EA007539B1 - Новые производные пиперазинона для лечения нарушений, связанных с 5-нт2а-рецептором - Google Patents
Новые производные пиперазинона для лечения нарушений, связанных с 5-нт2а-рецептором Download PDFInfo
- Publication number
- EA007539B1 EA007539B1 EA200500235A EA200500235A EA007539B1 EA 007539 B1 EA007539 B1 EA 007539B1 EA 200500235 A EA200500235 A EA 200500235A EA 200500235 A EA200500235 A EA 200500235A EA 007539 B1 EA007539 B1 EA 007539B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ethyl
- piperazinyl
- pyrazinone
- alkyl
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0202287A SE0202287D0 (sv) | 2002-07-19 | 2002-07-19 | New compounds |
| US42624002P | 2002-11-14 | 2002-11-14 | |
| PCT/SE2003/001102 WO2004009586A1 (en) | 2002-07-19 | 2003-06-25 | Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200500235A1 EA200500235A1 (ru) | 2005-08-25 |
| EA007539B1 true EA007539B1 (ru) | 2006-10-27 |
Family
ID=20288606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200500235A EA007539B1 (ru) | 2002-07-19 | 2003-06-25 | Новые производные пиперазинона для лечения нарушений, связанных с 5-нт2а-рецептором |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP4831966B2 (ja) |
| EA (1) | EA007539B1 (ja) |
| SE (1) | SE0202287D0 (ja) |
| SI (1) | SI1534391T1 (ja) |
| ZA (1) | ZA200500205B (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2008129679A (ru) * | 2005-12-21 | 2010-01-27 | Янссен Фармацевтика Н.В. (Be) | Новые замещенные пиразиноновые производные для применения при мсн-1-опосредованных заболеваниях |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1440722A (en) * | 1973-07-13 | 1976-06-23 | Merck & Co Inc | 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity |
| GB1492528A (en) * | 1975-04-21 | 1977-11-23 | Merck & Co Inc | Pyrazinyl piperazine derivatives |
| US4163849A (en) * | 1978-03-17 | 1979-08-07 | Merck & Co., Inc. | Piperazinylpyrazines |
| WO1995033721A1 (en) * | 1994-06-08 | 1995-12-14 | H. Lundbeck A/S | 4-aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidines, tetrahydropyridines or piperazines |
| WO2000076984A2 (en) * | 1999-05-21 | 2000-12-21 | Biovitrum Ab | Novel compounds, their use and preparation |
-
2002
- 2002-07-19 SE SE0202287A patent/SE0202287D0/xx unknown
-
2003
- 2003-06-25 SI SI200330754T patent/SI1534391T1/sl unknown
- 2003-06-25 JP JP2004522879A patent/JP4831966B2/ja not_active Expired - Fee Related
- 2003-06-25 EA EA200500235A patent/EA007539B1/ru not_active IP Right Cessation
-
2005
- 2005-01-10 ZA ZA200500205A patent/ZA200500205B/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1440722A (en) * | 1973-07-13 | 1976-06-23 | Merck & Co Inc | 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity |
| GB1492528A (en) * | 1975-04-21 | 1977-11-23 | Merck & Co Inc | Pyrazinyl piperazine derivatives |
| US4163849A (en) * | 1978-03-17 | 1979-08-07 | Merck & Co., Inc. | Piperazinylpyrazines |
| WO1995033721A1 (en) * | 1994-06-08 | 1995-12-14 | H. Lundbeck A/S | 4-aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidines, tetrahydropyridines or piperazines |
| WO2000076984A2 (en) * | 1999-05-21 | 2000-12-21 | Biovitrum Ab | Novel compounds, their use and preparation |
Non-Patent Citations (3)
| Title |
|---|
| Chem. Pharm. Bull., Volume 41, no. 10, 1993, Manabu Hori et al.: "Design and Syntheses of a Series of Novel Serotonin3 Antagonists", page 1832-page 1841 * |
| Journal of Medicinal Chemistry, Volume 21, no. 6, 1978, William C. Lumma, Jr. et al.: "Piperazinylpyrazines with Central Serotoninmimetic Activity", page 536-page 542 * |
| Journal of Medicinal Chemistry, Volume 24, no. 1, 1981, William C. Lumma, Jr. et al.: "Piperazinylquinoxalines with Central Serotoninmimetic Activity", page 93-page 101 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005533847A (ja) | 2005-11-10 |
| ZA200500205B (en) | 2006-07-26 |
| SI1534391T1 (sl) | 2007-06-30 |
| EA200500235A1 (ru) | 2005-08-25 |
| JP4831966B2 (ja) | 2011-12-07 |
| SE0202287D0 (sv) | 2002-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |