EA012746B1 - Порошкообразная композиция и способ ее получения, фармацевтическая лекарственная форма и способ ее получения, применение аморфного кремнезема - Google Patents
Порошкообразная композиция и способ ее получения, фармацевтическая лекарственная форма и способ ее получения, применение аморфного кремнезема Download PDFInfo
- Publication number
- EA012746B1 EA012746B1 EA200601588A EA200601588A EA012746B1 EA 012746 B1 EA012746 B1 EA 012746B1 EA 200601588 A EA200601588 A EA 200601588A EA 200601588 A EA200601588 A EA 200601588A EA 012746 B1 EA012746 B1 EA 012746B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- solvent
- steroid
- composition
- surface area
- pharmaceutically acceptable
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 108
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 52
- 238000004519 manufacturing process Methods 0.000 title abstract description 13
- 229940079593 drug Drugs 0.000 title abstract description 5
- 239000002904 solvent Substances 0.000 claims abstract description 86
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- 238000001953 recrystallisation Methods 0.000 claims abstract description 6
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- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims description 4
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- JBXXREPMUABISH-RGKMBJPFSA-N 3-[(7r,8r,9s,10r,13s,14s,17r)-17-hydroxy-7-methoxycarbonyl-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl]propanoic acid Chemical compound C1C[C@]2(C)[C@@](CCC(O)=O)(O)CC[C@H]2[C@@H]2[C@H](C(=O)OC)CC3=CC(=O)CC[C@]3(C)[C@H]21 JBXXREPMUABISH-RGKMBJPFSA-N 0.000 claims description 4
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- CETKWEWBSMKADK-GSXVSZIWSA-N epostane Chemical compound C([C@]1(C)[C@@](C)(O)CC[C@H]1[C@@H]1CC2)C[C@@H]1[C@]1(C)[C@]32O[C@]3(C)C(O)=C(C#N)C1 CETKWEWBSMKADK-GSXVSZIWSA-N 0.000 claims description 4
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- SYWHXTATXSMDSB-GSLJADNHSA-N fludrocortisone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O SYWHXTATXSMDSB-GSLJADNHSA-N 0.000 claims description 4
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- FBRAWBYQGRLCEK-UHFFFAOYSA-N [17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6h-cyclopenta[a]phenanthren-17-yl] butanoate Chemical compound C1CC2=CC(=O)C=CC2(C)C2(F)C1C1CC(C)C(C(=O)CCl)(OC(=O)CCC)C1(C)CC2=O FBRAWBYQGRLCEK-UHFFFAOYSA-N 0.000 claims description 3
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55133004P | 2004-03-10 | 2004-03-10 | |
| EP04075714 | 2004-03-10 | ||
| PCT/IB2005/000748 WO2005087199A2 (en) | 2004-03-10 | 2005-03-10 | Stabilised supersaturated solid solutions of steroidal drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200601588A1 EA200601588A1 (ru) | 2007-02-27 |
| EA012746B1 true EA012746B1 (ru) | 2009-12-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200601588A EA012746B1 (ru) | 2004-03-10 | 2005-03-10 | Порошкообразная композиция и способ ее получения, фармацевтическая лекарственная форма и способ ее получения, применение аморфного кремнезема |
Country Status (32)
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| US (1) | US8715735B2 (https=) |
| EP (2) | EP2087883B1 (https=) |
| JP (1) | JP5006185B2 (https=) |
| KR (1) | KR101210695B1 (https=) |
| CN (1) | CN1984644B (https=) |
| AR (1) | AR048500A1 (https=) |
| AT (1) | ATE442131T1 (https=) |
| AU (1) | AU2005221403B8 (https=) |
| BR (1) | BRPI0507342A (https=) |
| CA (1) | CA2558582C (https=) |
| CR (1) | CR8630A (https=) |
| DE (1) | DE602005016551D1 (https=) |
| DK (1) | DK1765290T3 (https=) |
| EA (1) | EA012746B1 (https=) |
| EC (1) | ECSP066902A (https=) |
| ES (2) | ES2390406T3 (https=) |
| GT (1) | GT200500045A (https=) |
| HR (1) | HRP20090614T1 (https=) |
| IL (1) | IL177894A0 (https=) |
| MY (1) | MY142989A (https=) |
| NO (1) | NO20064473L (https=) |
| NZ (1) | NZ549793A (https=) |
| PA (1) | PA8626101A1 (https=) |
| PE (1) | PE20060016A1 (https=) |
| PL (1) | PL1765290T3 (https=) |
| PT (1) | PT1765290E (https=) |
| RS (1) | RS51076B (https=) |
| SI (1) | SI1765290T1 (https=) |
| SV (1) | SV2005002044A (https=) |
| TW (1) | TWI345986B (https=) |
| UY (1) | UY28803A1 (https=) |
| WO (1) | WO2005087199A2 (https=) |
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| CN101232869B (zh) * | 2005-06-16 | 2016-03-02 | 沃纳奇尔科特有限责任公司 | 局部给药的凝胶组合物 |
| JP2009536165A (ja) * | 2006-05-10 | 2009-10-08 | エボニック デグサ ゲーエムベーハー | 医薬組成物におけるロール圧縮された熱分解的に製造された二酸化ケイ素の使用 |
| MX2009008935A (es) | 2007-02-23 | 2009-11-02 | Gilead Sciences Inc | Moduladores de las propiedades farmacocineticas de productos terapeuticos. |
| ES2575549T3 (es) * | 2007-04-11 | 2016-06-29 | John A. Mccarty | Comprimido de melatonina y métodos de preparación y uso |
| BRPI0908477A2 (pt) * | 2008-02-13 | 2018-03-27 | Bayer Schering Pharma Ag | sistema de distribuição de medicamento contendo estradiol |
| CN102083467B (zh) | 2008-03-11 | 2013-12-25 | Aska制药株式会社 | 固体分散体及其药物组合物、以及它们的制备方法 |
| MX2010011963A (es) | 2008-05-02 | 2010-12-06 | Gilead Sciences Inc | Uso de particulas trasportadoras solidas para mejorar la capacidad de procesamiento de un agente farmaceutico. |
| WO2009138224A1 (en) * | 2008-05-14 | 2009-11-19 | Helm Ag | Pharmaceutical composition comprising drospirenone |
| JP2012505253A (ja) * | 2008-10-10 | 2012-03-01 | テバ ウィメンズ ヘルス インコーポレイテッド | 低用量酢酸シプロテロンを用いる、去勢された前立腺癌患者における血管運動症状の治療方法 |
| WO2010094623A1 (en) * | 2009-02-18 | 2010-08-26 | Bayer Schering Pharma Aktiengesellschaft | Formulation comprising drospirenone for subcutaneous or intramuscular administration |
| WO2010111397A1 (en) * | 2009-03-24 | 2010-09-30 | Adds Pharmaceuticals Llc | Stabilized solubility-enhanced formulations for oral delivery |
| FR2947178B1 (fr) * | 2009-06-29 | 2012-07-06 | Effik | Composition pharmaceutique a base de progesterone micronisee et ses utilisations |
| AR081670A1 (es) | 2010-06-29 | 2012-10-10 | Leon Farma Sa Lab | Composicion farmaceutica que comprende drospirenona y kit anticonceptivo |
| US11351122B1 (en) | 2010-07-28 | 2022-06-07 | Laboratorios Leon Farma Sa | Synthetic progestogens and pharmaceutical compositions comprising the same |
| US10849857B2 (en) | 2010-07-28 | 2020-12-01 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
| US9603860B2 (en) | 2010-07-28 | 2017-03-28 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
| WO2012120365A1 (en) | 2011-03-07 | 2012-09-13 | Aurobindo Pharma Limited | Stable pharmaceutical composition comprising ethinyl estradiol |
| US20140178479A1 (en) * | 2011-08-12 | 2014-06-26 | Perosphere, Inc. | Concentrated Felbamate Formulations for Parenteral Administration |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US8633178B2 (en) | 2011-11-23 | 2014-01-21 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
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| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20140303128A1 (en) * | 2013-03-14 | 2014-10-09 | Pharmaceutical Productions Inc. | Transmucosal hormone delivery system |
| EP3145489A1 (en) | 2014-05-22 | 2017-03-29 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| ES2995732T3 (en) | 2014-07-21 | 2025-02-11 | Pharmaceutical Productions Inc | Solid dosage form composition for buccal or sublingual administration of cannabinoids |
| RU2016141135A (ru) | 2014-07-29 | 2018-08-28 | Терапьютиксмд, Инк. | Трансдермальный крем |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| CN106109420B (zh) * | 2016-08-11 | 2018-07-06 | 吴启旸 | 依普利酮固体分散体及其制剂 |
| AU2018222468B2 (en) * | 2017-02-14 | 2023-05-11 | Dsm Ip Assets B.V. | Water dispersible formulations |
| KR102605784B1 (ko) * | 2017-02-14 | 2023-11-24 | 디에스엠 아이피 어셋츠 비.브이. | 저장-안정성 제형 |
| CN110013467B (zh) * | 2018-01-10 | 2021-09-17 | 上海汉都医药科技有限公司 | 一种固体微粒及其制备方法和含其的药物组合物 |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| JP7847966B2 (ja) * | 2020-10-23 | 2026-04-20 | 富士製薬工業株式会社 | 医薬製剤およびその製造方法 |
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-
2005
- 2005-03-09 MY MYPI20050963A patent/MY142989A/en unknown
- 2005-03-10 DE DE602005016551T patent/DE602005016551D1/de not_active Expired - Lifetime
- 2005-03-10 HR HR20090614T patent/HRP20090614T1/hr unknown
- 2005-03-10 BR BRPI0507342-1A patent/BRPI0507342A/pt not_active IP Right Cessation
- 2005-03-10 AU AU2005221403A patent/AU2005221403B8/en not_active Ceased
- 2005-03-10 CN CN2005800150633A patent/CN1984644B/zh not_active Expired - Fee Related
- 2005-03-10 EP EP09161378A patent/EP2087883B1/en not_active Expired - Lifetime
- 2005-03-10 PA PA20058626101A patent/PA8626101A1/es unknown
- 2005-03-10 AR ARP050100924A patent/AR048500A1/es not_active Application Discontinuation
- 2005-03-10 UY UY28803A patent/UY28803A1/es not_active Application Discontinuation
- 2005-03-10 ES ES09161378T patent/ES2390406T3/es not_active Expired - Lifetime
- 2005-03-10 PT PT05718248T patent/PT1765290E/pt unknown
- 2005-03-10 PL PL05718248T patent/PL1765290T3/pl unknown
- 2005-03-10 ES ES05718248T patent/ES2332229T3/es not_active Expired - Lifetime
- 2005-03-10 WO PCT/IB2005/000748 patent/WO2005087199A2/en not_active Ceased
- 2005-03-10 US US11/076,022 patent/US8715735B2/en not_active Expired - Fee Related
- 2005-03-10 SV SV2005002044A patent/SV2005002044A/es unknown
- 2005-03-10 SI SI200530840T patent/SI1765290T1/sl unknown
- 2005-03-10 JP JP2007502437A patent/JP5006185B2/ja not_active Expired - Fee Related
- 2005-03-10 GT GT200500045A patent/GT200500045A/es unknown
- 2005-03-10 TW TW094107345A patent/TWI345986B/zh not_active IP Right Cessation
- 2005-03-10 DK DK05718248T patent/DK1765290T3/da active
- 2005-03-10 CA CA2558582A patent/CA2558582C/en not_active Expired - Fee Related
- 2005-03-10 AT AT05718248T patent/ATE442131T1/de active
- 2005-03-10 PE PE2005000277A patent/PE20060016A1/es not_active Application Discontinuation
- 2005-03-10 NZ NZ549793A patent/NZ549793A/en unknown
- 2005-03-10 RS RSP-2009/0508A patent/RS51076B/sr unknown
- 2005-03-10 EP EP05718248A patent/EP1765290B1/en not_active Expired - Lifetime
- 2005-03-10 EA EA200601588A patent/EA012746B1/ru not_active IP Right Cessation
-
2006
- 2006-09-05 IL IL177894A patent/IL177894A0/en unknown
- 2006-09-14 CR CR8630A patent/CR8630A/es unknown
- 2006-10-02 NO NO20064473A patent/NO20064473L/no not_active Application Discontinuation
- 2006-10-02 EC EC2006006902A patent/ECSP066902A/es unknown
- 2006-10-09 KR KR1020067020937A patent/KR101210695B1/ko not_active Expired - Fee Related
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