EA029271B1 - Анти-hpg моноклональное антитело, полинуклеотид, кодирующий его цепи, экспрессионный вектор, клетка-хозяин, фармацевтическая композиция и набор, содержащие это моноклональное антитело, и способы его применения - Google Patents
Анти-hpg моноклональное антитело, полинуклеотид, кодирующий его цепи, экспрессионный вектор, клетка-хозяин, фармацевтическая композиция и набор, содержащие это моноклональное антитело, и способы его применения Download PDFInfo
- Publication number
- EA029271B1 EA029271B1 EA201200597A EA201200597A EA029271B1 EA 029271 B1 EA029271 B1 EA 029271B1 EA 201200597 A EA201200597 A EA 201200597A EA 201200597 A EA201200597 A EA 201200597A EA 029271 B1 EA029271 B1 EA 029271B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibody
- monoclonal antibody
- monoclonal antibodies
- lrs
- progastrin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G01N33/57535—
-
- G01N33/57585—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/595—Gastrins; Cholecystokinins [CCK]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25262509P | 2009-10-16 | 2009-10-16 | |
| PCT/EP2010/006329 WO2011045080A2 (en) | 2009-10-16 | 2010-10-15 | Monoclonal antibodies to progastrin and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201200597A1 EA201200597A1 (ru) | 2012-12-28 |
| EA029271B1 true EA029271B1 (ru) | 2018-03-30 |
Family
ID=43086711
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201200597A EA029271B1 (ru) | 2009-10-16 | 2010-10-15 | Анти-hpg моноклональное антитело, полинуклеотид, кодирующий его цепи, экспрессионный вектор, клетка-хозяин, фармацевтическая композиция и набор, содержащие это моноклональное антитело, и способы его применения |
| EA201791876A EA201791876A1 (ru) | 2009-10-16 | 2010-10-15 | Моноклональные антитела к прогастрину и их применение |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201791876A EA201791876A1 (ru) | 2009-10-16 | 2010-10-15 | Моноклональные антитела к прогастрину и их применение |
Country Status (42)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008076454A1 (en) | 2006-12-19 | 2008-06-26 | The Board Of Regents Of The University Of Texas System | Immunogenic compositions comprising progastrin and uses thereof |
| US8136651B2 (en) * | 2007-12-14 | 2012-03-20 | The Procter & Gamble Company | Method and apparatus for orienting articles |
| PL3421493T3 (pl) * | 2009-10-16 | 2024-04-29 | Progastrine Et Cancers S.À R.L. | Przeciwciała monoklonalne przeciwko progastrynie i ich zastosowania |
| US8900588B2 (en) * | 2010-01-08 | 2014-12-02 | Les Laboratories Servier | Methods for treating breast cancer |
| US8900817B2 (en) | 2010-01-08 | 2014-12-02 | Les Laboratories Servier | Progastrin and liver pathologies |
| US20150071912A1 (en) * | 2010-03-24 | 2015-03-12 | Centre National De La Recherche Scientifique (Cnrs) | Prophylaxis of colorectal and gastrointestinal cancer |
| SG187544A1 (en) * | 2010-07-26 | 2013-03-28 | Servier Lab | Methods and compositions for liver cancer therapy |
| US8785603B2 (en) * | 2011-05-20 | 2014-07-22 | Siemens Healthcare Diagnostics Inc. | Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
| EP2715364A1 (en) | 2011-06-01 | 2014-04-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for predicting the risk of developing a colonic neoplasia |
| CN105517572B (zh) * | 2013-07-05 | 2019-05-31 | 华盛顿大学商业中心 | 用于治疗癌症的中和可溶性mic的单克隆抗体 |
| US10023651B2 (en) | 2014-04-18 | 2018-07-17 | The Research Foundation For The State University Of New York | Humanized anti-TF-antigen antibodies |
| ES2843546T3 (es) * | 2014-04-18 | 2021-07-19 | The Research Foundation Of The State Univ Of New York | Anticuerpos humanizados anti-antígeno-TF |
| WO2016066671A1 (en) | 2014-10-29 | 2016-05-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating resistant cancers using progastrin inhibitors |
| WO2017048629A1 (en) * | 2015-09-15 | 2017-03-23 | The Scripps Research Institute | Antibodies for generating anti-inflammatory macrophage and related uses |
| PL3397964T3 (pl) * | 2015-12-31 | 2022-02-07 | Progastrine Et Cancers S.À R.L. | Kompozycje i sposoby do wykrywania i leczenia raka jajnika |
| MA43550A (fr) * | 2015-12-31 | 2018-11-07 | Syncerus S A R L | Compositions et procédés d'évaluation du risque d'apparition d'un cancer |
| ES2899360T3 (es) | 2015-12-31 | 2022-03-11 | Progastrine Et Cancers S A R L | Composiciones y procedimientos para detectar y tratar cáncer gástrico |
| AU2018246368B2 (en) * | 2017-03-30 | 2023-02-09 | Ecs-Progastrin Sa | Compositions and methods for detecting lung cancer |
| KR102317805B1 (ko) * | 2017-03-30 | 2021-10-27 | 이씨에스-프로가스트린 에스에이 | 전립선암을 검출하기 위한 조성물 및 방법 |
| PL3720879T3 (pl) * | 2017-12-05 | 2022-09-12 | Progastrine Et Cancers S.À R.L. | Terapia skojarzona przeciwciałami przeciwko progastynie i immunoterapią w leczeniu nowotworu |
| CN112004560A (zh) | 2017-12-08 | 2020-11-27 | Ecs生物识别系统有限公司 | 癌症诊断中的放射性标记的前胃液素 |
| TW201940881A (zh) | 2018-01-26 | 2019-10-16 | 瑞士商Ｅｃｓ前胃泌激素公司 | 在癌症診斷中結合前胃泌激素檢測與其他癌症生物標記的技術 |
| KR102699073B1 (ko) * | 2018-02-27 | 2024-08-26 | 이씨에스-프로가스트린 에스에이 | 면역치료요법용 생체표지자로서 프로가스트린 |
| TWI793238B (zh) * | 2018-12-27 | 2023-02-21 | 偉喬生醫股份有限公司 | 體外檢測生物樣品之胃源性蛋白的方法及套組 |
| US20220372125A1 (en) * | 2019-10-02 | 2022-11-24 | Aslan Pharmaceuticals Pte. Ltd. | Antigen Specific Binding Domains and Antibody Molecules |
| CN112062846A (zh) * | 2020-04-27 | 2020-12-11 | 杭州博茵生物技术有限公司 | 一种g-17单克隆抗体及其应用 |
| CN115785273B (zh) * | 2021-09-10 | 2023-10-31 | 东莞市朋志生物科技有限公司 | 一种抗胃蛋白酶原i的抗体及其应用 |
| CN115724949A (zh) * | 2022-12-12 | 2023-03-03 | 郑州伊美诺生物技术有限公司 | 一种鼠源lgG单克隆抗体及其制备方法、应用 |
| CN116143920A (zh) * | 2022-12-30 | 2023-05-23 | 南京岚煜生物科技有限公司 | 胃泌素17的单克隆抗体及其细胞株的制备方法和应用 |
| EP4509528A1 (en) * | 2023-08-16 | 2025-02-19 | Barrelman Biosciences LLC | Monoclonal antibodies against veterinary progastrin-like molecules and their uses |
| CN117567611B (zh) * | 2023-11-22 | 2024-05-14 | 艾维可生物科技有限公司 | 抗成熟型胃泌素17的单克隆抗体及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2006032980A1 (en) * | 2004-09-22 | 2006-03-30 | Receptor Biologix, Inc. | Monoclonal antibolies to progastrin |
| WO2007135542A2 (en) * | 2006-05-22 | 2007-11-29 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Progastrin inhibitors in the treatment of colon cancer |
| WO2008076454A1 (en) * | 2006-12-19 | 2008-06-26 | The Board Of Regents Of The University Of Texas System | Immunogenic compositions comprising progastrin and uses thereof |
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| PL3421493T3 (pl) * | 2009-10-16 | 2024-04-29 | Progastrine Et Cancers S.À R.L. | Przeciwciała monoklonalne przeciwko progastrynie i ich zastosowania |
| US20150071912A1 (en) * | 2010-03-24 | 2015-03-12 | Centre National De La Recherche Scientifique (Cnrs) | Prophylaxis of colorectal and gastrointestinal cancer |
| SG187544A1 (en) * | 2010-07-26 | 2013-03-28 | Servier Lab | Methods and compositions for liver cancer therapy |
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2010
- 2010-10-15 PL PL18185172.6T patent/PL3421493T3/pl unknown
- 2010-10-15 SI SI201031788T patent/SI2488551T1/sl unknown
- 2010-10-15 KR KR1020127012677A patent/KR20120091221A/ko not_active Ceased
- 2010-10-15 ES ES10768878.0T patent/ES2690943T3/es active Active
- 2010-10-15 NZ NZ701709A patent/NZ701709A/en unknown
- 2010-10-15 TW TW099135321A patent/TWI537002B/zh active
- 2010-10-15 UA UAA201205759A patent/UA106771C2/uk unknown
- 2010-10-15 PL PL10768878T patent/PL2488551T3/pl unknown
- 2010-10-15 PT PT10768878T patent/PT2488551T/pt unknown
- 2010-10-15 EA EA201200597A patent/EA029271B1/ru not_active IP Right Cessation
- 2010-10-15 RS RS20181241A patent/RS57966B1/sr unknown
- 2010-10-15 WO PCT/EP2010/006329 patent/WO2011045080A2/en not_active Ceased
- 2010-10-15 EA EA201791876A patent/EA201791876A1/ru unknown
- 2010-10-15 AP AP2012006262A patent/AP2012006262A0/xx unknown
- 2010-10-15 CN CN201080057237.3A patent/CN102791735B/zh active Active
- 2010-10-15 MX MX2012004400A patent/MX351635B/es active IP Right Grant
- 2010-10-15 PH PH1/2012/500711A patent/PH12012500711B1/en unknown
- 2010-10-15 IN IN3348DEN2012 patent/IN2012DN03348A/en unknown
- 2010-10-15 JP JP2012533531A patent/JP5985987B2/ja active Active
- 2010-10-15 EP EP18185172.6A patent/EP3421493B1/en active Active
- 2010-10-15 KR KR1020157017085A patent/KR101640520B1/ko active Active
- 2010-10-15 ES ES18185172T patent/ES2973217T3/es active Active
- 2010-10-15 GE GEAP201012707A patent/GEP201706604B/en unknown
- 2010-10-15 SM SM20180628T patent/SMT201800628T1/it unknown
- 2010-10-15 AR ARP100103784A patent/AR078659A1/es active IP Right Grant
- 2010-10-15 LT LTEP10768878.0T patent/LT2488551T/lt unknown
- 2010-10-15 EP EP10768878.0A patent/EP2488551B1/en active Active
- 2010-10-15 US US12/906,041 patent/US9611320B2/en active Active
- 2010-10-15 NZ NZ599971A patent/NZ599971A/en unknown
- 2010-10-15 SG SG10201704933PA patent/SG10201704933PA/en unknown
- 2010-10-15 AU AU2010306119A patent/AU2010306119A1/en not_active Abandoned
- 2010-10-15 CA CA2777691A patent/CA2777691C/en active Active
- 2010-10-15 DK DK10768878.0T patent/DK2488551T3/en active
- 2010-10-15 CN CN201410752851.1A patent/CN104628857A/zh active Pending
- 2010-10-15 PE PE2012000434A patent/PE20121649A1/es active IP Right Grant
- 2010-10-15 BR BR112012008818-1A patent/BR112012008818B1/pt active IP Right Grant
- 2010-10-15 HR HRP20181645TT patent/HRP20181645T1/hr unknown
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2012
- 2012-04-03 IL IL219019A patent/IL219019B/en active IP Right Grant
- 2012-04-04 TN TNP2012000159A patent/TN2012000159A1/en unknown
- 2012-04-11 CL CL2012000914A patent/CL2012000914A1/es unknown
- 2012-04-12 ZA ZA2012/02642A patent/ZA201202642B/en unknown
- 2012-04-13 CR CR20120184A patent/CR20120184A/es unknown
- 2012-04-13 HN HN2012000708A patent/HN2012000708A/es unknown
- 2012-04-13 NI NI201200054A patent/NI201200054A/es unknown
- 2012-04-13 EC ECSP12011796 patent/ECSP12011796A/es unknown
- 2012-04-16 CU CUP2012000060A patent/CU24196B1/es active IP Right Grant
- 2012-04-16 GT GT201200114A patent/GT201200114A/es unknown
- 2012-05-11 MA MA34864A patent/MA33747B1/fr unknown
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2015
- 2015-03-04 JP JP2015042849A patent/JP6272793B2/ja active Active
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2017
- 2017-03-06 US US15/451,253 patent/US10385124B2/en active Active
- 2017-03-06 US US15/451,268 patent/US10385125B2/en active Active
- 2017-03-06 US US15/451,275 patent/US10377821B2/en active Active
- 2017-03-06 US US15/451,280 patent/US10385126B2/en active Active
- 2017-06-21 JP JP2017121372A patent/JP2017212992A/ja active Pending
- 2017-08-15 IL IL254004A patent/IL254004B2/en unknown
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2018
- 2018-10-22 CY CY181101081T patent/CY1120913T1/el unknown
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2019
- 2019-06-28 US US16/456,328 patent/US11299542B2/en active Active
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2022
- 2022-03-07 US US17/687,909 patent/US20220195035A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2006032980A1 (en) * | 2004-09-22 | 2006-03-30 | Receptor Biologix, Inc. | Monoclonal antibolies to progastrin |
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