DK57079A - Fremgangsmaade og reagens til bestemmelse af biologisk aktivt heparin i plasma - Google Patents

Fremgangsmaade og reagens til bestemmelse af biologisk aktivt heparin i plasma

Info

Publication number
DK57079A
DK57079A DK57079A DK57079A DK57079A DK 57079 A DK57079 A DK 57079A DK 57079 A DK57079 A DK 57079A DK 57079 A DK57079 A DK 57079A DK 57079 A DK57079 A DK 57079A
Authority
DK
Denmark
Prior art keywords
reagent
plasma
determination
procedure
biological active
Prior art date
Application number
DK57079A
Other languages
English (en)
Other versions
DK149475C (da
DK149475B (da
Inventor
K Bartl
H Lill
J Ziegenhorn
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK57079A publication Critical patent/DK57079A/da
Publication of DK149475B publication Critical patent/DK149475B/da
Application granted granted Critical
Publication of DK149475C publication Critical patent/DK149475C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10Anilides
    • C12Q2337/12Para-Nitroanilides p-NA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81Protease inhibitors
    • G01N2333/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8114Kunitz type inhibitors
    • G01N2333/8117Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433Serine endopeptidases (3.4.21)
    • G01N2333/96441Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96444Factor X (3.4.21.6)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974Thrombin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
    • G01N2400/40Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331Preservative, buffer, anticoagulant or diluent
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK57079A 1978-03-23 1979-02-12 Fremgangsmaade og reagens til bestemmelse af den biologiske aktivitet af herapin i plasma DK149475C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2812943 1978-03-23
DE2812943A DE2812943C3 (de) 1978-03-23 1978-03-23 Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma

Publications (3)

Publication Number Publication Date
DK57079A true DK57079A (da) 1979-09-24
DK149475B DK149475B (da) 1986-06-23
DK149475C DK149475C (da) 1986-12-01

Family

ID=6035376

Family Applications (1)

Application Number Title Priority Date Filing Date
DK57079A DK149475C (da) 1978-03-23 1979-02-12 Fremgangsmaade og reagens til bestemmelse af den biologiske aktivitet af herapin i plasma

Country Status (22)

Country Link
US (1) US4234682A (da)
EP (1) EP0004271A3 (da)
JP (1) JPS54128796A (da)
AR (1) AR217503A1 (da)
AT (1) AT362080B (da)
AU (1) AU512206B2 (da)
BE (1) BE875014A (da)
CA (1) CA1111334A (da)
CH (1) CH642749A5 (da)
DD (1) DD141952A5 (da)
DE (1) DE2812943C3 (da)
DK (1) DK149475C (da)
FI (1) FI62859C (da)
FR (1) FR2420764A1 (da)
GB (1) GB2017298B (da)
HU (1) HU176068B (da)
IE (1) IE48067B1 (da)
IT (1) IT1112966B (da)
LU (1) LU81070A1 (da)
NL (1) NL7902259A (da)
SE (1) SE445560B (da)
ZA (1) ZA79622B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2903701C2 (de) * 1979-01-31 1980-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Kontrollreagens für die Bestimmung der Heparinaktivität
US4244865A (en) * 1979-12-03 1981-01-13 Abbott Laboratories α hydroxy tripeptide substrates
DE3005540A1 (de) * 1980-02-14 1981-08-20 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagens zur bestimmung der biologischen aktivitaet von heparin im plasma
DE3019612A1 (de) * 1980-05-22 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilisiertes thrombinpraeparat
WO1982001377A1 (en) * 1980-10-09 1982-04-29 Lill Helmut Method for determining a bm-antithrombin
US4473639A (en) * 1982-09-15 1984-09-25 Miles Laboratories, Inc. Reagent strip test for antithrombin-III
US4543335A (en) * 1982-12-20 1985-09-24 Miles Laboratories, Inc. Device and method for the quantitative determination of heparin in mammalian blood plasma
US4948724A (en) * 1985-09-05 1990-08-14 Yin E Thye Composition, kit and method for assaying heparin and a method for making the composition
US4946775A (en) * 1985-09-05 1990-08-07 Yin E Thye Composition, kit and method for assaying heparin and a method for making the composition
US4851336A (en) * 1985-09-05 1989-07-25 Yin E Thye Composition, kit, and method for assaying heparinano a method for making the composition
ATE64470T1 (de) * 1985-09-05 1991-06-15 E Thye Yin Verfahren und zusammensetzungen zur bestimmung von heparin.
US5939325A (en) * 1989-07-20 1999-08-17 Analytical Control Systems, Inc. Stable whole blood coagulation controls
EP0482088B1 (en) * 1989-07-20 1999-03-31 Analytical Control Systems, Inc. Improved stable coagulation controls
DE69108896T2 (de) * 1990-11-05 1995-08-24 Baxter Diagnostics Inc Verfahren zur bestimmung der konzentration von antikoagulantien.
US5308755A (en) * 1992-06-08 1994-05-03 Research Corporation Technologies, Inc. Method for measuring heparin
EP1325962A1 (en) * 2001-12-17 2003-07-09 Gentium S.p.A. A method for determining the biological activity of defibrotide
EP1745145A4 (en) * 2004-05-11 2008-03-26 Heptest Lab Inc COMPOSITIONS, KIT AND METHOD IN ONE STEP FOR MONITORING COMPOUNDS HAVING XA AND / OR ANTIFACTOR IIA ANTIFACTOR ACTIVITIES
US7219827B2 (en) 2004-11-19 2007-05-22 General Electric Company Braze end isolation layer for generator armature winding bar and method for applying the isolation layer
DE102005038418A1 (de) * 2005-08-12 2007-02-15 Dade Behring Marburg Gmbh Faktor Xa-basierter Heparinassay unter Verwendung einer Heparin-modifizierenden Komponente
AU2010363814B2 (en) 2010-11-12 2016-05-19 Gentium S.R.L. Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD).
EP2484775A1 (de) 2011-02-07 2012-08-08 Siemens Healthcare Diagnostics Products GmbH Heparin-insensitives Verfahren zur Bestimmung von direkten Gerinnungsfaktorinhibitoren
KR20150044877A (ko) 2012-06-22 2015-04-27 젠티엄 에스피에이 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법
EP2843416A1 (de) 2013-09-02 2015-03-04 Siemens Healthcare Diagnostics Products GmbH Kontroll- und Kalibratormaterial für die Bestimmung von direkten Antikoagulanzien
EP3026122A1 (en) 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide
EP3348649A1 (de) 2017-01-16 2018-07-18 Siemens Healthcare Diagnostics Products GmbH Universales kontrollmaterial für gerinnungsfaktorinhibitor-teste

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769617A (en) * 1971-12-09 1973-10-30 Rca Corp Transmission line using a pair of staggered broad metal strips
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
US4162941A (en) * 1974-12-05 1979-07-31 Ab Kabi Method for determining a proteolytic enzyme
CH587439A5 (da) * 1974-12-10 1977-04-29 Daimler Benz Ag
CH622286A5 (da) * 1975-06-23 1981-03-31 Pentapharm Ag
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates
SE407405B (sv) * 1975-07-11 1979-03-26 Kabi Ab Nya kromogena trombinsubstrat
DE2601372C3 (de) * 1976-01-15 1980-03-27 Behringwerke Ag, 3550 Marburg Verfahren zur Bestimmung von Antithrombin III
NL7602423A (nl) * 1976-03-08 1977-09-12 Leuven Res & Dev Vzw Bepaling van heparine in bloedplasma.
US4067777A (en) * 1976-05-13 1978-01-10 Innerfield Irving Determination of heparin in the blood

Also Published As

Publication number Publication date
DE2812943C3 (de) 1981-05-14
FR2420764A1 (fr) 1979-10-19
DK149475C (da) 1986-12-01
US4234682A (en) 1980-11-18
IE790238L (en) 1979-09-23
EP0004271A2 (de) 1979-10-03
BE875014A (fr) 1979-09-24
DE2812943B2 (de) 1980-08-14
FI62859C (fi) 1983-03-10
AR217503A1 (es) 1980-03-31
CH642749A5 (de) 1984-04-30
IT1112966B (it) 1986-01-20
JPS5726120B2 (da) 1982-06-02
GB2017298A (en) 1979-10-03
SE445560B (sv) 1986-06-30
LU81070A1 (de) 1979-06-19
ATA32179A (de) 1980-09-15
DK149475B (da) 1986-06-23
FI790476A (fi) 1979-09-24
IT7921220A0 (it) 1979-03-22
AT362080B (de) 1981-04-27
GB2017298B (en) 1982-07-07
ZA79622B (en) 1980-03-26
DD141952A5 (de) 1980-05-28
DE2812943A1 (de) 1979-10-04
FI62859B (fi) 1982-11-30
EP0004271A3 (de) 1980-04-02
CA1111334A (en) 1981-10-27
SE7902555L (sv) 1979-09-24
FR2420764B1 (da) 1983-07-29
AU512206B2 (en) 1980-09-25
NL7902259A (nl) 1979-09-25
HU176068B (en) 1980-12-28
JPS54128796A (en) 1979-10-05
IE48067B1 (en) 1984-09-19
AU4382579A (en) 1979-09-27

Similar Documents

Publication Publication Date Title
DK57079A (da) Fremgangsmaade og reagens til bestemmelse af biologisk aktivt heparin i plasma
DK315679A (da) Fremgangsmaade og reagens til kvantitativ enzymatisk bestemmelse af adenosindiphosphat
DK144949C (da) Fremgangsmaade og reagens til bestemmelse af substrater eller enzymaktiviteter
DK372178A (da) Fremgangsmaade og reagens til bestemmelse af alfa-amylase
DK535679A (da) Diagnostisk middel til paavisning af proteolytiske enzymer og dertil egnede chromogener
DK381579A (da) Fremgangsmaade til fremstilling af antioxygenstoffer og anvedelse af disse stoffer
DK162909C (da) Fremgangsmaade til paavisning af tilstedevaerelsen af en analyt-ligand i en proeve og reagens til anvendelse ved fremgangsmaaden
DK419286A (da) Fremgangsmaade til hurtig bestemmelse af en forskel i taelling af hvide blodceller i en proeve og middel til anvendelse ved fremgangsmaaden
DK158526C (da) Reagens til lipasebestemmelse og fremgangsmaade til fremstilling deraf
DK156667C (da) Middel og testmateriale til paavisning af tilstedevaerelsen af glucose i en forsoegsproeve
DK204088D0 (da) Chromogen kryptahemisfaerand og dens anvendelse til detektering af elektrolytter i en vandig proeve
DK186978A (da) Fremgangsmaade ved bestemmelse af glucosekoncentrationer og et reagens hertil
DK160511C (da) Fremgangsmaade og reagens til bestemmelse af antithrombin-bm
DK376677A (da) Fremgangsmaade og indretning til loebende bestemmelse af et enzymsubstrars koncentration
DK571978A (da) Fremgangsmaade og reagens til prothrombinbestemmelse
DK331776A (da) Fremgangsmade og reagens til bestemmelse af triglycerider
DK6179A (da) Fremgangsmaade til fremstilling af prostaglandinderivater og midler indeholdende disse
DK194577A (da) Fremgangsmade til bestemmelse af lipaseaktivetet og reagens til brug herved
DK320279A (da) Fremgangsmaade og reagens til gennemfoerelse af enzymatiske bestemmelser
DK350578A (da) Fremgangsmaade til kombineret udnyttelse af skrald og bearbejdelse af spildevand
DK173884D0 (da) Fremgangsmaade til kvantitativ bestemmelse af haemoglobinkoncentrationen i en biologisk proeve
DK175080A (da) Radioreceptor-bestemmelse af benzodiazepiner i plasma og andre biologiske proever
DK390779A (da) Phosphatpufferoploesninger til kontrol af haemogasanalysatorer og fremgangsmaade til fremstilling af saadanne oploesninger
DK172678A (da) Fremgangsmaade og reagens til bestemmelse af urinsyre
DK221380A (da) Lipase-bestemmelsesmetode og reagens