UA (enExample) |
| WO (1) | WO2013123152A2 (enExample) |
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| HUE031902T2 (en) | 2008-05-23 | 2017-08-28 | Siwa Corp | Procedures and Preparations to Promote Regeneration |
| US20160319032A1 (en) * | 2013-10-01 | 2016-11-03 | Medlmmune Limited | Methods of treating and diagnosing alpha-v-beta-6 overexpressing cancer |
| AU2014337555C1 (en) | 2013-10-15 | 2021-01-28 | Seagen Inc. | PEGylated drug-linkers for improved Ligand-Drug Conjugate pharmacokinetics |
| WO2015123679A1 (en) | 2014-02-17 | 2015-08-20 | Seattle Genetics, Inc. | Hydrophilic antibody-drug conjugates |
| US20170233452A1 (en) * | 2014-04-23 | 2017-08-17 | Immusoft Corporation | Chimeric antigen receptors specific to avb6 integrin and methods of use thereof to treat cancer |
| CA2961603C (en) | 2014-09-19 | 2021-07-13 | Siwa Corporation | Anti-age antibodies for treating inflammation and auto-immune disorders |
| US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
| US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
| TWI852735B (zh) | 2015-12-04 | 2024-08-11 | 美商思進公司 | 四級胺化妥布賴森(tubulysin)化合物之結合物 |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| KR102786111B1 (ko) | 2016-02-19 | 2025-03-26 | 시와 코퍼레이션 | 고급 당화 최종 산물(age)에 대한 항체를 사용하여 암을 치료하고, 전이성 암 세포를 사멸시키고, 암 전이를 예방하기 위한 방법 및 조성물 |
| KR102626498B1 (ko) | 2016-03-25 | 2024-01-19 | 씨젠 인크. | 페길화된 약물-링커 및 그의 중간체의 제조를 위한 공정 |
| AU2017250301A1 (en) | 2016-04-15 | 2018-11-15 | Siwa Corporation | Anti-age antibodies for treating neurodegenerative disorders |
| MX2019001302A (es) | 2016-08-09 | 2019-06-12 | Seattle Genetics Inc | Conjugados de farmaco con enlazadores autoestabilizantes que tienen propiedades fisioquimicas mejoradas. |
| CN109843334A (zh) | 2016-10-18 | 2019-06-04 | 西雅图基因公司 | 烟酰胺腺嘌呤二核苷酸补救途径抑制剂的靶向递送 |
| CN109952376B (zh) | 2016-11-01 | 2023-09-05 | 箭头药业股份有限公司 | αvβ6整联蛋白配体及其应用 |
| WO2018107116A1 (en) * | 2016-12-09 | 2018-06-14 | Abbvie Stemcentrx Llc | Methods of reducing toxicity of antibody drug conjugates, and compositions produced thereby |
| JP7244987B2 (ja) | 2016-12-14 | 2023-03-23 | シージェン インコーポレイテッド | 多剤抗体薬物コンジュゲート |
| US11730822B2 (en) | 2017-03-24 | 2023-08-22 | Seagen Inc. | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
| EP3609923A1 (en) | 2017-04-13 | 2020-02-19 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
| WO2018201087A1 (en) | 2017-04-27 | 2018-11-01 | Seattle Genetics, Inc. | Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates |
| KR102762143B1 (ko) | 2017-11-01 | 2025-02-07 | 애로우헤드 파마슈티컬스 인코포레이티드 | 인테그린 리간드 및 그의 용도 |
| US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
| US11857565B2 (en) | 2018-02-20 | 2024-01-02 | Seagen Inc. | Hydrophobic Auristatin F compounds and conjugates thereof |
| US20240199735A1 (en) * | 2019-07-22 | 2024-06-20 | The Methodist Hospital | Microfibrillar-Associated Protein 5 (MFAP5)-Targeting Monoclonal Antibodies and Methods for Use in Treating Cancer |
| IL293195A (en) * | 2019-12-05 | 2022-07-01 | Seagen Inc | Anti-avb6 antibodies and antibody-drug conjugates |
| EP4087657A1 (en) | 2020-01-08 | 2022-11-16 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
| BR112022020332A2 (pt) | 2020-04-10 | 2022-12-13 | Seagen Inc | Composto conjugado anticorpo-droga, composição, método de tratamento de câncer e de um distúrbio autoimune |
| CA3213636A1 (en) | 2021-03-18 | 2022-09-22 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| BR112023020626A2 (pt) | 2021-04-08 | 2023-12-19 | Arrowhead Pharmaceuticals Inc | Agentes de rnai para inibir a expressão do receptor para produtos finais de glicação avançada, composições dos mesmos e métodos de uso |
| MX2023012364A (es) | 2021-04-20 | 2023-11-01 | Seagen Inc | Modulacion de citotoxicidad celular dependiente de anticuerpos. |
| IL308795A (en) | 2021-05-28 | 2024-01-01 | Seagen Inc | Anthracycline antibody conjugates |
| IL315508A (en) | 2022-03-17 | 2024-11-01 | Seagen Inc | Camptothecin conjugates |
| WO2024129756A1 (en) | 2022-12-13 | 2024-06-20 | Seagen Inc. | Site-specific engineered cysteine antibody drug conjugates |
| EP4637731A1 (en) | 2022-12-21 | 2025-10-29 | Gilead Sciences, Inc. | Combination therapy for treating cancer |
| WO2024263932A2 (en) | 2023-06-23 | 2024-12-26 | Mythic Therapeutics, Inc. | Itgb6-binding proteins and uses thereof |
| WO2025149947A1 (en) | 2024-01-12 | 2025-07-17 | Seagen Inc. | Antibody-drug conjugates |
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| US20050090648A1 (en) * | 2001-04-30 | 2005-04-28 | Naoya Tsurushita | Humanized antibodies |
| US20050287538A1 (en) * | 2004-06-29 | 2005-12-29 | Wing-Tai Cheung | Frame-shifting PCR for germline immunoglobulin genes retrieval and antibody engineering |
| US20060204506A1 (en) * | 2005-03-10 | 2006-09-14 | Wolfgang Ebel | Anti-mesothelin antibodies |
| US7465449B2 (en) * | 2002-03-13 | 2008-12-16 | Biogen Idec Ma Inc. | Anti-αvβ6 antibodies |
| US20110059469A1 (en) * | 2008-01-11 | 2011-03-10 | Hiroyuki Aburatani | Anti-cldn6 antibody |
| WO2011046309A2 (en) * | 2009-10-12 | 2011-04-21 | Korea Research Institute Of Bioscience And Biotechnology | A diagnostic marker for hepatocellular carcinoma comprising anti-fasn autoantibodies and a diagnostic composition for hepatocellular carcinoma comprising antigens thereof |
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| US5962643A (en) | 1991-07-11 | 1999-10-05 | The Regents Of The University Of California | Integrin β subunit and uses thereof |
| EP0996460B1 (en) | 1997-08-08 | 2005-01-12 | The Regents of the University of California | Treatment of kidney fibrosis with antibodies against integrin alpha-v-beta 6 |
| CN100509851C (zh) * | 2002-03-13 | 2009-07-08 | 拜奥根Idec马萨诸塞公司 | 抗αvβ6抗体 |
| EP1492870A4 (en) | 2002-04-12 | 2005-08-03 | Raven Biotechnologies Inc | ANTIBODIES BINDING TO INTEGRIN-ALPHA-V-BETA-6 AND METHOD OF USE THEREOF |
| CA2582194A1 (en) | 2004-10-05 | 2006-04-20 | Neuralab Limited | Methods and compositions for improving recombinant protein production |
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-
2013
- 2013-02-14 US US14/378,746 patent/US9493566B2/en not_active Expired - Fee Related
- 2013-02-14 KR KR1020147025536A patent/KR102084806B1/ko not_active Expired - Fee Related
- 2013-02-14 WO PCT/US2013/026087 patent/WO2013123152A2/en not_active Ceased
- 2013-02-14 SG SG11201404354UA patent/SG11201404354UA/en unknown
- 2013-02-14 EP EP13749647.7A patent/EP2814509B1/en active Active
- 2013-02-14 CN CN201510418545.9A patent/CN105017420B/zh not_active Expired - Fee Related
- 2013-02-14 BR BR112014019861A patent/BR112014019861A2/pt not_active IP Right Cessation
- 2013-02-14 JP JP2014557760A patent/JP6273214B2/ja not_active Expired - Fee Related
- 2013-02-14 EA EA201491541A patent/EA031069B1/ru unknown
- 2013-02-14 MX MX2014009751A patent/MX360141B/es active IP Right Grant
- 2013-02-14 AU AU2013221585A patent/AU2013221585B2/en not_active Ceased
- 2013-02-14 CN CN201380009160.6A patent/CN104220094A/zh active Pending
- 2013-02-14 CA CA2862319A patent/CA2862319C/en active Active
-
2014
- 2014-07-22 IL IL233742A patent/IL233742B/en active IP Right Grant
-
2016
- 2016-09-07 US US15/258,699 patent/US20160376368A1/en not_active Abandoned
-
2019
- 2019-09-30 US US16/588,331 patent/US20200031938A1/en not_active Abandoned
-
2021
- 2021-01-08 US US17/144,869 patent/US20210340260A1/en not_active Abandoned
-
2023
- 2023-02-17 US US18/170,742 patent/US20230242648A1/en not_active Abandoned
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050090648A1 (en) * | 2001-04-30 | 2005-04-28 | Naoya Tsurushita | Humanized antibodies |
| US7465449B2 (en) * | 2002-03-13 | 2008-12-16 | Biogen Idec Ma Inc. | Anti-αvβ6 antibodies |
| US20050287538A1 (en) * | 2004-06-29 | 2005-12-29 | Wing-Tai Cheung | Frame-shifting PCR for germline immunoglobulin genes retrieval and antibody engineering |
| US20060204506A1 (en) * | 2005-03-10 | 2006-09-14 | Wolfgang Ebel | Anti-mesothelin antibodies |
| US20110059469A1 (en) * | 2008-01-11 | 2011-03-10 | Hiroyuki Aburatani | Anti-cldn6 antibody |
| WO2011046309A2 (en) * | 2009-10-12 | 2011-04-21 | Korea Research Institute Of Bioscience And Biotechnology | A diagnostic marker for hepatocellular carcinoma comprising anti-fasn autoantibodies and a diagnostic composition for hepatocellular carcinoma comprising antigens thereof |
Non-Patent Citations (2)
| Title |
|---|
| MUNK C. et al. Uniprot Submission with Accession No. D3Q6V1 [online]. 30 November 2010 [retrieved on 02 April 2013]. Retrieved from the Internet: <URL:http://www.uniprot.org/uniprot/D3Q6V1.txt?version=7>, page 1 * |
| TANFOUS N.G.-B. et al. Characterization of a Novel Monoclonal Antibody with Restricted Specificity to the Free b2 Integrin aM CD11b Subunit. Hybridoma. 2007, vol 26(6), pages 373-379: Table 2; abstract * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20230242648A1 (en) | 2023-08-03 |
| CN105017420B (zh) | 2019-05-28 |
| US20210340260A1 (en) | 2021-11-04 |
| MX2014009751A (es) | 2015-02-24 |
| IL233742A0 (en) | 2014-09-30 |
| CN105017420A (zh) | 2015-11-04 |
| CN104220094A (zh) | 2014-12-17 |
| EP2814509B1 (en) | 2018-05-16 |
| JP2015509938A (ja) | 2015-04-02 |
| BR112014019861A2 (pt) | 2017-07-04 |
| EP2814509A4 (en) | 2015-12-09 |
| AU2013221585A1 (en) | 2014-08-14 |
| US20200031938A1 (en) | 2020-01-30 |
| MX360141B (es) | 2018-10-24 |
| KR20140127875A (ko) | 2014-11-04 |
| CA2862319C (en) | 2021-11-30 |
| IL233742B (en) | 2019-08-29 |
| WO2013123152A3 (en) | 2014-11-13 |
| JP6273214B2 (ja) | 2018-01-31 |
| HK1211035A1 (en) | 2016-05-13 |
| KR102084806B1 (ko) | 2020-03-04 |
| WO2013123152A2 (en) | 2013-08-22 |
| EA201491541A1 (ru) | 2016-05-31 |
| US20160376368A1 (en) | 2016-12-29 |
| US20160009806A1 (en) | 2016-01-14 |
| EP2814509A2 (en) | 2014-12-24 |
| CA2862319A1 (en) | 2013-08-22 |
| AU2013221585B2 (en) | 2017-03-30 |
| US9493566B2 (en) | 2016-11-15 |
| SG11201404354UA (en) | 2014-10-30 |
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