EA008213B1 - Способ защиты эндотелиальных и эпителиальных клеток во время химиотерапии - Google Patents
Способ защиты эндотелиальных и эпителиальных клеток во время химиотерапии Download PDFInfo
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- EA008213B1 EA008213B1 EA200401448A EA200401448A EA008213B1 EA 008213 B1 EA008213 B1 EA 008213B1 EA 200401448 A EA200401448 A EA 200401448A EA 200401448 A EA200401448 A EA 200401448A EA 008213 B1 EA008213 B1 EA 008213B1
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- Eurasian Patent Office
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- cells
- defibrotide
- immunosuppressant
- patient
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- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Toxicology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38411402P | 2002-05-31 | 2002-05-31 | |
| US38743802P | 2002-06-11 | 2002-06-11 | |
| PCT/EP2003/005753 WO2003101468A1 (en) | 2002-05-31 | 2003-06-02 | Method for the protection of endothelial and epithelial cells during chemotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200401448A1 EA200401448A1 (ru) | 2005-06-30 |
| EA008213B1 true EA008213B1 (ru) | 2007-04-27 |
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|---|---|---|---|
| EA200401448A EA008213B1 (ru) | 2002-05-31 | 2003-06-02 | Способ защиты эндотелиальных и эпителиальных клеток во время химиотерапии |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1509235A1 (is) |
| JP (1) | JP2005527636A (is) |
| CN (1) | CN1304011C (is) |
| AU (1) | AU2003238189A1 (is) |
| CA (1) | CA2487171A1 (is) |
| EA (1) | EA008213B1 (is) |
| HR (1) | HRP20041213A2 (is) |
| IL (1) | IL165353A0 (is) |
| IS (1) | IS7548A (is) |
| MX (1) | MXPA04011941A (is) |
| NO (1) | NO20045655L (is) |
| NZ (1) | NZ536864A (is) |
| PL (1) | PL374402A1 (is) |
| RS (1) | RS102504A (is) |
| UA (1) | UA83628C2 (is) |
| WO (1) | WO2003101468A1 (is) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20031714A1 (it) * | 2003-09-05 | 2005-03-06 | Gentium Spa | Formazioni ad azione antitumorale. |
| WO2012063272A1 (en) * | 2010-11-12 | 2012-05-18 | Gentium S.P.A. | Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd). |
| KR20150044877A (ko) | 2012-06-22 | 2015-04-27 | 젠티엄 에스피에이 | 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법 |
| EP3026122A1 (en) * | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998048843A1 (en) * | 1997-04-28 | 1998-11-05 | Arsinur Burcoglu | Method of treating hiv infection and related secondary infections thereof |
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2003
- 2003-06-02 WO PCT/EP2003/005753 patent/WO2003101468A1/en active Application Filing
- 2003-06-02 MX MXPA04011941A patent/MXPA04011941A/es unknown
- 2003-06-02 UA UA20041109654A patent/UA83628C2/ru unknown
- 2003-06-02 PL PL03374402A patent/PL374402A1/xx not_active Application Discontinuation
- 2003-06-02 NZ NZ536864A patent/NZ536864A/en unknown
- 2003-06-02 JP JP2004508823A patent/JP2005527636A/ja active Pending
- 2003-06-02 AU AU2003238189A patent/AU2003238189A1/en not_active Abandoned
- 2003-06-02 CN CNB038125013A patent/CN1304011C/zh not_active Expired - Fee Related
- 2003-06-02 RS YU102504A patent/RS102504A/sr unknown
- 2003-06-02 CA CA002487171A patent/CA2487171A1/en not_active Abandoned
- 2003-06-02 EP EP03735516A patent/EP1509235A1/en not_active Withdrawn
- 2003-06-02 EA EA200401448A patent/EA008213B1/ru not_active IP Right Cessation
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2004
- 2004-11-23 IL IL16535304A patent/IL165353A0/xx unknown
- 2004-11-24 IS IS7548A patent/IS7548A/is unknown
- 2004-12-27 HR HR20041213A patent/HRP20041213A2/xx not_active Application Discontinuation
- 2004-12-27 NO NO20045655A patent/NO20045655L/no not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998048843A1 (en) * | 1997-04-28 | 1998-11-05 | Arsinur Burcoglu | Method of treating hiv infection and related secondary infections thereof |
Non-Patent Citations (9)
| Title |
|---|
| BAIREY OSNAT ET AL.: "Clinical severe hepatic venoocclusive disease during induction treatment of acute monoblastic 1eukemia managed with defibrotide.," AMERICAN JOURNAL OF HEMATOLOGY, vol. 69, no. 4, April 2002 (2002-04), pages 281-284, XP008022853, April, 2002, ISSN: 0361-8609, page 282, left-hand column page 283, left-hand column, paragraph 2 page 284, left-hand column, line 1 * |
| CHOPRA R. ET AL.: "Defibrotide for the treatment of hepatic veno-occlusive disease: Results of the European compassionate-use study," BRITISH JOURNAL OF HAEMATOLOGY, vol. 111, no. 4, December 2000 (2000-12), pages 1122-1129, XP002256489, ISSN: 0007-1048 * page 1128, left-hand column, last paragraph * * page 1128, right-hand column, last paragraph * * |
| MAISANO ROBERTO ET AL.: "Defibrotide in the prevention of venous irritation by vinorelbine administration," ANTICANCER RESEARCH, vol. 17, no. 4A, 1997, pages 2775-2777, XP008022875, ISSN: 0250-7005 * page 2775, "Patients and Methods" * page 2776, right-hand column, paragraph 2 * |
| MIRANDA N. ET AL.: "Treatment of hepatic veno-occlusive disease (VOD) with defibrotide: Results in 5 stem cell transplant recipients.," BLOOD, vol. 94, no. 10 SUPPL. 1 PART 2, 15 November 1999 (1999-11-15), page 359b, XP008022854, Forty-first Annual Meeting of the American Society of Hematology; New Orleans, Louisiana, USA; December 3-7, 1999, ISSN: 0006-4971* abstract* * |
| RICHARDSON P. G. ET AL.: "Multi-Institutional phase II, randomized dose finding study of defibrotide (DF) in patients (pts) with severe veno-occlusive disease (VOD) and multisystem organ failure (MOF) post stem cell transplantation (SCT): Promising response rate without significant toxicity in a high risk population," BLOOD, vol. 98, no. 11 Part 1, 16 November 2001 (2001-11-16), page 853a, XP008022856, 43rd Annual Meeting of the American Society of Hematology, Part 1; Orlando, Florida, USA; December 07-11, 2001, November 16, 2001, ISSN: 0006-4971 * abstract * * |
| RICHARDSON PAUL G. ET AL.: "Treatment of severe veno-occlusive disease with defibrotide: Compassionate use results in response without significant toxicity in a high-risk population." BLOOD, vol. 92, no. 3, 1 August 1998 (1998-08-01), pages 737-744, XP002256488, ISSN: 0006-4971 * page 741, right-hand column, last paragraph * page 742, right-hand column, paragraph 1 * |
| SAYER H. G. ET AL.: "Hepatic veno-occlusive disease (VOD) with complete occlusion of liver venules after tandem autologous stem cell transplantation: Successful treatment with high-dose methylprednisolone and defibrotide." JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol. 128, no. 3, March 2002 (2002-03), pages 148-152. XP002256487, ISSN: 0171-5216, page 149, left-hand column -right-hand column page 150, left-hand column, paragraph 1 * |
| SCHROEDER HENNING: "Defibrotide protects endothelial cells, but not L929 tumour cells, from tumour necrosis factor-alpha-mediated cytotoxicity," JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 47, no. 3, 1995, pages 250-252, XP008022870, ISSN: 0022-3573 * page 251, left-hand column, last paragraph to right-hand column, first paragraph ** page 251, right-hand column, last paragraph * * |
| SHAW B.E. ET AL.: "The use of defibrotide in the management of vascular endothelial complications (VOD/HUS/TTP) of stem cell transplantation." BLOOD, vol. 94, no. 10 SUPPL. 1 PART 1, 15 November 1999 (1999-11-15), page 608a, XP008022855, Forty-first Annual Meeting of the American Society of Hematology; New Orleans, Louisiana, USA; December 3-7, 1999, ISSN: 0006-4971 *abstract* * |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ536864A (en) | 2008-08-29 |
| CN1655801A (zh) | 2005-08-17 |
| WO2003101468A1 (en) | 2003-12-11 |
| CN1304011C (zh) | 2007-03-14 |
| PL374402A1 (en) | 2005-10-17 |
| CA2487171A1 (en) | 2003-12-11 |
| NO20045655L (no) | 2004-12-27 |
| JP2005527636A (ja) | 2005-09-15 |
| UA83628C2 (ru) | 2008-08-11 |
| EA200401448A1 (ru) | 2005-06-30 |
| RS102504A (en) | 2006-12-15 |
| EP1509235A1 (en) | 2005-03-02 |
| MXPA04011941A (es) | 2005-07-26 |
| AU2003238189A1 (en) | 2003-12-19 |
| IL165353A0 (en) | 2006-01-15 |
| IS7548A (is) | 2004-11-24 |
| HRP20041213A2 (en) | 2006-04-30 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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