EA021401B1 - Антитела к dkk-1 - Google Patents

Антитела к dkk-1 Download PDF

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Publication number
EA021401B1
EA021401B1 EA201171237A EA201171237A EA021401B1 EA 021401 B1 EA021401 B1 EA 021401B1 EA 201171237 A EA201171237 A EA 201171237A EA 201171237 A EA201171237 A EA 201171237A EA 021401 B1 EA021401 B1 EA 021401B1
Authority
EA
Eurasian Patent Office
Prior art keywords
zeg
amino acid
acid sequence
tug
rgo
Prior art date
Application number
EA201171237A
Other languages
English (en)
Russian (ru)
Other versions
EA201171237A1 (ru
Inventor
Марсио Чедид
Райан Джеймс Дарлинг
Рашель Жанетт Гелвин
Барбара Энн Свэнсон
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201171237A1 publication Critical patent/EA201171237A1/ru
Publication of EA021401B1 publication Critical patent/EA021401B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201171237A 2009-04-10 2010-04-06 Антитела к dkk-1 EA021401B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16841109P 2009-04-10 2009-04-10
PCT/US2010/030039 WO2010117980A1 (en) 2009-04-10 2010-04-06 Dkk-1 antibodies

Publications (2)

Publication Number Publication Date
EA201171237A1 EA201171237A1 (ru) 2012-04-30
EA021401B1 true EA021401B1 (ru) 2015-06-30

Family

ID=42199718

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171237A EA021401B1 (ru) 2009-04-10 2010-04-06 Антитела к dkk-1

Country Status (30)

Country Link
US (1) US8148498B2 (https=)
EP (3) EP2417158B9 (https=)
JP (1) JP5759977B2 (https=)
KR (3) KR20110124364A (https=)
CN (1) CN102388065B (https=)
AR (1) AR075989A1 (https=)
AU (1) AU2010234611B2 (https=)
BR (1) BRPI1014157B1 (https=)
CA (1) CA2758252C (https=)
CY (3) CY1119399T1 (https=)
DK (3) DK3514173T3 (https=)
EA (1) EA021401B1 (https=)
ES (3) ES2644244T3 (https=)
HR (3) HRP20171400T1 (https=)
HU (3) HUE043904T2 (https=)
IL (1) IL214845A (https=)
LT (3) LT2417158T (https=)
ME (2) ME03378B (https=)
MX (1) MX2011010707A (https=)
NZ (1) NZ595011A (https=)
PL (3) PL2417158T3 (https=)
PT (3) PT3514173T (https=)
RS (3) RS58612B1 (https=)
SG (1) SG175244A1 (https=)
SI (3) SI2417158T1 (https=)
TR (1) TR201907261T4 (https=)
TW (1) TWI546079B (https=)
UA (1) UA103916C2 (https=)
WO (1) WO2010117980A1 (https=)
ZA (1) ZA201107256B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ596274A (en) 2009-05-12 2013-11-29 Pfizer Blocking anti-dkk-1 antibodies and their uses
AU2013359419B2 (en) 2012-12-10 2018-03-15 Biogen Ma Inc. Anti-blood dendritic cell antigen 2 antibodies and uses thereof
US10584174B2 (en) 2015-05-18 2020-03-10 Eli Lilly And Company Anti-Dkk-1-anti-RANKL bispecific antibody compounds
KR20180054639A (ko) * 2015-08-28 2018-05-24 알렉터 엘엘씨 항-siglec-7 항체 및 이의 사용 방법
PE20181326A1 (es) 2015-11-03 2018-08-20 Janssen Biotech Inc Anticuerpos que se unen especificamente a pd-1 y sus usos
CA3041325A1 (en) * 2016-10-26 2018-05-03 Leap Therapeutics, Inc. Use of beta-catenin as a biomarker for treating cancers using anti-dkk-1 antibody
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
CN119841953A (zh) 2018-06-08 2025-04-18 艾利妥 抗siglec-7抗体及其使用方法
KR20210044783A (ko) * 2018-07-11 2021-04-23 모멘타 파머슈티컬스 인코포레이티드 CTLA-4 표적화 조작된 Fc-항원 결합 도메인 작제물에 관련된 조성물 및 방법
CN112121147B (zh) * 2019-06-24 2023-07-04 中国人民解放军海军特色医学中心 多肽在治疗或预防骨髓瘤药物中的应用、多肽、核酸、药物及重组表达载体
CA3151228A1 (en) * 2019-09-19 2021-03-25 Leap Therapeutics, Inc. Use of dkk-1 inhibitors for treating cancer
EP4061419A1 (en) * 2019-11-22 2022-09-28 Leap Therapeutics, Inc. Methods of treating cancer using dkk-1-inhibitors
KR102494042B1 (ko) * 2020-11-20 2023-02-07 주식회사 하울바이오 인간모유두세포의 성장을 촉진하는 항-dkk-1 항체 및 이의 용도
CN112592402B (zh) * 2020-12-02 2022-04-26 杭州奕安济世生物药业有限公司 抗dkk2抗体、包含该抗dkk2抗体的组合物及其用途
CA3206789A1 (en) * 2021-02-05 2022-08-11 Gregory A. Demopulos Biomarker for assessing the risk of developing acute covid-19 and post-acute covid-19
WO2023039249A1 (en) 2021-09-10 2023-03-16 Leap Therapeutics, Inc. Combination therapy
WO2023143444A1 (zh) * 2022-01-28 2023-08-03 上海君实生物医药科技股份有限公司 抗dkk1抗体、其药物组合物及用途
IL318268A (en) 2022-07-12 2025-03-01 Leap Therapeutics Inc Combined treatment
CN116589590B (zh) * 2023-03-21 2024-03-26 浙江大学 一种特异性抗异菌脲的单克隆抗体及其重组表达质粒

Citations (3)

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WO2006015373A2 (en) * 2004-08-04 2006-02-09 Amgen Inc Antibodies to dkk-1
WO2007084344A2 (en) * 2006-01-13 2007-07-26 Novartis Ag Compositions and methods of use for antibodies of dickkopf-1 and/or -4
WO2008097510A1 (en) * 2007-02-08 2008-08-14 Merck & Co., Inc. Antibodies specific for dkk-1

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US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE69842225D1 (de) 1997-04-16 2011-05-26 Millennium Pharm Inc Zusammensetzung, umfassend einen Antikörper, der selektiv an ein cysteinreiches sekretiertes Protein (CRSP) bindet
DE19747418C1 (de) 1997-10-27 1999-07-15 Deutsches Krebsforsch Inhibitor-Protein des wnt-Signalwegs
US7446181B2 (en) * 1998-01-15 2008-11-04 Millennium Pharmaceuticals, Inc. Antibodies that bind human Dickkopf-1 proteins
ES2312205T3 (es) 1998-03-10 2009-02-16 Genentech, Inc. Nuevo polipeptido y acidos nucleicos que lo codifican.
CA2399776A1 (en) 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
JP2005512508A (ja) 2001-05-17 2005-05-12 ゲノム　セラピューティックス　コーポレーション Ｄｋｋ媒介性相互作用を変調する試薬および方法
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WO2007084344A2 (en) * 2006-01-13 2007-07-26 Novartis Ag Compositions and methods of use for antibodies of dickkopf-1 and/or -4
WO2008097510A1 (en) * 2007-02-08 2008-08-14 Merck & Co., Inc. Antibodies specific for dkk-1

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DIARRA DANIELLE ET AL: "Dickkopf-1 is a master regulator of joint remodeling", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US LNKD-DOI:10.1038/NM1538, vol. 13, no. 2, 1 February 2007 (2007-02-01), pages 156-163, XP002486201, ISSN: 1078-8956 [retrieved on 2007-01-21], the whole document *
ETTENBERG SETH A. ET AL.: "BHQ880, a novel anti-DKKl neutralizing antibody, inhibits tumor-induced osteolytic bone disease". PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, US, vol. 49, 1 April 2008 (2008-04-01), page 947, XP009134334, ISSN: 0197-016X, the whole document *
FILIPPO CARACI ET AL.: "The Wnt Antagonist, Dickkopf-1, as a Target for the Treatment of Neurodegenerative Disorders". NEUROCHEMICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE LNKD DOI:10.1007/S11064-008-9710-0, vol. 33, no. 12, 22 April 2008 (2008-04-22), pages 2401-2406, XP019647587, ISSN: 1573-6903, the whole document *
FULCINITI MARIATERESA ET AL.: "Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma". BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, UNITED STATES LNKD-DOI:10.1182/BLOOD-2008-11-191577, vol. 114, no. 2, 9 July 2009 (2009-07-09), pages 371-379, XP009134332, ISSN: 1528-0020 [retrieved on 2009-05-05], the whole document *
GAVRIATOPOULOU MARIA ET AL.: "Dickkopf-l: a suitable target for the management of myeloma bone disease". EXPERT OPINION ON THERAPEUTIC TARGETS, JUL. 2009, LNKD-PUBMED:19530987, vol. 13, no. 7, July 2009 (2009-07), pages 839-848, XP009134320, ISSN: 1744-7631, the whole document *
HALL CHRISTOPHER L. ET AL.: "Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis". PROSTATE, WILEY-LISS, NEW YORK, NY, US LNKD-DOI:10.1002/PROS.20805, vol. 68, no. 13, 15 September 2008 (2008-09-15), pages 1396-1404, XP009134318, ISSN: 0270-4137 [retrieved on 2008-06-16], the whole document *
HEATH DEBORAH J. ET AL.: "Inhibiting Dickkopf-1 (Dkkl) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma". JOURNAL OF BONE AND MINERAL RESEARCH, AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH, NEW YORK, NY, US LNKD-DOI:10.1359/JBMR.081104, vol. 24, no. 3, 1 March 2009 (2009-03-01), pages 425-436, XP009134333, ISSN: 0884-0431 [retrieved on 2009-12-04], the whole document *
KRAJ MARIA: "Multiple myeloma bone disease and novel anti-myeloma agents". ACTA HAEMATOLOGICA POLONICA, vol. 39, no. 2, 2008, pages 163-178, XP009134337, ISSN: 0001-5814, the whole document *
TERPOS E.: "Antibodies to dickkopf-1 protein". EXPERT OPINION ON THERAPEUTIC PATENTS, INFORMA HEALTHCARE, GB LNKD-DOI:10.1517/13543776.16.10.1453, vol. 16, no. 10, 1 October 2006 (2006-10-01), pages 1453-1458, XP002486202, ISSN: 1354-3776, the whole document *
YACCOBY SHMUEL ET AL: "Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US LNKD-DOI:10.1182/BLOOD-2006-09-047712, vol. 109, no. 5, 1 March 2007 (2007-03-01), pages 2106-2111, XP002486200, ISSN: 0006-4971 [retrieved on 2006-10-26], the whole document *
ZHOU XIAO-LEI ET AL.: "Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signaling". ACTA PHARMACOLOGICA SINICA, vol. 31, no. 2, February 2010 (2010-02), pages 202-210, XP009134321, the whole document *

Also Published As

Publication number Publication date
DK2417158T3 (en) 2017-10-16
KR20140090273A (ko) 2014-07-16
KR101461362B1 (ko) 2014-11-13
CY1124412T1 (el) 2022-07-22
IL214845A0 (en) 2011-11-30
EP3514173B8 (en) 2021-08-04
SI2417158T1 (sl) 2017-10-30
SI2930184T1 (sl) 2019-06-28
CA2758252C (en) 2015-02-24
PL2930184T3 (pl) 2019-10-31
RS58612B1 (sr) 2019-05-31
UA103916C2 (xx) 2013-12-10
ZA201107256B (en) 2013-03-27
EP2930184B1 (en) 2019-03-27
HRP20190643T1 (hr) 2019-05-31
CN102388065B (zh) 2014-09-03
CY1121637T1 (el) 2020-07-31
HUE034625T2 (en) 2018-02-28
SG175244A1 (en) 2011-12-29
ME02798B (me) 2018-01-20
TR201907261T4 (tr) 2019-06-21
HRP20171400T1 (hr) 2017-11-03
CN102388065A (zh) 2012-03-21
CA2758252A1 (en) 2010-10-14
RS62214B1 (sr) 2021-09-30
AR075989A1 (es) 2011-05-11
EP3514173B1 (en) 2021-06-23
DK3514173T3 (da) 2021-08-02
EP2417158B1 (en) 2017-08-02
CY1119399T1 (el) 2018-02-14
LT2417158T (lt) 2017-10-10
PL2417158T3 (pl) 2017-12-29
PL3514173T3 (pl) 2022-01-17
WO2010117980A1 (en) 2010-10-14
EP2417158A1 (en) 2012-02-15
ES2887176T3 (es) 2021-12-22
EP2417158B9 (en) 2017-12-06
TWI546079B (zh) 2016-08-21
EP2930184A1 (en) 2015-10-14
PT3514173T (pt) 2021-08-16
EP3514173A1 (en) 2019-07-24
HRP20211343T1 (hr) 2021-11-26
US20100260754A1 (en) 2010-10-14
HUE043904T2 (hu) 2019-09-30
IL214845A (en) 2016-06-30
NZ595011A (en) 2013-05-31
PT2417158T (pt) 2017-10-23
RS56505B1 (sr) 2018-02-28
AU2010234611B2 (en) 2013-02-07
DK2417158T4 (da) 2018-01-29
JP2012523417A (ja) 2012-10-04
PT2930184T (pt) 2019-06-17
KR20140033523A (ko) 2014-03-18
LT3514173T (lt) 2021-09-10
BRPI1014157B1 (pt) 2022-01-18
US8148498B2 (en) 2012-04-03
TW201100101A (en) 2011-01-01
SI3514173T1 (sl) 2021-09-30
AU2010234611A1 (en) 2011-10-20
HUE055376T2 (hu) 2021-11-29
MX2011010707A (es) 2012-02-28
BRPI1014157A2 (pt) 2020-09-29
LT2930184T (lt) 2019-05-10
ME03378B (me) 2020-01-20
KR20110124364A (ko) 2011-11-16
ES2644244T3 (es) 2017-11-28
EA201171237A1 (ru) 2012-04-30
JP5759977B2 (ja) 2015-08-05
ES2728911T3 (es) 2019-10-29
DK2930184T3 (da) 2019-05-13

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