DK685587A - Fremgangsmaade til oprensning af rekombinant beta-interferon - Google Patents

Fremgangsmaade til oprensning af rekombinant beta-interferon

Info

Publication number
DK685587A
DK685587A DK685587A DK685587A DK685587A DK 685587 A DK685587 A DK 685587A DK 685587 A DK685587 A DK 685587A DK 685587 A DK685587 A DK 685587A DK 685587 A DK685587 A DK 685587A
Authority
DK
Denmark
Prior art keywords
purification
procedure
beta interferon
recombinant beta
recombinant
Prior art date
Application number
DK685587A
Other languages
Danish (da)
English (en)
Other versions
DK685587D0 (da
Inventor
Susan Hershenson
Zeve Shaked
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of DK685587D0 publication Critical patent/DK685587D0/da
Publication of DK685587A publication Critical patent/DK685587A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK685587A 1986-12-23 1987-12-23 Fremgangsmaade til oprensning af rekombinant beta-interferon DK685587A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/946,083 US4894330A (en) 1986-12-23 1986-12-23 Purification of recombinant beta-interferon incorporating RP-HPLC

Publications (2)

Publication Number Publication Date
DK685587D0 DK685587D0 (da) 1987-12-23
DK685587A true DK685587A (da) 1988-06-24

Family

ID=25483933

Family Applications (1)

Application Number Title Priority Date Filing Date
DK685587A DK685587A (da) 1986-12-23 1987-12-23 Fremgangsmaade til oprensning af rekombinant beta-interferon

Country Status (8)

Country Link
US (1) US4894330A (fr)
EP (1) EP0274900A3 (fr)
JP (1) JPS63169995A (fr)
AU (1) AU617656B2 (fr)
CA (1) CA1295087C (fr)
DK (1) DK685587A (fr)
IE (1) IE873498L (fr)
NO (1) NO875355L (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1222427B (it) * 1987-07-31 1990-09-05 Sclavo Spa Procedimento per la purificazione di interferone
US5094960A (en) * 1988-10-07 1992-03-10 New York Blood Center, Inc. Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography
US5216128A (en) * 1989-06-01 1993-06-01 Yeda Research And Development Co., Ltd. IFN-β2/IL-6 receptor its preparation and pharmaceutical compositions containing it
CA2057014C (fr) * 1990-03-30 2001-07-24 Toshihiko Kaminuma Methode de purification de polypeptides
US5034133A (en) * 1990-07-26 1991-07-23 Schering-Corporation Purification of human interleukin-4 from a CHO-cell line culture medium
KR950701934A (ko) * 1993-04-30 1995-05-17 아사이 잇뻬이 소수성 폴리펩티드의 정제방법(purification method for hydrophobic polypeptide)
US5451660A (en) * 1993-12-13 1995-09-19 Genentech, Inc. Method for purifying polypeptides
US7544354B2 (en) * 2000-10-27 2009-06-09 Novartis Vaccines And Diagnostics Methods of protein purification and recovery
JP4129178B2 (ja) * 2000-11-07 2008-08-06 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 安定化されたインターフェロン組成物
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
CN102180944A (zh) 2001-10-10 2011-09-14 诺和诺德公司 肽的重构和糖缀合
ZA200700168B (en) 2001-10-10 2010-02-24 Novo Nordisk As Remodeling and glycoconjugation of peptides
AU2004236174B2 (en) 2001-10-10 2011-06-02 Novo Nordisk A/S Glycopegylation methods and proteins/peptides produced by the methods
GEP20084486B (en) * 2002-12-26 2008-09-25 Mountain View Pharmaceuticals Polymer conjugates of interferon-beta with enhanced biological potency
JP2006519170A (ja) * 2002-12-26 2006-08-24 マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド サイトカイン、ケモカイン、増殖因子、ポリペプチドホルモン、およびレセプター結合活性が保存されたそのアンタゴニストのポリマー結合体
US8906676B2 (en) * 2004-02-02 2014-12-09 Ambrx, Inc. Modified human four helical bundle polypeptides and their uses
JP2007526317A (ja) * 2004-03-01 2007-09-13 エンゾン ファーマスーティカルズ インコーポレイテッド インターフェロン−ベータ・ポリマー結合体
US20080076729A1 (en) * 2005-05-19 2008-03-27 Schering Aktiengesellachaft Interferon-beta gene therapy using an improved, regulated expression system
PE20061416A1 (es) * 2005-05-19 2007-01-26 Schering Ag Sistema de expresion genetica que comprende un interferon-beta
US20060281703A1 (en) * 2005-05-19 2006-12-14 Schering Aktiengesellschaft Treatment of disease using an improved regulated expression system
US20070179113A1 (en) * 2005-05-19 2007-08-02 Schering Aktiengesellachaft GM-CSF gene therapy for Crohn's disease using an improved regulated expression system
AU2008247815B2 (en) 2007-05-02 2012-09-06 Ambrx, Inc. Modified interferon beta polypeptides and their uses
EP2207890A4 (fr) * 2007-10-05 2010-12-15 Barofold Inc Traitement sous haute pression d'interférons agrégés
DE102009032179A1 (de) 2009-07-07 2011-01-13 Biogenerix Ag Verfahren zur Reinigung von Interferon beta

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (fr) * 1978-11-24 1982-12-04 Hoffmann La Roche
US4289689A (en) * 1980-03-14 1981-09-15 Hoffmann-La Roche Inc. Preparation of homogeneous human fibroblast interferon
CH648331A5 (de) * 1979-07-31 1985-03-15 Hoffmann La Roche Homogenes fibroblasten-interferon und dessen herstellung.
DE2943016C2 (de) * 1979-10-24 1984-09-06 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Verfahren zur Reinigung von Interferon
US4462940A (en) * 1982-09-23 1984-07-31 Cetus Corporation Process for the recovery of human β-interferon-like polypeptides
US4485017A (en) * 1982-12-22 1984-11-27 Cetus Corporation Isolation of human interferon by immunosorbent and high performance liquid chromatography
IL67896A (en) * 1983-02-13 1987-03-31 Yeda Res & Dev Two biologically active human gama interferon subtypes,purification thereof and pharmaceutical compositions containing them
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
DD235077A1 (de) * 1985-03-04 1986-04-23 Akad Wissenschaften Ddr Verfahren zur gewinnung von hochreinem interleukin-2
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts

Also Published As

Publication number Publication date
EP0274900A2 (fr) 1988-07-20
DK685587D0 (da) 1987-12-23
CA1295087C (fr) 1992-01-28
JPS63169995A (ja) 1988-07-13
IE873498L (en) 1988-06-23
US4894330A (en) 1990-01-16
AU617656B2 (en) 1991-12-05
EP0274900A3 (fr) 1989-08-23
NO875355D0 (no) 1987-12-21
NO875355L (no) 1988-06-24
AU8292287A (en) 1988-06-23

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment