EA020531B1 - КОМБИНИРОВАННАЯ ТЕРАПИЯ АНТИКОАГУЛИРУЮЩЕГО СРЕДСТВА С СОЕДИНЕНИЕМ, КОТОРОЕ ДЕЙСТВУЕТ КАК ИНГИБИТОР ФАКТОРА Ха - Google Patents
КОМБИНИРОВАННАЯ ТЕРАПИЯ АНТИКОАГУЛИРУЮЩЕГО СРЕДСТВА С СОЕДИНЕНИЕМ, КОТОРОЕ ДЕЙСТВУЕТ КАК ИНГИБИТОР ФАКТОРА Ха Download PDFInfo
- Publication number
- EA020531B1 EA020531B1 EA200970946A EA200970946A EA020531B1 EA 020531 B1 EA020531 B1 EA 020531B1 EA 200970946 A EA200970946 A EA 200970946A EA 200970946 A EA200970946 A EA 200970946A EA 020531 B1 EA020531 B1 EA 020531B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- iminomethyl
- carbonylamino
- carboxamide
- methoxyphenyl
- Prior art date
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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| US91185207P | 2007-04-13 | 2007-04-13 | |
| PCT/US2008/004760 WO2008127682A2 (en) | 2007-04-13 | 2008-04-11 | Combination anticoagulant therapy with a compound that acts as a factor xa inhibitor |
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| EA200970946A1 EA200970946A1 (ru) | 2010-04-30 |
| EA020531B1 true EA020531B1 (ru) | 2014-11-28 |
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| CN (2) | CN101743001B (enExample) |
| AU (1) | AU2008239659B2 (enExample) |
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| CA (1) | CA2683793C (enExample) |
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| NZ (1) | NZ580162A (enExample) |
| TN (1) | TN2009000408A1 (enExample) |
| WO (1) | WO2008127682A2 (enExample) |
Families Citing this family (29)
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| CA2401778C (en) | 2000-02-29 | 2010-12-21 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| BRPI0512273A (pt) | 2004-06-18 | 2008-02-19 | Millennium Pharm Inc | inibidores do fator xa |
| US7696352B2 (en) * | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
| US20090186810A1 (en) * | 2006-03-27 | 2009-07-23 | Portola Pharmaceuticals, Inc. | Potassium channel modulators and platelet procoagulant activity |
| EP2016072B1 (en) | 2006-05-05 | 2014-07-16 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
| WO2008057972A1 (en) * | 2006-11-02 | 2008-05-15 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor xa inhibitor |
| US20080293704A1 (en) * | 2007-01-05 | 2008-11-27 | Millennium Pharmaceuticals, Inc. | FACTOR Xa INHIBITORS |
| EA020045B1 (ru) * | 2007-05-02 | 2014-08-29 | Портола Фармасьютиклз, Инк. | Комбинированная терапия соединением, проявляющим активность ингибитора рецептора адф на тромбоцитах |
| US9427448B2 (en) | 2009-11-11 | 2016-08-30 | The Medicines Company | Methods of treating, reducing the incidence of, and/or preventing ischemic events |
| WO2011060066A2 (en) | 2009-11-11 | 2011-05-19 | The Medicines Company | Methods of treating or preventing stent thrombosis |
| US10376532B2 (en) | 2009-11-11 | 2019-08-13 | Chiesi Farmaceutici, S.P.A. | Methods of treating, reducing the incidence of, and/or preventing ischemic events |
| CN104774176A (zh) | 2009-12-17 | 2015-07-15 | 米伦纽姆医药公司 | 合成Xa因子抑制剂的方法 |
| WO2011075602A1 (en) * | 2009-12-17 | 2011-06-23 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
| JP5796872B2 (ja) * | 2009-12-17 | 2015-10-21 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 第Ｘａ因子阻害剤の結晶性塩 |
| ES2550033T3 (es) * | 2009-12-23 | 2015-11-04 | Ratiopharm Gmbh | Forma de dosificación farmacéutica sólida de ticagrelor |
| US20120052058A1 (en) * | 2010-08-30 | 2012-03-01 | Emory University | Methods of managing the blood coagulation and pharmaceutical compositions related thereto |
| AR082804A1 (es) | 2010-09-01 | 2013-01-09 | Portola Pharm Inc | Formas cristalinas de un inhibidor del factor xa |
| TW201240664A (en) * | 2010-09-01 | 2012-10-16 | Portola Pharm Inc | Methods and formulations of treating thrombosis with betrixaban and a P-glycoprotein inhibitor |
| US20140346397A1 (en) | 2012-12-27 | 2014-11-27 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
| US9200268B2 (en) | 2012-12-27 | 2015-12-01 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
| US10603316B2 (en) | 2013-08-21 | 2020-03-31 | Morehouse School Of Medicine | Composition and methods for preventing or reducing the incidence of transient ischemic attacks |
| WO2015038968A1 (en) * | 2013-09-13 | 2015-03-19 | The General Hospital Corporation | Activatable fibrin-binding probes |
| TW201613581A (en) * | 2014-09-02 | 2016-04-16 | Daiichi Sankyo Co Ltd | Pharmaceutical composition for suppression of thromboembolization after stent placement |
| WO2017091757A1 (en) | 2015-11-24 | 2017-06-01 | Portola Pharmaceuticals, Inc. | Isotopically enriched betrixaban |
| WO2017208169A1 (en) * | 2016-06-02 | 2017-12-07 | Dr. Reddy’S Laboratories Limited | Polymorphs of betrixaban & its maleate salt |
| WO2018234565A1 (en) | 2017-06-23 | 2018-12-27 | Chiesi Farmaceutici S.P.A. | Method of preventing of systemic-to-pulmonary-artery shunt thrombosis |
| CN112888312A (zh) * | 2018-08-28 | 2021-06-01 | 莫尔豪斯医学院 | 用于预防或降低短暂性脑缺血发作发病率的组合物及方法 |
| CN116782911A (zh) * | 2020-09-17 | 2023-09-19 | 艾克赛特赫拉制药有限责任公司 | 治疗性化合物、组合物及其使用方法 |
| EP4070658A1 (de) * | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Verwendung von blutgerinnungshemmenden verbindungen als rodentizide |
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2008
- 2008-04-11 WO PCT/US2008/004760 patent/WO2008127682A2/en not_active Ceased
- 2008-04-11 BR BRPI0809655A patent/BRPI0809655B8/pt not_active IP Right Cessation
- 2008-04-11 EP EP08742820.7A patent/EP2155195B1/en active Active
- 2008-04-11 EA EA200970946A patent/EA020531B1/ru not_active IP Right Cessation
- 2008-04-11 JP JP2010503078A patent/JP5469595B2/ja not_active Expired - Fee Related
- 2008-04-11 MX MX2009010953A patent/MX2009010953A/es active IP Right Grant
- 2008-04-11 CN CN200880019506XA patent/CN101743001B/zh not_active Expired - Fee Related
- 2008-04-11 KR KR1020097023491A patent/KR101473207B1/ko not_active Expired - Fee Related
- 2008-04-11 US US12/101,644 patent/US20080254036A1/en not_active Abandoned
- 2008-04-11 CA CA2683793A patent/CA2683793C/en not_active Expired - Fee Related
- 2008-04-11 EP EP12196044.7A patent/EP2591783A1/en not_active Withdrawn
- 2008-04-11 NZ NZ580162A patent/NZ580162A/xx not_active IP Right Cessation
- 2008-04-11 CN CN2012105706089A patent/CN103071154A/zh active Pending
- 2008-04-11 AU AU2008239659A patent/AU2008239659B2/en not_active Ceased
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2009
- 2009-10-07 GT GT200900260A patent/GT200900260A/es unknown
- 2009-10-09 TN TNP2009000408A patent/TN2009000408A1/fr unknown
- 2009-10-11 IL IL201433A patent/IL201433A/en active IP Right Grant
- 2009-10-12 DO DO2009000244A patent/DOP2009000244A/es unknown
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2011
- 2011-08-19 US US13/213,912 patent/US8455440B2/en not_active Expired - Fee Related
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2013
- 2013-05-08 US US13/889,982 patent/US20130315897A1/en not_active Abandoned
- 2013-06-18 JP JP2013127495A patent/JP2013177459A/ja active Pending
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| WO2005097784A1 (de) * | 2004-04-07 | 2005-10-20 | Bayer Healthcare Ag | Phenylthioessigsäure-derivate und ihre verwendung |
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