EA027690B1 - Mineral-vegetable complex for plaque removal, composition for oral hygiene, and toothpaste - Google Patents

Abstract

The invention is related to cosmetology, namely, to a mineral-vegetable complex for plaque removal, and to compositions for oral hygiene including said complex, in particular, to toothpastes and other compositions. The mineral-vegetable complex for tooth enamel strenthening and whitening comprises, per 1 weight part of hydroxyapatite, 1-5 weight parts of tetrasodium glutamate diacetate, 2-8 weight parts of sodium bicarbonate, 150-250 weight parts of dicalcium phosphate dihydrate, and 0.1-0.8 weight parts of each of plantain extract and birch leaf extract. Further, various compositions for oral hygiene using the claimed mineral-vegetable complex are disclosed. The invention makes it possible to improve efficiency of plague removal, ensure prolonged anti-plaque action of the complex and the complex-based products during 12 hours, and reduce plaque formation.

Description

Technical field

The invention relates to cosmetology, in particular to a mineral-vegetable complex for removing plaque, as well as to compositions for oral hygiene, including this complex, in particular to toothpastes and other compositions.

State of the art

In the patent literature there are a large number of publications disclosing the use in various compositions for oral hygiene of both individual minerals and mineral complexes, in particular, containing calcium hydroxyapatite (calcium hydroxyphosphate).

A known complex comprising calcium hydroxyapatite and potassium citrate. Potassium citrate reduces the response of nerve fibers in the exposed dentinal tubules to temperature, osmotic and tactile stimuli. Hydroxyapatite, in turn, fills the dentinal tubules from the inlet deep into the tubule, while tightly clogging the inlet itself, which stops the outflow of cerebrospinal fluid from the dentinal tubules to the outside. As a result, intra-tubular osmotic pressure is restored and the pain symptom complex to external stimuli is significantly reduced. The complex is aimed at improving the desensitive effectiveness of hygiene products for the oral cavity (see Leontiev A.A. et al. Clinical Studies of Asepta Sensitive Toothpaste // Dentistry Today, 2009, No. 7 (87)).

Toothpaste is also known from this source, which, in addition to the described complex, includes thermal mud, marigold, sweet clover and calamus extracts, xylitol and the papain enzyme, which in the complex allows the paste to exert not only a desensitizing, but also anti-inflammatory and anti-flying effect.

The use of mineral complexes in the compositions for oral hygiene can improve the mineralization of teeth, increase enamel resistance, etc.

The disadvantages of the known complexes include insufficient cleaning properties of hygiene products using these complexes, as well as poor teeth whitening.

The closest complex to the proposed disclosed in the patent KI2494725. The complex contains hydroxyapatite and tannase in the following ratio of components: per 100 parts by weight hydroxyapatite - 0.2-10 hours of tannase, and may also optionally contain grape seed extract.

The patent also discloses a composition for oral hygiene, containing the given mineral-enzymatic complex in an effective amount and an acceptable carrier, and a toothpaste composition comprising the given mineral complex.

Tannase is an enzyme that provides strengthening and whitening of tooth enamel in this complex and products based on it, together with hydroxyapatite.

However, the aforementioned complex and oral hygiene products including this complex do not provide highly effective plaque removal.

Disclosure of invention

The objective of the invention is the effective cleansing of plaque, the prolonged action of the complex and products based on it against the formation of plaque within 12 hours, and also to reduce the formation of plaque.

The problem is solved by a mineral-plant complex for removing plaque, including calcium hydroxyapatite, tetrasodium glutamate diacetate, sodium bicarbonate, dicalcium phosphate dihydrate, plantain extract and birch leaf extract in the following ratio, wt.h .:

Hydroxyapatite 1

Tetrasodium glutamate diacetate 1-5

Sodium bicarbonate 2-8

Dicalcium Phosphate Dihydrate 150-250

Plantain Extract 0.1-0.8

Birch Leaf Extract 0.1-0.8

In particular embodiments of the invention, the object is achieved by an oral hygiene composition that contains the above-described mineral-plant complex for removing plaque in an effective amount and an acceptable carrier.

This composition may be a toothpaste.

Or it may be a tooth powder.

The composition may also be chewing gum.

The problem is also solved by toothpaste, which contains the above-described mineral-vegetable complex in an effective amount and an acceptable carrier containing substances selected from the group consisting of abrasive substances, moisturizers, thickeners, surfactants and solvents.

In private embodiments of this invention, the toothpaste contains as abrasive substances

- 1,027,690 silicon dioxide, as a humectant, contains at least one substance selected from the group comprising sorbitol and glycerin, as a thickener contains at least one substance selected from the group comprising sodium carboxymethyl cellulose and xanthan gum, as a surface active substances it contains at least one of the substances selected from the group including decyl glucoside, sodium lauryl sarcosinate, sodium cocosulfate, and as a solvent, water in the following ratio of components, wt.% :

Mineral and vegetable complex 10.0-30.0

Abrasive substance

Humidifier

Thickener

Surfactant

1,0-60,0

0.5-70.0

0.1-10.0

0.01-10.0

Solvent rest

Toothpaste may additionally contain substances selected from the group including antimicrobial and antiseptic substances, enzymatic substances, flavoring and aromatic substances, preservatives and mixtures thereof in the following ratio, wt.%:

Antimicrobial and antiseptic substances no more than 5.00 no more than 1.00 no more than 10.00 no more than 1.0

Enzymatic substances Flavoring and aromatic substances Preservatives

In the latter case, the tooth may additionally contain table salt, and as an abrasive substance - silicon dioxide and pink clay, as a humectant - sorbitol and glycerin, as a thickener - sodium carboxymethyl cellulose and xanthan gum, as a surfactant - sodium cocosulfate, as antimicrobial and antiseptic substances - zinc citrate, thyme essential oil, and algae extracts selected from the group including kelp, spirulina and fucus in the following ratio of components, wt.%:

Mineral and vegetable complex

Silica

Pink clay

Sorbitol

Glycerol

Sodium carboxymethyl cellulose Xanthan gum Coco sodium sulfate Zinc citrate Thyme essential oil Algae extracts selected from the group consisting of kelp, spirulina and fucus Salt

10.0-30.0 to 35.0 to 4.0 to 20.0 to 20.0 to 4.0 to 4.0 to 5.0 to 5.0 to 5.0

UP TO 5.0 UP TO 5.0 Else

Solvent

The invention consists in the following.

The following components are included in the mineral-plant complex: hydroxyapatite, tetrasodium glutamate diacetate, sodium bicarbonate, dicalcium phosphate dihydrate and extracts of plantain and birch leaves.

Hydroxyapatite is a building component of enamel, it is a biological calcium phosphate devoid of impurities, it is the main mineral in tooth enamel (by 97%) and dentin (by 70%).

Human saliva, which contains a large amount of calcium ions and phosphate ions, is a kind of saturated solution of hydroxyapatite. It protects teeth by neutralizing plaque acids and compensates for the loss of minerals during demineralization.

Tetrasodium glutamate diacetate is a biodegradable chelating agent that does not cause skin irritation. It provides removal of pigmented plaque. Its additional functions also include the fact that it enhances the preservative properties of specially introduced

- 2,027,690 for this substance.

Soda (sodium bicarbonate) and dicalcium phosphate dihydrate in the aggregate provide quick but gentle purification, while dicalcium phosphate dihydrate has a remineralizing ability, because similar in composition to the enamel-forming substance. Having a lamellar structure is a soft abrasive and allows you to clean plaque without damaging the tooth enamel.

In addition, soda has weak antiseptic properties and is able to lower the level of bacteria (including 8. MI1Ai8) in the oral cavity.

Extracts of birch and plantain also have antiseptic properties.

The antiseptic effect is due to the presence of phytoncides, which normalize the microflora of the oral cavity and slow down the formation of plaque, and also provide a refreshing effect.

The pharmacological activity of the complex is primarily due to the presence of iridoids, polysaccharides and flavonoids. These effects are also closely related to the ability of plantain to increase the resistance of cells and tissues to a lack of oxygen.

Birch leaf extract contains components such as triterpenoids (betulafolientriol, betulinic acid), tannins, coumarins, flavonoids, vitamins E, PP, carotene.

The extract is used as a component that has an antiseptic, stimulating softening, calming, tonic, disinfecting effect. In addition, polyphenols of birch leaves have a pronounced antibacterial effect in relation to certain types of bacteria.

As follows from the above data, the functions of each individual component of the complex do not directly provide the declared technical result - the prolonged action of the complex and products based on it against the formation of plaque, as well as a noticeable decrease in the formation of plaque.

However, quite unexpectedly, we found that the presence of all these components in a synergistic manner provides the declared technical result, and to achieve this result, it is important not only the presence of all these components in the complex, but also the intervals of their content. When these contents of each of the components are outside these ranges, the technical result is not achieved or is not completely achieved, for example, there will be a cleaning ability with respect to plaque, but there will be no protection against plaque for 12 hours.

Compositions for oral hygiene in the broadest sense are understood to mean a composition containing the above mineral-enzymatic complex for strengthening tooth enamel as an active active principle in an effective amount and an acceptable carrier.

The effective amount of the mineral-enzymatic complex may be different depending on the type of composition, the specific composition or combination of substances in the complex, etc.

This effective amount in any individual case can be determined by a person skilled in the art through routine experimentation.

For some embodiments of the invention (toothpaste), this amount is determined by us and is given in the claims.

An acceptable carrier is understood to be a carrier that allows the desired composition for oral hygiene to be obtained in the form of, for example, toothpaste, rinse liquid, tooth powder, gel, foam, chewing gum, etc.

In this sense, the composition of the present invention can be semi-solid - in the form of toothpaste or gel for cleaning teeth, or solid, for example, in the form of chewing gum or tooth powder.

If the composition is a chewing gum, then an acceptable carrier includes synthetic or natural polymers with plasticizers, flavors, flavors, preservatives, sweeteners and other additives.

If the composition is a toothpaste, then an acceptable carrier includes solvents, thickeners, surfactants, abrasives, emulsifiers, solubilizers, moisturizers, sweeteners, flavors, preservatives and mixtures thereof.

An analysis of the prior art shows that for toothpaste, the abrasive content in the paste, as a rule, ranges from 1 to 60 wt.%, Which corresponds to the content of abrasives in the inventive paste. Abrasive materials preferred for use in the present invention include silica-based materials, which are used in the following examples of silicon dioxide of the brand δοφοβ компания (manufacturer of PO Sogrogayoi) and brand ΤίχοδίΙ (manufacturer of RNOF). However, the invention is not limited to these substances as abrasive substances - alumina, calcium carbonate, sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, dihydrated dicalcium phosphate, aluminum silicate, calcined alumina, bentonite or other silicon materials can also be used as abrasive substances. or combinations thereof.

For some embodiments of the invention (toothpaste), pink clay was also used as an abrasive.

- 3 027690

An acceptable carrier useful for preparing a paste or chewing gum composition may contain a humectant.

The humectant is preferably sorbitol, glycerin and / or polyethylene glycol PEG-400; however, you can also use other humectants and mixtures thereof with a molecular weight in the range of 200-1000. In known technical solutions, the concentration of the humidifier is usually from about 0.5 to about 70 wt.% The composition.

Typically, oral hygiene compositions include thickeners that are present in the compositions in amounts of up to 10% by weight. Thickeners include natural and synthetic resins and colloids. In the present invention, thickeners are sodium carboxymethyl cellulose as well as xanthan gum. In the best embodiments of the invention, the amount of thickener does not exceed 4.0 wt.%.

In any of the above compositions, any suitable flavoring or sweetening agents may additionally be present.

Various other substances can be incorporated into toothpastes, including preservatives, such as methyl paraben, methyl paraben sodium and chlorophilic compounds. Such excipients are introduced into the compositions in amounts that do not adversely affect the desired properties and characteristics. In accordance with the best embodiment of the invention, benzyl alcohol is used as a preservative and its amount does not exceed 1.0 wt.%.

The introduction of emulsion stabilizers into the paste ensures the dispersed state of fats and oils in aqueous emulsions.

Toothpaste may contain surfactants and, in particular, anionic surfactants, such as sodium lauryl sulfate, sodium cocosulfate, sodium lauryl sarcosinate, etc., which have a multifunctional effect: solubilizing, dispersing and wetting. In addition, their function is to formulate emulsions with other components of the oral hygiene compositions, including those with flavoring additives. In addition to the above surfactants, other anionic surfactants can also be used, as well as cationic, nonionic, amphoteric, zwitterionic or a mixture of these surfactants.

The effect of the presence of a surfactant is that it promotes foaming of toothpaste. The introduction of a surfactant with a high degree of foaming helps to create a sensation of effective cleansing of the oral cavity.

The oral hygiene compositions of the present invention can be prepared by mixing the ingredients.

In the table. 1 shows the compositions of toothpastes using the claimed mineral-vegetable complex.

In the table. 2 shows the composition of the tooth powder using the claimed mineral-complex.

In the table. 3 shows the composition of chewing gum using the claimed mineral-complex.

An example implementation of the invention.

Toothpaste, the compositions of which are given in table. 1, was made as follows: humidifiers — glycerin and sorbitol were dispersed in water with stirring in an ordinary mixer. Thickeners, a sweetener, a preservative, any salts that are active components, and foam stabilizers were added to the dispersion. These ingredients were mixed until a homogeneous phase was obtained. The mixture was then transferred to a high-speed vacuum mixer, in which an inorganic thickener based on silicon dioxide was added to the mixture, then a silicon dioxide-based abrasive was used sequentially with other abrasives for use in the composition, a mineral-vegetable complex. The mineral-vegetable complex before its introduction is a powder with a weak specific taste and smell with a hydrogen index (pH), 5% r-p not more than 8.5.

Flavors and surfactants were also added, any water-insoluble component was added along with a moisturizer. The resulting product in each case was a homogeneous semi-solid paste or gel product.

Cooked pastes were tested according to the following.

Clinical trials of pastes of formulations A, B and Ό (placebo) were conducted.

The study involved volunteers aged 18 to 35 years.

1. Evaluation of the cleansing effect during the day.

10 volunteers took part who once used samples of pastes A and B. The hygiene index was determined after brushing and after 12 hours.

2. Assessment of the cleansing effect within a week.

The study involved 30 volunteers who brushed their teeth with pastes of compositions A, B and I (placebo). The hygiene index was determined at the initial examination and after a week.

3. Evaluation of the cleaning effectiveness with prolonged use (within a month).

The study involved 20 volunteers - 10 volunteers used paste composition A,

- 4,027,690 and 10 others - a placebo formation of composition Ώ. Participants brushed their teeth twice a day for 2 minutes with the presented samples of toothpastes and identical medium-hard toothbrushes. Control examinations were carried out at the beginning of the study (after the initial determination of the hygiene index, the cleaning effect was evaluated after a single brushing), after 1, 2, 3 and 4 weeks. For this, a controlled brushing of the teeth was performed using the presented samples of complex toothpastes. The hygiene index was redefined:

after 30 s brushing your teeth; after 2 minutes of brushing your teeth.

Evaluation of the hygienic condition of the oral cavity was carried out taking into account the index of effectiveness of oral hygiene (PHR), which was calculated by the following method.

Using a solution for indicating plaque, its presence and indication were revealed on the vestibular and lingual surfaces of the teeth, where each tooth was visually divided into five sections, using the following codes and evaluation criteria: 0 - no staining, 1 - detection of staining.

The code for each tooth was determined by adding the codes for each area and the pH index was determined using the following formula:

RNR = (sum of RNR points) / n, where n is the number of teeth.

Interpretation of the results.

Index Value Oral Hygiene Level Excellent

0.1-0.6 good

0.7-1.6 satisfactory

More than 1.7 unsatisfactory

The results on the dynamics of the indicators of the pH index of hygiene during the day are given in table. 4.

The results on the dynamics of the indicators of the pH index of hygiene during the week are given in table. 5.

The results on the dynamics of the indicators of the pH index with a single brushing are shown in table.

6.

The results on the dynamics of the pH index when brushing your teeth for a month are given in table. 7.

Table 1

Toothpaste Compositions

Toothpaste Components Interval content components wt.% The composition of the toothpaste, wt.% BUT IN FROM 0 COMPLEX FOR REMOVAL DENTAL PLAINS Calcium Hydroxyapatite 10-30 0,1 ² (May 1. H) 0,1 ² (May 1. H) 0,1 ² (May 1. H) - Tetrasodium glutamate di acetate 0.3 (May 3. H) 0.1 (May 1. H) 0.5 (May 5, h) - Bicarbonate of soda 0.5 (May 5, h) 0.2 (May 2, h) 0.8 (May 8, h) - Dicalcium Phosphate Dihydrate 20.0 (May 200. h) 15.0 (150 parts by weight) 25.0 (May 250. h) - Birch Leaf Extract 0.025 (0.25 wt.h) 0.01 (May 0.1.h) 0.08 (0.8 may. H) - Plantain extract 0.08 (0.8 may. H) 0.02 (0.2 wt.h) 0.01 (May 0.1.h) HUMIDIFIERS Sorbitol, 70% 0.5-70 25 15,5 35.0 25 Glycerol 0.5-70 7.5 18.0 - 7.5 THICKENERS STRUCTURE- EDUCATION- BODIES Sodium Carboxymethyl Cellulose 0.5-4.0 1,5 1,5 1,5 1,5 Xanthan gum 0.1-4.0 0.1 0.5 0.5 0.1 Abrasive SUBSTANCES Silica 1-60 7.5 8.5 20,0 7.5 Pink clay 0.1-4.0 0.2 - 0.2 ANTIMIK- Zinc Citrate Up to 5.0 0.5 0.5 0.5 SUBSTANCES Spirulina extract Up to 5.0 Fucus Extract Up to 5.0 ENZYME- TIVY SUBSTANCES Papain Up to 1.0 0.1 Bromelain Up to 1.0 0.05 Surfactant Decyl glucoside Up to 5.0 0.05 (dry matter) Sodium Lauroyl Sarcosinate Up to 10.0 1,0 Coco Sulfate Up to 5.0 1.95 1.7 1.95 TASTE AND AROMATIC SKY SUBSTANCES Stevia Dry Extract Up to 5.0 0.002 0.02 - 0.002 Flavoring Up to 5.0 0.7 0.9 0.7 Natural crystalline menthol Up to 10.0 0.14 0.05 - 0.14 Mentyl Lactate Up to 10.0 0.06 0.15 0.06 OTHER FUNCTION- Cash ADDITIVES Gasoline alcohol ³ Up to 1.0 0.4 0.4 0.4 0.4 Arginine 1-ag§1P1pe ⁴ Up to 5.0 0.1 0.1 - 0.1 Salt ⁵ Up to 5.0 1.7 1.7 SOLUTIONS- TEL Water rest

³ Preservative.

⁴ Arginine, in combination with calcium-containing agents, significantly reduces tooth hypersensitivity.

⁵ Salt provides a preventive effect for gingivitis.

- 5,027,690

table 2

Tooth Powder Components The spread in the content of toothpaste, wt.% Composition one Composition 2 Composition 3 COMPLEX FOR REMOVAL DENTAL PLAINS Calcium Hydroxyapatite May 1 h 10-25 fifteen 10 25 Tetrasodium glutamate diacetate May 3. hours Sodium bicarbonate 5 parts by weight Dicalcium Phosphate Dihydrate 200 parts by weight Birch leaf extract 0.5 wt.h. Plantain extract 0.5 parts by weight TASTE AND AROMATI- CHOSE ADDITIVES Flavoring 0.01-5% Preferred 0.1-1.5% 0.1 0.5 1,5 Abrasive SUBSTANCES Calcium Carbonate (chalk) rest

Table 3

Chewing Gum Components The spread in the content in the toothpaste, Composition one Composition 2 Composition 3 wt.% COMPLEX FOR REMOVAL DENTAL PLAINS Calcium Hydroxyapatite May 1 h 10-25 fifteen 10 25 Tetrasodium glutamate diacetate May 3. hours Sodium bicarbonate 5 parts by weight Dicalcium Phosphate Dihydrate 200 parts by weight Birch leaf extract 0.5 wt.h. Plantain extract 0.5 parts by weight MOISTURE- BODIES Glycerol 1-5 2 2 2 TASTE AND AROMATI- CHOSE ADDITIVES Flavoring 0.01-5% Preferred 0.1-1.5% OD 1,0 1,5 THE BASIS Rubber / rubber the basis rest

Table 4

Sample After brushing your teeth After 12 hours R Composition A 0.58 ± 0, 14 1.17 ± 0.21 <0.05 Composition B 0.49 ± 0.07 1.02 ± 0.10

- 6,027,690

Table 5

Sample Initial inspection Chere s week R Cleansing efficiency, % BUT 2.54 ± 0.25 1.19 ± 0.16 <0.001 53.1 IN 2.38 ± 0.22 1.26 ± 0, 24 <0.01 47.2 ϋ 2.43 ± 0.49 1,61 ± 0, 32 > 0.05 33.7

Table 6

Sample Source inspection (one) Across 30 s (2) R (1-2) Cleansing efficiency, % Across 2 minutes (3) R (1-3) Cleansing efficiency, _ BUT 3.11 ± 0.33 1.98 ± 0.21 <0.01 36.3 1.76 ± 0.17 <0.01 43,4 ϋ 3.00 ± 0.38 2.20 ± 0.32 > 0.05 26.7 1.94 ± 0.28 <0.05 35.3

Table 7

Sample Source inspection (one) Across 1 week (2) R (1-2) Across 2 weeks (3) R (1-3) Across 3 weeks (4) P (3-4) Across 4 weeks (5) P (4-5) P (1-5) Purification that is effects in fact % BUT 3.11 ± 0.33 1.42 ± 0.24 <0.001 1.34 ± 0.21 > 0.05 1.27 ± 0.20 > 0.05 1.23 ± 0.17 > 0.05 <0.01 60.5 ϋ 3.00 ± 0.38 1.77 ± 0.23 <0.05 1.88 ± 0.28 > 0.05 1.95 ± 0.27 > 0.05 1.97 ± 0.31 > 0.05 <0.05 34.3

CLAIM

Claims (7)

1. Mineral-plant complex for plaque removal, characterized in that it includes calcium hydroxyapatite, tetrasodium glutamate diacetate, sodium bicarbonate, dicalcium phosphate dihydrate, plantain extract and birch leaf extract in the following ratio, wt.h .: hydroxyapatite - 1 tetrasodium glutamate diacetate - 1-5, sodium bicarbonate - 2-8, dicalcium phosphate dihydrate - 150-250, plantain extract - 0.1-0.8, birch leaf extract - 0.1-0.8. 2. Composition for oral hygiene, characterized in that it contains a mineral-complex for removing plaque in accordance with claim 1 in an effective amount and an acceptable carrier. 3. The composition according to claim 2, characterized in that it is a toothpaste. 4. The composition according to claim 2, characterized in that it is a tooth powder. 5. The composition according to claim 2, characterized in that it is a chewing gum. 6. Toothpaste for oral hygiene, characterized in that it contains a mineral-complex in accordance with claim 1 in an effective amount and an acceptable carrier containing substances selected from the group consisting of abrasive substances, moisturizers, thickeners, surfactants and solvents. 7. Toothpaste according to claim 6, characterized in that it contains silicon dioxide as an abrasive substance, contains at least one substance selected from the group consisting of sorbitol and glycerin as a humectant, and contains at least one substance as a thickener selected from the group consisting of sodium carboxymethyl cellulose and xanthan gum, it contains at least one of the substances selected from the group consisting of decyl glucoside, sodium lauryl sarcosinate, cocosulfa as surfactants t of sodium, and as a solvent, water in the following ratio of components, wt.%: mineral-vegetable complex - 10.0-30.0, abrasive substance - 1.0-60.0, humidifier - 0.5-70, 0, thickener - 0.1-10.0, surfactant - 0.01-10.0, solvent - the rest. 8. Toothpaste according to claim 7, characterized in that the toothpaste further comprises substances selected from the group including antimicrobial and antiseptic substances, enzymatic substances, flavoring and aromatic substances, preservatives and mixtures thereof in the following ratio, wt.%: Antimicrobial and antiseptic substances - not more than 5.00, enzymatic substances - not more than 1.00, flavoring and aromatic substances - not more than 10.00, preservatives - not more than 1.0. 9. Toothpaste according to claim 8, characterized in that it additionally contains table salt, and as an abrasive substance it contains silicon dioxide and pink clay, sorbitol and glycerin as a humectant, sodium carboxymethyl cellulose and xanthan gum as a thickener, as a surfactant, sodium cocosulfate, as antimicrobial and antiseptic substances, zinc citrate, thyme essential oil and algae extracts selected from the group consisting of kelp, spirulina and fucus in the wake ratio of components - 7 027690 wt.%: Mineral-vegetable complex - 10.0-30.0, silicon dioxide - up to 35.0, pink clay - up to 4.0, sorbitol - up to 20.0, glycerin - up to 20.0, sodium carboxymethyl cellulose - up to 4.0, xanthan gum up to 4.0, sodium cocosulfate - up to 5.0, zinc citrate - up to 5.0, thyme essential oil - up to 5.0, algae extracts selected from the group comprising kelp, spirulina and fucus - up to 5.0, table salt - up to 5.0, solvent - the rest.