EA017187B1 - Конденсированные производные тиазола в качестве ингибиторов киназ - Google Patents

Конденсированные производные тиазола в качестве ингибиторов киназ Download PDF

Info

Publication number
EA017187B1
EA017187B1 EA201000038A EA201000038A EA017187B1 EA 017187 B1 EA017187 B1 EA 017187B1 EA 201000038 A EA201000038 A EA 201000038A EA 201000038 A EA201000038 A EA 201000038A EA 017187 B1 EA017187 B1 EA 017187B1
Authority
EA
Eurasian Patent Office
Prior art keywords
methyl
dimethyl
thiazolo
pyridin
oxo
Prior art date
Application number
EA201000038A
Other languages
English (en)
Russian (ru)
Other versions
EA201000038A1 (ru
Inventor
Рикки Питер Александер
Павандип Сингх Ауджла
Карен-Вивьян-Люсиль Крепи
Анне Мари Фоли
Ричард Джереми Франклин
Original Assignee
Юсб Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0612644A external-priority patent/GB0612644D0/en
Priority claimed from GB0620062A external-priority patent/GB0620062D0/en
Application filed by Юсб Фарма С.А. filed Critical Юсб Фарма С.А.
Priority claimed from PCT/GB2008/002194 external-priority patent/WO2009001089A1/en
Publication of EA201000038A1 publication Critical patent/EA201000038A1/ru
Publication of EA017187B1 publication Critical patent/EA017187B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EA201000038A 2006-06-26 2008-06-24 Конденсированные производные тиазола в качестве ингибиторов киназ EA017187B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0612644A GB0612644D0 (en) 2006-06-26 2006-06-26 Therapeutic agents
GB0620062A GB0620062D0 (en) 2006-10-10 2006-10-10 Therapeutic agents
PCT/GB2007/002390 WO2008001076A1 (en) 2006-06-26 2007-06-26 Fused thiazole derivatives as kinase inhibitors
PCT/GB2008/002194 WO2009001089A1 (en) 2007-06-26 2008-06-24 Fused thiazole derivatives as kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201000038A1 EA201000038A1 (ru) 2010-06-30
EA017187B1 true EA017187B1 (ru) 2012-10-30

Family

ID=38671000

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000038A EA017187B1 (ru) 2006-06-26 2008-06-24 Конденсированные производные тиазола в качестве ингибиторов киназ

Country Status (20)

Country Link
US (3) US8242116B2 (OSRAM)
EP (2) EP2035436B1 (OSRAM)
CN (1) CN101687885B (OSRAM)
AT (1) ATE510840T1 (OSRAM)
AU (1) AU2008269577B2 (OSRAM)
CA (1) CA2692085C (OSRAM)
CO (1) CO6270229A2 (OSRAM)
CY (1) CY1114419T1 (OSRAM)
DK (1) DK2170906T3 (OSRAM)
EA (1) EA017187B1 (OSRAM)
ES (2) ES2365258T3 (OSRAM)
HR (1) HRP20130523T1 (OSRAM)
IL (1) IL202659A0 (OSRAM)
ME (1) ME01592B (OSRAM)
MX (1) MX2009013740A (OSRAM)
MY (1) MY148852A (OSRAM)
PL (1) PL2170906T3 (OSRAM)
PT (1) PT2170906E (OSRAM)
RS (1) RS52824B (OSRAM)
WO (1) WO2008001076A1 (OSRAM)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009071890A1 (en) * 2007-12-04 2009-06-11 Ucb Pharma S.A. Tricyclic kinase inhibitors
WO2009071895A1 (en) * 2007-12-04 2009-06-11 Ucb Pharma S.A. Fused thiazole and thiophene derivatives as kinase inhibitors
BRPI0821209A2 (pt) 2007-12-19 2019-09-24 Amgen Inc composto, composição farmacêutica, métodos de tratar câncer, para reduzir o tamanho de tumor, para tratar distúrbios, e para reduzir metástase em um tumor.
ATE531372T1 (de) 2008-04-07 2011-11-15 Amgen Inc Gem-disubstituierte und spirocyclische aminopyridine/pyrimidine als zellcyclus- inhibitoren
WO2009130900A1 (ja) * 2008-04-24 2009-10-29 日本曹達株式会社 オキシム誘導体、中間体化合物および植物病害防除剤
US8603945B2 (en) * 2008-07-23 2013-12-10 The Regents Of The University Of California Methods and compositions for providing salicyclic acid-independent pathogen resistance in plants
WO2010027002A1 (ja) * 2008-09-05 2010-03-11 塩野義製薬株式会社 Ｐｉ３ｋ阻害活性を有する縮環モルホリン誘導体
AU2010216219A1 (en) 2009-02-17 2011-09-01 Vertex Pharmaceuticals Incorporated Tetrahydrothiazolopyridine inhibitors of phosphatidylinositol 3-kinase
WO2010107765A1 (en) * 2009-03-18 2010-09-23 Schering Corporation Bicyclic compounds as inhibitors of diacylglycerol acyltransferase
UY32582A (es) * 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
JP5554833B2 (ja) * 2009-05-20 2014-07-23 グラクソスミスクライン エルエルシー Ｐｉ３キナーゼ阻害剤としてのチアゾロピリミジノン誘導体
GB0912946D0 (en) 2009-07-24 2009-09-02 Addex Pharmaceuticals Sa New compounds 5
EP2467387B1 (en) 2009-08-20 2015-01-07 Karus Therapeutics Limited Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors.
WO2011073347A1 (en) * 2009-12-18 2011-06-23 Janssen Pharmaceutica Nv Bicyclic thiazoles as allosteric modulators of mglur5 receptors
BR112012014436A2 (pt) 2009-12-18 2019-09-24 Janssen Pharmaceutica Nv tiazóis bicíclicos como moduladores alostéricos de receptores mglur5
MX2012014575A (es) 2010-06-15 2013-02-07 Bayer Ip Gmbh Nuevos derivados de arilamida orto-sustituidos.
BR112013007056A2 (pt) 2010-10-01 2019-09-24 Basf Se compostos de imina
WO2012051410A2 (en) * 2010-10-13 2012-04-19 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
AU2011332859A1 (en) * 2010-11-24 2013-06-20 Exelixis, Inc. Benzoxazepines as inhibitors of mTOR and methods of their use and manufacture
CN102649777B (zh) * 2011-02-25 2014-03-12 中国中化股份有限公司 一种制备1-芳基-3-羧基-5-吡唑啉酮类化合物的方法
MX2013010871A (es) 2011-03-23 2014-01-31 Amgen Inc Inhibidores dobles triciclicos fusionados de cdk 4/6 y flt3.
PT2794600T (pt) 2011-12-22 2018-03-13 Novartis Ag Derivados de 2,3-di-hidro-benzo[1,4]oxazina e compostos relacionados como inibidores de fosfoinositídeo-3-cinase (pi3k) para o tratamento de, por exemplo, artrite reumatoide
EP2970133B1 (en) 2013-03-14 2018-10-24 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
WO2014153208A1 (en) 2013-03-14 2014-09-25 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
WO2014153235A2 (en) 2013-03-14 2014-09-25 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
SG11201506972PA (en) 2013-03-14 2015-10-29 Epizyme Inc Arginine methyltransferase inhibitors and uses thereof
US8952026B2 (en) 2013-03-14 2015-02-10 Epizyme, Inc. PRMT1 inhibitors and uses thereof
WO2014144659A1 (en) 2013-03-14 2014-09-18 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
US9133189B2 (en) 2013-03-14 2015-09-15 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9365527B2 (en) 2013-03-14 2016-06-14 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
JP2016514164A (ja) 2013-03-14 2016-05-19 エピザイム，インコーポレイティド アルギニンメチルトランスフェラーゼ阻害剤としてのピラゾール誘導体およびその使用
KR102325919B1 (ko) * 2013-10-21 2021-11-12 우미코레 아게 운트 코 카게 방향족 아민의 모노아릴화
GB201402431D0 (en) 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds
GB201514754D0 (en) * 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514758D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Formulation
GB201514760D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds and method of use
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
CN108570043A (zh) * 2018-06-20 2018-09-25 王延娇 一种化合物及其作为选择性pi3k抑制剂在治疗肿瘤中的应用
US20220202824A1 (en) 2018-09-13 2022-06-30 Stemline Therapeutics, Inc. Methods for Treating Centronuclear Myopathy
KR20210108416A (ko) 2018-12-19 2021-09-02 레오 파마 에이/에스 Il-17의 소분자 조절제로서의 아미노산 아닐라이드
TWI834795B (zh) * 2019-01-08 2024-03-11 日商杏林製藥股份有限公司 15-pgdh抑制劑
WO2020160151A1 (en) 2019-01-31 2020-08-06 Kyorin Pharmaceutical Co., Ltd. 15-pgdh inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006114606A1 (en) * 2005-04-26 2006-11-02 Ucb Pharma S.A. Fused thiazole derivatives as kinase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006114606A1 (en) * 2005-04-26 2006-11-02 Ucb Pharma S.A. Fused thiazole derivatives as kinase inhibitors

Also Published As

Publication number Publication date
CN101687885B (zh) 2012-08-22
AU2008269577A1 (en) 2008-12-31
EA201000038A1 (ru) 2010-06-30
WO2008001076A1 (en) 2008-01-03
IL202659A0 (en) 2010-06-30
EP2170906A1 (en) 2010-04-07
US20110003785A1 (en) 2011-01-06
MX2009013740A (es) 2010-02-01
US8242116B2 (en) 2012-08-14
US20100137302A1 (en) 2010-06-03
ME01592B (me) 2014-09-20
US20130079330A1 (en) 2013-03-28
DK2170906T3 (da) 2013-06-24
CN101687885A (zh) 2010-03-31
HRP20130523T1 (en) 2013-07-31
PT2170906E (pt) 2013-06-25
EP2035436A1 (en) 2009-03-18
CO6270229A2 (es) 2011-04-20
PL2170906T3 (pl) 2013-08-30
MY148852A (en) 2013-06-14
ES2416364T3 (es) 2013-07-31
CA2692085C (en) 2015-10-13
ES2365258T3 (es) 2011-09-27
EP2170906B1 (en) 2013-04-03
ATE510840T1 (de) 2011-06-15
EP2035436B1 (en) 2011-05-25
US8710054B2 (en) 2014-04-29
CA2692085A1 (en) 2008-12-31
RS52824B (OSRAM) 2013-10-31
CY1114419T1 (el) 2016-08-31
AU2008269577B2 (en) 2012-12-20
US8338592B2 (en) 2012-12-25

Similar Documents

Publication Publication Date Title
EA017187B1 (ru) Конденсированные производные тиазола в качестве ингибиторов киназ
JP5249787B2 (ja) Ｍｅｋ阻害剤としてのチエノピリジン誘導体
EP2231641B1 (en) Quinoxaline and quinoline derivatives as kinase inhibitors
EP2183253B1 (en) Thieno-pyridine derivatives as mek inhibitors
EP1881827B1 (en) Fused thiazole derivatives as kinase inhibitors
JP2005526814A (ja) 新規な化合物
US8168634B2 (en) Thiazole derivatives as kinase inhibitors
KR101577314B1 (ko) 키나제 억제제로서의 접합된 티아졸 유도체
JP2016540812A (ja) 癌の治療用のｆａｓｎ阻害剤として有用なイミダゾリン−５−オン誘導体
HK1140756B (en) Fused thiazole derivatives as kinase inhibitors
MX2008009610A (en) Thieno-pyridine derivatives as mek inhibitors
HK1125924B (en) Thieno-pyridine derivatives as mek inhibitors

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG MD TJ TM