JP6162691B2 - 二本鎖切断を模倣するｄｎａ分子と温熱療法との組み合わせによるガンの処置 - Google Patents
二本鎖切断を模倣するｄｎａ分子と温熱療法との組み合わせによるガンの処置 Download PDFInfo
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| EP11305650A EP2527440A1 (en) | 2011-05-27 | 2011-05-27 | Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia |
| EP11305650.1 | 2011-05-27 | ||
| PCT/EP2012/059799 WO2012163814A1 (en) | 2011-05-27 | 2012-05-25 | Cancer treatment by combining dna molecules mimicking double strand breaks with hyperthermia |
Publications (3)
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| JP2014516977A JP2014516977A (ja) | 2014-07-17 |
| JP2014516977A5 JP2014516977A5 (enExample) | 2015-07-02 |
| JP6162691B2 true JP6162691B2 (ja) | 2017-07-12 |
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| EP2585113A1 (en) * | 2010-06-22 | 2013-05-01 | DNA Therapeutics | Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates |
| EP2857513A4 (en) * | 2012-05-26 | 2016-05-25 | Bonac Corp | Single-stranded nucleic acid molecule controlling the expression of a gene transporter |
| WO2015099122A1 (ja) | 2013-12-26 | 2015-07-02 | 学校法人東京医科大学 | 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途 |
| RU2697094C2 (ru) | 2013-12-27 | 2019-08-12 | Бонак Корпорейшн | ИСКУССТВЕННАЯ мкРНК С СООТВЕТСТВИЕМ ДЛЯ КОНТРОЛЯ ЭКСПРЕССИИ ГЕНОВ И ЕЕ ПРИМЕНЕНИЕ |
| CA2971827A1 (en) | 2014-12-27 | 2016-06-30 | Bonac Corporation | Naturally occuring mirna for controlling gene expression, and use of same |
| CN108064289A (zh) | 2015-03-27 | 2018-05-22 | 株式会社博纳克 | 具有递送功能和基因表达调控能力的单链核酸分子 |
| CA2993270C (en) * | 2015-07-23 | 2019-07-16 | Institut Curie | Use of a combination of dbait molecule and parp inhibitors to treat cancer |
| EP3423068A1 (en) * | 2016-03-01 | 2019-01-09 | Onxeo | Treatment of cancer by systemic administration of dbait molecules |
| JP7107503B2 (ja) * | 2016-12-01 | 2022-07-27 | 国立大学法人埼玉大学 | 薬物送達系用エンドサイトーシス増強剤 |
| US20220054524A1 (en) * | 2018-12-21 | 2022-02-24 | Onxeo | New conjugated nucleic acid molecules and their uses |
| CN114364798A (zh) * | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
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| WO1991014696A1 (en) * | 1990-03-29 | 1991-10-03 | Gilead Sciences, Inc. | Oligonucleotide-transport agent disulfide conjugates |
| DK0765313T3 (da) | 1994-06-17 | 2003-12-08 | Hoffmann La Roche | N,N'-bis (quinolin-4-yl)-diaminderivater, fremstilling deraf og anvendelse deraf som midler mod malaria |
| AUPN741696A0 (en) * | 1996-01-05 | 1996-01-25 | Commonwealth Scientific And Industrial Research Organisation | Delivery of nucleic acids ii |
| EA003832B1 (ru) * | 1997-09-15 | 2003-10-30 | Дженетик Иммьюнити, Ллс. | Ген-доставочный комплекс для чрескожной доставки чужеродного генетического материала в антиген-презентирующие клетки и способы его использования |
| AU750313B2 (en) * | 1998-07-27 | 2002-07-18 | St. Jude Pharmaceuticals, Inc. | Chemically induced intracellular hyperthermia |
| DE60231868D1 (de) | 2001-04-24 | 2009-05-20 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
| EP1526177A1 (en) | 2003-10-24 | 2005-04-27 | Institut Curie | Nucleic acids useful for triggering tumor cell lethality |
| US7476729B2 (en) * | 2003-10-24 | 2009-01-13 | Institut Curie | Dbait and uses thereof |
| WO2006007712A1 (en) | 2004-07-19 | 2006-01-26 | Protiva Biotherapeutics, Inc. | Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents |
| WO2007040469A2 (en) | 2005-09-15 | 2007-04-12 | Kosak Ken M | Chloroquine coupled compositions and methods for their synthesis |
| US20070293449A1 (en) | 2006-06-20 | 2007-12-20 | Nastech Pharmaceutical Company Inc. | Compositions and methods for delivery of double-stranded rna |
| KR101133799B1 (ko) | 2006-08-18 | 2012-04-24 | 에프. 호프만-라 로슈 아게 | 폴리뉴클레오타이드의 생체내 전달을 위한 다가접합체 |
| EP1944369A1 (en) | 2007-01-12 | 2008-07-16 | The Centre National de la Recherche Scientifique | Dbait and its standalone uses thereof |
| JPWO2009063998A1 (ja) * | 2007-11-14 | 2011-03-31 | 株式会社リボミック | 疎水性物質付加核酸及びその使用 |
| WO2009126933A2 (en) | 2008-04-11 | 2009-10-15 | Alnylam Pharmaceuticals, Inc. | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
| AU2008363813A1 (en) | 2008-11-07 | 2010-05-14 | Children's Hospital Medical Center | Fusogenic properties of saposin C and related proteins and peptides for application to transmembrane drug delivery systems |
| JP2012509273A (ja) | 2008-11-17 | 2012-04-19 | エンゾン ファーマシューティカルズ，インコーポレーテッド | 核酸送達系のための放出可能融合性脂質 |
| CA2742689A1 (en) * | 2008-11-17 | 2010-05-20 | Enzon Pharmaceuticals, Inc. | Branched cationic lipids for nucleic acids delivery system |
| WO2010082813A1 (en) | 2009-01-13 | 2010-07-22 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Method of treating cancer |
| EP2585113A1 (en) * | 2010-06-22 | 2013-05-01 | DNA Therapeutics | Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates |
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| CN103732746A (zh) | 2014-04-16 |
| WO2012163814A1 (en) | 2012-12-06 |
| EP2714905B1 (en) | 2017-11-08 |
| US9205101B2 (en) | 2015-12-08 |
| EA201301336A1 (ru) | 2014-04-30 |
| IL228943A (en) | 2017-08-31 |
| AU2012264899A1 (en) | 2013-12-19 |
| EA023793B1 (ru) | 2016-07-29 |
| EP2714905A1 (en) | 2014-04-09 |
| US20140100266A1 (en) | 2014-04-10 |
| IL228943A0 (en) | 2013-12-31 |
| AU2012264899B2 (en) | 2016-04-21 |
| CN103732746B (zh) | 2016-01-20 |
| CA2834194A1 (en) | 2012-12-06 |
| EP2527440A1 (en) | 2012-11-28 |
| JP2014516977A (ja) | 2014-07-17 |
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