DOP2014000041A - Anticuerpos a pcsk9 y usos de los mismos - Google Patents

Anticuerpos a pcsk9 y usos de los mismos

Info

Publication number
DOP2014000041A
DOP2014000041A DO2014000041A DO2014000041A DOP2014000041A DO P2014000041 A DOP2014000041 A DO P2014000041A DO 2014000041 A DO2014000041 A DO 2014000041A DO 2014000041 A DO2014000041 A DO 2014000041A DO P2014000041 A DOP2014000041 A DO P2014000041A
Authority
DO
Dominican Republic
Prior art keywords
pcsk9
antibodies
same
antigen binding
binding fragments
Prior art date
Application number
DO2014000041A
Other languages
English (en)
Inventor
Barrett Allan
Ryan James Darling
Julian Davies
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DOP2014000041A publication Critical patent/DOP2014000041A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a anticuerpos a convertasa de proproteína subtilisina/quexina tipo 9 (PCSK9), o fragmentos enlazantes al antígeno de los mismos, composiciones que comprenden tales anticuerpos de PCSK9 o fragmentos enlazantes al antígeno, y métodos para usar los mismos para el tratamiento de hiperlipidemia o hipercolesterolemia.
DO2014000041A 2011-09-16 2014-02-26 Anticuerpos a pcsk9 y usos de los mismos DOP2014000041A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161535625P 2011-09-16 2011-09-16

Publications (1)

Publication Number Publication Date
DOP2014000041A true DOP2014000041A (es) 2014-06-30

Family

ID=46881177

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2014000041A DOP2014000041A (es) 2011-09-16 2014-02-26 Anticuerpos a pcsk9 y usos de los mismos

Country Status (28)

Country Link
US (1) US8530414B2 (es)
EP (1) EP2756003A1 (es)
JP (1) JP6013487B2 (es)
KR (1) KR101607783B1 (es)
CN (1) CN103781802B (es)
AP (1) AP2014007499A0 (es)
AR (1) AR087715A1 (es)
AU (1) AU2012308786B2 (es)
BR (1) BR112014005799A2 (es)
CA (1) CA2845706C (es)
CL (1) CL2014000590A1 (es)
CO (1) CO6910164A2 (es)
CR (1) CR20140087A (es)
DO (1) DOP2014000041A (es)
EA (1) EA024430B1 (es)
EC (1) ECSP14013242A (es)
GT (1) GT201400049A (es)
IL (1) IL231282A0 (es)
MA (1) MA35433B1 (es)
MX (1) MX347475B (es)
MY (1) MY168961A (es)
PE (1) PE20141147A1 (es)
SG (1) SG2014014187A (es)
TN (1) TN2014000094A1 (es)
TW (1) TWI586687B (es)
UA (1) UA114604C2 (es)
WO (1) WO2013039958A1 (es)
ZA (1) ZA201401267B (es)

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Also Published As

Publication number Publication date
US20130071405A1 (en) 2013-03-21
EA201490470A1 (ru) 2014-06-30
US8530414B2 (en) 2013-09-10
EA024430B1 (ru) 2016-09-30
SG2014014187A (en) 2014-05-29
MX2014003175A (es) 2015-03-05
KR20140044939A (ko) 2014-04-15
KR101607783B1 (ko) 2016-03-30
WO2013039958A1 (en) 2013-03-21
NZ622393A (en) 2015-11-27
CA2845706C (en) 2016-03-22
PE20141147A1 (es) 2014-09-22
EP2756003A1 (en) 2014-07-23
MY168961A (en) 2019-01-28
AP2014007499A0 (en) 2014-03-31
AU2012308786B2 (en) 2016-12-15
AR087715A1 (es) 2014-04-09
IL231282A0 (en) 2014-04-30
GT201400049A (es) 2015-05-28
TW201323444A (zh) 2013-06-16
UA114604C2 (uk) 2017-07-10
CN103781802B (zh) 2016-08-24
MX347475B (es) 2017-04-27
CN103781802A (zh) 2014-05-07
JP2014530188A (ja) 2014-11-17
CL2014000590A1 (es) 2014-10-17
MA35433B1 (fr) 2014-09-01
JP6013487B2 (ja) 2016-10-25
CR20140087A (es) 2014-05-02
CO6910164A2 (es) 2014-03-31
ZA201401267B (en) 2015-11-25
TN2014000094A1 (en) 2015-07-01
BR112014005799A2 (pt) 2017-03-28
CA2845706A1 (en) 2013-03-21
AU2012308786A1 (en) 2014-02-27
ECSP14013242A (es) 2014-07-31
TWI586687B (zh) 2017-06-11

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