EA009179B1 - Вакцина на основе вирусоподобных частиц вируса папилломы человека 16 и вируса папилломы человека 18 l1 - Google Patents

Вакцина на основе вирусоподобных частиц вируса папилломы человека 16 и вируса папилломы человека 18 l1 Download PDF

Info

Publication number
EA009179B1
EA009179B1 EA200500834A EA200500834A EA009179B1 EA 009179 B1 EA009179 B1 EA 009179B1 EA 200500834 A EA200500834 A EA 200500834A EA 200500834 A EA200500834 A EA 200500834A EA 009179 B1 EA009179 B1 EA 009179B1
Authority
EA
Eurasian Patent Office
Prior art keywords
nru
types
group
hpv
infection
Prior art date
Application number
EA200500834A
Other languages
English (en)
Russian (ru)
Other versions
EA200500834A1 (ru
Inventor
Гари Дьюбин
Брюс Иннис
Монсеф Мохаммед Слэйоу
Мартина Энн Сесиль Веттендорфф
Original Assignee
Глаксосмитклайн Байолоджикалс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксосмитклайн Байолоджикалс С.А. filed Critical Глаксосмитклайн Байолоджикалс С.А.
Publication of EA200500834A1 publication Critical patent/EA200500834A1/ru
Publication of EA009179B1 publication Critical patent/EA009179B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EA200500834A 2002-12-20 2003-12-18 Вакцина на основе вирусоподобных частиц вируса папилломы человека 16 и вируса папилломы человека 18 l1 EA009179B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43503502P 2002-12-20 2002-12-20
US49665303P 2003-08-20 2003-08-20
PCT/EP2003/014562 WO2004056389A1 (en) 2002-12-20 2003-12-18 Hpv-16 and -18 l1 vlp vaccine

Publications (2)

Publication Number Publication Date
EA200500834A1 EA200500834A1 (ru) 2006-02-24
EA009179B1 true EA009179B1 (ru) 2007-12-28

Family

ID=32685362

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200500834A EA009179B1 (ru) 2002-12-20 2003-12-18 Вакцина на основе вирусоподобных частиц вируса папилломы человека 16 и вируса папилломы человека 18 l1
EA200701633A EA200701633A1 (ru) 2002-12-20 2003-12-18 Вакцина на основе вирусоподобных частиц вируса папилломы человека 16 и вируса папилломы человека 18 l1

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200701633A EA200701633A1 (ru) 2002-12-20 2003-12-18 Вакцина на основе вирусоподобных частиц вируса папилломы человека 16 и вируса папилломы человека 18 l1

Country Status (28)

Country Link
US (2) US20060251676A1 (OSRAM)
EP (1) EP1572233B1 (OSRAM)
JP (1) JP5475939B2 (OSRAM)
KR (3) KR101361769B1 (OSRAM)
AP (1) AP2005003347A0 (OSRAM)
AR (1) AR042530A1 (OSRAM)
AT (1) ATE503492T1 (OSRAM)
AU (1) AU2003293942B2 (OSRAM)
BE (3) BE2015C068I2 (OSRAM)
BR (1) BR0317544A (OSRAM)
CA (1) CA2510457C (OSRAM)
CY (1) CY1111552T1 (OSRAM)
DE (1) DE60336581D1 (OSRAM)
DK (1) DK1572233T3 (OSRAM)
EA (2) EA009179B1 (OSRAM)
EC (1) ECSP055869A (OSRAM)
IL (1) IL169085A (OSRAM)
IS (1) IS2811B (OSRAM)
MA (1) MA27581A1 (OSRAM)
MX (1) MXPA05006764A (OSRAM)
MY (1) MY144492A (OSRAM)
NO (1) NO20052846L (OSRAM)
NZ (1) NZ540811A (OSRAM)
OA (1) OA13147A (OSRAM)
PL (1) PL215257B1 (OSRAM)
PT (1) PT1572233E (OSRAM)
TW (1) TWI349557B (OSRAM)
WO (1) WO2004056389A1 (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ301212B6 (cs) 1998-10-16 2009-12-09 Smithkline Beecham Biologicals S. A. Vakcinacní prostredek
GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
US7858098B2 (en) 2002-12-20 2010-12-28 Glaxosmithkline Biologicals, S.A. Vaccine
US7758866B2 (en) 2004-06-16 2010-07-20 Glaxosmithkline Biologicals, S.A. Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52
JP2008502633A (ja) * 2004-06-16 2008-01-31 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Ｈｐｖ１６およびｈｐｖ１８ならびにｈｐｖ３１、４５または５２から選ばれる少なくとも１つの別のｈｐｖ型に対するワクチン
CA2604909A1 (en) 2005-04-15 2006-10-26 The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen
EP1877086A2 (en) * 2005-04-26 2008-01-16 GlaxoSmithKline Biologicals SA Vaccine
SG159529A1 (en) * 2005-04-26 2010-03-30 Glaxosmithkline Biolog Sa Vaccine
EP2154147B1 (en) * 2007-04-29 2015-10-07 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. A truncated l1 protein of human papillomavirus 16
DK2147926T3 (en) 2007-04-29 2016-11-28 Beijing Wantai Biological Pharmacy Entpr Co Ltd Truncated human papillomavirus type 18 L1 protein
AU2010220824A1 (en) 2009-03-05 2011-10-20 Jenny Colleen Mccloskey Treatment of infection
AU2009348078B2 (en) * 2009-06-19 2013-03-14 Eyegene Inc. Vaccine for cervical cancer
WO2015114506A2 (en) 2014-01-31 2015-08-06 Marini Bruna Biosensor for the determination of infections and associated pathologies
AU2015335652B2 (en) 2014-10-24 2020-07-02 Hpvvax, Llc. Cancer and skin lesion treatment
US10799574B2 (en) 2014-10-24 2020-10-13 Hpvvax. Llc Method and composition for treating cancer or skin lesion using a vaccine
AU2016273638B2 (en) * 2015-06-02 2019-06-06 Terumo Kabushiki Kaisha Adjuvant composition containing aluminum and vaccine composition containing the same
AU2019231654B2 (en) * 2018-03-06 2025-12-11 Precigen, Inc. Human papillomavirus vaccines and uses of the same
AU2019231652B2 (en) 2018-03-06 2025-05-22 Precigen, Inc. Hepatitis B vaccines and uses of the same
CN110551182A (zh) * 2018-06-04 2019-12-10 厦门大学 一种人乳头瘤病毒18型l1蛋白的突变体
JP7558167B2 (ja) 2018-12-03 2024-09-30 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム オリゴベンズアミド類似体およびがん処置におけるそれらの使用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332596A1 (de) * 1993-09-24 1995-03-30 Martin Josef Dr Sapp Monoklonale Antikörper
WO2001017551A2 (en) * 1999-09-07 2001-03-15 Smithkline Beecham Biologicals S.A. Combined vaccine compositions
US6251678B1 (en) * 1999-02-05 2001-06-26 Merck & Co., Inc. Human papillomavirus vaccine formulations
WO2001097840A1 (en) * 2000-06-21 2001-12-27 Medimmune, Inc. Chimeric human papillomavirus (hpv) l1 molecules and uses therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69835294T2 (de) 1997-09-05 2007-07-26 Medimmune, Inc. Methode zur in vitro auseinander- und wiederzusammensetzung von papillomavirus virusähnlichen teilchen (vlps)
US6245568B1 (en) 1999-03-26 2001-06-12 Merck & Co., Inc. Human papilloma virus vaccine with disassembled and reassembled virus-like particles
KR100919266B1 (ko) * 2000-06-26 2009-09-30 엔벤타 바이오파마슈티컬스 코포레이션 인간 파필로마 바이러스 치료법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332596A1 (de) * 1993-09-24 1995-03-30 Martin Josef Dr Sapp Monoklonale Antikörper
US6251678B1 (en) * 1999-02-05 2001-06-26 Merck & Co., Inc. Human papillomavirus vaccine formulations
WO2001017551A2 (en) * 1999-09-07 2001-03-15 Smithkline Beecham Biologicals S.A. Combined vaccine compositions
WO2001097840A1 (en) * 2000-06-21 2001-12-27 Medimmune, Inc. Chimeric human papillomavirus (hpv) l1 molecules and uses therefor

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BACHTIARY BARBARA ET AL.: "Impact of multiple HPV Infection on response to treatment and survival 1n patients receiving radical radiotherapy for cervical cancer." INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER. UNITED STATES 20 NOV 2002, vol. 102, no. 3, 20 November 2002 (2002-11-20), pages 237-243, XP002278801, ISSN: 0020-7136, abstract page 237, left-hand column, paragraphs 1,3 -right-hand column, paragraph 1 page 242, left-hand column, paragraph 2 *
BALSLEY J.F. ET AL.: "Progress in the development of human papillomavirus vaccines for HPV-11 and HPV-16/18 and mapping of a critical neutralizing epitope". 18TH INTERNATIONAL PAPILLOMAVIRUS CONFERENCE 2000, 'Online! 2000, XP002278802, Retrieved from the Internet: <URL:http://www.hpv2000.com/idabstract.asp ?id=366> 'retrieved on 2004-05-03! the whole document *
BASS E.: "Progress in the Search of a vaccine against human papilloma virus" IAVI REPORT OCTOBER/NOVEMBER 2002, 'Online! 10 October 2002 (2002-10-10), XP002281262, Retrieved from the Internet: <URL:www.aegis.com/pubs/iavi/2002/IAVI2002-1003.html> 'retrieved on 2004-04-21! abstract *
Brown-DR et al., A dose-ranging study of the safety and immunogenicity profiles of a quadrivalent HPV (types 6, 11, 16 and 18) L1 VLP candidate vaccine in younghealthy women. ABstr 0-51 19th International Papillomavirus Conference, Sept-2001, Florianopolis, Brazil, XP002278803, abstract *
COMBITA ALBA-LUCIA ET AL.: "Identification of two cross-neutralizing linear epitopes within the L1 major capsid protein of human papillomaviruses". JOURNAL OF VIROLOGY. UNITED STATES JUL 2002, vol. 76, no. 13, July 2002 (2002-07), pages 6480-6486, XP002278799, ISSN: 0022-538X, abstract, page 6485, left-hand column, paragraphs 2, 3 page 6484, right-hand column, paragraph 4 *
HPV Clinical Workshop & 20th International Papillomavirus Conference 2002, October 4-9, Paris, Institut Pasteur. Villa-L et al., A dose-ranging safety and immunogenicity study of a quadrivalent HPV (type 6/11/16/18) L1 VLP vaccine in women, XP002281268, abstract *
SCHILLER J.T. ET AL.: "PAPILLOMAVIRUS-LIKE PARTICLE BASED VACCINES: CERVICAL CANCER AND BEYOND" EXPERT OPINION ON BIOLOGICAL THERAPY, ASHLEY, LONDON, GB, vol. 1, no. 4, July 2001 (2001-07), pages 571-581, XP008028179, ISSN: 1471-2598, abstract, paragraphs '02.2!-'02.3! *
STELLER MICHAEL A.: "Cervical cancer vaccines: progress and prospects." JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION. UNITED STATES 2002 SEP-OCT, vol. 9, no. 5, September 2002 (2002-09), pages 254-264, XP002278800, ISSN: 1071-5576, the whole document *

Also Published As

Publication number Publication date
MY144492A (en) 2011-09-30
ATE503492T1 (de) 2011-04-15
EA200500834A1 (ru) 2006-02-24
PL215257B1 (pl) 2013-11-29
JP2006512413A (ja) 2006-04-13
BE2015C067I2 (OSRAM) 2024-08-08
PL377710A1 (pl) 2006-02-06
KR20050086924A (ko) 2005-08-30
KR20120123616A (ko) 2012-11-08
KR101361769B1 (ko) 2014-02-10
BE2015C069I2 (OSRAM) 2024-08-08
AR042530A1 (es) 2005-06-22
HK1085378A1 (en) 2006-08-25
DK1572233T3 (da) 2011-06-27
JP5475939B2 (ja) 2014-04-16
TW200423957A (en) 2004-11-16
DE60336581D1 (de) 2011-05-12
EP1572233A1 (en) 2005-09-14
ECSP055869A (es) 2005-09-20
AU2003293942A1 (en) 2004-07-14
TWI349557B (en) 2011-10-01
PT1572233E (pt) 2011-06-07
US20060251676A1 (en) 2006-11-09
AP2005003347A0 (en) 2005-06-30
CA2510457C (en) 2011-12-06
EA200701633A1 (ru) 2007-12-28
BR0317544A (pt) 2005-11-22
IL169085A0 (en) 2007-07-04
IS7885A (is) 2005-06-09
MXPA05006764A (es) 2005-09-08
IS2811B (is) 2012-11-15
KR20120118087A (ko) 2012-10-25
WO2004056389A1 (en) 2004-07-08
CY1111552T1 (el) 2015-08-05
NZ540811A (en) 2007-03-30
NO20052846L (no) 2005-07-13
BE2015C068I2 (OSRAM) 2024-08-08
CA2510457A1 (en) 2004-07-08
US20050287161A1 (en) 2005-12-29
AU2003293942B2 (en) 2009-12-10
IL169085A (en) 2014-04-30
OA13147A (en) 2006-12-13
MA27581A1 (fr) 2005-10-03
EP1572233B1 (en) 2011-03-30

Similar Documents

Publication Publication Date Title
EA009179B1 (ru) Вакцина на основе вирусоподобных частиц вируса папилломы человека 16 и вируса папилломы человека 18 l1
US7939084B1 (en) Vaccine against varicella zoster virus
EP1434859A2 (en) Use of glycosylceramides as adjuvants for vaccines against infections and cancer
JP2012102132A (ja) Ｈｐｖ１６およびｈｐｖ１８ならびにｈｐｖ３１、４５または５２から選ばれる少なくとも１つの別のｈｐｖ型に対するワクチン
WO2004052395A1 (en) L2-peptide of the human papillomavirus associated with virus-like particles
RU2420313C2 (ru) Вакцина против вирусов папилломы человека hpv 16 и hpv 18 и по меньшей мере еще одного типа hpv, выбранного из hpv 31, 45 или 52
CN100418577C (zh) Hpv-16和hpv-18l1vlp疫苗
EA013326B1 (ru) Вакцина
ES2361913T3 (es) Uso de hpv16 y hpv18 como vacunas con uno o más oncógenos de los tipos 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68.
HK1085378B (en) Use of hpv16 and hpv18 as vaccine against one or more of oncogenic hpv type 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68
EA013325B1 (ru) Вакцина
CN101217975A (zh) 疫苗

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU