EA008587B1 - Новый кристаллический ангидрат с антихолинергическим действием - Google Patents

Новый кристаллический ангидрат с антихолинергическим действием Download PDF

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Publication number
EA008587B1
EA008587B1 EA200600853A EA200600853A EA008587B1 EA 008587 B1 EA008587 B1 EA 008587B1 EA 200600853 A EA200600853 A EA 200600853A EA 200600853 A EA200600853 A EA 200600853A EA 008587 B1 EA008587 B1 EA 008587B1
Authority
EA
Eurasian Patent Office
Prior art keywords
tiotropium bromide
inhalation
cyclodextrin
crystalline
capsules
Prior art date
Application number
EA200600853A
Other languages
English (en)
Russian (ru)
Other versions
EA200600853A1 (ru
Inventor
Вальдемар Пфренгле
Петер Зигер
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200600853A1 publication Critical patent/EA200600853A1/ru
Publication of EA008587B1 publication Critical patent/EA008587B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA200600853A 2003-11-03 2004-10-29 Новый кристаллический ангидрат с антихолинергическим действием EA008587B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025077 2003-11-03
PCT/EP2004/012269 WO2005042527A1 (de) 2003-11-03 2004-10-29 Neues kristallines anhydrat mit anticholinerger wirksamkeit

Publications (2)

Publication Number Publication Date
EA200600853A1 EA200600853A1 (ru) 2006-10-27
EA008587B1 true EA008587B1 (ru) 2007-06-29

Family

ID=34530662

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600853A EA008587B1 (ru) 2003-11-03 2004-10-29 Новый кристаллический ангидрат с антихолинергическим действием

Country Status (34)

Country Link
EP (1) EP1682542B1 (de)
JP (1) JP4553902B2 (de)
KR (2) KR101313904B1 (de)
CN (1) CN100509809C (de)
AR (1) AR046319A1 (de)
AT (1) ATE453641T1 (de)
AU (1) AU2004285684B2 (de)
BR (1) BRPI0415636A (de)
CA (1) CA2544352C (de)
CO (1) CO5690641A2 (de)
CY (1) CY1110339T1 (de)
DE (1) DE502004010602D1 (de)
DK (1) DK1682542T3 (de)
EA (1) EA008587B1 (de)
EC (1) ECSP066543A (de)
ES (1) ES2338563T3 (de)
HK (1) HK1099752A1 (de)
HR (1) HRP20100029T1 (de)
IL (1) IL175126A (de)
ME (1) ME00349B (de)
MX (1) MX272045B (de)
MY (1) MY146628A (de)
NO (1) NO20062569L (de)
NZ (1) NZ547581A (de)
PE (1) PE20050996A1 (de)
PL (1) PL1682542T3 (de)
PT (1) PT1682542E (de)
RS (2) RS51599B (de)
SI (1) SI1682542T1 (de)
TW (1) TWI336330B (de)
UA (1) UA82909C2 (de)
UY (1) UY28596A1 (de)
WO (1) WO2005042527A1 (de)
ZA (1) ZA200602344B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007013691A (es) * 2005-05-02 2008-01-21 Boehringer Ingelheim Int Nuevas formas cristalinas de bromuro de tiotropio.
ES2396978T5 (es) 2005-12-19 2015-12-04 Sicor, Inc. Forma cristalina novedosa de bromuro de tiotropio y procedimiento para la preparación de la misma
RU2453547C2 (ru) * 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
EA015353B1 (ru) * 2006-01-04 2011-06-30 Бёрингер Ингельхайм Интернациональ Гмбх Применение солей тиотропия для лечения персистирующей астмы средней тяжести
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
CN101032484B (zh) * 2007-04-02 2010-05-26 南京卡文迪许生物工程技术有限公司 一种噻托溴铵胶囊型吸入粉雾剂
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
NZ592549A (en) * 2008-11-04 2012-09-28 Cipla Ltd A compex of tiotropium bromide and polyvinylpyrrolidone having a low degree of crystallinity
MX2011004730A (es) * 2008-11-04 2011-05-30 Cipla Ltd Composicion farmaceutica en aerosol.
NZ624602A (en) * 2009-08-07 2015-11-27 Generics Uk Ltd Anhydrate of tiotropium bromide
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
UA115888C2 (uk) 2012-11-05 2018-01-10 Зентіва, К.С. Стабілізація сольватів тіотропію
EP2913332A1 (de) 2014-02-27 2015-09-02 Euticals S.P.A. Kristalline Form von Tiotropiumbromid mit Lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
EP3414243A1 (de) 2016-02-11 2018-12-19 Sima Patent Ve Lisanslama Hizmetleri Ltd. STI Kristalline form von tiotropiumbromidanhydrat
EP4108230A1 (de) 2021-06-24 2022-12-28 Laboratoires SMB Neue trockenpulverzusammensetzung von tiotropium zur inhalation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0418716A1 (de) * 1989-09-16 1991-03-27 Boehringer Ingelheim Kg Neue Thienylcarbonsäureester von Aminoalkoholen, ihre Quaternierungsprodukte sowie die Herstellung und Verwendung dieser Verbindungen
WO2002030928A1 (de) * 2000-10-12 2002-04-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10111843A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
RS50441B (sr) * 2001-06-22 2010-03-02 Boehringer Ingelheim Pharma Gmbh. & Co.Kg. Kristalni antiholinergik, postupak za njegovo pripremanje i njegova primena u proizvodnji leka

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0418716A1 (de) * 1989-09-16 1991-03-27 Boehringer Ingelheim Kg Neue Thienylcarbonsäureester von Aminoalkoholen, ihre Quaternierungsprodukte sowie die Herstellung und Verwendung dieser Verbindungen
WO2002030928A1 (de) * 2000-10-12 2002-04-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DISSE, B. ET AL.: "Tiotropium (Spiriva TM) Mechanistical Considerations and Clinical Profile in Obstructive Lung Disease", LIFE SCIENCES, Bd. 64, Nr. 6, 1999, XP002268933, das ganze Dokument *
STAHL, P.H.; WERMUTH, C.G.: "Handbook of Pharmaceutical Salts Properties, Selection and Use", 2002, WILEY-VCH, WEINHEIM-NEW YORK, XP002268934, Seite 98 *

Also Published As

Publication number Publication date
EP1682542A1 (de) 2006-07-26
HRP20100029T1 (hr) 2010-02-28
RS51599B (en) 2011-08-31
UA82909C2 (en) 2008-05-26
MEP51708A (en) 2011-02-10
IL175126A0 (en) 2006-09-05
ZA200602344B (en) 2007-07-25
ECSP066543A (es) 2006-10-17
EP1682542B1 (de) 2009-12-30
MXPA06004940A (es) 2006-07-20
DK1682542T3 (da) 2010-05-10
EA200600853A1 (ru) 2006-10-27
SI1682542T1 (sl) 2010-04-30
RS20060291A (en) 2008-06-05
KR101313904B1 (ko) 2013-09-30
BRPI0415636A (pt) 2006-12-12
CA2544352A1 (en) 2005-05-12
PT1682542E (pt) 2010-01-27
AU2004285684A1 (en) 2005-05-12
JP2007509894A (ja) 2007-04-19
ME00349B (de) 2011-05-10
ATE453641T1 (de) 2010-01-15
IL175126A (en) 2010-11-30
CA2544352C (en) 2013-07-16
DE502004010602D1 (de) 2010-02-11
NO20062569L (no) 2006-07-12
CY1110339T1 (el) 2015-01-14
WO2005042527A1 (de) 2005-05-12
JP4553902B2 (ja) 2010-09-29
KR101285571B1 (ko) 2013-07-15
MY146628A (en) 2012-09-14
KR20120036381A (ko) 2012-04-17
CN1875019A (zh) 2006-12-06
UY28596A1 (es) 2005-06-30
PE20050996A1 (es) 2005-12-20
CO5690641A2 (es) 2006-10-31
TWI336330B (en) 2011-01-21
KR20060121131A (ko) 2006-11-28
AU2004285684B2 (en) 2011-07-14
PL1682542T3 (pl) 2010-06-30
MX272045B (en) 2009-11-23
NZ547581A (en) 2009-03-31
CN100509809C (zh) 2009-07-08
AR046319A1 (es) 2005-11-30
TW200526652A (en) 2005-08-16
ES2338563T3 (es) 2010-05-10
HK1099752A1 (en) 2007-08-24

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