DK95081A - CARBOXYLIC ACID AMIDES AND THEIR PREPARATION AND USE IN PHARMACEUTICAL PREPARATIONS - Google Patents

CARBOXYLIC ACID AMIDES AND THEIR PREPARATION AND USE IN PHARMACEUTICAL PREPARATIONS

Info

Publication number
DK95081A
DK95081A DK95081A DK95081A DK95081A DK 95081 A DK95081 A DK 95081A DK 95081 A DK95081 A DK 95081A DK 95081 A DK95081 A DK 95081A DK 95081 A DK95081 A DK 95081A
Authority
DK
Denmark
Prior art keywords
carboxylic acid
pharmaceutical preparations
preparation
acid amides
amidines
Prior art date
Application number
DK95081A
Other languages
Danish (da)
Other versions
DK157757B (en
DK157757C (en
Inventor
U Renner
K A Jaeggi
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK95081A publication Critical patent/DK95081A/en
Publication of DK157757B publication Critical patent/DK157757B/en
Application granted granted Critical
Publication of DK157757C publication Critical patent/DK157757C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Gasification And Melting Of Waste (AREA)
  • Dental Preparations (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Carbon And Carbon Compounds (AREA)

Abstract

Novel amidines, especially N,N'- bridged carboxylic acid amidines of the general formula <IMAGE> in which R1 represents an aromatic radical, R2 represents optionally esterified or amidated 1-carboxy- lower alkyl, Ph represents optionally substituted 1,2-phenylene and alk represents an aliphatic hydrocarbon radical separating the imino group from the methane group by from 1 to 3 carbon atoms, and their salts, have, inter alia, anti-inflammatory activity and can be used as active medicament substances in pharmaceutical preparations. They are produced according to methods known per se.
DK095081A 1980-03-04 1981-03-03 METHOD OF ANALOGY FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE PYRIMIDOOE 1,6-AAA INDOL-5-ACETIC ACID DERIVATIVES OR SALTS THEREOF DK157757C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH170380 1980-03-04
CH170380 1980-03-04

Publications (3)

Publication Number Publication Date
DK95081A true DK95081A (en) 1981-09-05
DK157757B DK157757B (en) 1990-02-12
DK157757C DK157757C (en) 1990-07-16

Family

ID=4216625

Family Applications (1)

Application Number Title Priority Date Filing Date
DK095081A DK157757C (en) 1980-03-04 1981-03-03 METHOD OF ANALOGY FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE PYRIMIDOOE 1,6-AAA INDOL-5-ACETIC ACID DERIVATIVES OR SALTS THEREOF

Country Status (24)

Country Link
EP (1) EP0035474B1 (en)
JP (1) JPS56138188A (en)
KR (5) KR850000045B1 (en)
AT (1) ATE13673T1 (en)
AU (1) AU544236B2 (en)
CA (1) CA1161433A (en)
CY (1) CY1340A (en)
DD (1) DD156599A5 (en)
DE (1) DE3170801D1 (en)
DK (1) DK157757C (en)
ES (3) ES499973A0 (en)
FI (1) FI74007C (en)
GB (1) GB2070608B (en)
GR (1) GR74470B (en)
HK (1) HK80086A (en)
HU (1) HU186385B (en)
IE (1) IE50985B1 (en)
IL (1) IL62249A (en)
KE (1) KE3646A (en)
MY (1) MY8600361A (en)
NO (1) NO156012C (en)
NZ (1) NZ196393A (en)
PT (1) PT72597B (en)
ZA (1) ZA811398B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444768A (en) * 1980-03-04 1984-04-24 Ciba-Geigy Corporation Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them
DE3270406D1 (en) * 1981-08-03 1986-05-15 Ciba Geigy Ag Amidines, process for their preparation, pharmaceutical compounds containing them and their use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307234A (en) * 1978-09-11 1981-12-22 American Home Products Corp. Pyrimido[1,6-a]indole derivatives

Also Published As

Publication number Publication date
HK80086A (en) 1986-10-31
KR850000062B1 (en) 1985-02-15
KR850000061B1 (en) 1985-02-15
HU186385B (en) 1985-07-29
DD156599A5 (en) 1982-09-08
DK157757B (en) 1990-02-12
KR850000044B1 (en) 1985-02-14
AU6801681A (en) 1981-09-10
AU544236B2 (en) 1985-05-23
ES8301989A1 (en) 1983-01-16
NO810719L (en) 1981-09-07
EP0035474A1 (en) 1981-09-09
ES8305763A1 (en) 1983-04-16
ATE13673T1 (en) 1985-06-15
JPH0338273B2 (en) 1991-06-10
DK157757C (en) 1990-07-16
ZA811398B (en) 1982-04-28
FI74007B (en) 1987-08-31
FI74007C (en) 1987-12-10
CY1340A (en) 1987-01-16
IL62249A (en) 1985-08-30
KR850000045B1 (en) 1985-02-14
NZ196393A (en) 1983-12-16
DE3170801D1 (en) 1985-07-11
FI810647L (en) 1981-09-05
NO156012B (en) 1987-03-30
GB2070608B (en) 1983-11-02
CA1161433A (en) 1984-01-31
EP0035474B1 (en) 1985-06-05
NO156012C (en) 1987-07-08
KR830005226A (en) 1983-08-03
GB2070608A (en) 1981-09-09
JPS56138188A (en) 1981-10-28
ES499973A0 (en) 1983-01-16
IE50985B1 (en) 1986-09-03
MY8600361A (en) 1986-12-31
ES514590A0 (en) 1983-04-16
PT72597A (en) 1981-04-01
ES8402301A1 (en) 1984-01-16
KE3646A (en) 1986-07-11
KR850000060B1 (en) 1985-02-15
PT72597B (en) 1982-03-26
ES509645A0 (en) 1984-01-16
GR74470B (en) 1984-06-28
IE810455L (en) 1981-09-04

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment
PBP Patent lapsed