DK537289D0 - 4h-1-benzopyran-4-on-derivater, deres fremstilling og anvendelse - Google Patents

4h-1-benzopyran-4-on-derivater, deres fremstilling og anvendelse

Info

Publication number
DK537289D0
DK537289D0 DK537289A DK537289A DK537289D0 DK 537289 D0 DK537289 D0 DK 537289D0 DK 537289 A DK537289 A DK 537289A DK 537289 A DK537289 A DK 537289A DK 537289 D0 DK537289 D0 DK 537289D0
Authority
DK
Denmark
Prior art keywords
derivatives
benzopyran
benzopyrane
preparation
compounds
Prior art date
Application number
DK537289A
Other languages
English (en)
Other versions
DK175228B1 (da
DK537289A (da
Inventor
Ramchandra Ganapati Naik
Bansi Lal
Richard Helmut Rupp
Hans Harald Sedlacek
Gerhard Dickneite
Joerg Czech
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK537289D0 publication Critical patent/DK537289D0/da
Publication of DK537289A publication Critical patent/DK537289A/da
Application granted granted Critical
Publication of DK175228B1 publication Critical patent/DK175228B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
DK198905372A 1988-10-28 1989-10-27 Anvendelse af 4H-1-benzopyran-4-on-derivater til fremstilling af et lægemiddel med en virkning mod tumorer DK175228B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3836676A DE3836676A1 (de) 1988-10-28 1988-10-28 Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel
DE3836676 1988-10-28

Publications (3)

Publication Number Publication Date
DK537289D0 true DK537289D0 (da) 1989-10-27
DK537289A DK537289A (da) 1990-04-29
DK175228B1 DK175228B1 (da) 2004-07-19

Family

ID=6366059

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198905372A DK175228B1 (da) 1988-10-28 1989-10-27 Anvendelse af 4H-1-benzopyran-4-on-derivater til fremstilling af et lægemiddel med en virkning mod tumorer

Country Status (14)

Country Link
EP (1) EP0366061B1 (da)
JP (1) JP2879910B2 (da)
KR (1) KR100194505B1 (da)
AT (1) ATE133170T1 (da)
AU (1) AU628409B2 (da)
CA (1) CA1336715C (da)
CY (1) CY2026A (da)
DE (2) DE3836676A1 (da)
DK (1) DK175228B1 (da)
ES (1) ES2084593T3 (da)
GR (1) GR3018739T3 (da)
HK (1) HK1006167A1 (da)
IE (1) IE69982B1 (da)
PT (1) PT92145B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
EP0508347A1 (en) * 1991-04-10 1992-10-14 Hoechst Aktiengesellschaft 5,7-Dihydroxy-2-methyl-8-[4-(3-hydroxy-1-(1-propyl)) piperidinyl]-4H-1-benzopyran-4-one, its preparation and its use
US5464871A (en) * 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
ATE316799T1 (de) * 1996-03-12 2006-02-15 Sanofi Aventis Deutschland Neuartige prodrugs für die therapie von tumoren und entzündlichen erkrankungen
DE19802449A1 (de) 1998-01-23 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin
DE19959546A1 (de) * 1999-12-09 2001-06-21 Rhone Poulenc Rorer Gmbh Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen
JP2003520798A (ja) * 2000-01-18 2003-07-08 アベンテイス・フアーマシユーチカルズ・インコーポレーテツド （−）−シス−２−（２−クロロフェニル）−５，７−ジヒドロキシ−８［４ｒ−（３ｓ−ヒドロキシ−１−メチル）ピペリジニル］−４ｈ−１−ベンゾピラン−４−オンのエタノール溶媒化合物
US6576647B2 (en) 2000-01-18 2003-06-10 Aventis Pharmaceuticals Inc. Pseudopolymorph of (—)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy -1-methyl)piperidinyl]-4H-1-benzopyran-4-one
US6821990B2 (en) 2000-01-18 2004-11-23 Aventis Pharma Deutschland Gmbh Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one
FR2805538B1 (fr) * 2000-02-29 2006-08-04 Hoechst Marion Roussel Inc Nouveaux derives de flavones, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
KR100392468B1 (ko) * 2000-09-18 2003-07-22 주식회사 엘지생명과학 사이클린 의존 키나아제의 저해제로서 유용한3-히드록시크로멘-4-온 유도체
DE10113513A1 (de) * 2001-03-20 2002-10-02 Medinnova Ges Med Innovationen Kombinationspräparat zur Prophylaxe und/oder Therapie von Nervenzell- und/oder Gliazellschäden durch ein neues Behandlungsverfahren
WO2003007931A1 (fr) * 2001-06-08 2003-01-30 Institute Of Medicinal Molecular Design. Inc. Derives de sulfonamide
MXPA04010240A (es) 2002-04-17 2005-06-08 Cytokinetics Inc Compuestos, composiciones y metodos.
TWI331034B (en) * 2002-07-08 2010-10-01 Piramal Life Sciences Ltd Inhibitors of cyclin-dependent kinases and their use
DE60326248D1 (de) 2002-07-17 2009-04-02 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen
EP2429292B1 (en) * 2009-05-08 2019-04-03 Georgia State University Research Foundation Compounds and compositions comprising cdk inhibitors and their use in the treatment of cancer
WO2011159726A2 (en) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
EP2593099A1 (en) 2010-07-12 2013-05-22 DKFZ Deutsches Krebsforschungszentrum Wogonin for the prevention and therapy of cardiac hypertrophy
WO2013113762A1 (en) 2012-01-31 2013-08-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting the risk of having a cutaneous melanoma in a subject
KR20180018507A (ko) 2015-04-20 2018-02-21 톨레로 파마수티컬스, 인크. 미토콘드리아 프로파일링에 의한 알보시딥에 대한 반응 예측
EP3298021B1 (en) 2015-05-18 2019-05-01 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs having increased bioavailability
KR20180034538A (ko) 2015-08-03 2018-04-04 톨레로 파마수티컬스, 인크. 암의 치료를 위한 병행 요법
WO2018094275A1 (en) 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
WO2019055579A1 (en) 2017-09-12 2019-03-21 Tolero Pharmaceuticals, Inc. TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR
EP3890749A4 (en) 2018-12-04 2022-08-03 Sumitomo Dainippon Pharma Oncology, Inc. CDK9 INHIBITORS AND POLYMORPHS THEREOF FOR USE AS CANCER TREATMENT AGENT
WO2020191326A1 (en) 2019-03-20 2020-09-24 Sumitomo Dainippon Pharma Oncology, Inc. Treatment of acute myeloid leukemia (aml) with venetoclax failure
CN110028475B (zh) * 2019-05-13 2022-07-01 中国药科大学 基于苯并吡喃结构的新型cdk9抑制剂、其制备方法及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3329186A1 (de) * 1983-08-12 1985-02-21 Hoechst Ag, 6230 Frankfurt Chromonalkaloid, verfahren zu seiner isolierung aus dysoxylum binectariferum, und seine verwendung als arzneimittel
IN164232B (da) * 1986-04-11 1989-02-04 Hoechst India

Also Published As

Publication number Publication date
AU628409B2 (en) 1992-09-17
JP2879910B2 (ja) 1999-04-05
KR100194505B1 (ko) 1999-06-15
DE3836676A1 (de) 1990-05-03
DK175228B1 (da) 2004-07-19
IE69982B1 (en) 1996-10-16
GR3018739T3 (en) 1996-04-30
EP0366061B1 (de) 1996-01-17
DE58909573D1 (de) 1996-02-29
ES2084593T3 (es) 1996-05-16
DK537289A (da) 1990-04-29
PT92145A (pt) 1990-04-30
CA1336715C (en) 1995-08-15
KR900006325A (ko) 1990-05-07
CY2026A (en) 1998-02-20
IE893481L (en) 1990-04-28
PT92145B (pt) 1995-06-30
ATE133170T1 (de) 1996-02-15
JPH02178225A (ja) 1990-07-11
HK1006167A1 (en) 1999-02-12
EP0366061A1 (de) 1990-05-02
AU4384189A (en) 1990-05-03

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