EA018630B1 - Специфичные к меланокортиновым рецепторам пептиды для лечения сексуальной дисфункции - Google Patents

Специфичные к меланокортиновым рецепторам пептиды для лечения сексуальной дисфункции Download PDF

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Publication number
EA018630B1
EA018630B1 EA201001722A EA201001722A EA018630B1 EA 018630 B1 EA018630 B1 EA 018630B1 EA 201001722 A EA201001722 A EA 201001722A EA 201001722 A EA201001722 A EA 201001722A EA 018630 B1 EA018630 B1 EA 018630B1
Authority
EA
Eurasian Patent Office
Prior art keywords
peptides
peptide
present
cyclic
cyclic peptide
Prior art date
Application number
EA201001722A
Other languages
English (en)
Russian (ru)
Other versions
EA201001722A1 (ru
Inventor
Йи-Цунь Ши
Шубх Д. Шарма
Вей Янг
Синь Чэнь
Original Assignee
Палатин Текнолоджиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Палатин Текнолоджиз, Инк. filed Critical Палатин Текнолоджиз, Инк.
Publication of EA201001722A1 publication Critical patent/EA201001722A1/ru
Publication of EA018630B1 publication Critical patent/EA018630B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • C07K14/685—Alpha-melanotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EA201001722A 2008-06-09 2009-06-08 Специфичные к меланокортиновым рецепторам пептиды для лечения сексуальной дисфункции EA018630B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5991008P 2008-06-09 2008-06-09
PCT/US2009/046571 WO2009152079A1 (en) 2008-06-09 2009-06-08 Melanocortin receptor-specific peptides for treatment of sexual dysfunction

Publications (2)

Publication Number Publication Date
EA201001722A1 EA201001722A1 (ru) 2011-08-30
EA018630B1 true EA018630B1 (ru) 2013-09-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001722A EA018630B1 (ru) 2008-06-09 2009-06-08 Специфичные к меланокортиновым рецепторам пептиды для лечения сексуальной дисфункции

Country Status (14)

Country Link
US (2) US8487073B2 (cg-RX-API-DMAC7.html)
EP (1) EP2300036B1 (cg-RX-API-DMAC7.html)
JP (1) JP5628796B2 (cg-RX-API-DMAC7.html)
KR (1) KR101687037B1 (cg-RX-API-DMAC7.html)
CN (1) CN102131514B (cg-RX-API-DMAC7.html)
AU (1) AU2009257631B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0909947A2 (cg-RX-API-DMAC7.html)
CA (1) CA2727317C (cg-RX-API-DMAC7.html)
EA (1) EA018630B1 (cg-RX-API-DMAC7.html)
IL (1) IL209867A (cg-RX-API-DMAC7.html)
MX (1) MX2010013436A (cg-RX-API-DMAC7.html)
NZ (1) NZ590254A (cg-RX-API-DMAC7.html)
WO (1) WO2009152079A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201009165B (cg-RX-API-DMAC7.html)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA018630B1 (ru) 2008-06-09 2013-09-30 Палатин Текнолоджиз, Инк. Специфичные к меланокортиновым рецепторам пептиды для лечения сексуальной дисфункции
UY32690A (es) * 2009-06-08 2011-01-31 Astrazeneca Ab Péptidos específicos para receptores de melanocortina
WO2010144341A2 (en) 2009-06-08 2010-12-16 Palatin Technologies, Inc. Lactam-bridged melanocortin receptor-specific peptides
NZ596617A (en) * 2009-06-08 2014-04-30 Palatin Technologies Inc Melanocortin receptor-specific peptides
CN102712674A (zh) 2009-11-23 2012-10-03 帕拉丁科技公司 黑皮质素-1受体-特异性的线性肽
NZ599774A (en) 2009-11-23 2014-11-28 Palatin Technologies Inc Melanocortin-1 receptor-specific cyclic peptides
PT3539551T (pt) 2011-12-29 2021-11-04 Rhythm Pharmaceuticals Inc Método de tratamento de distúrbios associados ao recetor de melanocortina-4 em portadores heterozigóticos
CN102702330B (zh) * 2012-03-01 2015-04-01 张嘎 环状核心序列与生物素或穿膜肽相连而成的促黑激素类似物
EP2814501A4 (en) * 2012-03-13 2016-03-02 Tensive Controls Inc MELANOCORTINANALOGA WITH INCREASED EFFECTIVENESS AND TRANSPORTATION OF THEREOF
WO2014071339A2 (en) 2012-11-05 2014-05-08 Palatin Technologies, Inc. Uses of bremelanotide in therapy for female sexual dysfunction
WO2016168388A2 (en) 2015-04-14 2016-10-20 Palatin Technologies, Inc. Therapies for obesity, diabetes and related indications
AU2016330773A1 (en) 2015-09-30 2018-04-19 Charité-Universitätsmedizin Berlin Method of treating melanocortin-4 receptor pathway-associated disorders
RU2655763C2 (ru) * 2016-10-24 2018-05-29 Общество С Ограниченной Ответственностью "Айвикс" Фармацевтическая композиция и способ лечения женских сексуальных дисфункций
WO2019195756A1 (en) 2018-04-06 2019-10-10 Rhythm Pharmaceuticals, Inc. Compositions for treating kidney disease
US11590209B2 (en) 2020-01-21 2023-02-28 Palatin Technologies, Inc. Use of bremelanotide in patients with controlled hypertension
CN115279390A (zh) * 2020-02-03 2022-11-01 帕拉丁科技公司 反向酰胺连接的促黑素受体特异性环状肽

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Also Published As

Publication number Publication date
WO2009152079A1 (en) 2009-12-17
JP5628796B2 (ja) 2014-11-19
EP2300036B1 (en) 2017-04-05
US8487073B2 (en) 2013-07-16
ZA201009165B (en) 2012-03-28
EA201001722A1 (ru) 2011-08-30
BRPI0909947A2 (pt) 2017-06-27
IL209867A (en) 2015-08-31
US20110065652A1 (en) 2011-03-17
EP2300036A1 (en) 2011-03-30
IL209867A0 (en) 2011-02-28
MX2010013436A (es) 2011-06-21
EP2300036A4 (en) 2012-01-18
JP2011522839A (ja) 2011-08-04
CN102131514B (zh) 2014-08-20
AU2009257631B2 (en) 2014-07-24
CA2727317A1 (en) 2009-12-17
KR20110040819A (ko) 2011-04-20
CN102131514A (zh) 2011-07-20
NZ590254A (en) 2012-07-27
US8729224B2 (en) 2014-05-20
AU2009257631A1 (en) 2009-12-17
KR101687037B1 (ko) 2016-12-15
US20130288987A1 (en) 2013-10-31
CA2727317C (en) 2015-02-17

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