EA028062B1 - Лечение рака ингибиторами tor киназы - Google Patents

Лечение рака ингибиторами tor киназы Download PDF

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Publication number
EA028062B1
EA028062B1 EA201491701A EA201491701A EA028062B1 EA 028062 B1 EA028062 B1 EA 028062B1 EA 201491701 A EA201491701 A EA 201491701A EA 201491701 A EA201491701 A EA 201491701A EA 028062 B1 EA028062 B1 EA 028062B1
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EA
Eurasian Patent Office
Prior art keywords
overexpression
castration
patient
prostate cancer
transcription factor
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EA201491701A
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English (en)
Russian (ru)
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EA201491701A1 (ru
Inventor
Шуйчань Сюй
Шуйчань СЮЙ
Кристен Мей Хедж
Хитер Рэймон
Тосия Цудзи
Лиза Сапиносо
Original Assignee
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
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Publication of EA201491701A1 publication Critical patent/EA201491701A1/ru
Publication of EA028062B1 publication Critical patent/EA028062B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201491701A 2012-03-15 2013-03-14 Лечение рака ингибиторами tor киназы EA028062B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261611428P 2012-03-15 2012-03-15
US61/611,428 2012-03-15
US201261715327P 2012-10-18 2012-10-18
US61/715,327 2012-10-18
PCT/US2013/031217 WO2013138560A1 (en) 2012-03-15 2013-03-14 Treatment of cancer with tor kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201491701A1 EA201491701A1 (ru) 2015-01-30
EA028062B1 true EA028062B1 (ru) 2017-10-31

Family

ID=48045717

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491701A EA028062B1 (ru) 2012-03-15 2013-03-14 Лечение рака ингибиторами tor киназы

Country Status (21)

Country Link
US (1) US20130245028A1 (enExample)
EP (1) EP2825171B1 (enExample)
JP (2) JP2015511964A (enExample)
KR (1) KR102057357B1 (enExample)
CN (2) CN109846884A (enExample)
AU (2) AU2013202992B2 (enExample)
BR (1) BR112014022700A2 (enExample)
CA (1) CA2867174C (enExample)
EA (1) EA028062B1 (enExample)
ES (1) ES2668279T3 (enExample)
IL (1) IL234639B (enExample)
MX (1) MX359227B (enExample)
MY (1) MY198666A (enExample)
NI (1) NI201400110A (enExample)
NZ (1) NZ628420A (enExample)
PH (1) PH12014502047B1 (enExample)
SG (1) SG11201405686PA (enExample)
TW (1) TWI622395B (enExample)
UA (1) UA114194C2 (enExample)
WO (1) WO2013138560A1 (enExample)
ZA (1) ZA201406708B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
SG11201505446WA (en) 2013-01-16 2015-08-28 Signal Pharm Llc Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
WO2014172436A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
HK1221168A1 (zh) 2013-04-17 2017-05-26 西格诺药品有限公司 用於治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯醯胺的组合疗法
WO2014172425A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Treatment of cancer with dihydropyrazino-pyrazines
MY189663A (en) * 2013-04-17 2022-02-23 Signal Pharm Llc Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
JP6382946B2 (ja) 2013-04-17 2018-08-29 シグナル ファーマシューティカルズ，エルエルシー ジヒドロピラジノ−ピラジンによる癌治療
EP3549940A1 (en) 2013-04-17 2019-10-09 Signal Pharmaceuticals, LLC Pharmaceutical formulations, of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
CA2908742C (en) 2013-04-17 2021-06-01 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer
CN107474051B (zh) 2013-05-29 2020-10-30 西格诺药品有限公司 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
WO2015160880A1 (en) 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
EP3131552B1 (en) 2014-04-16 2020-07-15 Signal Pharmaceuticals, LLC Methods for treating cancer using tor kinase inhibitor combination therapy
NZ629796A (en) 2014-07-14 2015-12-24 Signal Pharm Llc Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
WO2016010886A1 (en) 2014-07-14 2016-01-21 Signal Pharmaceuticals, Llc Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
US20180369241A1 (en) * 2015-06-24 2018-12-27 Celgene Corporation Treatment of cancer with dnapk inhibitors
WO2017132235A1 (en) * 2016-01-26 2017-08-03 Dana-Farber Cancer Institute, Inc. METHODS FOR TREATING BRAIN METASTASES USING COMBINATIONS OF ANTI-P13K AND ANTI-mTOR AGENTS
IL271491B2 (en) 2017-06-22 2023-09-01 Celgene Corp Treatment of carcinoma of the liver characterized by hepatitis b virus infection

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008051494A1 (en) * 2006-10-19 2008-05-02 Signal Pharmaceuticals, Llc Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors
WO2008051493A2 (en) * 2006-10-19 2008-05-02 Signal Pharmaceuticals, Llc Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
WO2010044893A1 (en) * 2008-10-17 2010-04-22 Merck & Co. Combination therapy
WO2010062571A1 (en) * 2008-10-27 2010-06-03 Signal Pharmaceuticals, Llc Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5279828B2 (ja) * 2008-07-10 2013-09-04 Ｊｘ日鉱日石金属株式会社 ハイブリッドシリコンウエハ及びその製造方法
WO2010022243A1 (en) * 2008-08-20 2010-02-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chemoprevention of head and neck squamous cell carcinomas
EP2367939A4 (en) * 2008-11-20 2012-07-04 Oncotherapy Science Inc METHOD FOR DIAGNOSIS OR TREATMENT OF PROSTATE CANCER
CA2760778A1 (en) * 2009-05-13 2010-11-18 Amgen Inc. Heteroaryl compounds as pikk inhibitors
NZ599549A (en) 2009-10-26 2013-11-29 Signal Pharm Llc Methods of synthesis and purification of heteroaryl compounds
AR078793A1 (es) * 2009-10-27 2011-12-07 Orion Corp Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008051494A1 (en) * 2006-10-19 2008-05-02 Signal Pharmaceuticals, Llc Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors
WO2008051493A2 (en) * 2006-10-19 2008-05-02 Signal Pharmaceuticals, Llc Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
WO2010044893A1 (en) * 2008-10-17 2010-04-22 Merck & Co. Combination therapy
WO2010062571A1 (en) * 2008-10-27 2010-06-03 Signal Pharmaceuticals, Llc Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
A. M. SMITH, V. J. FINDLAY, S. G. BANDURRAGA, E. KISTNER-GRIFFIN, L. S. SPRUILL, A. LIU, A. R. GOLSHAYAN, D. P. TURNER: "ETS1 transcriptional activity is increased in advanced prostate cancer and promotes the castrate-resistant phenotype", CARCINOGENESIS, ¬IRL PRESS|, vol. 33, no. 3, 1 March 2012 (2012-03-01), pages 572 - 580, XP055061467, ISSN: 01433334, DOI: 10.1093/carcin/bgs007 *
EMMANUEL S. ANTONARAKIS, MICHAEL A. CARDUCCI, MARIO A. EISENBERGER: "Novel targeted therapeutics for metastatic castration-resistant prostate cancer", CANCER LETTERS, ELSEVIER, vol. 291, no. 1, 1 May 2010 (2010-05-01), pages 1 - 13, XP055062463, ISSN: 03043835, DOI: 10.1016/j.canlet.2009.08.012 *
H. WANG, C. ZHANG, A. RORICK, D. WU, M. CHIU, J. THOMAS-AHNER, Z. CHEN, H. CHEN, S. K. CLINTON, K. K. CHAN, Q. WANG: "CCI-779 Inhibits Cell-Cycle G2-M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 71, no. 14, 15 July 2011 (2011-07-15), pages 4866 - 4876, XP055062470, ISSN: 00085472, DOI: 10.1158/0008-5472.CAN-10-4576 *
LORI BERK; MONICA M. MITA; JEFF KREISBERG; CAMILLE L. BEDROSIAN; ANTHONY W. TOLCHER; TIM CLACKSON; VICTOR M. RIVERA: "Analysis of the pharmacodynamic activity of the mTOR inhibitor ridaforolimus (AP23573, MK-8669) in a phase 1 clinical trial", CANCER CHEMOTHERAPY AND PHARMACOLOGY, SPRINGER, BERLIN, DE, vol. 69, no. 5, 10 January 2012 (2012-01-10), Berlin, DE, pages 1369 - 1377, XP035047366, ISSN: 1432-0843, DOI: 10.1007/s00280-011-1813-7 *
MORGAN T M, KORECKIJ TD, COREY E.: "Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway.", NIH PUBLIC ACCESS AUTHOR MANUSCRIPT, PUBLISHED IN FINAL EDITED FORM AS: CURR CANCER DRUG TARGETS. 2009 MARCH; 9(2):237-249., 1 March 2009 (2009-03-01), pages 1 - 24, XP002696902, DOI: 10.2174/156800909787580999 *
SCHAYOWITZ A, SABNIS G, GOLOUBEVA O, NJAR V C, BRODIE A M: "Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR", BRITISH JOURNAL OF CANCER, NATURE PUBLISHING GROUP, GB, vol. 103, no. 7, 28 September 2010 (2010-09-28), GB, pages 1001 - 1007, XP002696900, ISSN: 0007-0920, DOI: 10.1038/sj.bjc.6605882 *
SCHIEWER M J, DEN R, HOANG D T, AUGELLO M A, LAWRENCE Y R, DICKER A P, KNUDSEN K E: "mTOR is a selective effector of the radiation therapy response in androgen receptor-positive prostate cancer", ENDOCRINE - RELATED CANCER, BIOSCIENTIFICA LTD., GB, vol. 19, no. 1, 9 January 2012 (2012-01-09), GB, pages 1 - 12, XP002696901, ISSN: 1351-0088, DOI: 10.1530/ERC-11-0072 *

Also Published As

Publication number Publication date
US20130245028A1 (en) 2013-09-19
ES2668279T3 (es) 2018-05-17
AU2015213353A1 (en) 2015-09-03
KR102057357B1 (ko) 2019-12-18
UA114194C2 (uk) 2017-05-10
JP2015511964A (ja) 2015-04-23
EP2825171B1 (en) 2018-03-14
CN104271138A (zh) 2015-01-07
SG11201405686PA (en) 2014-10-30
MX359227B (es) 2018-09-20
EP2825171A1 (en) 2015-01-21
TWI622395B (zh) 2018-05-01
MX2014011116A (es) 2015-04-08
CA2867174A1 (en) 2013-09-19
TW201343166A (zh) 2013-11-01
IL234639A0 (en) 2014-11-30
EA201491701A1 (ru) 2015-01-30
NZ628420A (en) 2016-04-29
PH12014502047A1 (en) 2014-12-10
KR20140138928A (ko) 2014-12-04
HK1202247A1 (en) 2015-09-25
JP6470822B2 (ja) 2019-02-13
CA2867174C (en) 2020-06-23
JP2018058861A (ja) 2018-04-12
MY198666A (en) 2023-09-14
AU2015213353B2 (en) 2017-07-27
AU2013202992B2 (en) 2015-09-03
PH12014502047B1 (en) 2014-12-10
WO2013138560A1 (en) 2013-09-19
ZA201406708B (en) 2016-05-25
BR112014022700A2 (pt) 2020-06-30
AU2013202992A1 (en) 2013-10-03
CN109846884A (zh) 2019-06-07
NI201400110A (es) 2015-01-12
IL234639B (en) 2020-05-31

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