EA025365B1 - Применение антитела к cd37 для лечения пациента из группы высокого риска, страдающего хроническим лимфолейкозом (cll), способ истощения экспрессирующих cd37 в-клеток в популяции клеток с дефицитом тр53 - Google Patents
Применение антитела к cd37 для лечения пациента из группы высокого риска, страдающего хроническим лимфолейкозом (cll), способ истощения экспрессирующих cd37 в-клеток в популяции клеток с дефицитом тр53 Download PDFInfo
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- EA025365B1 EA025365B1 EA201201660A EA201201660A EA025365B1 EA 025365 B1 EA025365 B1 EA 025365B1 EA 201201660 A EA201201660 A EA 201201660A EA 201201660 A EA201201660 A EA 201201660A EA 025365 B1 EA025365 B1 EA 025365B1
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
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- Mycology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10169795 | 2010-07-16 | ||
| EP10175586 | 2010-09-07 | ||
| PCT/EP2011/062133 WO2012007576A1 (en) | 2010-07-16 | 2011-07-15 | Superior efficacy of cd37 antibodies in cll blood samples |
Publications (2)
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| EA201201660A1 EA201201660A1 (ru) | 2013-07-30 |
| EA025365B1 true EA025365B1 (ru) | 2016-12-30 |
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| EA201201660A EA025365B1 (ru) | 2010-07-16 | 2011-07-15 | Применение антитела к cd37 для лечения пациента из группы высокого риска, страдающего хроническим лимфолейкозом (cll), способ истощения экспрессирующих cd37 в-клеток в популяции клеток с дефицитом тр53 |
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| EP (2) | EP2593479A1 (enExample) |
| JP (2) | JP2013538790A (enExample) |
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| CN (2) | CN105749276A (enExample) |
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| BR (1) | BR112013001012A2 (enExample) |
| CA (1) | CA2799036A1 (enExample) |
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| IL (1) | IL222775A (enExample) |
| MX (1) | MX341463B (enExample) |
| NZ (2) | NZ703225A (enExample) |
| PH (1) | PH12013500118A1 (enExample) |
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| PE20120259A1 (es) * | 2007-08-09 | 2012-04-04 | Boehringer Ingelheim Int | Anticuerpos anti-cd37 |
| US20130287797A1 (en) * | 2012-04-26 | 2013-10-31 | Boehringer Ingelheim International Gmbh | Combination of cd37 antibodies with bendamustine |
| EP2849784A1 (en) | 2012-05-16 | 2015-03-25 | Boehringer Ingelheim International GmbH | Combination of cd37 antibodies with ice (ifosfamide, carboplatin, etoposide) |
| SG11201707089WA (en) * | 2015-04-13 | 2017-10-30 | Pfizer | Chimeric antigen receptors targeting b-cell maturation antigen |
| WO2018132506A1 (en) | 2017-01-10 | 2018-07-19 | The General Hospital Corporation | Chimeric antigen receptors based on alternative signal 1 domains |
| AU2018236450A1 (en) | 2017-03-16 | 2019-10-03 | The General Hospital Corporation | Chimeric antigen receptors targeting CD37 |
| UA127586C2 (uk) | 2017-03-31 | 2023-10-25 | Ґенмаб Холдінґ Б.В. | Біспецифічні анти-cd37-антитіла, моноклональні анти-cd37-антитіла та способи їх застосування |
| US12275797B2 (en) | 2018-06-22 | 2025-04-15 | Genmab Holding B.V. | Anti-CD37 antibodies and anti-CD20 antibodies, compositions and methods of use thereof |
| MA53812A (fr) | 2018-10-04 | 2021-08-11 | Genmab Holding B V | Compositions pharmaceutiques comprenant des anticorps anti-cd37 bispécifiques |
| EP4412715A1 (en) | 2021-10-06 | 2024-08-14 | Nordic Nanovector ASA | Humanized hh1 |
| WO2023057595A1 (en) | 2021-10-06 | 2023-04-13 | Nordic Nanovector Asa | Humanized hh1 rew |
| WO2025083205A1 (en) | 2023-10-18 | 2025-04-24 | Debiopharm International S.A. | Drug combination comprising anti-cd37 antibody maytansine conjugate and bcl2 inhibitor or pi3k inhibitor |
Citations (5)
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| WO2007014278A2 (en) * | 2005-07-25 | 2007-02-01 | Trubion Pharmaceuticals, Inc. | B-cell reduction using cd37-specific and cd20-specific binding molecules |
| WO2009019312A2 (en) * | 2007-08-09 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Anti cd37 antibodies |
| WO2009023386A2 (en) * | 2007-07-06 | 2009-02-19 | Trubion Pharmaceuticals, Inc. | Binding peptides having a c-terminally disposed specific binding domain |
| WO2009126944A1 (en) * | 2008-04-11 | 2009-10-15 | Trubion Pharmaceuticals, Inc. | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
| WO2010057047A1 (en) * | 2008-11-13 | 2010-05-20 | Trubion Pharmaceutics, Inc. | Cd37 immunotherapeutic combination therapies and uses thereof |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
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2011
- 2011-07-14 US US13/182,471 patent/US20120189618A1/en not_active Abandoned
- 2011-07-15 EP EP11732464.0A patent/EP2593479A1/en not_active Withdrawn
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- 2011-07-15 EA EA201201660A patent/EA025365B1/ru not_active IP Right Cessation
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- 2011-07-15 EP EP17174088.9A patent/EP3252077A1/en not_active Withdrawn
- 2011-07-15 CA CA2799036A patent/CA2799036A1/en not_active Abandoned
- 2011-07-15 WO PCT/EP2011/062133 patent/WO2012007576A1/en not_active Ceased
- 2011-07-15 PH PH1/2013/500118A patent/PH12013500118A1/en unknown
- 2011-07-15 KR KR1020127032811A patent/KR20130100918A/ko not_active Ceased
- 2011-07-15 MX MX2012013613A patent/MX341463B/es active IP Right Grant
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2012
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2013
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2015
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Also Published As
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| CA2799036A1 (en) | 2012-01-19 |
| IL222775A0 (en) | 2012-12-31 |
| WO2012007576A1 (en) | 2012-01-19 |
| KR20130100918A (ko) | 2013-09-12 |
| NZ603161A (en) | 2015-02-27 |
| MX341463B (es) | 2016-08-22 |
| US20120189618A1 (en) | 2012-07-26 |
| EP2593479A1 (en) | 2013-05-22 |
| MX2012013613A (es) | 2012-12-17 |
| JP2017019800A (ja) | 2017-01-26 |
| US20130236454A1 (en) | 2013-09-12 |
| CL2013000101A1 (es) | 2013-12-27 |
| CN103003309A (zh) | 2013-03-27 |
| PH12013500118A1 (en) | 2013-03-11 |
| EP3252077A1 (en) | 2017-12-06 |
| AU2011278227A1 (en) | 2012-11-15 |
| CN105749276A (zh) | 2016-07-13 |
| EA201201660A1 (ru) | 2013-07-30 |
| JP2013538790A (ja) | 2013-10-17 |
| US20150266967A1 (en) | 2015-09-24 |
| BR112013001012A2 (pt) | 2016-05-24 |
| NZ703225A (en) | 2016-11-25 |
| IL222775A (en) | 2017-10-31 |
| AU2011278227B2 (en) | 2017-03-02 |
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