EA023793B1 - Лечение рака комбинацией молекул днк, имитирующих двухнитевые разрывы, и гипертермии - Google Patents
Лечение рака комбинацией молекул днк, имитирующих двухнитевые разрывы, и гипертермии Download PDFInfo
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- EA023793B1 EA023793B1 EA201301336A EA201301336A EA023793B1 EA 023793 B1 EA023793 B1 EA 023793B1 EA 201301336 A EA201301336 A EA 201301336A EA 201301336 A EA201301336 A EA 201301336A EA 023793 B1 EA023793 B1 EA 023793B1
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- Prior art keywords
- cancer
- agent
- hyperthermia
- nucleic acid
- treatment
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| EP11305650A EP2527440A1 (en) | 2011-05-27 | 2011-05-27 | Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia |
| PCT/EP2012/059799 WO2012163814A1 (en) | 2011-05-27 | 2012-05-25 | Cancer treatment by combining dna molecules mimicking double strand breaks with hyperthermia |
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| EA201301336A1 EA201301336A1 (ru) | 2014-04-30 |
| EA023793B1 true EA023793B1 (ru) | 2016-07-29 |
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| EA201301336A EA023793B1 (ru) | 2011-05-27 | 2012-05-25 | Лечение рака комбинацией молекул днк, имитирующих двухнитевые разрывы, и гипертермии |
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| EP (2) | EP2527440A1 (enExample) |
| JP (1) | JP6162691B2 (enExample) |
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| AU (1) | AU2012264899B2 (enExample) |
| CA (1) | CA2834194A1 (enExample) |
| EA (1) | EA023793B1 (enExample) |
| IL (1) | IL228943A (enExample) |
| WO (1) | WO2012163814A1 (enExample) |
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| AU2011269041B2 (en) * | 2010-06-22 | 2015-05-07 | Centre National De La Recherche Scientifique | Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates |
| CN109810977A (zh) | 2012-05-26 | 2019-05-28 | 株式会社博纳克 | 具有递送功能的基因表达调控用单链核酸分子 |
| EP3088524A4 (en) | 2013-12-26 | 2017-08-09 | Tokyo Medical University | Artificial mimic mirna for controlling gene expression, and use of same |
| CA2935022A1 (en) | 2013-12-27 | 2015-07-02 | Bonac Corporation | Artificial match-type mirna for controlling gene expression and use therefor |
| AU2015368293B2 (en) | 2014-12-27 | 2021-07-22 | Bonac Corporation | Naturally occuring miRNA for controlling gene expression, and use of same |
| EP3276003B1 (en) | 2015-03-27 | 2022-07-20 | Bonac Corporation | Single-chain nucleic acid molecule having delivery function and gene expression control ability |
| EP3325623B3 (en) * | 2015-07-23 | 2021-01-20 | Institut Curie | Use of a combination of dbait molecule and parp inhibitors to treat cancer |
| KR102441432B1 (ko) * | 2016-03-01 | 2022-09-07 | 옹쎄오 | Ｄｂａｉｔ 분자의 전신 투여에 의한 암 치료법 |
| EP3549609A4 (en) * | 2016-12-01 | 2020-07-29 | Saitama University | ENDOCYTOSIS ACTIVATOR FOR DRUG DELIVERY SYSTEMS |
| US20220054524A1 (en) * | 2018-12-21 | 2022-02-24 | Onxeo | New conjugated nucleic acid molecules and their uses |
| KR20210142154A (ko) * | 2019-03-21 | 2021-11-24 | 옹쎄오 | 암 치료를 위한 키나제 억제제와 조합된 dbait 분자 |
Citations (2)
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| WO2008034866A2 (en) * | 2006-09-21 | 2008-03-27 | Institut Curie | Dbait and uses thereof |
| WO2010082821A1 (en) * | 2009-01-13 | 2010-07-22 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Method of treating cancer |
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| WO1991014696A1 (en) * | 1990-03-29 | 1991-10-03 | Gilead Sciences, Inc. | Oligonucleotide-transport agent disulfide conjugates |
| PT765313E (pt) | 1994-06-17 | 2003-11-28 | Hoffmann La Roche | Derivados de n,n'-bis(quinolin-4-il)-diamina a sua preparacao e a sua utilizacao como agentes anti-malaria |
| AUPN741696A0 (en) * | 1996-01-05 | 1996-01-25 | Commonwealth Scientific And Industrial Research Organisation | Delivery of nucleic acids ii |
| BR9813202B1 (pt) * | 1997-09-15 | 2011-11-01 | complexo de administração de genes; processo de transdução de células com material genético estranho, composição útil para administração de material genético e uso de um complexo de administração de genes. | |
| US7635722B1 (en) * | 1998-07-27 | 2009-12-22 | Saint Jude Pharmaceuticals, Inc. | Chemical induced intracellular hyperthermia |
| EP1389209B1 (en) | 2001-04-24 | 2009-04-08 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
| EP1526177A1 (en) * | 2003-10-24 | 2005-04-27 | Institut Curie | Nucleic acids useful for triggering tumor cell lethality |
| WO2006007712A1 (en) | 2004-07-19 | 2006-01-26 | Protiva Biotherapeutics, Inc. | Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents |
| WO2007040469A2 (en) | 2005-09-15 | 2007-04-12 | Kosak Ken M | Chloroquine coupled compositions and methods for their synthesis |
| US20070293449A1 (en) | 2006-06-20 | 2007-12-20 | Nastech Pharmaceutical Company Inc. | Compositions and methods for delivery of double-stranded rna |
| CN101500548A (zh) | 2006-08-18 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 用于体内递送多核苷酸的多缀合物 |
| EP1944369A1 (en) | 2007-01-12 | 2008-07-16 | The Centre National de la Recherche Scientifique | Dbait and its standalone uses thereof |
| WO2009063998A1 (ja) * | 2007-11-14 | 2009-05-22 | Ribomic Inc. | 疎水性物質付加核酸及びその使用 |
| EP2274425A2 (en) | 2008-04-11 | 2011-01-19 | Alnylam Pharmaceuticals Inc. | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
| EP2365796A4 (en) | 2008-11-07 | 2015-04-29 | Childrens Hosp Medical Center | FUSOGENIC PROPERTIES OF SAPOSIN C AND RELATED PROTEINS AND PEPTIDES FOR APPLICATION TO TRANSMEMBRANOESE DRUG DISPENSING SYSTEMS |
| EP2355799A4 (en) | 2008-11-17 | 2012-09-05 | Enzon Pharmaceuticals Inc | CLEANABLE FUSOGENIC LIPIDS FOR NUCLEIC ACID RELIEF SYSTEMS |
| JP2012509258A (ja) * | 2008-11-17 | 2012-04-19 | エンゾン ファーマシューティカルズ，インコーポレーテッド | 核酸送達系のための分岐カチオン性脂質 |
| AU2011269041B2 (en) * | 2010-06-22 | 2015-05-07 | Centre National De La Recherche Scientifique | Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates |
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2011
- 2011-05-27 EP EP11305650A patent/EP2527440A1/en not_active Withdrawn
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2012
- 2012-05-25 JP JP2014513133A patent/JP6162691B2/ja not_active Expired - Fee Related
- 2012-05-25 CA CA2834194A patent/CA2834194A1/en not_active Abandoned
- 2012-05-25 AU AU2012264899A patent/AU2012264899B2/en not_active Ceased
- 2012-05-25 US US14/118,583 patent/US9205101B2/en not_active Expired - Fee Related
- 2012-05-25 EA EA201301336A patent/EA023793B1/ru not_active IP Right Cessation
- 2012-05-25 CN CN201280025978.2A patent/CN103732746B/zh not_active Expired - Fee Related
- 2012-05-25 EP EP12723213.0A patent/EP2714905B1/en not_active Not-in-force
- 2012-05-25 WO PCT/EP2012/059799 patent/WO2012163814A1/en not_active Ceased
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2008034866A2 (en) * | 2006-09-21 | 2008-03-27 | Institut Curie | Dbait and uses thereof |
| WO2010082821A1 (en) * | 2009-01-13 | 2010-07-22 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Method of treating cancer |
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| M. QUANZ ET AL.: "Small-Molecule Drugs Mimicking DNA Damage: A New Strategy for Sensitizing Tumors to Radiotherapy", CLINICAL CANCER RESEARCH, vol. 15, no. 4, 15 February 2009 (2009-02-15), pages 1308-1316, XP055008265, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-08-2108 cited in the application the whole document * |
| WIEBKE SOLASS ET AL.: "Therapeutic approach of human peritoneal carcinomatosis with Dbait in combination with capnoperitoneum: proof of concept", SURGICAL ENDOSCOPY, vol. 26, no. 3, 1 November 2011 (2011-11-01), pages 847-852, XP55034686, ISSN: 0930-2794, DOI: 10.1007/s00464-011-1964-y the whole document * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014516977A (ja) | 2014-07-17 |
| CN103732746B (zh) | 2016-01-20 |
| EP2527440A1 (en) | 2012-11-28 |
| IL228943A0 (en) | 2013-12-31 |
| IL228943A (en) | 2017-08-31 |
| US9205101B2 (en) | 2015-12-08 |
| CA2834194A1 (en) | 2012-12-06 |
| WO2012163814A1 (en) | 2012-12-06 |
| CN103732746A (zh) | 2014-04-16 |
| EP2714905A1 (en) | 2014-04-09 |
| JP6162691B2 (ja) | 2017-07-12 |
| AU2012264899B2 (en) | 2016-04-21 |
| EP2714905B1 (en) | 2017-11-08 |
| US20140100266A1 (en) | 2014-04-10 |
| EA201301336A1 (ru) | 2014-04-30 |
| AU2012264899A1 (en) | 2013-12-19 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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